EXHIBIT 3.1

               CERTIFICATE OF DESIGNATIONS, RIGHTS AND PREFERENCES
                                     OF THE
            SERIES D 8% CUMULATIVE CONVERTIBLE VOTING PREFERRED STOCK
                                       OF
                         SPECTRUM PHARMACEUTICALS, INC.

    (Pursuant to Section 151 of the General Corporation Law of the State of
                                   Delaware)

         The undersigned, being the Chief Executive Officer of Spectrum
Pharmaceuticals, Inc., a Delaware corporation (the "Corporation"), does hereby
certify, that the following resolution has been duly adopted by the board of
directors of the Corporation:

                  RESOLVED, that pursuant to the authority expressly granted to
         and vested in the board of directors of the Corporation (the "Board")
         pursuant to the General Corporation Law of the State of Delaware, as
         amended, and by the provisions of the Corporation's Certificate of
         Incorporation, as amended to date (the "Certificate of Incorporation"),
         the Board hereby creates a series of preferred stock of the
         Corporation, par value $0.001 per share, each share having a stated
         value (the "Stated Value") of $10,000.00, such series consisting of 444
         shares (which shall not be subject to increase without the consent of
         the Holders (as defined below) of a majority of the outstanding
         Preferred Stock, which majority shall include each Holder who acquired
         in the aggregate more than 100 shares of Preferred Stock so long as
         such Holder continues to hold more than 100 shares of Preferred Stock,
         which such majority is hereinafter referred to as a "Special
         Majority"), which shall be designated as the "Series D 8% Cumulative
         Convertible Voting Preferred Stock" (hereinafter, the "Convertible
         Preferred Stock" or the "Preferred Stock"), which series shall have the
         following powers, designations, preferences and relative participating,
         optional, voting or other rights, and the following qualifications,
         limitations or restrictions:

         1.       Dividends. The holders of the Convertible Preferred Stock
(each, a "Holder" and collectively, the "Holders") shall be entitled to receive,
when, if and as declared by the Corporation's Board of Directors, out of funds
legally available therefor, cumulative dividends payable as set forth in this
Section 1.

                  a.       Dividends on the Convertible Preferred Stock shall
accrue and shall be cumulative from the date of issuance of the shares of
Convertible Preferred Stock (the "Date of Original Issue"), whether or not
earned or declared by the Board of Directors of the Corporation. Until paid, the
right to receive dividends on the Convertible Preferred Stock shall accumulate,
and shall be payable in cash or shares of common stock, par value $0.001 per
share, of the Corporation, or stock of any other class into which such shares
may hereafter have been reclassified or changed (the "Common Stock"), in
arrears, on March 31, June 30, September 30 and December 31 of each year (a
"Dividend Payment Date"), commencing on June 30, 2003 (the "Initial Dividend
Payment Date") except that if such Dividend Payment Date is not a business day,
then the Dividend Payment Date will be the immediately preceding business day.
The decision whether to pay dividends

                                        1



hereunder in Common Stock or cash shall be at the discretion of the Corporation;
provided, however, that if the Corporation elects to pay a dividend in Common
Stock and the receipt thereof by a Holder would be in excess of the Beneficial
Ownership Cap (as defined in Section 5(g)), then such dividend shall cumulate
for up to 10 years (the "Final Distribution Date") and shall be paid, in whole
or in part, on the first date when such payment would not be in excess of the
Beneficial Ownership Cap, and the unpaid portion of any such dividend shall
continue to cumulate and be paid thereafter on the next date when such payment
would not be in excess of the Beneficial Ownership Cap. Any dividends not paid
pursuant to the preceding sentence shall be paid on the Final Distribution Date.
It shall be the responsibility of each Holder to determine such Holder's
compliance with the Beneficial Ownership Cap and to advise the Corporation of
whether or not, and how much, if any, of the dividends payable in Common Stock
may then be paid to such Holder, and the Corporation, when advised in writing to
make such dividend payment, shall do so promptly. Subject to the foregoing, each
such dividend declared by the Board of Directors on the Convertible Preferred
Stock shall be paid to the Holders of record as they appear on the stock
register of the Corporation on the Record Date (defined below). Dividends in
arrears for any past dividend period may be declared by the Board of Directors
of the Corporation and, subject to the provisions with respect to the Beneficial
Ownership Cap, paid on shares of the Convertible Preferred Stock on any date
fixed by the Board of Directors of the Corporation, whether or not a regular
Dividend Payment Date, to Holders of record as they appear on the Corporation's
stock register on the record date. The record date (the "Record Date"), shall be
fixed in advance by the Board of Directors, or to the extent not fixed, shall be
the business day immediately preceding the date such dividend is paid. Any
dividend payment made on shares of the Convertible Preferred Stock shall first
be credited against the dividends accumulated with respect to the earliest
dividend period for which dividends have not been paid. Dividends not paid on a
Dividend Payment Date shall bear interest, whether or not such dividend has been
declared, at the Dividend Rate (or such lesser rate equal to the highest rate
permitted by applicable law) until paid.

                  b.       The dividend rate (the "Dividend Rate") on each share
of Convertible Preferred Stock shall be 8% per share per annum compounded
quarterly on the Stated Value of each such share for the period from the Date of
Original Issue until the Initial Dividend Payment Date and, for each dividend
period thereafter, which shall commence on the last day of the preceding
dividend period and shall end on the next Dividend Payment Date, shall be at the
Dividend Rate on such Stated Value. The amount of dividends per share of the
Convertible Preferred Stock payable for each dividend period or part thereof
(the "Dividend Value") shall be computed by multiplying the Dividend Rate for
such dividend period by a fraction the numerator of which shall be the number of
days in the dividend period or part thereof (calculated by counting the first
day thereof but excluding the last day thereof) on which such share was
outstanding and the denominator of which shall be 360 and multiplying the result
by the Stated Value. If a dividend is to be paid in kind in Common Stock, the
Common Stock shall be valued at the Current Market Price (as hereinafter
defined) as of the Record Date for such payment date. In furtherance thereof,
the Corporation shall reserve out of the authorized but unissued shares of
Common Stock, solely for issuance in respect of the payment of dividends as
herein described, a sufficient number of shares of Common Stock to pay such
dividends, when, if and as declared by the Board of Directors.

                                        2



                  For purposes hereof, "Current Market Price" means, in respect
of any share of Common Stock on any date herein specified:

                                    (i)      if there shall not then be a public
         market for the Common Stock, the Appraised Value (as hereinafter
         defined) per share of Common Stock at such date, or

                                    (ii)     if there shall then be a public
         market for the Common Stock, the average of the daily market prices for
         the 20 consecutive trading days immediately before such date. The daily
         market price for each such trading day shall be (I) the last sale price
         on such day on the principal stock exchange (including NASDAQ) on which
         such Common Stock is then listed or admitted to trading, or quoted, as
         applicable, (II) if no sale takes place on such day on any such
         exchange, the average of the last reported closing bid and asked prices
         on such day as officially quoted on any such exchange (including
         NASDAQ), (III) if the Common Stock is not then listed or admitted to
         trading on any stock exchange, the average of the last reported closing
         bid and asked prices on such day in the over-the-counter market, as
         furnished by the National Association of Securities Dealers Automatic
         Quotation System or the National Quotation Bureau, Inc., (IV) if
         neither such corporation at the time is engaged in the business of
         reporting such prices, as furnished by any similar firm then engaged in
         such business, or (V) if there is no such firm, as furnished by any
         member of the NASD selected mutually by the Holders of a Special
         Majority of the Preferred Stock and the Corporation or, if they cannot
         agree upon such selection, as selected by two such members of the NASD,
         one of which shall be selected by a Special Majority of the Holders and
         one of which shall be selected by the Corporation.

                           For purposes hereof, "Appraised Value" means, in
         respect of any share of Common Stock on any date herein specified, the
         fair saleable value of such share of Common Stock (determined without
         giving effect to the discount for (i) a minority interest or (ii) any
         lack of liquidity of the Common Stock or to the fact that the
         Corporation may have no class of equity registered under the Securities
         Exchange Act of 1934, as amended (the "Exchange Act")) as of the last
         day of the most recent fiscal month end prior to such date specified,
         based on the value of the Corporation, as determined by a nationally
         recognized investment banking firm selected by the Corporation's Board
         of Directors and having no prior relationship with the Corporation, and
         reasonably acceptable to a Special Majority of the Holders.

                  c.       Except as hereinafter provided, no dividends shall be
declared or paid or set apart for payment on the shares of Common Stock or any
other class or series of capital stock of the Corporation for any dividend
period unless full cumulative dividends have been or contemporaneously are
declared and paid on the Convertible Preferred Stock through the most recent
Dividend Payment Date. If full cumulative dividends have not been paid on shares
of the Convertible Preferred Stock, all dividends declared on shares of the
Convertible Preferred Stock shall be paid pro rata to the Holders in proportion
to the full accrued but unpaid dividends attributable to each such Holder's
Preferred Stock. No dividend on any other class or series of capital stock of
the Corporation shall be paid unless, at the time of such payment, all accrued

                                        3



dividends on the Series D Preferred Stock have been paid, and the Corporation
has on hand cash and other liquid assets sufficient to pay in full, in cash, the
Liquidation Preference that would be payable to the holders of the Series D
Preferred Stock under Section 3(a) below, as if such Liquidation Preference were
then payable.

                  d.       So long as any shares of the Convertible Preferred
Stock are outstanding, the Corporation may not, without the prior consent of the
Holders of a Special Majority of the outstanding Preferred Stock, purchase or
otherwise acquire for any consideration (except through a redemption of all the
outstanding shares of the Convertible Preferred Stock) any shares of the Common
Stock or any other outstanding shares of the capital stock of the Corporation.

         2.       Voting Rights. Except as otherwise provided herein or by law,
the Holders shall have full voting rights and powers, subject to the Beneficial
Ownership Cap (as defined in Section 5(g)), equal to the voting rights and
powers of holders of Common Stock and shall be entitled to notice of any
stockholders meeting in accordance with the Bylaws of the Corporation, and shall
be entitled to vote, with respect to any question upon which holders of Common
Stock have the right to vote, including, without limitation, the right to vote
for the election of directors, voting together with the holders of Common Stock
as one class. Each Holder shall be entitled to the number of votes equal to the
number of shares of Common Stock into which such shares of Convertible Preferred
Stock could be converted on the record date for the taking of a vote at the then
current Conversion Value (as hereinafter defined), subject to the Beneficial
Ownership Cap, or, if no record date is established, at the day prior to the
date such vote is taken or any written consent of shareholders is first
executed. Fractional votes shall not be permitted, and any fractional voting
rights resulting from the above formula (after aggregating all shares into which
shares of Convertible Preferred Stock held by each Holder could be converted)
shall be rounded to the nearest whole number (with one-half being rounded
upward), subject to the Beneficial Ownership Cap.

         3.       Rights on Liquidation.

                  a.       In the event of any voluntary or involuntary
liquidation, dissolution or winding up of the Corporation (any such event being
hereinafter referred to as a "Liquidation"), before any distribution of assets
of the Corporation shall be made to or set apart for the holders of Common
Stock, the Holders shall be entitled to receive payment out of such assets of
the Corporation in an amount equal to the greater of (i) the Liquidation
Preference for the Convertible Preferred Stock, or (ii) the cash or other
property distributable upon such Liquidation with respect to the shares of
Common Stock into which such shares of Series D Preferred Stock, including any
accrued dividends thereon, could have been converted immediately prior to such
payment. The "Liquidation Preference for the Convertible Preferred Stock shall
be an amount equal to 120% of the Stated Value per share of Convertible
Preferred Stock plus any accumulated and unpaid dividends thereon (whether or
not earned or declared). If the assets of the Corporation available for
distribution to the Holders shall not be sufficient to make in full the payment
herein required, such assets shall be distributed pro-rata among the Holders
based on the aggregate Liquidation Preferences of the shares of Convertible
Preferred Stock held by each such Holder.

                                        4



                  b.       If the assets of the Corporation available for
distribution to shareholders exceed the aggregate amount of payable pursuant to
paragraph 3(a) above with respect to all shares of Convertible Preferred Stock
then outstanding, then, after the payment required by paragraph 3(a) above shall
have been made or irrevocably set aside, the holders of Common Stock shall be
entitled to receive with respect to each share of Common Stock payment of a pro
rata portion of such assets based on the aggregate number of shares of Common
Stock held by each such holder.

         4.       Actions Requiring the Consent of Holders. As long as more than
20% of the shares of Convertible Preferred Stock issued on the Date of Original
Issue are outstanding, the consent of the Holders of a Special Majority of the
outstanding Preferred Stock, given in person or by proxy, either in writing
without a meeting or by vote at a meeting called for the purpose, shall be
necessary for effecting or validating any of the following transactions or acts:

                  (a)      Any amendment, alteration or repeal of any provision
of the Charter or Bylaws which adversely affects the terms of the Preferred
Stock or the relative rights, preferences and privileges of the Holders of the
Preferred Stock as such holders;

                  (b)      Any amendments or changes to the Rights Plan or the
adoption of any other similar plans or arrangements, provided that nothing
herein shall be deemed to restrict the right of the Corporation to redeem all,
but not less than all, of the outstanding Rights (as defined in the Rights Plan)
or otherwise terminate the Rights Plan (as defined in Section 5(h) hereof);

                  (c)      The offer, sale, designation or issuance by the
Corporation or any of its Subsidiaries of any equity or debt security senior to
or pari passu with the Preferred Stock in any respect;

                  (d)      The sale or issuance of any shares of Common Stock,
any warrant, option, subscription or purchase right with respect to shares of
Common Stock, any security convertible into, exchangeable for, or otherwise
entitling the holder thereof to acquire shares of Common Stock, or any warrant,
option, subscription or purchase right with respect to any such convertible,
exchangeable or other security at a price below the Conversion Value (as
hereinafter defined), other than (A) options, warrants, and other rights
outstanding on the date hereof to acquire, directly or indirectly, Common Stock,
and the Common Stock acquirable thereunder, and (B) options granted hereafter to
any employee, officer, Director or consultant pursuant to any plan approved by
stockholders for the benefit of employees, officers, Directors and consultants
("Incentive Options"), and the Common Stock acquirable thereunder, and (C)
awards presently outstanding or hereafter awarded under the Seller's employee
stock purchase plan effective as of January 26, 2001 (the "ESPP"), provided that
the aggregate number of shares of Common Stock acquirable under such Incentive
Options and awards under the ESPP, and the options which may hereafter be issued
as disclosed in Schedule 3.21, is not greater than 1,300,000;

                  (e)      The entering into by the Corporation or any
Subsidiary of any bank or other non-trade indebtedness for borrowed money;

                                        5



                  (f)      The granting or making by the Corporation or any of
its Subsidiaries of any mortgage or pledge, or the assumption or suffering to
exist on, or the imposition on, any of its material properties or assets any
Lien;

                  (g)      The liquidation, dissolution or winding-up of the
Corporation or any of its Subsidiaries or any merger or consolidation of the
Corporation or any of its Subsidiaries with or into another entity or the sale,
conveyance or other disposition of all, or substantially all, the assets,
property or business of the Corporation or any of its Subsidiaries;

                  (h)      The reorganization, recapitalization, sale,
conveyance, or other disposition of or encumbrance of all or substantially all
of the property or business of the Corporation or any of its Subsidiaries or the
merger into or consolidation with any other corporation (other than a wholly
owned subsidiary corporation) or effect any transaction or series of related
transactions in which, in any case, more than 20% of the voting power of the
corporation is disposed of;

                  (i)      The redemption, purchase, repurchase or other
acquisition, directly or indirectly, of any shares of capital stock of the
Corporation or any of its Subsidiaries or any option, warrant or other right to
purchase or acquire any such shares;

                  (j)      The declaration or payment of any dividend or other
distribution (whether cash, stock or property) with respect to the capital stock
of the Corporation, other than the Preferred Stock; and

                  (k)      The taking of any action by the Corporation with the
primary intent of causing the Common Stock to be delisted from any securities
exchange or quotation system upon which the Common Stock is then listed.

         The restrictions contained in this Section 4 shall cease to apply if
for no less than 20 trading days during any period of 30 consecutive trading
days following the Date of Original Issue (i) the Fair Market Value (as defined
in that certain purchase agreement between the Corporation and the original
purchasers of the Convertible Preferred Stock by which such purchasers agreed to
acquire the Convertible Preferred Stock on the Original Issue Date (the
"Purchase Agreement")) of the Common Stock exceeds five dollars ($5) per share,
(ii) all of the Conversion Shares, Warrants Shares and Dividend Shares (as
defined in the Purchase Agreement) have been duly registered for sale under an
effective registration statement pursuant to the Securities Act of 1933, as
amended (the "Securities Act") and such registration statement is effective
throughout the aforesaid 30-day period, and (iii) the actual daily trading
volume of the Common Stock is greater than 100,000 shares per day on each day on
which the Fair Market Value is greater than five dollars ($5).

         5.       Conversion.

                  a.       Right to Convert. Subject to the limitation set forth
in Section 5(g) hereof, each Holder shall have the right at any time, at such
Holder's option, to convert all or any whole number of such Holder's shares of
Convertible Preferred Stock into such number of fully paid and non-assessable
shares of Common Stock as is determined by dividing (i) the aggregate Stated
Value of the shares of Convertible Preferred Stock to be converted plus any
accrued but unpaid dividends

                                        6



thereon by (ii) the Conversion Value (as hereinafter defined) then in effect for
such Convertible Preferred Stock. No fractional shares or scrip representing
fractional shares shall be issued upon the conversion of any Convertible
Preferred Stock. With respect to any fraction of a share of Common Stock called
for upon any conversion, the Corporation shall pay to the Holder an amount in
cash equal to such fraction multiplied by the Current Market Price per share of
the Common Stock.

                  b.       Mechanics of Conversion. Such right of conversion
shall be exercised by any Holder by delivering to the Corporation a conversion
notice in the form attached hereto as Exhibit A (the "Conversion Notice"),
appropriately completed and duly signed and specifying the number of whole
shares of Convertible Preferred Stock that the Holder elects to convert (the
"Converting Shares") into shares of Common Stock on the date specified in the
Conversion Notice (which date shall not be earlier than the date on which the
Conversion Notice is delivered to the Corporation), and by surrender of the
certificate or certificates representing such Converting Shares. The Conversion
Notice shall also contain a statement of the name or names (with addresses and
tax identification or social security numbers) in which the certificate or
certificates for Common Stock shall be issued, if other than the name in which
the Converting Shares are registered. Promptly, but in no event more than two
business days, after the receipt of the Conversion Notice and surrender of the
Converting Shares, the Corporation shall issue and deliver, or cause to be
delivered, to the holder of the Converting Shares or such holder's nominee, a
certificate or certificates for the number of shares of Common Stock issuable
upon the conversion of such Converting Shares together with cash in lieu of any
fractional interest in a share of Common Stock together with a new certificate
covering the number of shares of Preferred Stock representing the unconverted
portion of the shares represented by the Preferred Stock certificate
surrendered. Such conversion shall be deemed to have been effected as of the
close of business on the date specified in the Conversion Notice in accordance
with the terms hereof (the "Conversion Date"), and the person or persons
entitled to receive the shares of Common Stock issuable upon conversion shall be
treated for all purposes as the holder or holders of record of such shares of
Common Stock as of the close of business on the Conversion Date.

                  c.       Common Stock Reserved. The Corporation shall at all
times reserve and keep available out of its authorized but unissued Common
Stock, solely for issuance upon the conversion of shares of Convertible
Preferred Stock as herein provided, such number of shares of Common Stock as
shall from time to time be issuable upon the conversion of all the shares of
Convertible Preferred Stock at the time outstanding.

                  d.       Conversion Value. The initial conversion value for
the Convertible Preferred Stock shall be $2.35 per share of Common Stock, such
value to be subject to adjustment in accordance with the provisions of this
Section 5. Such conversion value in effect from time to time, as adjusted
pursuant to this Section 5, is referred to herein as a "Conversion Value." All
of the remaining provisions of this Section 5 shall apply separately to each
Conversion Value in effect from time to time with respect to Convertible
Preferred Stock.

                  e.       Stock Dividends, Subdivisions and Combinations. If at
any time while the Preferred Stock is outstanding, the Corporation shall:

                                        7



                  i.       take a record of the holders of its Common Stock for
         the purpose of entitling them to receive a dividend payable in, or
         other distribution of, additional shares of Common Stock,

                  ii.      subdivide its outstanding shares of Common Stock into
         a larger number of shares of Common Stock, or

                  iii.     combine its outstanding shares of Common Stock into a
         smaller number of shares of Common Stock,

then in each such case the Conversion Value shall be multiplied by a fraction of
which the numerator shall be the number of shares of Common Stock (excluding
treasury shares, if any) outstanding immediately before such event and of which
the denominator shall be the number of shares of Common Stock (excluding
treasury shares, if any) outstanding immediately after such event. Any
adjustment made pursuant to clause (i) of this paragraph shall become effective
immediately after the record date for the determination of shareholders entitled
to receive such dividend or distribution, and any adjustment pursuant to clauses
(ii) or (iii) of this paragraph shall become effective immediately after the
effective date of such subdivision or combination. If any event requiring an
adjustment under this paragraph occurs during the period that a Conversion Value
is calculated hereunder, then the calculation of such Conversion Value shall be
adjusted appropriately to reflect such event.

                  f.       Certain Other Distributions. If, at any time while
the Series D Preferred Stock is outstanding, the Corporation shall take a record
of the holders of its Common Stock for the purpose of entitling them to receive
any dividend or other distribution of:

                           i.       cash (other than a cash dividend payable out
         of earnings or earned surplus legally available for the payment of
         dividends under the laws of the jurisdiction of incorporation of the
         Corporation),

                           ii.      any evidences of its indebtedness, any
         shares of stock of any class or any other securities or property of any
         nature whatsoever (other than cash, convertible securities or
         additional shares of Common Stock), or

                           iii.     any warrants or other rights to subscribe
         for or purchase any evidences of its indebtedness, any shares of stock
         of any class or any other securities or property of any nature
         whatsoever (other than cash, convertible securities or additional
         shares of Common Stock) (in each case set forth in subparagraphs (i),
         (ii) and (iii) hereof, the "Distributed Property"),

then upon any conversion of Series D Preferred Stock that occurs after such
record date, the holder of Series D Preferred Stock shall be entitled to
receive, in addition to the Conversion Shares otherwise issuable upon such
conversion, the Distributed Property that such holder would have been entitled
to receive if the Series D Preferred Stock had been converted into Common Stock
as of such

                                        8



record date. If the Distributed Property consists of property other than cash,
then the fair value of such Distributed Property shall be as determined in good
faith by the Board of Directors and set forth in reasonable detail in a written
valuation report (the "Valuation Report") prepared by the Board of Directors.
The Corporation shall give written notice of such determination and a copy of
the Valuation Report to all holders of Series D Preferred Stock, and if the
holders of 25% of the outstanding Series D Preferred Stock object to such
determination within twenty (20) business days following the date such notice is
given to all of the holders of Series D Preferred Stock, the Corporation shall
submit such valuation to an investment banking firm of recognized national
standing selected by holders of not less than 75% of the Series D Preferred
Stock, and the opinion of such investment banking firm shall be binding upon the
Corporation and the holders of all the Series D Preferred Stock. A
reclassification of the Common Stock (other than a change in par value, or from
par value to no par value or from no par value to par value) into shares of
Common Stock and shares of any other class of stock shall be deemed a
distribution by the Corporation to the holders of its Common Stock of such
shares of such other class of stock within the meaning of this Section 5(f); and
if the outstanding shares of Common Stock shall be changed into a larger or
smaller number of shares of Common Stock as a part of such reclassification,
such change shall be deemed a subdivision or combination, as the case may be, of
the outstanding shares of Common Stock within the meaning of Section 5(e).

                  g.       Blocking Provision. Notwithstanding any contrary or
inconsistent provision hereof, the number of shares of Convertible Preferred
Stock that may be acquired by any Holder upon any conversion of Convertible
Preferred Stock or that shall be entitled to voting rights under Section 2
hereof shall be limited to the extent necessary to insure that, following such
conversion, the number of shares of Common Stock then beneficially owned by such
Holder and any other persons or entities whose beneficial ownership of Common
Stock would be aggregated with the Holder's for purposes of Section 13(d) of the
Exchange Act (including shares held by any "group" of which the Holder is a
member) does not exceed 4.95% of the total number of shares of Common Stock of
the Corporation then issued and outstanding (the "Beneficial Ownership Cap").
For purposes hereof, "group" has the meaning set forth in Section 13(d) of the
Exchange Act and applicable regulations of the Securities and Exchange
Commission, and the percentage held by the Holder shall be determined in a
manner consistent with the provisions of Section 13(d) of the Exchange Act. Each
delivery of a Conversion Notice by a Holder will constitute a representation by
such Holder that it has evaluated the limitation set forth in this paragraph and
determined, subject to the accuracy of information filed under the Securities
Act and the Exchange Act by any person other than such Holder with respect to
the outstanding Common Stock of the Corporation (including securities or
property convertible into or exchangeable for Common Stock, with or without the
payment of consideration), that the issuance of the full number of shares of
Common Stock requested in such Conversion Notice is permitted under this
paragraph, and the Corporation shall have no obligations to such Holder to
verify compliance with the Beneficial Ownership Cap. This paragraph shall be
construed and administered in such manner as shall be consistent with the intent
of the first sentence of this paragraph. Any provision hereof which would
require a result that is not consistent with such intent shall be deemed severed
herefrom and of no force or effect with respect to the conversion contemplated
by a particular Conversion Notice.

                                        9



                  h.       Rights Distributed Under Rights Agreement.
Capitalized terms used in this Section 5(h) and which are not otherwise defined
herein, shall have the meanings ascribed to them in the Rights Agreement (the
"Rights Agreement") dated as of December, 13, 2000 between the Corporation and
U.S. Stock Transfer Corporation. While the Rights Agreement or any other poison
pill, rights plan or similar arrangement (each, a "Rights Plan") shall be in
effect:

                           i.       Holders who convert Preferred Stock before
                                    the Distribution Date or before any Rights
                                    Certificates or similar right (each a
                                    "Right") shall be evidenced by a separate
                                    rights certificate or shall otherwise be
                                    transferable otherwise than in connection
                                    with the transfer of the underlying shares
                                    of Common Stock (the date of the occurrence
                                    of any of the foregoing being referred to
                                    herein as a "Rights Distribution Date"),
                                    will receive, in addition to shares of
                                    Common Stock issued on conversion, one Right
                                    for each such shares of Common Stock.

                           ii.      Upon the occurrence of a Rights Distribution
                                    Date, each Holder shall receive, without any
                                    further action by the Corporation, such
                                    number of Rights equal to the number of
                                    Rights such Holder would have held if,
                                    immediately prior to the Rights Distribution
                                    Date, all of the shares of Convertible
                                    Preferred Stock had been converted into
                                    shares of Common Stock at the then current
                                    Conversion Value. The Corporation shall
                                    issue to each Holder certificates evidencing
                                    such Rights, no later than five business
                                    days following such Rights Distribution
                                    Date. In the event the applicable Rights
                                    Plan does not permit such Rights to be
                                    granted to each Holder, the Corporation
                                    shall promptly (i) amend the applicable
                                    Rights Plan to permit the Corporation to
                                    take the actions set forth in this Section
                                    5(h), or (ii) issue to each Holder an
                                    option, right or similar arrangement giving
                                    each Holder the same rights and benefits as
                                    they would have held upon the receipt of the
                                    applicable number of Rights.

         6.       Other Provisions Applicable to Adjustments. The following
provisions shall be applicable to the making of adjustments of the number of
shares of Common Stock into which the Preferred Stock is convertible and the
current Conversion Value provided for in Section 5:

                  a.       When Adjustments to Be Made. The adjustments required
by Section 5 shall be made whenever and as often as any specified event
requiring an adjustment shall occur, except that any adjustment to the
Conversion Value that would otherwise be required may be postponed up to, but
not beyond the Conversion Date if such adjustment either by itself or with other
adjustments not previously made adds or subtracts less than 1% of the shares of
Common Stock into which the Preferred Stock is convertible immediately prior to
the making of such adjustment. Any adjustment representing a change of less than
such minimum amount (except as aforesaid) which is postponed shall be carried
forward and made as soon as such adjustment, together with other adjustments
required by Section 5 and not previously made, would result in a minimum
adjustment or on the

                                       10



Conversion Date. For the purpose of any adjustment, any specified event shall be
deemed to have occurred at the close of business on the date of its occurrence.

                  b.       Fractional Adjustments. In computing adjustments
under Section 5, fractional adjustments to the Conversion Value shall be taken
into account to the nearest 1/100th of a cent.

                  c.       Escrow of Stock. If after any property becomes
distributable pursuant to Section 5 by reason of the taking of any record of the
holders of Common Stock, but prior to the occurrence of the event for which such
record is taken, a holder of the Preferred Stock converts the Preferred Stock,
such holder of Preferred Stock shall continue to be entitled to receive any
shares of Common Stock issuable upon conversion under Section 5 by reason of
such adjustment and such shares or other property shall be held in escrow for
the holder of the Preferred Stock by the Corporation to be issued to holder of
the Preferred Stock upon and to the extent that the event actually takes place.
Notwithstanding any other provision to the contrary herein, if the event for
which such record was taken fails to occur or is rescinded, then such escrowed
shares shall be canceled by the Corporation and escrowed property returned to
the Corporation.

         7.       Merger, Consolidation or Disposition of Assets. If, while the
Preferred Stock is outstanding, there occurs: (i) an acquisition by an
individual or legal entity or group (as defined in Rule 13-d of the Exchange
Act) of more than one-half of the voting rights or equity interests in the
Corporation; or (ii) a merger or consolidation of the Corporation or a sale,
transfer or other disposition of all or substantially all the Corporation's
property, assets or business to another corporation where the holders of the
Corporation's voting securities prior to such transaction fail to continue to
hold at least a majority of the voting power of the surviving or acquiring
corporation (a "Change of Control"), and, pursuant to the terms of such Change
of Control, shares of common stock of the surviving or acquiring corporation, or
any cash, shares of stock or other securities or property of any nature
whatsoever (including warrants or other subscription or purchase rights) in
addition to or in lieu of common stock of the successor or acquiring corporation
("Other Property"), are to be received by or distributed to the holders of
Common Stock of the Corporation, then the certificates evidencing the
Convertible Preferred Stock shall, as of and after the Change of Control,
evidence only the right to receive, at each Holder's election, which must be
delivered by each Holder to the Corporation within 20 days after receiving
notice from the Corporation of the right to make such election, either:

                  i.       the number of shares of common stock of the successor
         or acquiring corporation or of the Corporation, if it is the surviving
         corporation, and Other Property receivable upon or as a result of such
         Change of Control by a holder of the number of shares of Common Stock
         into which the Convertible Preferred Stock is convertible immediately
         prior to such event, or

                  ii.      at the effective time of such Change of Control, such
         Holder's Liquidation Preference.

If a timely election is not made pursuant to this Section 7(a), the holder shall
receive the benefit of Section 7(a)(i) and shall not be entitled to the benefit
of Section 7(a)(ii). If notice of a Change of

                                       11



Control is given but the Change of Control transaction is not, for any reason,
consummated, the elections of the Holders given in connection with such notice
shall be of no force or effect, ab initio.

         8.       Other Action Affecting Common Stock. In case at any time or
from time to time the Corporation shall take any action in respect of its Common
Stock, other than the payment of dividends permitted by Section 5 or any other
action described in Section 5, then, unless such action will not have a
materially adverse effect upon the rights of the holder of Convertible Preferred
Stock, the number of shares of Common Stock or other stock into which the
Convertible Preferred Stock is convertible exercisable and/or the purchase price
thereof shall be adjusted in such manner as may be equitable in the
circumstances.

         9.       Certain Limitations. Notwithstanding anything herein to the
contrary, the Corporation agrees not to enter into any transaction which, by
reason of any adjustment hereunder, would cause the current Conversion Value to
be less than the par value per share of Common Stock.

         10.      Stock Transfer Taxes. The issue of stock certificates upon
conversion of the Convertible Preferred Stock shall be made without charge to
the converting holder for any tax in respect of such issue; provided, however,
that the Corporation shall be entitled to withhold any applicable withholding
taxes with respect to such issue, if any.

         11.      Certificate as to Adjustments. Upon the occurrence of each
adjustment or readjustment of the Conversion Value, the Corporation, at its
expense, shall promptly compute such adjustment or readjustment in accordance
with the terms hereof and prepare and furnish to each Holder a certificate
setting forth such adjustment or readjustment and showing in detail the facts
upon which such adjustment or readjustment is based. The Corporation shall, upon
the written request at any time of any Holder, furnish or cause to be furnished
to such holder a like certificate setting forth (i) such adjustments and
readjustments, (ii) the Conversion Value at the time in effect for the
Convertible Preferred Stock and (iii) the number of shares of Common Stock and
the amount, if any, or other property which at the time would be received upon
the conversion of Convertible Preferred Stock owned by such holder.

         12.      Notices of Record Date. In the event of any fixing by the
Corporation of a record date for the holders of any class of securities for the
purpose of determining the holders thereof who are entitled to receive any
dividend (other than a cash dividend) or other distribution, any shares of
Common Stock or other securities, or any right to subscribe for, purchase or
otherwise acquire, or any option for the purchase of, any shares of stock of any
class or any other securities or property, or to receive any other right, the
Corporation shall mail to each Holder at least twenty (20) days prior to the
date specified therein, a notice specifying the date on which any such record is
to be taken for the purpose of such dividend, distribution or rights, and the
amount and character of such dividend, distribution or right.

         13.      Redemption.

                  a.       Redemption at the Holders' Elections. If a Redemption
Triggering Event (as defined below) has occurred, and a holder has so elected,
the Corporation shall redeem the

                                       12



Convertible Preferred Stock of any Holder who gives a Demand for Redemption (as
defined below). The Corporation shall, promptly thereafter, redeem the shares of
Convertible Preferred Stock as set forth in the Demand for Redemption, to the
extent permitted under Section 160 of the Delaware General Corporation Law. The
Corporation shall effect such redemption by paying in cash for each such share
to be redeemed an amount equal to the sum of such Holder's Liquidation
Preference (the "Redemption Price"). A "Redemption Triggering Event" is any one
of the following:

                           i.       The Corporation's failure or refusal to
         convert any shares of Convertible Preferred Stock in accordance with
         the terms hereof, or the Corporation's breach of any other term or
         provision of the terms of the Convertible Preferred Stock, other than
         Section 4(d) hereof; provided, however, that with respect to the
         Corporation's obligation to deliver certificates evidencing the Common
         Stock acquired upon conversion of the Convertible Preferred Stock, the
         Corporation shall have a grace period of 3 business days in addition to
         the two trading days within which the Corporation is required to issue
         such certificates in Section 5(b) (Mechanics of Conversion) hereof, it
         being understood that the aforesaid grace period is applicable only
         with respect to the right of the Holder to make a Demand for
         Redemption, and such grace period is not applicable with respect to any
         other liability of the Corporation arising out of the Corporation's
         failure or refusal to deliver certificates evidencing such Common Stock
         within the period of two business days required by Section 5(b) hereof.

                           ii.      Any breach of any warranty, covenant (other
         than Section 5.8(d) of the Purchase Agreement), or representation of
         the Corporation or any of its subsidiaries in the Purchase Agreement or
         the Registration Rights Agreement (as such term are defined in the
         Purchase Agreement) that is reasonably likely to have a material
         adverse effect on the Corporation or the Preferred Stock and which
         breach, if reasonably capable of being cured, has not been cured within
         ten (10) days after the Corporation has notice of such breach (the
         "Breach Cure Period"); provided, however, that for purposes of this
         Section 13(a)(ii), the Corporation's breach of, among other provisions,
         any provision of paragraph (c) of Section 4 of this Certificate of
         Designation or paragraph (c) of Section 5.8 of the Purchase Agreement
         shall be deemed to constitute a breach "that is reasonably likely to
         have a material adverse effect on the Corporation or the Preferred
         Stock"; provided, further, that the preceding clause shall not be
         construed to imply that any breach of any other paragraph of Section 4
         of the Certificate of Designation or any other paragraph of Section 5.8
         of the Purchase Agreement does not constitute a breach "that is
         reasonably likely to have a material adverse effect on the Corporation
         or the Preferred Stock."

The Corporation shall promptly notify each Holder of the occurrence of a
Redemption Triggering Event.

                  b.       Demand for Redemption. A Holder desiring to elect a
redemption as herein provided shall deliver a notice (the "Demand for
Redemption") to the Corporation specifying the following:

                           i.       The approximate date and nature of the
         Redemption Triggering Event;

                           ii.      The number of shares of Convertible
         Preferred Stock to be redeemed; and

                                       13



                           iii.     The address to which the payment of the
         Redemption Price shall be delivered, or, at the election of the Holder,
         wire instructions with respect to the account to which payment of the
         Redemption Price shall be required.

A Holder may deliver the certificates evidencing the Convertible Preferred Stock
to be redeemed with the Demand for Redemption or under separate cover. Payment
of the Redemption Price shall be made not later than two (2) business days
following the Redemption Date. The Redemption Date shall be the date on which
each of the following conditions has been satisfied: (i) a Holder has delivered
a Demand for Redemption and the certificates evidencing the shares of
Convertible Preferred Stock to be redeemed; and (ii) the Breach Cure Period has
expired.

                  c.       Early Redemption at the Corporation's Election.

                           i.       If, at any time after the third anniversary
         of the issuance of the first share of Preferred Stock, (A) the Common
         Stock is traded on any national securities exchange or quoted on the
         Nasdaq National Market or Nasdaq SmallCap Market, and (B) the closing
         price per share of the Common Stock exceeds $10.00 per share for at
         least 20 consecutive trading days (the "Trading Period"), and (C) in
         such Trading Period the average daily trading volume is greater than
         200,000 shares per day, then the Corporation may, not later than 5
         business days after the end of any such Trading Period (the "Call
         Notice Period"), call for the redemption of all (but not less than all)
         the Preferred Stock. If the Corporation does not timely call for such
         redemption, the Corporation may thereafter call for redemption as
         herein provided only if the conditions set forth in clauses (A), (B),
         and (C) of the preceding sentence are again fulfilled, and the
         Corporation calls for redemption within the new Call Notice Period.

                           ii.      If the Corporation elects to redeem the
         Preferred Stock, the Corporation shall give written notice thereof (the
         "Call for Redemption"), signed by the Chief Executive Officer or Chief
         Financial Officer, to the Holders of the Preferred Stock not later than
         the end of the Call Notice Period. The Call for Redemption shall (A)
         specify the beginning and end of the Trading Period and shall (B) set
         forth the Corporation's undertaking to pay the Stated Value on each
         outstanding share of Preferred Stock plus any accrued but unpaid
         dividends thereon, and (C) certify that the Corporation has the funds
         on hand to make such payments, and that the Corporation is not under
         any lawful order of any court or other governmental authority
         restricting or prohibiting such payment and not bound by any agreement,
         undertaking or other obligation which would prohibit or restrict the
         authority of the Corporation to make such payment, and (D) set forth
         the name and address of the Corporation or, if applicable, any transfer
         or paying agent, to which the Holders shall deliver their certificates
         evidencing the Preferred Stock to obtain payment therefor.

                           iii.     Simultaneously with the Corporation's
         issuance of any Call for Redemption, the Corporation shall set aside,
         in a segregated account, sufficient funds to pay all amounts owed to
         the Holders of the Preferred Stock on account of such redemption.

                                       14



                           iv.      The issuance of a Call for Redemption shall
         not impair or diminish in any way the right of the Holders of the
         Preferred Stock to convert the Preferred Stock into Common Stock;
         provided, however, that sixty days after the Call for Redemption, the
         Preferred Stock not otherwise converted or redeemed shall be deemed
         redeemed, and the certificates therefor shall evidence only the right
         of the Holder to receive the payments payable by the Corporation upon
         redemption.

                           v.       Payment of the Stated Value, plus all
         accrued, accumulated and unpaid dividends, shall be made to each Holder
         not later than two (2) business days following the Corporation's
         receipt of such Holder's certificates evidencing the Preferred Stock,
         or the usual and customary proof of loss of such certificates, if
         applicable.

                  d.       Status of Redeemed or Purchased Shares. Any shares of
the Convertible Preferred Stock at any time purchased, redeemed or otherwise
acquired by the Corporation shall not be reissued and shall be retired.

                  e.       Insufficient Funds. If the funds of the Corporation
legally available for redemption of shares of the Preferred Stock on any
Redemption Date are insufficient to redeem the total number of shares of
Preferred Stock to be redeemed on such date, those funds which are legally
available, if any, will be used to redeem the maximum possible number of such
shares ratably among the Holders of such shares to be redeemed based upon the
total Redemption Price applicable to each such Holder's shares of Preferred
Stock which are subject to redemption on such Redemption Date. The shares of
Preferred Stock not redeemed shall remain outstanding and entitled to all the
rights and preferences provided herein. At any time thereafter when additional
funds of the Corporation are legally available for the redemption of shares of
the Preferred Stock, such funds will immediately be used to redeem the balance
of the shares which the Corporation has become obliged to redeem on any
Redemption Date but which it has not redeemed.

         14.      Notices. Any and all notices or other communications or
deliveries required or permitted to be provided hereunder shall be in writing
and shall be deemed given and effective on the earliest of (a) the date of
transmission, if such notice or communication is delivered via facsimile at the
facsimile number specified in this Section prior to 4:00 p.m. (New York City
time) on a business day, (b) the next business day after the date of
transmission, if such notice or communication is delivered via facsimile at the
facsimile number specified in this Section on a day that is not a business day
or later than 4:00 p.m. (New York City time) on any business day, or (c) the
business day following the date of mailing, if sent by U.S. nationally
recognized overnight courier service such as Federal Express. The address for
such notices and communications shall be as follows: (i) if to the Corporation,
to 157 Technology Drive , Irvine, California 92618, facsimile: 949.788.6706,
Attention: Chief Executive Officer or (ii) if to a holder of Preferred Stock, to
the address or facsimile number appearing on the Corporation's shareholder
records or, in either case, to such other address or facsimile number as the
Corporation or a holder of Preferred Stock may provide to the other in
accordance with this Section.

         IN WITNESS WHEREOF, the undersigned has executed this Certificate of
Designation on behalf of the Corporation this 6th day of May, 2003.

                                    /s/Rajesh C. Shrotriya
                                    --------------------------------------------
                                    Name: Rajesh C. Shrotriya, M.D.
                                    Title: Chairman, Chief Executive
                                           Officer and President

                                       15



                                                                       EXHIBIT A

                            FORM OF CONVERSION NOTICE

(To be executed by the registered Holder in order to convert shares of Preferred
Stock)

The undersigned hereby irrevocably elects to convert the number of shares of
Series D 8% Cumulative Convertible Voting Preferred Stock (the "PREFERRED
STOCK") indicated below into shares of common stock, par value $.001 per share
(the "COMMON STOCK"), of Spectrum Pharmaceuticals, Inc., a Delaware corporation
(the "COMPANY"), according to the Certificate of Designations of the Preferred
Stock and the conditions hereof, as of the date written below. The undersigned
hereby requests that certificates for the shares of Common Stock to be issued to
the undersigned pursuant to this Conversion Notice be issued in the name of, and
delivered to, the undersigned or its designee as indicated below. A copy of the
certificate representing the Preferred Stock being converted is attached hereto.

________________________________________________________________________________
Date to Effect Conversion

________________________________________________________________________________
Number of shares of Preferred Stock owned prior to Conversion

________________________________________________________________________________
Number of shares of Preferred Stock to be Converted

________________________________________________________________________________
Stated Value of Preferred Stock to be Converted

________________________________________________________________________________
Amount of accumulated and unpaid dividends on shares of Preferred Stock to be
Converted

________________________________________________________________________________
Number of shares of Common Stock to be Issued (including conversion of accrued
but unpaid dividends on shares of Preferred Stock to be Converted)

________________________________________________________________________________
Applicable Conversion Value

________________________________________________________________________________
Number of shares of Preferred Stock owned subsequent to Conversion

                                    i of iii



Conversion Information:    [NAME OF HOLDER]

                           By:__________________________________________________
                              Name:
                              Title:

                           Address of Holder:

                           _____________________________________________________

                           _____________________________________________________

                           Issue Common Stock to (if different than above):

                           Name:________________________________________________

                           Address:_____________________________________________

                                   _____________________________________________

The undersigned represents, subject to the accuracy of information filed under
the Securities Act and the Exchange Act by any person other than such holder
with respect to the outstanding Common Stock of the Company (including
securities or property convertible into or exchangeable for Common Stock, with
or without the payment of consideration), as of the date hereof that, after
giving effect to the conversion of Preferred Shares pursuant to this Conversion
Notice, the undersigned will not exceed the "Beneficial Ownership Cap" contained
in Section 5(g) of the Certificate of Designations of the Preferred Stock.

                           _____________________________________________________
                           Name of Holder

                           By:__________________________________________________
                           Name:________________________________________________
                           Title:_______________________________________________

                                       ii