EXHIBIT 99.2


               CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350,
      AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

I, Bert W. Hogue, Chief Financial Officer of Epoch Biosciences, Inc. (the
"Company"), certify pursuant to Section 906 of the Sarbanes-Oxley Act of 2002,
18 U.S.C. Section 1350, that:

(3)  the Quarterly Report on Form 10-Q of the Company for the quarterly period
     ended June 30, 2002 (the "Report") fully complies with the requirements of
     Section 13(a) or 15(d) of the Securities Exchange Act of 1934 (15 U.S.C.
     78m or 780(d)); and

(4)  the information contained in the Report fairly presents, in all material
     respects, the financial condition and results of operations of the Company.

Date: August 14, 2002                  By: /s/ Bert W. Hogue
                                           -------------------------------------
                                           Bert W. Hogue
                                           Vice President and Chief Financial
                                              Officer