AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON JUNE 18, 2007

                                                 1933 ACT FILE NO. 333-_________
                                                   1940 ACT FILE NO. 811 - 03763

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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                             -----------------------

                            REGISTRATION STATEMENT ON
                                    FORM S-6

                            ------------------------

                FOR REGISTRATION UNDER THE SECURITIES ACT OF 1933
                     OF SECURITIES OF UNIT INVESTMENT TRUSTS
                            REGISTERED ON FORM N-8B-2

     A.   EXACT NAME OF TRUST: CLAYMORE SECURITIES DEFINED PORTFOLIOS,
          SERIES 406

     B.   NAME OF DEPOSITOR: CLAYMORE SECURITIES, INC.

     C.   COMPLETE ADDRESS OF DEPOSITOR'S PRINCIPAL EXECUTIVE OFFICES:

                            Claymore Securities, Inc.
                            2455 Corporate West Drive
                              Lisle, Illinois 60532

     D.   NAME AND COMPLETE ADDRESS OF AGENT FOR SERVICE:

  Copies to:

      NICHOLAS DALMASO, ESQ.                   ERIC F. FESS
      Senior Managing Director and
      General Counsel
      Claymore Securities, Inc.             Chapman and Cutler LLP
      2455 Corporate West Drive             111 West Monroe Street
      Lisle, Illinois  60532                Chicago, Illinois 60603
      (630) 505-3736                        (312) 845-3000


It is proposed that this filing will become effective (check appropriate box)

/ /      immediately upon filing pursuant to paragraph (b)

/ /      on (date) pursuant to paragraph (b)

/ /      60 days after filing pursuant to paragraph (a)

/ /      on (date) pursuant to paragraph (a) of rule 485 or 486

/ /      This post-effective amendment designates a new effective date for a
         previously filed post-effective amendment.

     E.   TITLE OF SECURITIES BEING REGISTERED: Units of fractional undivided
          beneficial interest.

     F.   APPROXIMATE DATE OF PROPOSED SALE TO PUBLIC: As soon as practicable
          after the effective date of the Registration Statement.

/ /      Check box if it is proposed that this filing will become effective on
         (date) at (time) pursuant to Rule 487.

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The registration hereby amends this Registration Statement on such date or dates
as may be necessary to delay its effective date until the registrant shall file
a further amendment which specifically states that this Registration Statement
shall thereafter become effective in accordance with Section 8(a) of the
Securities Act of 1933 or until the Registration Statement shall become
effective on such date as the Commission, acting pursuant to said Section 8(a)
may determine.


                   PRELIMINARY PROSPECTUS DATED JUNE 18, 2007

               CLAYMORE SECURITIES DEFINED PORTFOLIOS, SERIES 406

                      Strategic Income Portfolio, Series 14
                         (the "Strategic Income Trust")

                    Strategic Income Portfolio Plus, Series 5
                       (the "Strategic Income Plus Trust")

               Closed-End New Jersey Municipal Portfolio, Series 3
                  (the "Closed-End New Jersey Municipal Trust")


                     10,000 Units (A Unit Investment Trust)


         The above-referenced series is comprised of the Strategic Income
Portfolio, Series 14, Strategic Income Portfolio Plus, Series 5 and Closed-End
New Jersey Municipal Portfolio, Series 3 (each, a "trust" and together, the
"trusts").

         The attached final prospectuses for the prior series of each respective
trust are hereby used as the preliminary prospectuses for the above-referenced
Series. The narrative information and structure of the attached final
prospectuses will be substantially similar to that of the final prospectus for
each trust in this Series. Information with respect to pricing, the number of
units, dates and summary information regarding the characteristics of securities
to be deposited in this Series is not available as of this date and will be
different because each series has a unique portfolio. Accordingly, the
information contained herein with regard to the previous series of each trust
should be considered as being included for informational purposes only. Ratings
of the securities in this Series are expected to be comparable to those of the
securities deposited in the previous series of each trust.

         The registration statement relating to the units of this Series is not
complete, may be changed and is not yet effective. Information contained herein
is subject to completion or amendment. The units of this Series may neither be
sold nor may an offer to buy such units be accepted prior to the time the
registration statement becomes effective. This prospectus shall neither
constitute an offer to sell nor be considered a solicitation of an offer to buy
the units. There shall be no sale of the units in any state in which such offer,
solicitation or sale would be unlawful prior to registration or qualification
under the securities laws of any such state.

         For purposes of the Strategic Income Trust, incorporated herein by
reference are portions of the final prospectus for Series 399 (Registration No.
333-142965) as filed on June 13, 2007, which portions shall be used as the
preliminary prospectus for such Strategic Income Trust. For purposes of the
Strategic Income Plus Trust, incorporated herein by reference are portions of
the final prospectus for Series 376 (Registration No. 333-141183) as filed on
April 18, 2007, which portions shall be used as the preliminary prospectus for
such Strategic Income Plus Trust. For purposes of the Closed-End New Jersey
Municipal Trust, incorporated herein by reference are portions of the final
prospectus for Series 362 (Registration No. 333-139909) as filed on January 18,
2007, which portions shall be used as the preliminary prospectus for such
Closed-End New Jersey Municipal Trust.

                       CONTENTS OF REGISTRATION STATEMENT

          A.    Bonding Arrangements of Depositor:

   The Depositor has obtained the following Securities Dealer Blanket Bond for
its officers, directors and employees:

                    INSURER/POLICY NO.                     AMOUNT

               National Union Fire Insurance
            Company of Pittsburgh, Pennsylvania           $250,000
                         959-9000

   This Registration Statement comprises the following papers and documents.

                  The Facing Sheet
                  The Prospectus
                  The Signatures
                  Consents of Counsel

   The following exhibits:

     1.1  Reference Trust Agreement (to be supplied by amendment).

   1.1.1  Standard Terms and Conditions of Trust (Reference is made to Exhibit
          1.1.1 to Amendment No. 1 to the Registration Statement on Form S-6 for
          Claymore Securities Defined Portfolios, Series 116 (File No. 333-72828
          filed on December 18, 2001).

     2.1  Code of Ethics (Reference is made to Exhibit 2.1 to the Registration
          Statement on Form S-6 for Claymore Securities Deferred Portfolios,
          Series 213 (File No. 333-122184 filed on February 9, 2005).

     3.1  Opinion of counsel as to legality of the securities being registered
          including a consent to the use of its name in the Registration
          Statement (to be supplied by amendment).

     3.2  Opinion of counsel as to Federal Income tax status of the securities
          being registered including a consent to the use of its name in the
          Registration Statement (to be supplied by amendment).

     3.3  Opinion of counsel as to New York Income tax status of the securities
          being registered including a consent to the use of its name in the
          Registration Statement (to be supplied by amendment).

     3.4  Opinion of counsel as to the Trustee and the Trust (s) including a
          consent to the use of its name in the Registration Statement (to be
          supplied by amendment).

     4.1  Consent of Independent Registered Public Accounting Firm (to be
          supplied by amendment).


                                   SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, the
Registrant, Claymore Securities Defined Portfolios, Series 406 has duly caused
this Registration Statement to be signed on its behalf by the undersigned
thereunto duly authorized, in the City of Lisle, and State of Illinois, on the
18th day of June, 2007.

                              CLAYMORE SECURITIES DEFINED PORTFOLIOS, SERIES 406
                                                                      Registrant

                                                   By: CLAYMORE SECURITIES, INC.
                                                                       Depositor

                                                        By: /s/ Nicholas Dalmaso
                                                      --------------------------
                                                                Nicholas Dalmaso

         Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed below on June 18, 2007 by the following
persons, who constitute a majority of the Board of Directors of Claymore
Securities, Inc.




     SIGNATURE*                           TITLE**                               DATE
                                                                                  
                                                                            )    By:    /s/ Nicholas Dalmaso
                                                                                        --------------------
                                                                            )               Nicholas Dalmaso
                                                                            )              Attorney-in-Fact*
                                                                            )
DAVID HOOTEN*                             Chief Executive Officer and       )           June 18, 2007
                                          Chairman of the Board of          )
                                          Directors                         )

MICHAEL RIGERT*                           President and Director            )           June 18, 2007

ANTHONY DILEONARDI*                       Senior Managing Director          )           June 18, 2007

BRUCE ALBELDA*                            Chief Financial Officer and                   June 18, 2007
                                          Director

/s/ Nicholas Dalmaso                      General Counsel, Secretary and                June 18, 2007
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    NICHOLAS DALMASO                      Senior Managing Director



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     *    An executed copy of the related power of attorney was filed as Exhibit
          6.0 to Registration Statement No. 333-142967 on May 15, 2007.

     **   The titles of the persons named herein represent their capacity in and
          relationship to Claymore Securities, Inc., the Depositor.



            CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

         The consent of Grant Thornton LLP to the use of its report and to the
reference to such firm in the Prospectus included in the Registration Statement
will be filed as Exhibit 4.1 to the Registration Statement.

                        CONSENT OF CHAPMAN AND CUTLER LLP

         The consent of Chapman and Cutler LLP to the use of its name in the
Prospectus included in the Registration Statement will be contained in its
opinions to be filed as Exhibits 3.1 and 3.2 to the Registration Statement.

                         CONSENT OF DORSEY & WHITNEY LLP

         The consent of Dorsey & Whitney LLP to the use of its name in the
Prospectus included in the Registration Statement will be contained in its
opinions to be filed as Exhibits 3.3 and 3.4 to the Registration Statement.

                                   MEMORANDUM

             Re: Claymore Securities Defined Portfolios, Series 406

         The list of securities comprising the trust of the fund, the
evaluation, record and distribution dates and other changes pertaining
specifically to the new series, such as size and number of units of the trust in
the fund and the statement of financial condition of the new fund will be filed
by amendment.

                                    1940 ACT

                              FORMS N-8A AND N-8B-2

         Form N-8A and Form N-8B-2 were filed in respect of Claymore Securities
Defined Portfolios, Series 116 (and subsequent series) (File No. 811-03763).

                                    1933 ACT

                                  THE INDENTURE

         The form of the proposed Standard Terms and Conditions of Trust is
expected to be in all respects consistent with the form of the Standard Terms
and Conditions of Trust dated December 18, 2001 relative to Claymore Securities
Defined Portfolios, Series 116.

                                                          CHAPMAN AND CUTLER LLP

Chicago, Illinois
June 18, 2007