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                                                                     EXHIBIT 4.2

                               __________________

                               WARRANT AGREEMENT

                                    BETWEEN

                          EPOCH PHARMACEUTICALS, INC.

                                      AND

                    AMERICAN STOCK TRANSFER & TRUST COMPANY

                           DATED AS OF JUNE 21, 1996

                               __________________






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                               TABLE OF CONTENTS



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ARTICLE  I

  DISTRIBUTION OF WARRANT CERTIFICATES  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .     1

  1.1  Appointment of Warrant Agent . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .     1
  1.2  Form of Warrant Certificates . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .     1
  1.3  Execution of Warrant Certificates  . . . . . . . . . . . . . . . . . . . . . . . . . . . . .     2
  1.4  Issuance and Distribution of Warrant Certificates  . . . . . . . . . . . . . . . . . . . . .     2

ARTICLE II

  WARRANT EXERCISE PRICE AND EXERCISE OF WARRANTS . . . . . . . . . . . . . . . . . . . . . . . . .     2

  2.1  Exercise Price . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .     2
  2.2  Registration of Common Stock and Exercisability of Warrants  . . . . . . . . . . . . . . . .     2
  2.3  Procedure for Exercise of Warrants . . . . . . . . . . . . . . . . . . . . . . . . . . . . .     3
  2.4  Issuance of Warrant Shares . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .     3
  2.5  Certificates for Unexercised Warrants  . . . . . . . . . . . . . . . . . . . . . . . . . . .     3
  2.6  Reservation of Shares  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .     3
  2.7  Disposition of Proceeds  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .     3

ARTICLE III

  CALL OF WARRANTS  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .     4

  3.1  Call Price and Trigger Price . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .     4
  3.2  Payment of Call Price  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .     4

ARTICLE IV

  ADJUSTMENTS AND NOTICE PROVISIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .     4

  4.1  Adjustment of Exercise Price . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .     4
  4.2  Current Market Price . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .     5
  4.3  No Adjustments to Exercise Price . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .     5
  4.4  Deferral of Adjustments to Exercise Price  . . . . . . . . . . . . . . . . . . . . . . . . .     6
  4.5  Adjustment to Number of Shares . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .     6
  4.6  Reorganizations  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .     6
  4.7  Reclassification . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .     7
  4.8  Adjustment of Call Trigger Price . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .     7
  4.9  Verification of Computations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .     7
  4.10 Notice of Certain Actions  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .     7
  4.11 Notice of Call . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .     8
  4.12 Notice of Adjustments  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .     8
  4.13 Warrant Certificate Amendment  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .     9
  4.14 Fractional Shares  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .     9

ARTICLE V

  OTHER PROVISIONS RELATING TO RIGHTS OF REGISTERED HOLDERS OF WARRANT CERTIFICATES . . . . . . . .     9

  5.1  Rights of Warrant Holders  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .     9
  5.2  Lost, Stolen, Mutilated or Destroyed Warrant Certificates  . . . . . . . . . . . . . . . . .     9






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ARTICLE VI

  SPLIT UP, COMBINATION, EXCHANGE, TRANSFER AND CANCELLATION OF WARRANT CERTIFICATES  . . . . . . . . . . . .   10

  6.1  Split Up, Combination, Exchange and Transfer of Warrant Certificates . . . . . . . . . . . . . . . . .   10
  6.2  Cancellation of Warrant Certificates . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   10
  6.3  Agreement of Warrant Certificate Holders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   10

ARTICLE VII

  PROVISIONS CONCERNING THE WARRANT AGENT AND OTHER MATTERS . . . . . . . . . . . . . . . . . . . . . . . . .   11

  7.1  Payment of Taxes and Charges . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   11
  7.2  Resignation or Removal of Warrant Agent  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   11
  7.3  Notice of Appointment  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   12
  7.4  Merger of Warrant Agent  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   12
  7.5  Company Responsibilities . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   12
  7.6  Certification for the Benefit of Warrant Agent . . . . . . . . . . . . . . . . . . . . . . . . . . . .   12
  7.7  Books and Records  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   12
  7.8  Liability of Warrant Agent . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   13
  7.9  Use of Attorneys, Agents and Employees . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   13
  7.10 Indemnification  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   13
  7.11 Acceptance of Agency . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   13
  7.12 Changes to Agreement . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   13
  7.13 Assignment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   14
  7.14 Successor to Company . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   14
  7.15 Notices  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   14
  7.16 Defects in Notice  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   15
  7.17 Governing Law  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   15
  7.18 Standing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   15
  7.19 Headings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   15
  7.20 Counterparts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   15
  7.21 Conflict of Interest . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   15
  7.22 Availability of the Agreement  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   15







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                               WARRANT AGREEMENT


         WARRANT AGREEMENT dated as of June 21, 1996, between EPOCH
PHARMACEUTICALS, INC., a Delaware corporation (the "Company"), and AMERICAN
STOCK TRANSFER & TRUST COMPANY, a corporation organized under the banking laws
of the State of New York (the "Warrant Agent").


                              W I T N E S S E T H:

         WHEREAS, the Company has made a private placement of units consisting
of one (1) share of the Company's Common Stock, par value $.01 per share (the
"Common Stock"), and one (1) Class C Redeemable Common Stock Purchase Warrants
(the "Warrants") to purchase one-half (1/2) share of the Company's Common
Stock; and

         WHEREAS, the Company desires the Warrant Agent, and the Warrant Agent
agrees, to act on behalf of the Company in connection with the issuance,
transfer, exchange, replacement, redemption and surrender of certificates
representing the Warrants (the "Warrant Certificates"); and

         WHEREAS, the Company and the Warrant Agent desire to set forth in this
Warrant Agreement, among other things, the form and provisions of the Warrant
Certificates and the terms and conditions under which they may be issued,
transferred, exchanged, replaced, redeemed and surrendered in connection with
the exercise and redemption of the Warrants;

         NOW, THEREFORE, in consideration of the premises and of the mutual
agreements herein contained, the parties hereto agree as follows:


                                   ARTICLE  I

                      DISTRIBUTION OF WARRANT CERTIFICATES

         1.1     Appointment of Warrant Agent.  The Company hereby appoints the
Warrant Agent to act on behalf of the Company in accordance with the
instructions hereinafter set forth in this Agreement, and the Warrant Agent
hereby accepts such appointment.

         1.2     Form of Warrant Certificates.  The Warrant Certificates shall
be issued in registered form only and, together with the purchase and
assignment forms to be printed on the reverse thereof, shall be substantially
in the form of Exhibit A attached hereto, and, in addition, may have such
letters, numbers or other marks of identification or designation and such
legends, summaries or endorsements stamped, printed, lithographed or engraved
thereon as the Company may deem appropriate and as are not inconsistent with
the provisions of this Agreement or as, in any particular case, may be
required, in the opinion of counsel for the Company, to comply with any law or
with any rule or regulation of any regulatory authority or agency or to conform
to customary usage.






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         1.3     Execution of Warrant Certificates.  The Warrant Certificates
shall be executed on behalf of the Company by its Chairman of the Board, Chief
Executive Officer or President or any Vice President, and by its Chief
Financial Officer or Treasurer or any Assistant Treasurer, or Secretary or any
Assistant Secretary, either manually or by facsimile signature printed thereon.
The Warrant Certificate shall be manually countersigned and dated the date of
the countersignature by the Warrant Agent and shall not be valid for any
purpose unless so countersigned and dated.  In case any authorized officer of
the Company who shall have signed any of the Warrant Certificates shall cease
to be such officer of the Company either before or after delivery thereof by
the Company to the Warrant Agent, the signature of such person on such Warrant
Certificates, nevertheless, shall be valid and such Warrant Certificates may be
countersigned by the Warrant Agent and issued and delivered to those persons
entitled to receive the Warrants represented thereby with the same force and
effect as though the person who signed such Warrant Certificates had not ceased
to be such officer of the Company.

         1.4     Issuance and Distribution of Warrant Certificates.  The
Company shall deliver to the Warrant Agent an adequate supply of Warrant
Certificates executed on behalf of the Company, as described in Section 1.3
hereof.  Upon receipt of an order from the Company, the Warrant Agent shall
within three business days complete and countersign Warrant Certificates and
shall deliver such Warrant Certificates pursuant to written instructions of the
Company.

                                   ARTICLE II

                WARRANT EXERCISE PRICE AND EXERCISE OF WARRANTS

         2.1     Exercise Price.  Each Warrant Certificate for the Warrants
shall, when signed by the Chairman, Chief Executive Officer or President or any
Vice President, and by the Chief Financial Officer or Treasurer or any
Assistant Treasurer, or Secretary or any Assistant Secretary, of the Company
and countersigned by the Warrant Agent, entitle the registered holder thereof,
subject to the provisions of Article III hereof, to purchase from the Company
one-half (1/2) share of Common Stock for each Warrant evidenced thereby, at the
purchase price of $1.25 per one-half (1/2) share, (the "Initial Exercise
Price"), or such adjusted number of shares at such adjusted purchase price as
may be established from time to time pursuant to the provisions of Article IV
hereof, payable in full at the time of exercise of the Warrant.  Except as the
context otherwise requires, the term "Exercise Price" as used in this Agreement
shall mean the purchase price of one share of Common Stock upon the exercise of
a Warrant, reflecting all appropriate adjustments made in accordance with the
provisions of Article IV hereof and Section 7.12 hereof.

         2.2     Registration of Common Stock and Exercisability of Warrants.
Each Warrant may be exercised at any time, but not after 5:00 P.M., New York,
City time, on the earlier of June 20, 2001 or the business day immediately
preceding the Call Date (as defined in Section 4.9).  The term "Exercise
Deadline" as used in this Agreement shall mean the latest time and date at
which the Warrants may be exercised.  Pursuant to the Subscription Agreements
under which the Warrants were sold, the Company is obligated to register the
shares issuable upon exercise of the Warrants.





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         2.3     Procedure for Exercise of Warrants.   During the period
specified in and subject to the provisions of Section 2.2 hereof, the Warrants
may be exercised by surrendering the Warrant Certificates representing such
Warrants to the Warrant Agent at its principal office (the "Principal Office"),
which is presently located at 40 Wall Street, New York, New York 10005, with
the election to purchase form set forth on the Warrant Certificate duly
completed and executed, with signatures guaranteed by a member firm of a
national securities exchange, a commercial bank or trust company located in the
United States, a member of the National Association of Securities Dealers, Inc.
("NASD") or other eligible guarantor institution which is a participant in a
signature guarantee program (as such terms are defined in Reg. 240.17Ad-15
under the Securities Exchange Act of 1934, as amended) acceptable to the
Warrant Agent ("Signatures Guaranteed"), accompanied by payment in full of the
Exercise Price as provided in Section 2.1 in effect at the time of such
exercise, together with such taxes as are specified in Section 7.1 hereof, for
each share of Common Stock with respect to which such Warrants are being
exercised.  Such Exercise Price and taxes shall be paid in full by certified
check or money order, payable in United States currency, to the Warrant Agent
for the account of the Company.  The date on which Warrants are exercised in
accordance with this Section 2.3(a) is sometimes referred to herein as the Date
of Exercise of such Warrants.

         2.4     Issuance of Warrant Shares.  As soon as practicable after the
Date of Exercise of any Warrants, the Company shall issue, or cause the
transfer agent for the Common Stock, if any, to issue a certificate or
certificates for the number of full shares of Common Stock to which such holder
is entitled, registered in accordance with the instructions set forth in the
election to purchase.  All Warrant Shares shall be validly authorized and
issued, fully paid and nonassessable and free from all taxes, liens and charges
created by the Company in respect of the issue thereof, and shall be previously
unissued shares.  Each person in whose name any such certificate for Warrant
Shares is issued shall for all purposes be deemed to have become the holder of
record of the Warrant Shares represented thereby on the Date of Exercise of the
Warrants resulting in the issuance of such shares, irrespective of the date of
issuance or delivery of such certificate for the Warrant Shares.

         2.5     Certificates for Unexercised Warrants.  In the event that less
than all of the Warrants represented by a Warrant Certificate are exercised,
the Warrant Agent shall execute and mail, by first-class mail, within 30 days
of the Date of Exercise, to the registered holder of such Warrant Certificate,
or such other person as shall be designated in the election to purchase, a new
Warrant Certificate representing the number of full Warrants not exercised.  In
no event shall a fraction of a Warrant be exercised, and the Warrant Agent
shall distribute no Warrant Certificates representing fractions of Warrants
under this or any other section of this Agreement.  Final fractions of shares
shall be treated as provided in Section 4.14.

         2.6     Reservation of Shares.  The Company shall at all times reserve
and keep available for issuance upon the exercise of Warrants a number of its
authorized but unissued shares of Common Stock that will be sufficient to
permit the exercise in full of all outstanding Warrants.

         2.7     Disposition of Proceeds.  The Warrant Agent shall account at
least monthly (or more frequently upon the request of the Company, provided
that in no event shall the Warrant Agent be required to account more frequently
than weekly) to the Company with respect to Warrants exercised and concurrently
deliver to the Company all funds.





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                                  ARTICLE III

                                CALL OF WARRANTS

         3.1     Call Price and Trigger Price.  The Company may, at its option,
upon not less than 30 days' nor more than 60 days' notice, call for redemption
of all or any portion of the then outstanding Warrants at a call price of $.05
per warrant (such price is hereinafter referred to as the "Call Price"), at any
time after 9:30 A.M., New York City time, on December 20, 1997, provided the
Current Market Price of the Company's Common Stock, as determined pursuant to
Section 4.2, has been at least 150% of the then effective Exercise Price of the
Warrants, as adjusted pursuant to Section 4.8 (the "Call Trigger Price") but
not giving effect to any decrease of such Exercise Price as permitted by
Section 7.12 hereof, for 20 consecutive business days ending within 15 days of
the date of the notice of such call shall have been given to the Warrant Agent
by the Company pursuant to Section 4.11, and provided further that the Company
has complied and continues to be in compliance with the provisions of Section
2.2 hereof.  In the event the Company exercises its right to redeem the
Warrants, such Warrants will be exercisable until the close of business on the
date fixed for redemption in such notice.  If any Warrant called for redemption
is not exercised by such time, such Warrant shall cease to be exercisable and
the holder thereof shall be entitled only to the redemption price..

         3.2     Payment of Call Price.  On or prior to the opening of business
on the Call Date (as defined in Section 4.11), the Company will deposit with
the Warrant Agent funds in form satisfactory to the Warrant Agent sufficient to
purchase all the Warrants which are to be called.  Payment of the Call Price
will be made by the Warrant Agent upon presentation and surrender of the
Warrant Certificates representing such Warrants to the Warrant Agent at its
Principal Office.


                                   ARTICLE IV

                       ADJUSTMENTS AND NOTICE PROVISIONS

         4.1     Adjustment of Exercise Price.  Subject to the provisions of
this Article IV, the Exercise Price in effect from time to time shall be
subject to adjustment, as follows:

                 (a)      In case the Company shall at any time after the date
hereof (i) declare a dividend on the outstanding Common Stock payable in shares
of its capital stock, (ii) subdivide the outstanding Common Stock, (iii)
combine the outstanding Common Stock into a smaller number of shares, or (iv)
issue any shares of its capital stock by reclassification of the Common Stock
(including any such reclassification in connection with a consolidation or
merger in which the Company is the continuing corporation), then, in each case,
the Exercise Price in effect, and the number of shares of Common Stock issuable
upon exercise of the Warrants outstanding, at the time of the record date for
such dividend or of the effective date of such subdivision, combination or
reclassification, shall be proportionately adjusted so that the holders of the
Warrants after such time shall be entitled to receive the aggregate number and
kind of shares which, if such Warrants had been exercised immediately prior to
such time, such holders would have owned upon such exercise and been entitled
to receive by virtue of such dividend,





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subdivision, combination or reclassification.  Such adjustment shall be made
successively whenever any event listed above shall occur.

                 (b)      In case the Company shall distribute to all holders
of Common Stock (including any such distribution made to the shareholders of
the Company in connection with a consolidation or merger in which the Company
is the continuing corporation) evidences of its indebtedness, cash or assets
(other than distributions and dividends payable in shares of Common Stock), or
rights, options or warrants to subscribe for or purchase Common Stock, or
securities convertible into or exchangeable for shares of Common Stock, then,
in each case, the Exercise Price shall be adjusted by multiplying the Exercise
Price in effect immediately prior to the record date for the determination of
shareholders entitled to receive such distribution by a fraction, the numerator
of which shall be the Current Market Price (as determined pursuant to Section
4.2 hereof) per share of Common Stock on such record date, less the fair market
value (as determined in good faith by the board of directors of the Company,
whose determination shall be conclusive absent manifest error) of the portion
of the evidences of indebtedness or assets so to be distributed, or of such
rights, options, or warrants or convertible or exchangeable securities, or the
amount of such cash, applicable to one share, and the denominator of which
shall be such Current Market Price per share of Common Stock.  Such adjustment
shall become effective at the close of business on such record date.

         4.2     Current Market Price.  For the purpose of any computation
under Section 3.1 and this Article IV, the Current Market Price per share of
Common Stock on any date shall be deemed to be the average of the daily closing
prices for the 20 consecutive trading days immediately preceding the date in
question.  For the purpose of any computation hereunder or under Section 3.1,
the closing price for each day shall be the last reported sales price regular
way or, in case no such reported sale takes place on such day, the closing bid
price regular way, in either case on the principal national securities exchange
(including, for purposes hereof, the NASDAQ National Market System) on which
the Common Stock is listed or admitted to trading or, if the Common Stock is
not listed or admitted to trading on any national securities exchange, the
highest reported bid price for the Common Stock as furnished by the NASD
through NASDAQ or a similar organization if NASDAQ is no longer reporting such
information.  If on any such date the Common Stock is not listed or admitted to
trading on any national securities exchange and is not quoted by NASDAQ or any
similar organization, the fair value of a share of Common Stock on such date as
determined in good faith by the board of directors of the Company, whose
determination shall be conclusive absent manifest error, shall be used.

         4.3     No Adjustments to Exercise Price.  No adjustment in the
Exercise Price shall be required if such adjustment is less than $.05;
provided, however, that any adjustments which by reason of this Article IV are
not required to be made shall be carried forward and taken into account in any
subsequent adjustment.  All calculations under this Article IV shall be made to
the nearest cent or to the nearest one hundredth of a share, as the case may
be.

         4.4     Deferral of Adjustments to Exercise Price.  In any case in
which this Article IV shall require that an adjustment in the Exercise Price be
made effective as of a record date for a specified event, the Company may elect
to defer, until the occurrence of such event, issuing to the holders of the
Warrants, if any holder has exercised a Warrant after such record date, the
shares of Common Stock, if any, issuable upon such exercise over and above the
shares of





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Common Stock, if any, issuable upon such exercise on the basis of the Exercise
price in effect prior to such adjustment; provided, however, that the Company
shall deliver to such exercising holder a due bill or other appropriate
instrument evidencing such holder's right to receive such additional shares
upon the occurrence of the event requiring such adjustment.

         4.5     Adjustment to Number of Shares.  Upon each adjustment of the
Exercise Price as a result of the calculations made in Section 4.1(b) hereof,
the Warrants shall thereafter evidence the right to purchase, at the adjusted
Exercise Price, that number of shares (calculated to the nearest hundredth)
obtained by dividing (A) the product obtained by multiplying the number of
shares purchasable upon exercise of the Warrants prior to adjustment of the
number of shares by the Exercise Price in effect prior to adjustment of the
Exercise Price by (B) the Exercise Price in effect after such adjustment of the
Exercise Price.

         4.6     Reorganizations.  In case of any capital reorganization, other
than in the cases referred to in Section 4.1 hereof, or the consolidation or
merger of the Company with or into another corporation (other than a merger or
consolidation in which the Company is the continuing corporation and which does
not result in any reclassification of the outstanding shares of Common Stock or
the conversion of such outstanding shares of Common Stock into shares of other
stock or other securities or property), or in the case of any sale, lease or
conveyance to another corporation of the property and assets of any nature of
the Company as an entirety or substantially as an entirety (such actions being
hereinafter collectively referred to as "Reorganizations"), there shall
thereafter be deliverable upon exercise of any Warrant (in lieu of the number
of shares of Common Stock theretofore deliverable) the number of shares of
stock or other securities or property to which a holder of the number of shares
of Common Stock which would otherwise have been deliverable upon the exercise
of such Warrant would have been entitled upon such Reorganization if such
Warrant had been exercised in full immediately prior to such Reorganization.
In case of any Reorganization, appropriate adjustment, as determined in good
faith by the Board of Directors of the Company, shall be made in the
application of the provisions herein set forth with respect to the rights and
interests of Warrant holders so that the provisions set forth herein shall
thereafter be applicable, as nearly as possible, in relation to any shares or
other property thereafter deliverable upon exercise of Warrants.  Any such
adjustment shall be made by and set forth in a supplemental agreement between
the Company, or any successor thereto, and the Warrant Agent and shall for all
purposes hereof conclusively be deemed to be an appropriate adjustment.  The
Company shall not effect any such Reorganization unless upon or prior to the
consummation thereof the successor corporation, or if the Company shall be the
surviving corporation in any such Reorganization and is not the issuer of the
shares of stock or other securities or property to be delivered to holders of
shares of the Common Stock outstanding at the effective time thereof, then such
issuer, shall assume by written instrument the obligation to deliver to the
registered holder of any Warrant Certificate such shares of stock, securities,
cash or other property as such holder shall be entitled to purchase in
accordance with the foregoing provisions.  In the event of sale, lease or
conveyance or other transfer of all or substantially all of the assets of the
Company as part of a plan for liquidation of the Company, all rights to
exercise any Warrant shall terminate 30 days after the Company gives written
notice to each registered holder of a Warrant Certificate that such sale or
conveyance or other transfer has been consummated.





                                       6
   10
         4.7     Reclassifications.  In case of any reclassification or change
of the shares of Common Stock issuable upon exercise of the Warrants (other
than a change in par value or from no par value to a specified par value, or as
a result of a subdivision or combination, but including any change in the
shares into two or more classes or series of shares), or in case of any
consolidation or merger of another corporation into the Company in which the
Company is the continuing corporation and in which there is a reclassification
or change (including a change to the right to receive cash or other property)
of the shares of Common Stock (other than a change in par value, or from no par
value to a specified par value, or as a result of a subdivision or combination,
but including any change in the shares into two or more classes or series of
shares), the holders of the Warrants shall have the right thereafter to receive
upon exercise of the Warrants solely the kind and amount of shares of stock and
other securities, property, cash, or any combination thereof receivable upon
such reclassification, change, consolidation or merger by a holder of the
number of shares of Common Stock for which the Warrants might have been
exercised immediately prior to such reclassification, change, consolidation or
merger.  Thereafter, appropriate provision shall be made for adjustments which
shall be as nearly equivalent as practicable to the adjustments in Article IV.
The above provisions of this Section 4.7 shall similarly apply to successive
reclassifications and changes of shares of Common Stock.

         4.8     Adjustment of Call Trigger Price.  Upon each adjustment of the
Exercise Price of the Warrants pursuant to Article IV hereof, the Call Trigger
Price shall be adjusted by multiplying such price as in effect prior to such
adjustment by a fraction, the numerator of which shall be the Exercise Price
subsequent to adjustment and the denominator of which shall be the Exercise
Price prior to such adjustment.  All calculations under this Section 4.8 shall
be made to the nearest cent.

         4.9     Verification of Computations.  Whenever the exercise price is
adjusted as provided in this Article IV, the Company will promptly obtain a
certificate of its Chief Financial Officer setting forth the exercise price as
so adjusted and a brief statement of the facts accounting for such adjustment,
and will make available a brief summary thereof to the holders of the Warrant
Certificates, at their addresses listed on the register maintained for that
purpose by the Warrant Agent (which summary may be included in any notice of
adjustment required by Section 4.12 hereof).

         4.10    Notice of Certain Actions.  In case at any time the Company
shall propose:

                 (a)      to pay any dividend or make any distribution on
         shares of Common Stock in shares of Common Stock or make any other
         distribution (other than regularly scheduled cash dividends which are
         not in a greater amount per share than the most recent such cash
         dividend) to all holders of Common Stock; or

                 (b)      to issue any rights, warrants or other securities to
         all holders of Common Stock entitling them to purchase any additional
         shares of Common Stock or any other rights, warrants or other
         securities; or





                                       7
   11
                 (c)      to effect any consolidation, merger, sale, lease, or
         conveyance of property, described in Section 4.6, or any
         reclassification or change of outstanding shares of Common Stock,
         described in Section 4.7; or

                 (d)      to effect any liquidation, dissolution or winding-up 
         of the Company; or

                 (e)      to take any other action which would cause an
         adjustment to the Exercise Price;

then, in each such case, the Company shall cause notice of such proposed action
to be mailed to the Warrant Agent.  Such notice shall specify the date on which
the books of the Company shall close, or a record shall be taken, for
determining holders of Common Stock entitled to receive such stock dividend or
other distribution or such rights or warrants, or the date on which such
reclassification, change, consolidation, merger, sale, lease, other
disposition, liquidation, dissolution, winding up or exchange or other action
shall take place or commence, as the case may be, and the date as of which it
is expected that holders of record of Common Stock shall be entitled to receive
securities or other property deliverable upon such action, if any such date has
been fixed.  The Company shall cause copies of such notice to be mailed to each
registered holder of a Warrant Certificate.  Such notice shall be mailed, in
the case of any action covered by Subsection 4.10(a) or 4.10(b) above, at least
15 days prior to the record date for determining holders of the Common Stock
for purposes of receiving such payment or offer; in the case of any action
covered by Subsection 4.10(c) or 4.10(d) above, at least 15 days prior to the
earlier of the date upon which such action is to take place or any record date
to determine holders of Common Stock entitled to receive such securities or
other property; and in the case of any action covered by Subsection 4.10(e)
above, no more than 15 days after such action.

         4.11    Notice of Call.  Notice of any call for redemption shall be
given to the Warrant Agent by the Company upon not less than 30 days nor more
than 60 days prior to the date established for such call (the "Call Date") and
the Company shall cause the Warrant Agent to mail such notice to all registered
holders of Warrant Certificates to be called promptly after the Company shall
have given such notice to the Warrant Agent.  Each such notice of call will
specify the Call Date and the Call Price.  The notice will state that payment
of the Call Price will be made by the Warrant Agent upon presentation and
surrender of the Warrant Certificates representing such Warrants to the Warrant
Agent at its Principal Office, and will also state that the right to exercise
the Warrants will terminate at 5:00 P.M., New York City time, on the business
day immediately preceding the Call Date.  The Company will also make prompt
public announcement of such redemption by news release and by notice to the
NASD or any national securities exchange on which the Warrants are listed for
trading.

         4.12    Notice of Adjustments.  Whenever any adjustment is made
pursuant to this Article IV, the Company shall cause written notice of such
adjustment to be sent by registered mail, postage prepaid to the Warrant Agent
within 15 days thereafter, such notice to include in reasonable detail (i) the
events precipitating the adjustment, (ii) the computation of any adjustments,
and (iii) the Exercise Price, the number of shares or the securities or other
property purchasable upon exercise of each Warrant and the Call Trigger Price
after giving effect to such adjustment.  The Company shall cause the Warrant
Agent, within 15 days after receipt for such




                                       8
   12
notice from the Company, to mail a similar notice to be mailed to each
registered holder of a Warrant Certificate.

         4.13    Warrant Certificate Amendment.  Irrespective of any
adjustments pursuant to this Article IV, Warrant Certificates theretofore or
thereafter issued need not be amended or replaced but certificates thereafter
issued shall bear an appropriate legend or other notice of any adjustments.

         4.14    Fractional Shares.  The Company shall not be required upon the
exercise of any Warrant to issue fractional shares of Common Stock which may
result from such exercise.  If more than one Warrant is exercised at one time
by the same registered holder, the number of full shares of Common Stock which
shall be deliverable shall be computed based on the number of shares
deliverable in exchange for the aggregate number of Warrants exercised.  With
respect to any final fraction of a share called for upon the exercise of any
Warrant or Warrants, the Company may pay a cash adjustment in respect of such
final fraction in an amount equal to the same fraction of the Current Market
Price of a share of Common Stock calculated in accordance with Section 4.2.


                                   ARTICLE V

                     OTHER PROVISIONS RELATING TO RIGHTS OF
                   REGISTERED HOLDERS OF WARRANT CERTIFICATES

         5.1     Rights of Warrant Holders.  No Warrant Certificate shall
entitle the registered holder thereof to any of the rights of a shareholder of
the Company, including, without limitation, the right to vote, to receive
dividends and other distributions, or to receive any notice of, or to attend,
meetings of shareholders or any other proceedings of the Company.

         5.2     Lost, Stolen, Mutilated or Destroyed Warrant Certificates.  If
any Warrant Certificate shall be mutilated, lost, stolen or destroyed, the
Company shall direct the Warrant Agent to execute and deliver, in exchange and
substitution for and upon cancellation of a mutilated Warrant Certificate, or
in lieu of or in substitution for a lost, stolen or destroyed Warrant
Certificate, a new Warrant Certificate for the number of Warrants represented
by the Warrant Certificate so mutilated, lost, stolen or destroyed but only
upon receipt of evidence of such loss, theft or destruction of such Warrant
Certificate, and of the ownership thereof, and indemnity, if requested, all
satisfactory to the Company and the Warrant Agent.  Applicants for such
substitute Warrant Certificates shall also comply with such other reasonable
regulations and pay such other reasonable charges incidental thereto as the
Company or Warrant Agent may prescribe.  Any such new Warrant Certificate shall
constitute an original contractual obligation of the Company, whether or not
the allegedly lost, stolen, mutilated or destroyed Warrant Certificate shall be
at any time enforceable by anyone.





                                       9
   13
                                   ARTICLE VI

                   SPLIT UP, COMBINATION, EXCHANGE, TRANSFER
                    AND CANCELLATION OF WARRANT CERTIFICATES

         6.1     Split Up, Combination, Exchange and Transfer of Warrant
Certificates.  Prior to the Exercise Deadline, Warrant Certificates, subject to
the provisions of Section 6.2, may be split up, combined or exchanged for other
Warrant Certificates representing a like aggregate number of Warrants or may be
transferred in whole or in part.  Any holder desiring to split up, combine or
exchange a Warrant Certificate or Warrant Certificates shall make such request
in writing delivered to the Warrant Agent at its Principal Office and shall
surrender the Warrant Certificate or Warrant Certificates so to be split up,
combined or exchanged at said office.  Subject to any applicable laws, rules or
regulations restricting transferability, any restriction on transferability
that may appear on a Warrant Certificate in accordance with the terms hereof,
or any "stop-transfer" instructions the Company may give to the Warrant Agent
to implement any such restrictions (which instructions the Company is expressly
authorized to give), transfer of outstanding Warrant Certificates may be
effected by the Warrant Agent from time to time upon the books of the Company
to be maintained by the Warrant Agent for that purpose, upon a surrender of the
Warrant Certificate to the Warrant Agent at its Principal Office, with the
assignment form set forth in the Warrant Certificate duly executed and with
Signatures Guaranteed.  Upon any such surrender for split up, combination,
exchange or transfer, the Warrant Agent shall execute and deliver to the person
entitled thereto a Warrant Certificate or Warrant Certificates, as the case may
be, as so requested.  The Warrant Agent may require the holder to pay a sum
sufficient to cover any tax or governmental charge that may be imposed in
connection with any split up, combination, exchange or transfer of Warrant
Certificates prior to the issuance of any new Warrant Certificate.

         6.2     Cancellation of Warrant Certificates.  Any Warrant Certificate
surrendered upon the exercise of Warrants or for split up, combination,
exchange or transfer, or purchased or otherwise acquired by the Company, shall
be cancelled and shall not be reissued by the Company; and, except as provided
(i) in Section 2.5, in case of the exercise of less than all of the Warrants
evidenced by a Warrant Certificate, or (ii) in Section 6.1, in case of a split
up, combination, exchange or transfer of the Warrants evidenced by a Warrant
Certificate, no Warrant Certificate shall be issued hereunder in lieu of such
cancelled Warrant Certificate.  Any Warrant Certificate so cancelled shall be
destroyed by the Warrant Agent unless otherwise directed by the Company.

         6.3     Agreement of Warrant Certificate Holders.  Every holder of a
Warrant Certificate by accepting the same consents and agrees with the Company
and the Warrant Agent and with every other holder of a Warrant Certificate
that:

                 (a)      transfer of the Warrant Certificates shall be
registered on the books of the Company maintained for that purpose by the
Warrant Agent only if surrendered at the Principal Office of the Warrant Agent,
duly endorsed or accompanied by a proper instrument of transfer, with
Signatures Guaranteed; and





                                       10
   14
                 (b)      prior to due presentment for registration of
transfer, the Company and the Warrant Agent may deem and treat the person in
whose name the Warrant Certificate is registered as the absolute owner thereof
and of the Warrants evidenced thereby (notwithstanding any notations of
ownership or writing on the Warrant Certificates made by anyone other than the
Company or the Warrant Agent) for all purposes whatsoever, and neither the
Company nor the Warrant Agent shall be affected by any notice to the contrary.


                                  ARTICLE VII

                    PROVISIONS CONCERNING THE WARRANT AGENT
                               AND OTHER MATTERS

         7.1     Payment of Taxes and Charges.  The Company will from time to
time promptly pay to the Warrant Agent, or make provisions satisfactory to the
Warrant Agent for the payment of, all taxes and charges that may be imposed by
the United States or any state upon the Company or the Warrant Agent in
connection with the issuance or delivery of shares of Common Stock upon the
exercise of any Warrants, but any transfer taxes in connection with the
issuance of Warrant Certificates or certificates for shares of Common Stock in
any name other than that of the registered holder of the Warrant Certificate
surrendered shall be paid by such registered holder; and, in such case, the
Company shall not be required to issue or deliver any Warrant Certificate or
certificate for shares of Common Stock until such taxes shall have been paid or
it has been established to the Company's satisfaction that no tax is due.

         7.2     Resignation or Removal of Warrant Agent.  The Warrant Agent
may resign its duties and be discharged from all further duties and liabilities
hereunder after giving 30 days' notice in writing to the Company, except that
such shorter notice may be given as the Company shall, in writing, accept as
sufficient.  Upon comparable notice to the Warrant Agent, the Company may
remove the Warrant Agent; provided, however, that in such event the Company
shall appoint a new Warrant Agent, as hereinafter provided, and the removal of
the Warrant Agent shall not be effective until a new Warrant Agent has been
appointed and has accepted such appointment.  If the office of Warrant Agent
becomes vacant by resignation or incapacity to act or otherwise, the Company
shall appoint in writing a new Warrant Agent.  If the Company shall fail to
make such appointment within a period of 30 days after it has been notified in
writing of such resignation or incapacity by the resigning or incapacitated
Warrant Agent or by the registered holder of any Warrant Certificate, then the
registered holder of any Warrant Certificate may apply to any court of
competent jurisdiction for the appointment of a new Warrant Agent.  Any
successor Warrant Agent, whether appointed by the Company or any such court,
shall be a registered transfer agent, bank or trust company in good standing
and incorporated under the United States banking laws or under the laws of any
State within the United States, having its principal office within the United
States.  Any new Warrant Agent appointed hereunder shall execute, acknowledge
and deliver to the former Warrant Agent last in office and to the Company, an
instrument accepting such appointment under substantially the same terms and
conditions as are contained herein and thereupon such new Warrant Agent,
without any further act or deed, shall become vested with the rights, powers,
duties and responsibilities of the Warrant Agent and the former Warrant Agent
shall cease to be the Warrant Agent; but if for any reason it becomes necessary
or expedient to have the former Warrant Agent execute and deliver any further





                                       11
   15
assurance, conveyance, act or deed, the same shall be done at the expense of
the Company and shall be legally and validly executed and delivered by the
former Warrant Agent.

         7.3     Notice of Appointment.  Not later than the effective date of
the appointment of a new Warrant Agent, the Company shall cause notice thereof
to be mailed to the former Warrant Agent and the transfer agent, if any, for
the Common Stock and shall forthwith cause a copy of such notice to be mailed
to each registered holder of a Warrant Certificate.  Failure to mail such
notice, or any defect contained therein, shall not affect the legality or
validity of the appointment of the successor Warrant Agent.

         7.4     Merger of Warrant Agent.  Any company into which the Warrant
Agent may be merged or with which it may be consolidated, or any company
resulting from any merger or consolidation to which the Warrant Agent shall be
a party, shall be the successor Warrant Agent under this Agreement without
further act, provided that such company would be eligible for appointment as a
successor Warrant Agent under the provisions of Section 7.2 hereof.  Any such
successor Warrant Agent may adopt the prior countersignature of any predecessor
Warrant Agent and distribute Warrant Certificates countersigned but not
distributed by such predecessor Warrant Agent, or may countersign the Warrant
Certificates in its own name.

         7.5     Company Responsibilities.  The Company agrees that it shall
(i) pay the Warrant Agent reasonable remuneration for its services as Warrant
Agent hereunder and will reimburse the Warrant Agent upon demand for all
expenses, advances and expenditures that the Warrant Agent may reasonably incur
in the execution of its duties hereunder (including fees and expenses of its
counsel); (ii) provide the Warrant Agent, upon request, with sufficient funds
to pay any cash due pursuant to Section 4.14 upon exercise of Warrants; and
(iii) perform, execute, acknowledge and deliver or cause to be performed,
executed, acknowledged and delivered all further and other acts, instruments
and assurances as may reasonably be required by the Warrant Agent for the
carrying out or performing by the Warrant Agent of the provisions of this
Agreement.

         7.6     Certification for the Benefit of Warrant Agent.  Whenever in
the performance of its duties under this Agreement the Warrant Agent shall deem
it necessary or desirable that any matter be proved or established or that any
instructions with respect to the performance of its duties hereunder be given
by the Company prior to taking or suffering any action hereunder, such matter
(unless other evidence in respect thereof be herein specifically prescribed)
may be deemed to be conclusively proved and established, or such instructions
may be given, by a certificate or instrument signed by the Chairman, the Chief
Executive Officer, the President, a Vice President, the Secretary or the
Treasurer of the Company and delivered to the Warrant Agent.  Such certificate
or instrument may be relied upon by the Warrant Agent for any action taken or
suffered in good faith by it under the provisions of this Agreement; but in its
discretion the Warrant Agent may in lieu thereof accept other evidence of such
matter or a may require such further or additional evidence as it may deem
reasonable.

         7.7     Books and Records.  The Warrant Agent shall maintain the
Company's books and records for registration and registration of transfer of
the Warrant Certificates issued hereunder.  Such books and records shall show
the names and addresses of the respective holders of the





                                       12
   16
Warrant Certificates, the number of Warrants evidenced on its face by each
Warrant Certificate and the date of each Warrant Certificate.

         7.8     Liability of Warrant Agent.  The Warrant Agent shall be liable
hereunder for its own negligence or willful misconduct.  The Warrant Agent
shall act hereunder solely as an agent for the Company and its duties shall be
determined solely by the provisions hereof.  The Warrant Agent shall not be
liable for or by reason of any of the statements of fact or recitals contained
in this Agreement or in the Warrant Certificates (except its counter-signature
thereof) or be required to verify the same, but all such statements and
recitals are and shall be deemed to have been made by the Company only.  The
Warrant Agent will not incur any liability or responsibility to the Company or
to any holder of any Warrant Certificate for any action taken, or any failure
to take action, in reliance on any notice, resolution, waiver, consent, order,
certificate or other paper, document or instrument reasonably believed by the
Warrant Agent to be genuine and to have been signed, sent or presented by the
proper party or parties.  The Warrant Agent shall not be under any
responsibility in respect of the validity of this Agreement or the execution
and delivery hereof by the Company or in respect of the validity or execution
of any Warrant Certificate (except its counter-signature thereof); nor shall it
be responsible for any breach by the Company of any covenant or condition
contained in this Agreement or in any Warrant Certificate; nor shall it be
responsible for the making of any adjustment required under the provisions of
Article IV hereof or responsible for the manner, method or amount of any such
adjustment or the facts that would require any such adjustment; nor shall it by
any act hereunder be deemed to make any representation or warranty as to the
authorization or reservation of any shares of Common Stock or other securities
to be issued pursuant to this Agreement or any Warrant Certificate or as to
whether any shares of Common Stock or other securities will, when issued, be
validly authorized and issued and fully paid and nonassessable.

         7.9     Use of Attorneys, Agents and Employees.  The Warrant Agent may
execute and exercise any of the rights or powers hereby vested in it or perform
any duty hereunder either itself or by or through its attorneys, agents or
employees.

         7.10    Indemnification.  The Company agrees to indemnify the Warrant
Agent and save it harmless against any and all losses, expenses or liabilities,
including judgements, costs and counsel fees arising out of or in connection
with its agency under this Agreement, except as a result of the negligence or
willful misconduct of the Warrant Agent.

         7.11    Acceptance of Agency.  The Warrant Agent hereby accepts the
agency established by this Agreement and agrees to perform the same upon the
terms and conditions herein set forth.

         7.12    Changes to Agreement.  The Warrant Agent may, without the
consent or concurrence of any registered holder of a Warrant Certificate, by
supplemental agreement or otherwise, join with the Company in making any
changes or corrections in this Agreement that they shall have been advised by
counsel (i) are required to cure any ambiguity or to correct any defective or
inconsistent provision or clerical omission or mistake or manifest error herein
contained, (ii) add to the covenants and agreements of the Company or the
Warrant Agent in this Agreement such further covenants and agreements
thereafter to be observed, or (iii) result in the surrender or modification of
any right or power reserved to or conferred upon the Company or





                                       13
   17
the Warrant Agent in this Agreement, including, without limitation, the
reduction of the Exercise Price (except for purposes of Article III hereof),
but which changes or corrections do not or will not adversely affect, alter or
change the rights, privileges or immunities of the registered holders of
Warrant Certificates.

         7.13    Assignment.  All the covenants and provisions of this
Agreement by or for the benefit of the Company or the Warrant Agent shall bind
and inure to the benefit of their respective successors and assigns.

         7.14    Successor to Company.  The Company will not merger or
consolidate with or into any other corporation or sell or otherwise transfer
its property, assets and business substantially as an entirety to a successor
corporation, unless the corporation resulting from such merger, consolidation,
sale or transfer (if not the Company) shall expressly assume, by supplemental
agreement satisfactory in form and substance to the Warrant Agent and delivered
to the Warrant Agent, the due and punctual performance and observance of each
and every covenant and condition of this Agreement to be performed and observed
by the Company.

         7.15    Notices.  Any notice or demand required by this Agreement to
be given or made by the Warrant Agent or by the registered holder of any
Warrant Certificate to or on the Company shall be sufficiently given or made if
sent by first-class or registered mail, postage prepaid, addressed (until
another address is filed in writing with the Warrant Agent by the Company) as
follows:

                          Epoch Pharmaceuticals, Inc.
                          1725 220th Street, S.E., No. 104
                          Bothell, Washington 98021
                          Attention:  Chief Financial Officer

Any notice or demand required by this Agreement to be given or made by the
registered holder of any Warrant Certificate or by the Company to or on the
Warrant Agent shall be sufficiently given or made if sent by first-class or
registered mail, postage prepaid, addressed (until another address is filed in
writing with the Company by the Warrant Agent), as follows:

                          American Stock Transfer & Trust Company
                          40 Wall Street
                          New York, New York 10005
                          Attention:  George Karfunkel

Any notice or demand required by this Agreement to be given or made by the
Company or the Warrant Agent to or on the registered holder of any Warrant
Certificate shall be sufficiently given or made, whether or not such holder
receives the notice, if sent by first-class or registered mail, postage
prepaid, addressed to such registered holder at his last address as shown on
the books of the Company maintained by the Warrant Agent.  Otherwise such
notice or demand shall be deemed given when received by the party entitled
thereto.





                                       14
   18
         7.16    Defects in Notice.  Failure to file any certificate or notice
or to mail any notice, or any defect in any certificate or notice pursuant to
this Agreement, shall not affect in any way the rights of any registered holder
of a Warrant Certificate or the legality or validity of any adjustment made
pursuant to Article IV hereof, or any transaction giving rise to any such
adjustment, or the legality or validity of any action taken or to be taken by
the Company.

         7.17    Governing Law.  The laws of the State of New York shall govern
this Warrant Agreement and the Warrant Certificates.

         7.18    Standing.  Nothing in this Agreement expressed and nothing
that may be implied from any of the provisions hereof is intended, or shall be
construed, to confer upon, or give to, any person or corporation other than the
Company, the Warrant Agent, and the registered holders of the Warrant
Certificates any right, remedy or claim under or by reason of this Agreement or
of any covenant, condition, stipulation, promise or agreement contained herein;
and all covenants, conditions, stipulations, promises and agreements contained
in this Agreement shall be for the sole and exclusive benefit of the Company
and the Warrant Agent and their respective successors and assigns, and the
registered holders of the Warrant Certificates.

         7.19    Headings.  The descriptive headings of the articles and
sections of this Agreement are inserted for convenience only and shall not
control or affect the meaning or construction of any of the provisions hereof.

         7.20    Counterparts.  This Agreement may be executed in any number of
counterparts, each of which so executed shall be deemed to be an original; but
such counterparts shall together constitute but one and the same instrument.

         7.21    Conflict of Interest.  The Warrant Agent and any shareholder,
director, officer or employee of the Warrant Agent may buy, sell or deal in any
of the Warrant Certificates or other securities of the Company or become
pecuniarily interested in any transaction in which the Company may be
interested, or contract with or lend money to the Company or otherwise act as
fully and freely as though the Warrant Agent were not Warrant Agent under this
Agreement.  Nothing herein shall preclude the Warrant Agent from acting in any
other capacity for the Company, including, without limitation, as trustee under
any indenture or as transfer agent for the Common Stock or any other securities
of the Company, or for any other legal entity.

         7.22    Availability of the Agreement.  The Warrant Agent shall keep
copies of this Agreement available for inspection by holders of Warrants during
normal business hours at its Principal Office.  Copies of this Agreement may be
obtained upon written request addressed to:

                 Epoch Pharmaceuticals, Inc.
                 1725 220th Street, S.E., No. 104
                 Bothell, Washington 98021
                 Attention:  Chief Financial Officer





                                       15
   19
         IN WITNESS WHEREOF, this Agreement has been duly executed by the
parties hereto as of the day and year first above written.

                                        EPOCH PHARMACEUTICALS, INC.



                                        By:  /s/ SANFORD ZWEIFACH              
                                             ------------------------------
                                             Name:   Sanford Zweifach
                                             Title:  President and Chief 
                                                     Financial Officer


                                        AMERICAN STOCK TRANSFER & TRUST COMPANY



                                        By:  /s/ HERBERT J. LEMMER            
                                             -----------------------------
                                             Name:   Herber J. Lemmer
                                             Title:  Vice President





                                       16
   20



WCC-____                      WARRANT CERTIFICATE

                            CERTIFICATE FOR WARRANTS

              NOT EXERCISABLE AFTER 5:00 P.M., NEW YORK CITY TIME,
                                ON JUNE 20, 2001


                          EPOCH PHARMACEUTICALS, INC.

          CLASS C REDEEMABLE COMMON STOCK PURCHASE WARRANT CERTIFICATE


THIS CERTIFIES that





or registered assigns is the registered holder (the "Registered Holder") of the
number of Warrants set forth above, each of which represents the right to
purchase one-half (1/2) fully paid and nonassessable share of Common Stock, par
value $.01 per share (the "Common Stock") of Epoch Pharmaceuticals, Inc., a
Delaware corporation (the "Company"), at the initial exercise price ("Exercise
Price") of $1.25 per one-half share at any time,but not after the Expiration
Date hereinafter referred to, by surrendering this Warrant Certificate, with
the form of election to purchase set forth hereon duly executed at the office
maintained pursuant to the Warrant Agreement hereinafter referred to for that
purpose by American Stock Transfer & Trust Company, or its successor as warrant
agent (any such warrant agent being herein called the "Warrant Agent"), and by
paying in full the Exercise Price, plus transfer taxes, if any.  Payment of the
Exercise Price shall be made in United States currency, by certified check or
money order payable to the Warrant Agent for the account of the Company.

         The Warrants are subject to call for redemption by the Company upon
not less than 30 days' nor more than 60 days' notice at a call price of $0.05
per warrant (the "Call Price"), at any time after 9:30 A.M, New York City time,
on December 20, 1997, provided that closing sale price of the Common Stock, as
determined pursuant to Section 4.2 of the Warrant Agreement, dated as of June
21, 1996, between the Company and the Warrant Agent (the "Warrant Agreement"),
shall have been at least 150% of the then effective exercise price of the
Warrants, as adjusted pursuant to Section 4.8 of the Warrant Agreement (the
"Call Trigger Price"), for a period of 20 consecutive business days ending
within 15 days of the date that the notice of such call (the "Call Notice") is
given by the Company to the Warrant Agent pursuant to Section 4.11 of the
Warrant Agreement, and provided further that the Company has complied and
continues to be in compliance with the provisions of Section 2.2 of the Warrant
Agreement.



   21
         No warrant may be executed after 5:00 P.M., New York City time, on the
expiration date (the "Expiration Date") which will be the earlier of June 20,
2001 or the business day preceding the call date specified in a Call Notice.
All warrants evidenced hereby shall thereafter become void.

         Prior to the Expiration Date, subject to any applicable laws, rules or
regulations restrictions transferability and to any restriction on
transferability that may appear on this Warrant Certificate in accordance with
the terms of the Warrant Agreement, the Registered Holder shall be entitled to
transfer this Warrant Certificate, in whole or in part, upon surrender of this
Warrant Certificate at the office of the Warrant Agent maintained for that
purpose with the form of assignment set forth hereon duly executed, with
signatures guaranteed by a member firm of a national securities exchange, a
commercial bank or a trust company located in the United States or a member of
the National Association of Securities Dealers, Inc. or other eligible
guarantor institution which is a participant in a signature guarantee program
(as such terms are defined in Reg. 240.17Ad-15 under the Securities Exchange
Act of 1934, as amended), acceptable to the Warrant Agent.  Upon any such
transfer, a new Warrant Certificate or Warrant Certificates representing the
same aggregate number of Warrants will be issued in accordance with
instructions in the form of assignment.

         Upon the exercise of less than all of the Warrants evidence by this
Warrant Certificate, there shall be issued to the Registered Holder a new
Warrant Certificate in respect of the Warrants not exercised.

         Prior to the Expiration Date, the Registered Holder shall be entitled
to exchange this Warrant Certificate with or without prior Warrant
Certificates, for another Warrant Certificate or Warrant Certificates of the
same aggregate number of Warrants upon surrender of this Warranter Certificate
at the office maintained for such purpose by the Warrant Agent.

         Upon certain events provided for in the Warrant Agreement hereinafter
referred to the Exercise Price, the number of shares of Common Stock issuable
upon the exercise of each Warrant and the Call Trigger Price are required to be
adjusted.

         No fractional shares will be issued upon the exercise of Warrants.  As
to any final fraction of a share which the registered holder of one or more
Warrant Certificates, the rights under which are exercised in the same
transaction, would otherwise be entitled to purchase upon such exercise, the
Company shall pay the cash value thereof determined as provided in the Warrant
Agreement.

         This Warrant Certificate is issued under and in accordance with the
Warrant Agreements and is subject to the terms and provisions contained in said
Warrant Agreement, to all of which terms and provisions the Registered Holder
consents by acceptance hereof.

         This Warrant Certificate shall not entitle the Registered Holder to
any of the rights of a shareholder of the Company, including without
limitation, the rights to vote, to receive dividends and other distributions,
or to attend or receive any notice of meetings of shareholders or any other
proceedings of the Company.




                                       2

   22
         This Warrant Certificate shall not be valid for any purpose unless and
until it shall have been countersigned by the Warrant Agent.

         IN WITNESS WHEREOF, the Company has caused this Warrant Certificate to
be duly executed under its facsimile Corporate Seal.


Dated:   June 21, 1996


                                          EPOCH PHARMACEUTICALS, INC.


                                          ATTEST:


                                          By:                                 
                                              -------------------------------
                                              Secretary


                                          By:                                 
                                              -------------------------------
                                              President






                                       3
   23
                              ELECTION TO PURCHASE

      The undersigned hereby irrevocably elects to exercise ____ of the
Warrants represented by this Warrant Certificate and to purchase the shares of
Common Stock issuable upon the exercise of said Warrants, and requests that
certificates for such shares be issued and delivered as follows:

ISSUE TO:


- -------------------------------------------------------------------------------
                                     (NAME)

- -------------------------------------------------------------------------------
                         (ADDRESS, INCLUDING ZIP CODE)

- -------------------------------------------------------------------------------
                 (SOCIAL SECURITY OR OTHER TAX IDENTIFYING NUMBER)

DELIVER TO:


- -------------------------------------------------------------------------------
                                     (NAME)

- -------------------------------------------------------------------------------
                         (ADDRESS, INCLUDING ZIP CODE)

      If the number of Warrants hereby exercised is less than all the Warrants
represented by this Warrant Certificate, the undersigned requests that a new
Warrant Certificate representing the number of full Warrants not exercised be
issued and delivered as set forth below.

      In full payment of the purchase price with respect to the Warrants
exercised and transfer taxes, if any, the undersigned hereby tenders payment of
$_________ by certified check or money order payable to Warrant Agent for the
account of the Company in United States currency.

Dated:

- ------------------------------------           --------------------------------
(Insert Social Security or other               (Signature of registered holder)
 identifying number(s) of holder(s))

                                               --------------------------------
                                               (Signature of registered holder, 
                                                of co-owned)
                                                
                                        NOTE:   Signature must conform in all
                                                respects to name of holder as
                                                specified on the face of the
                                                Warrant Certificate





                                       4
   24
                                   ASSIGNMENT

      FOR VALUE RECEIVED, the undersigned hereby sells, assigns and transfers
unto the Assignee named below all of the rights of the undersigned represented
by the within Warrant Certificate, with respect to the number of warrants set
forth below:


Name of Assignee               Address                  No. of Warrants


- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------


and does hereby irrevocably constitute and appoint ____________________________
_____________ to make such transfer on the books of Epoch Pharmaceuticals, Inc.
maintained for that purpose, with full power of substitution in the premises.

Dated:

- ------------------------------------           --------------------------------
(Insert Social Security or other               (Signature of registered holder)
 identifying number(s) of holder(s))

                                               ---------------------------------
                                               (Signature of registered holder,
                                                of co-owned)

                                        NOTE:  Signature must conform in all
                                               respects to name of holder as
                                               specified on the face of the
                                               Warrant Certificate


Signature(s) Guaranteed:





                                       5