1 As filed with the Securities and Exchange Commission on September 1, 1999 Registration No. 333-______ ================================================================================ SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 MICROCIDE PHARMACEUTICALS, INC. (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER) DELAWARE 94-3186021 (STATE OF INCORPORATION) (I.R.S. EMPLOYER IDENTIFICATION NO.) 850 MAUDE AVENUE MOUNTAIN VIEW, CALIFORNIA 94043 (ADDRESS, INCLUDING ZIP CODE, OF REGISTRANT'S PRINCIPAL EXECUTIVE OFFICES) 1993 AMENDED INCENTIVE STOCK PLAN 1996 DIRECTOR OPTION PLAN 1996 EMPLOYEE STOCK PURCHASE PLAN (FULL TITLE OF THE PLAN) JAMES E. RURKA PRESIDENT, CHIEF EXECUTIVE OFFICER, ACTING CHIEF FINANCIAL OFFICER AND DIRECTOR MICROCIDE PHARMACEUTICALS, INC. 850 MAUDE AVENUE MOUNTAIN VIEW, CALIFORNIA 94043 (650) 428-1550 (NAME, ADDRESS, AND TELEPHONE NUMBER, INCLUDING AREA CODE, OF AGENT FOR SERVICE) Copies to: ANTONE F. JOHNSON WILSON SONSINI GOODRICH & ROSATI PROFESSIONAL CORPORATION 650 PAGE MILL ROAD PALO ALTO, CA 94306 (650) 493-9300 ======================================================================================================= CALCULATION OF REGISTRATION FEE - ------------------------------------------------------------------------------------------------------- PROPOSED PROPOSED TITLE OF EACH CLASS MAXIMUM MAXIMUM AMOUNT OF TITLE OF EACH CLASS AMOUNT OFFERING AGGREGATE REGISTRATION OF SECURITIES TO TO BE PRICE OFFERING FEE BE REGISTERED REGISTERED(1) PER SHARE(2) PRICE - ------------------------------------------------------------------------------------------------------- Common Stock $0.001 par value............... 470,000 $4.96875 $2,335,313 $649.22 ======================================================================================================= (1) The shares covered by this Registration Statement represent 470,000 shares of Common Stock which have become available for issuance under the Registrant's 1993 Amended Incentive Stock Plan, 1996 Director Option Plan and 1996 Employee Stock Purchase Plan as a result of an amendment approved by the stockholders at the Registrant's Annual Meeting held on June 24, 1999 increasing the number of shares authorized for issuance thereunder from 2,480,000 to 2,950,000. (2) Estimated in accordance with Rule 457(c) solely for the purpose of calculating the registration fee based upon the average of the high and low prices of the Common Stock as reported on the Nasdaq National Market System on August 31, 1999. 2 STATEMENT UNDER GENERAL INSTRUCTION E REGISTRATION OF ADDITIONAL SECURITIES Unless as noted herein, the contents of the Registrant's Form S-8 Registration Statements (File Nos. 333-11759, 333-32785 and 333-58999) are incorporated by reference into this Registration Statement. PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT ITEM 8. EXHIBITS. Exhibit Number Document ------- -------- 5.1 Opinion of Wilson Sonsini Goodrich & Rosati, a Professional Corporation. 23.1 Consent of Ernst & Young LLP, Independent Auditors 23.2 Consent of Counsel (contained in Exhibit 5.1). 24.1 Power of Attorney (see page II-3). 3 SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the Registrant, Microcide Pharmaceuticals, Inc., certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Mountain View, State of California, on this 1st day of September, 1999. MICROCIDE PHARMACEUTICALS, INC. By: /s/ James E. Rurka ----------------------------------------- James E. Rurka President, Chief Executive Officer and Acting Chief Financial Officer II-2 4 POWER OF ATTORNEY KNOW ALL PERSONS BY THESE PRESENTS, that each such person whose signature appears below constitutes and appoints James E. Rurka his attorney-in-fact, with the power of substitution, for him in any and all capacities, to sign any amendments to this Registration Statement on Form S-8 (including post-effective amendments), and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, hereby ratifying and confirming all that said attorney-in-fact, or his substitute, may do or cause to be done by virtue hereof. PURSUANT TO THE REQUIREMENTS OF THE SECURITIES ACT OF 1933, THIS REGISTRATION STATEMENT HAS BEEN SIGNED BY THE FOLLOWING PERSONS IN THE CAPACITIES AND ON THE DATES INDICATED. SIGNATURE TITLE DATE --------- ----- ---- /s/ James E. Rurka President, Chief Executive Officer, September 1, 1999 - --------------------------------------------- Acting Chief Financial Officer and James E. Rurka Director (Principal Executive Officer and Principal Accounting and Financial Officer) /s/ John P. Walker Chairman of the Board of Directors September 1, 1999 - --------------------------------------------- John P. Walker /s/ Keith A. Bostian, Ph.D. Director September 1, 1999 - --------------------------------------------- Keith A. Bostian, Ph.D. /s/ Daniel L. Kisner, M.D. Director September 1, 1999 - --------------------------------------------- Daniel L. Kisner, M.D. /s/ Hugh Y. Rienhoff, Jr., M.D. Director September 1, 1999 - --------------------------------------------- Hugh Y. Rienhoff, Jr., M.D. /s/ David Schnell, M.D. Director September 1, 1999 - --------------------------------------------- David Schnell, M.D. /s/ Mark B. Skaletsky Director September 1, 1999 - --------------------------------------------- Mark B. Skaletsky II-3 5 INDEX TO EXHIBITS EXHIBIT NUMBER EXHIBIT - ------- ------- 5.1 Opinion of Wilson Sonsini Goodrich & Rosati, a Professional Corporation 23.1 Consent of Ernst & Young LLP, Independent Auditors 23.2 Consent of Counsel (included in Exhibit 5.1) 24.1 Power of Attorney (see page II-3)