AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON FEBRUARY 10, 2005

                                                    1933 ACT FILE NO. 333-______
                                                   1940 ACT FILE NO. 811 - 03763

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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                             -----------------------

                            REGISTRATION STATEMENT ON
                                    FORM S-6

                            ------------------------

                FOR REGISTRATION UNDER THE SECURITIES ACT OF 1933
                     OF SECURITIES OF UNIT INVESTMENT TRUSTS
                            REGISTERED ON FORM N-8B-2

     A.   EXACT NAME OF TRUST: CLAYMORE SECURITIES DEFINED PORTFOLIOS,
                               SERIES 216

     B.   NAME OF DEPOSITOR: CLAYMORE SECURITIES, INC.

     C.   COMPLETE ADDRESS OF DEPOSITOR'S PRINCIPAL EXECUTIVE OFFICES:

                            Claymore Securities, Inc.
                            2455 Corporate West Drive
                              Lisle, Illinois 60532

     D.   NAME AND COMPLETE ADDRESS OF AGENT FOR SERVICE:

  Copies to:

      NICHOLAS DALMASO, ESQ.                   ERIC F. FESS
      Senior Managing Director and
      General Counsel
      Claymore Securities, Inc.             Chapman and Cutler LLP
      2455 Corporate West Drive             111 West Monroe Street
      Lisle, Illinois  60532                Chicago, Illinois 60603
      (630) 505-3736                        (312) 845-3000

It is proposed that this filing will become effective (check appropriate box)

/ /      immediately upon filing pursuant to paragraph (b)

/ /      on (date) pursuant to paragraph (b)

/ /      60 days after filing pursuant to paragraph (a)

/ /      on (date) pursuant to paragraph (a) of rule 485 or 486

/ /      This post-effective amendment designates a new effective date for a
         previously filed post-effective amendment.

     E.   TITLE OF SECURITIES BEING REGISTERED: Units of fractional undivided
          beneficial interest.

     F.   APPROXIMATE DATE OF PROPOSED SALE TO PUBLIC: As soon as practicable
          after the effective date of the Registration Statement.

/ /      Check box if it is proposed that this filing will become effective on
         (date) at (time) pursuant to Rule 487.

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The registration hereby amends this Registration Statement on such date or dates
as may be necessary to delay its effective date until the registrant shall file
a further amendment which specifically states that this Registration Statement
shall thereafter become effective in accordance with Section 8(a) of the
Securities Act of 1933 or until the Registration Statement shall become
effective on such date as the Commission, acting pursuant to said Section 8(a)
may determine.




                 PRELIMINARY PROSPECTUS DATED FEBRUARY 10, 2005

                              SUBJECT TO COMPLETION

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Claymore Securities Defined Portfolios, Series 216

Herzfeld/Claymore Closed-End Opportunity Portfolio, Series 2

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         Final prospectuses for prior Series of the Claymore Securities Defined
Portfolios are hereby incorporated by reference and used as part of a
preliminary prospectus for Claymore Securities Defined Portfolios, Series 216
(the "Trust"). The final prospectus for the Trust is expected to be
substantially similar to the previous prospectuses. However, specific
information with respect to the Trust, including pricing, the size and
composition of the Trust's portfolio, the number of units of the Trust, dates
and summary information regarding the characteristics of securities to be
deposited in the Trust is not now available and will be different from that
shown since Trust has a unique portfolio. Accordingly, the information contained
herein with regard to the previous Trust should be considered as being included
for informational purposes only.

         The Securities and Exchange Commission has not approved or disapproved
these securities or passed upon the adequacy of this Prospectus. Any
representation to the contrary is a criminal offense.

         The information in this Prospectus is not complete and may be changed.
We may not sell these securities until the registration statement filed with the
Securities and Exchange Commission is effective. This Prospectus is not an offer
to sell the securities and it is not soliciting an offer to buy these securities
in any state where the offer or sale is not permitted.

Incorporated herein by reference is the prospectus from Claymore Securities
Defined Portfolios, Series 193 (Registration No. 333-120176) dated November 17,
2004. The final prospectus for Claymore Securities Defined Portfolios, Series
193, was filed pursuant to Rule 497 under the Securities Act on November 17,
2004.



                       CONTENTS OF REGISTRATION STATEMENT

          A.    Bonding Arrangements of Depositor:

         The Depositor has obtained the following Securities Dealer Blanket Bond
for its officers, directors and employees:

                    INSURER/POLICY NO.                          AMOUNT

               National Union Fire Insurance
            Company of Pittsburgh, Pennsylvania                $250,000
                         959-9000

         This Registration Statement comprises the following papers and
documents.

                  The Facing Sheet
                  The Prospectus
                  The Signatures
                  Consents of Counsel

         The following exhibits:

     1.1  Reference Trust Agreement (to be supplied by amendment).

   1.1.1  Standard Terms and Conditions of Trust (Reference is made to Exhibit
          1.1.1 to Amendment No.1 to the Registration Statement on Form S-6 for
          Claymore Securities Defined Portfolios, Series 116 (File No. 333-72828
          filed on December 18, 2001).

     2.1  Code of Ethics (Reference is made to Exhibit 2.1 to the Registration
          Statement on Form S-6 for Claymore Securities Deferred Portfolios,
          Series 213 (File No. 333-122184 filed on February 9, 2005).

     3.1  Opinion of counsel as to legality of the securities being registered
          including a consent to the use of its name in the Registration
          Statement (to be supplied by amendment).

     3.2  Opinion of counsel as to Federal Income tax status of the securities
          being registered including a consent to the use of its name in the
          Registration Statement (to be supplied by amendment).

     3.3  Opinion of counsel as to New York Income tax status of the securities
          being registered including a consent to the use of its name in the
          Registration Statement (to be supplied by amendment).

     3.4  Opinion of counsel as to the Trustee and the Trust (s) including a
          consent to the use of its name in the Registration Statement (to be
          supplied by amendment).

     4.1  Consent of Independent Registered Public Accounting Firm (to be
          supplied by amendment).





                                   SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, the
Registrant, Claymore Securities Defined Portfolios, Series 216 has duly caused
this to the Registration Statement to be signed on its behalf by the undersigned
thereunto duly authorized, in the City of Lisle, and State of Illinois, on the
10th day of February, 2005.

                             CLAYMORE SECURITIES DEFINED PORTFOLIOS, SERIES 216,
                                                                      Registrant

                                        By: CLAYMORE SECURITIES, INC., Depositor

                                                        By: /s/ Nicholas Dalmaso
                                                             -------------------
                                                                Nicholas Dalmaso

         Pursuant to the requirements of the Securities Act of 1933, this
amended Registration Statement has been signed below on February 10, 2005 by the
following persons, who constitute a majority of the Board of Directors of
Claymore Securities, Inc.




     SIGNATURE*                           TITLE**                               DATE
                                                                      

                                                                            )    By:    /s/ Nicholas Dalmaso
                                                                                        --------------------
                                                                            )                  Nicholas Dalmaso
                                                                            )                  Attorney-in-Fact*
                                                                            )
DAVID HOOTEN*                             Chairman of the Board of          )           February 10, 2005
                                          Directors                         )
                                                                            )

/S/ CHARLES MILLINGTON                    Chief Financial Officer                       February 10, 2005
- ----------------------
    CHARLES MILLINGTON

/S/ NICHOLAS DALMASO                      Executive Vice President,                     February 10, 2005
- --------------------
    NICHOLAS DALMASO                      Secretary, Treasurer and
                                          Director





     *    An executed copy of the related power of attorney was filed as Exhibit
          6.0 to Registration Statement No. 333-98345 on August 22, 2002.

     **   The titles of the persons named herein represent their capacity in and
          relationship to Claymore Securities, Inc., the Depositor.



            CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

         The consent of Grant Thornton LLP to the use of its report and to the
reference to such firm in the Prospectus included in the Registration Statement
will be filed as Exhibit 4.1 to the Registration Statement.

                        CONSENT OF CHAPMAN AND CUTLER LLP

         The consent of Chapman and Cutler LLP to the use of its name in the
Prospectus included in the Registration Statement will be contained in its
opinions to be filed as Exhibits 3.1 and 3.2 to the Registration Statement.

                      CONSENT OF EMMET, MARVIN & MARTIN LLP

         The consent of Emmet, Marvin & Martin LLP to the use of its name in the
Prospectus included in the Registration Statement will be contained in its
opinions to be filed as Exhibits 3.3 and 3.4 to the Registration Statement.

                                   MEMORANDUM

             Re: Claymore Securities Defined Portfolios, Series 216

         The list of securities comprising the trust of the fund, the
evaluation, record and distribution dates and other changes pertaining
specifically to the new series, such as size and number of units of the trust in
the fund and the statement of financial condition of the new fund will be filed
by amendment.

                                    1940 ACT

                              FORMS N-8A AND N-8B-2

         Form N-8A and Form N-8B-2 were filed in respect of Claymore Securities
Defined Portfolios, Series 116 (and subsequent series) (File No. 811-03763).

                                    1933 ACT

                                  THE INDENTURE

         The form of the proposed Standard Terms and Conditions of Trust is
expected to be in all respects consistent with the form of the Standard Terms
and Conditions of Trust dated December 18, 2001 relative to Claymore Securities
Defined Portfolios, Series 116.

                                                          CHAPMAN AND CUTLER LLP

Chicago, Illinois
February 10, 2005