EXHIBIT 32.1



                    CERTIFICATION OF CHIEF EXECUTIVE OFFICER

Pursuant to 18 U.S.C. Section 1350, as created by Section 906 of the
Sarbanes-Oxley Act of 2002, the undersigned officer of Spectrum
Pharmaceuticals, Inc., a Delaware corporation (the "Company"), hereby
certifies, to such officer's knowledge, that:

                   (i) the accompanying amendment number one to the Annual
Report on Form 10-K of the Company for the year ended December 31, 2003 (the
"Report") fully complies with the requirements of Section 13(a) or Section
15(d), as applicable, of the Securities Exchange Act of 1934, as amended; and

                  (ii) the information contained in the Report fairly presents,
in all material respects, the financial condition and results of operations of
the Company.



Dated:  April 29, 2004           /s/ RAJESH C. SHROTRIYA
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                                 Rajesh C. Shrotriya, M.D.
                                 Chairman, Chief Executive Officer and President