ORASURE TECHNOLOGIES, INC.
                   EMPLOYEE INCENTIVE AND NON-QUALIFIED STOCK
                                   OPTION PLAN


              As Amended and Restated Effective September 29, 2000
              ----------------------------------------------------

            The STC  Technologies,  Inc.  Employee  Incentive and  Non-Qualified
Stock Option Plan (the "STC Plan") was  originally  effective  May 29, 1996.  On
September 29, 2000, both STC  Technologies,  Inc. and Epitope,  Inc. merged with
and into  OraSure  Technologies,  Inc.,  a  Delaware  corporation.  The  OraSure
Technologies,  Inc. Employee Incentive and Non-Qualified  Stock Option Plan (the
"Plan")  is an  amendment  and  restatement  of the STC  Plan  and is  effective
September 29, 2000. The Plan reflects changes to the conditions and requirements
for employee benefit plans under Rule 16b-3, promulgated under Section 16 of the
Exchange Act (as defined below).

            Section 1.   Purposes.
                         --------
            The  purposes  of the  Plan  are  (a) to  recognize  and  compensate
selected  Employees of the Company and its  Subsidiaries  who  contribute to the
development and success of the Company and its Subsidiaries; (b) to maintain the
competitive  position of the  Company and its  Subsidiaries  by  attracting  and
retaining key Employees;  and (c) to provide incentive  compensation to such key
Employees based upon the Company's performance,  as measured by the appreciation
in Common  Stock.  The  Options  issued  pursuant  to the Plan are  intended  to
constitute either Incentive Stock Options,  or non-qualified  stock options,  as
determined by the Committee,  or the Board,  if no Committee has been appointed,
at the time of Award.  The type of  Options  Awarded  will be  specified  in the
Option  Agreement  between the Company and the



Optionee. The terms of this Plan shall be incorporated into the Option Agreement
to be executed by the Optionee.

            Section 2.   Definitions.
                         -----------
            (1) "Award" shall mean a grant of Options to an Employee pursuant to
the  provisions of this Plan.  Each separate grant of Options to an Employee and
each group of Options  which matures on a separate date is treated as a separate
Award.

            (2) "Board"  shall mean the Board of Directors  of the  Company,  as
constituted  from time to time.

            (a) "Change in Control" shall mean the happening of an event,  which
shall be deemed to have  occurred  upon the  earliest to occur of the  following
events:  (i)  the  date  the  stockholders  of the  Company  (or the  Board,  if
stockholder action is not required) approve a plan or other arrangement pursuant
to which the  Company  will be  dissolved  or  liquidated,  or (ii) the date the
stockholders  of the  Company  (or  the  Board,  if  stockholder  action  is not
required) approve a definitive  agreement to sell or otherwise dispose of all or
substantially  all  of  the  assets  of the  Company,  or  (iii)  the  date  the
stockholders  of the  Company  (or  the  Board,  if  stockholder  action  is not
required) and the stockholders of the other  constituent  corporations (or their
respective boards of directors,  if and to the extent that stockholder action is
not required) have approved a definitive  agreement to merge or consolidate  the
Company with or into another  corporation,  other than, in either case, a merger
or  consolidation  of the  Company in which  holders of shares of the  Company's
voting capital stock immediately prior to the merger or consolidation  will have
at  least  50% of  the  ownership  of  voting  capital  stock  of the  surviving

                                      -2-


corporation  immediately  after the merger or consolidation  (on a fully diluted
basis),  which voting  capital stock is to be held in the same  proportion (on a
fully diluted  basis) as such holders'  ownership of voting capital stock of the
Company  immediately  before the merger or  consolidation,  or (iv) the date any
entity,  person or group  (within  the  meaning of Section  13(d)(3)  or Section
14(d)(2) of the Exchange  Act),  other than (A) the  Company,  or (B) any of its
Subsidiaries,  or (C) any of the holders of the capital stock of the Company, as
determined  on the date that  this  Plan is  adopted  by the  Board,  or (D) any
employee  benefit plan (or related trust) sponsored or maintained by the Company
or any of its Subsidiaries or (E) any Affiliate (as such term is defined in Rule
405 promulgated  under the Securities  Act) of any of the foregoing,  shall have
acquired  beneficial  ownership of, or shall have acquired  voting  control over
more than 50% of the  outstanding  shares of the Company's  voting capital stock
(on a fully  diluted  basis),  unless  the  transaction  pursuant  to which such
person,  entity or group acquired such beneficial  ownership or control resulted
from the original  issuance by the Company of shares of its voting capital stock
and was approved by at least a majority of directors  who shall have been either
members  of the  Board on the date that  this  Plan is  adopted  by the Board or
members of the Board for at least  twelve (12) months  prior to the date of such
approval,  or (v) the first day after the date of this Plan when  directors  are
elected such that there shall have been a change in the composition of the Board
such that a majority of the Board shall have been  members of the Board for less
than twelve (12) months, unless the nomination for election of each new director
who was not a director at the  beginning  of such  twelve (12) month  period was
approved by a vote of at least sixty percent  (60%) of the directors  then still
in office who were  directors at the beginning of such period,  or (vi) the date
upon  which the Board  determines  (in its sole  discretion)  that based

                                      -3-


on then current available  information,  the events described in clause (iv) are
reasonably likely to occur.

            (3) "Code" shall mean the Internal Revenue Code of 1986, as amended.

            (4) "Committee"  shall mean the Committee  appointed by the Board in
accordance  with Section 4(a) of the Plan, if one is  appointed,  in which event
the Committee shall possess the power and authority of the Board.

            (5)  "Company"  shall mean  OraSure  Technologies,  Inc., a Delaware
corporation.

            (6) "Common Stock" shall mean common stock of the Company,  $.000001
par value per share.

            (7)  "Disability"  or  "Disabled"  shall  mean the  inability  of an
Optionee to perform his or her normal  employment  duties for the  Company,  its
Parent, any of its Subsidiaries or its successors, as the case may be, resulting
from a mental or physical  illness,  impairment or any other similar  occurrence
which can be  expected to result in death or which has lasted or can be expected
to last for a period of twelve (12)  consecutive  months,  as  determined by the
Board.

            (8)  "Employee"  shall  mean  any  person,  including  officers  and
directors,  employed by the Company,  its Parent, any of its Subsidiaries or its
successors.  The payment of directors' fees by the Company,  its Parent,  any of
its Subsidiaries or its successors,  as the case may be, shall not be sufficient
to constitute employment. Additionally, solely for purposes of determining those
persons  eligible  under the Plan to be recipients  of Awards of Options,  which
Options shall be limited to non-qualified stock options, and not for the purpose
of affecting the

                                      -4-


status  of the  relationship  between  such  person  and the  Company,  the term
"Employee"  shall include  independent  contractors  of and  consultants  to the
Company.

            (9) "Exchange Act" shall mean The  Securities  Exchange Act of 1934,
as amended.

            (10) "Fair Market Value" shall mean the fair market value of a share
of Common Stock, as determined pursuant to Section 8 hereof.

            (l1)  "Incentive  Stock  Option"  shall  mean an Option  which is an
incentive stock option within the meaning of Section 422 of the Code.

            (12)  "Non-Employee  Director" has the meaning set forth in Rule 16b
- -3(b)(3)(i)  promulgated  by the Securities  and Exchange  commission  under the
Exchange Act, or any successor definition adopted by the Securities and Exchange
Commission;  provided,  however,  that the Board or its  Committee  may,  to the
extent it is deemed  necessary or desirable to comply with Section 162(m) of the
Code and  applicable  regulations  thereunder,  ensure  that  each  Non-Employee
Director also qualifies as an "outside  director" as that term is defined in the
regulations under Section 162(m) of the Code.

            (13)   "Option"   shall  mean  an   Incentive   Stock  Option  or  a
non-qualified  stock option to purchase  Shares that is Awarded  pursuant to the
Plan.

            (14)   "Option   Agreement"   shall   mean  a   written   agreements
substantially  in the form of Exhibits  A-1 and A-2, or such other form or forms
as the Board (subject to the terms and conditions of this Plan) may from time to
time approve evidencing and reflecting the terms of an Option.

            (15) "Optionee" shall mean an Employee to whom an Option is Awarded.

                                      -5-


            (16)  "Parent"  shall  mean a "parent  corporation"  whether  now or
hereafter existing, as defined in Sections 424(e) and (g) of the Code.

            (17)  "Plan"  shall mean the  OraSure  Technologies,  Inc.  Employee
Incentive and Non-qualified Stock Option Plan, as amended from time to time.

            (18) "Pool" shall mean the pool of shares of Common Stock subject to
the Plan, as described and set forth in Section 6 hereof.

            (19) "Securities  Act" shall  mean The  Securities  Act of 1933,  as
amended.

            (20)  "Shares"  shall mean shares of Common  Stock  contained in the
Pool, as adjusted in accordance with Section 9 of the Plan.

            (21)   "Stock   Purchase   Agreement"   shall   mean  an   agreement
substantially  in the form  attached  hereto as Exhibit B, or such other form as
the Board  (subject to the terms and  conditions  of this Plan) may from time to
time approve,  which an Optionee  shall be required to execute as a condition of
purchasing Shares upon the exercise of an Option.

            (22) "Subsidiary" shall mean a subsidiary  corporation,  whether now
or hereafter existing, as defined in Sections 424(f) and (g) of the Code.

            Section 3.   Participation.
                         -------------

            Participants  in the Plan  shall be  selected  by the Board from the
Employees  (including  Employees  who also may be  members  of the Board) of the
Company, its Parent and its Subsidiaries or their successors. The Board may make
Awards at any time and from time to time to Employees.  Any Award may include or
exclude any Employee, as the Board shall determine in its sole discretion.

            Section 4.   Administration.
                         --------------

                                      -6-


            (1) Procedure.  The Plan shall be administered by the Board. Members
of the Board who are eligible for Options or have been Awarded  Options may vote
on any  matters  affecting  the  administration  of the Plan or the Award of any
Options  pursuant to the Plan,  except  that no such  member  shall act upon the
Award of an Option to himself, but any such member may be counted in determining
the existence of a quorum at any meeting of the Board or Committee  during which
action is taken with respect to the Award of Options to him.

           The Board may at any time  appoint a Committee consisting of not less
than two persons to administer the Plan on behalf of the Board,  subject to such
terms and conditions as the Board may prescribe.  Members of the Committee shall
serve for such period of time as the Board may determine.  From time to time the
Board may  increase the size of the  Committee  and appoint  additional  members
thereto,  remove  members  (with or without  cause) and  appoint  new members in
substitution  therefor,  fill vacancies however caused, or remove all members of
the Committee and thereafter directly  administer the Plan.  Notwithstanding the
foregoing,  in the event the Company has a class of equity securities registered
under the  Exchange  Act,  the  Committee  shall be  composed of two (2) or more
Non-Employee  Directors.

            (2) Powers of the Board.  Subject to the provisions of the Plan, the
Board or its Committee shall have the authority, in its discretion: (i) to Award
Options;  (ii)  to  determine,  upon  review  of  relevant  information  and  in
accordance with Section 8 of the Plan, the Fair Market Value per Share; (iii) to
determine  the exercise  price of the Options to be Awarded in  accordance  with
Sections 7 and 8 of the Plan;  (iv) to determine the Employees to whom,  and the
time or times at which, Options shall be Awarded, and the number of Shares to be
subject  to  each  Option;  (v)  to  prescribe,  amend  and  rescind  rules  and
regulations relating to the Plan; (vi) to


                                      -7-


determine the terms and provisions of each Option  Awarded under the Plan,  each
Option Agreement and each Stock Purchase  Agreement (which need not be identical
with  the  terms  of  other  Options,   Option  Agreements  and  Stock  Purchase
Agreements)  and,  with the  consent  of the  Optionee,  to  modify  or amend an
outstanding  Option,  Option  Agreement or Stock  Purchase  Agreement;  (vii) to
accelerate  the vesting or  exercise  date of any  Option;  (viii) to  determine
whether any Optionee will be required to execute a stock repurchase agreement or
other  agreement as a condition  to the exercise of an Option,  and to determine
the terms and provisions of any such agreement (which need not be identical with
the terms of any other such agreement) and, with the consent of the Optionee, to
amend any such  agreement;  (ix) to interpret the Plan or any agreement  entered
into with  respect to the Award or  exercise of Options;  (x) to  authorize  any
person to execute on behalf of the Company any instrument required to effectuate
the Award of an Option  previously  Awarded  by the Board or to take such  other
actions as may be necessary or appropriate  with respect to the Company's rights
pursuant to Options or agreements relating to the Award or exercise thereof; and
(xi) to make such other determinations and establish such other procedures as it
deems necessary or advisable for the administration of the Plan.

            (3) Effect of the Board's or  Committee's  Decision.  All decisions,
determinations and  interpretations of the Board or the Committee shall be final
and binding with respect to all Options and Optionees.

            (4) Limitation of Liability.  Notwithstanding anything herein to the
contrary (with the exception of Section 31 hereof), no member of the Board or of
the Committee shall be liable for any good faith  determination,  act or failure
to act in connection with the Plan or any Option Awarded hereunder.

                                      -8-


            Section 5.   Eligibility.
                         -----------

            Options may be Awarded only to  Employees.  An Employee who has been
Awarded an Option, if he or she is otherwise eligible, may be Awarded additional
Options.
            Section 6.   Stock Subject to the Plan.
                         -------------------------

            Subject  to the  provisions  of Section 9 of the Plan,  the  maximum
aggregate  number of Shares  which may be Awarded and sold under the Plan is Two
Hundred Forty Thousand  (240,000)  Shares  (collectively,  the "Pool").  Options
Awarded from the Pool may be either  Incentive  Stock  Options or  non-qualified
stock options,  as determined by the Board. If an Option should expire or become
unexercisable  for any reason  without  having been  exercised  in full,  or, if
Shares  are  subsequently   repurchased  by  the  Company,  the  unpurchased  or
repurchased Shares which were subject thereto shall,  unless the Plan shall have
been terminated,  return to the Plan and become available for future Award under
the Plan.

            Section 7. Terms and Conditions of Options.
                       -------------------------------

            Each Option Awarded  pursuant to the Plan shall be authorized by the
Board and shall be  evidenced  by an Option  Agreement in such form as the Board
may from time to time  determine.  Each Option  Agreement  shall  incorporate by
reference all other terms and  conditions  of the Plan,  including the following
terms and conditions:

            (1) Number of Shares.  The number of Shares  subject to the  Option,
which may include fractional Shares.

            (2) Option Price. The price per Share payable on the exercise of any
Option  which is an  Incentive  Stock  Option  shall  be  stated  in the  Option
Agreement  and  shall be no less  than the Fair  Market  Value  per share of the
Common Stock on the date such Option is Awarded,

                                       -9-


without  regard to any  restriction  other than a  restriction  which will never
lapse.  Notwithstanding the foregoing,  if an Option which is an Incentive Stock
Option shall be Awarded  under this Plan to any Employee who, at the time of the
Award of such Option,  owns stock possessing more than 10% of the total combined
voting  power of all  classes  of the  stock of the  Company  (or its  Parent or
Subsidiaries), the price per Share payable upon exercise of such Option shall be
no less than 110  percent  (110%) of the Fair  Market  Value of the stock on the
date such Option is Awarded.  The price per Share  payable on the exercise of an
Option  which is a  non-qualified  stock option shall be at least $.01 per Share
and shall be stated in the Option Agreement.

            (3) Consideration. The consideration to be paid for the Shares to be
issued upon the exercise of an Option, including the method of payment, shall be
determined  by the Board and may  consist  entirely of cash,  check,  promissory
notes or  shares  of  Common  Stock  having a Fair  Market  Value on the date of
surrender  equal to the aggregate  exercise price of the Shares as to which said
Option shall be exercised,  or any  combination  of such methods of payment,  or
such other consideration and method of payment permitted under any laws to which
the  Company  is  subject  and which is  approved  by the  Board.  In making its
determination  as to the  type of  consideration  to  accept,  the  Board  shall
consider if  acceptance  of such  consideration  may be  reasonably  expected to
benefit the Company.

                  (1) If the  consideration  for the  exercise of an Option is a
promissory  note,  it shall bear  interest at a per annum rate which is not less
than the applicable  federal rate  determined in accordance with Section 1274(d)
of the Code as of the date of  exercise.  In such an  instance  the  Company may
retain  the  Shares  purchased  upon the  exercise  of the  Option  in escrow as
security for payment of the promissory note.

                                      -10-


                  (2) If the consideration for the exercise of an Option is the
surrender of previously  acquired and owned shares of Common Stock, the Optionee
will be required to make  representations  and  warranties  satisfactory  to the
Company  regarding  his title to the  shares of Common  Stock used to effect the
purchase, including without limitation,  representations and warranties that the
Optionee has good and  marketable  title to such shares of Common Stock free and
clear of any and all liens,  encumbrances,  charges,  equities, claims, security
interests, options or restrictions, and has full power to deliver such shares of
Common  Stock  without  obtaining  the  consent  or  approval  of any  person or
governmental  authority  other than those which have  already  given  consent or
approval in a manner  satisfactory  to the  Company.  The value of the shares of
Common Stock used to effect the purchase  shall be the Fair Market Value of such
shares of Common Stock on the date of exercise as determined by the Board in its
sole  discretion,  exercised  in good  faith.

            (4) Form of  Option.  The  OptionAgreement  will state  whether  the
Option Awarded is an Incentive Stock Option or a non-qualified stock Option, and
will constitute a binding determination as to the form of Option Awarded.

            (5)  Exercise  of Options.  Any Option  Awarded  hereunder  shall be
exercisable at such times and under such  conditions as may be determined by the
Board  and as shall be  permissible  under  the  terms  of the  Plan,  including
performance  criteria with respect to the Company  and/or the  Optionee,  and as
shall be permissible under the terms of the Plan.

                  An Option may be exercised in accordance  with the  provisions
of this Plan as to all or any  portion of the Shares then  exercisable  under an
Option  from time to time  during the term of the  Option.  An Option may not be
exercised solely for a fraction of a Share.

                                      -11-


                  An Option shall be deemed to be exercised  when written notice
of such exercise has been given to the Company at its principal executive office
in accordance  with the terms of the Option  Agreement by the person entitled to
exercise  the Option and full  payment for the Shares with  respect to which the
Option is exercised has been received by the Company, accompanied by an executed
Stock Purchase  Agreement and any other agreements  required by the terms of the
Plan and/or Option Agreement. Full payment may consist of such consideration and
method of payment  allowable under Section 7 of the Plan. No adjustment shall be
made for a dividend  or other  right for which the  record  date is prior to the
date the Option is exercised, except as provided in Section 9 of the Plan.

                  As soon as practicable  after any proper exercise of an Option
in  accordance  with the  provisions  of the Plan,  the Company  shall,  without
transfer or issue tax to the Optionee,  deliver to the Optionee at the principal
executive  office of the Company or such other place as shall be mutually agreed
upon  between  the Company  and the  Optionee,  a  certificate  or  certificates
representing the Shares for which the Option shall have been exercised. The time
of issuance and delivery of the certificate(s) representing the Shares for which
the Option  shall have been  exercised  may be postponed by the Company for such
period as may be required by the Company, with reasonable  diligence,  to comply
with any applicable listing  requirements of any national or regional securities
exchange or any law or regulation applicable to the issuance or delivery of such
Shares.

            Exercise  of an Option in any manner  shall  result in a decrease in
the number of Shares which thereafter may be available, both for Award under the
Plan and for sale  under  the  Option,  by the  number of Shares as to which the
Option is exercised.

                                      -12-


            (6)   Term and Vesting of Options.
                  ---------------------------

                  (1)  Notwithstanding  any other  provision  of this  Plan,  no
Option  shall be (A) Awarded  under this Plan after ten (10) years from the date
on which this Plan is adopted by the  Board,  or (B)  exercisable  more than ten
(10) years from the date of Award; provided, however, that if an Incentive Stock
Option shall be Awarded  under this Plan to any Employee who, at the time of the
Award of such Option,  owns stock possessing more than 10% of the total combined
voting  power for all  classes  of the  stock of he  Company  (or its  Parent or
Subsidiaries), the foregoing clause (B) shall be deemed modified by substituting
"five (5) years" for the term "ten (10) years" that appears therein.

                  (2) No Option  Awarded to any Optionee  shall be treated as an
Incentive Stock Option, to the extent such Option would cause the aggregate Fair
Market Value of all Shares with  respect to which  Incentive  Stock  Options are
exercisable  by such  Optionee  for the first  time  during  any  calendar  year
(determined as of the date of Award of each such Option) to exceed $100,000. For
purposes of  determining  whether an  Incentive  Stock  Option  would cause such
aggregate  Fair Market Value to exceed the $100,000  limitation,  such Incentive
Stock Options shall be taken into account in the order Awarded.  For purposes of
this  subsection,  Incentive  Stock Options  include all incentive stock options
under  all  plans  of the  Company  and its  Parent  and  Subsidiaries  that are
incentive  stock  option  plans  within the  meaning of Section 422 of the Code.
Options  Awarded  hereunder  shall mature and become  exercisable in whole or in
part, in  accordance  with such vesting  schedule as the Board shall  determine,
which schedule shall be stated in the Option Agreement. Options may be exercised
in any order elected by the

                                      -13-


Optionee  whether or not the Optionee holds any  unexercised  Options under this
Plan or any other plan of the Company.

            (7)   Termination of Options.
                  ----------------------

                  (1) Unless sooner  terminated  as provided in this Plan,  each
Option shall be exercisable for the period of time as shall be determined by the
Board and set forth in the Option Agreement, and shall be void and unexercisable
thereafter.

                  (i)  Except as  otherwise  provided  herein  or in the  Option
Agreement,   upon  the  termination  of  the  Optionee's   employment  or  other
relationship with the Company for any reason, Options exercisable on the date of
termination of employment or such other relationship shall be exercisable by the
Optionee (or in the case of the  Optionee's  death  subsequent to termination of
employment  or  such  other  relationship,  by  the  Optionee's  executor(s)  or
administrator(s))  for a  period  of  three  (3)  months  from  the  date of the
Optionee's termination of employment or such other relationship.

                  (2) Upon the  Disability or death of an Optionee  while in the
employ of or engagement by the Company,  Options held by such Optionee which are
exercisable on the date of Disability or death shall be exercisable for a period
of twelve (12) months  commencing  on the date of the  Optionee's  Disability or
death, by the Optionee or his legal guardian or  representative  or, in the case
of death, by his executor(s) or  administrator(s);  provided,  however,  that if
such disabled  Optionee shall commence any employment or engagement  during such
one (1) year period with or by a competitor of the Company  (including,  but not
limited to, full or part-time  employment or independent  consulting  work),  as
determined solely in the judgment of

                                      -14-


the Board,  all Options held by such Optionee  which have not yet been exercised
shall terminate immediately upon the commencement thereof.

                  (3) Options may be terminated at any time by agreement between
the Company and the Optionee.

            (8)   Forfeiture.  Notwithstanding any other provision of this Plan,
if the  Optionee's  employment or engagement is terminated  for "cause" (as such
term  is  defined  in the  Optionee's  employment  agreement  or  invention  and
non-disclosure agreement with the Company, but if the Optionee is not a party to
any  such  agreement,  then,  as such  term is  defined  in the  Stock  Purchase
Agreement)  or if the Board  makes a  determination  that the  Optionee  (i) has
engaged in any type of disloyalty to the Company,  including without limitation,
fraud,  embezzlement,  theft,  or dishonesty in the course of his  employment or
engagement,  or (ii) has been convicted of a felony or (iii) has disclosed trade
secrets or  confidential  information  of the Company or (iv) has  breached  any
agreement   with  or  duty  to  the  Company  in  respect  of   confidentiality,
non-disclosure,  non-competition  or otherwise,  all  unexercised  Options shall
terminate  upon  the  earlier  of the  date  of  termination  of  employment  or
engagement  for  "cause" or the date of such a  finding.  In the event of such a
finding, in addition to immediate  termination of all unexercised  Options,  the
Optionee  shall  forfeit all Shares for which the Company has not yet  delivered
share  certificates to the Optionee and the Company shall refund to the Optionee
the Option  purchase price paid to it.  Notwithstanding  anything  herein to the
contrary,  the Company may withhold delivery of share  certificates  pending the
resolution of any inquiry that could lead to a finding resulting in forfeiture.

            Section 8.   Determination of Fair Market Value of Common Stock.
                         --------------------------------------------------

                                      -15-


            (1)   Except to the extent otherwise provided in this Section 8, the
Fair Market Value of a share of Common Stock shall be determined by the Board in
its sole discretion.

            (2)  Notwithstanding  the  provisions  of Section 8(a), in the event
that shares of Common Stock are traded in the over-the-counter  market, the Fair
Market  Value of a share of Common  Stock shall be the mean of the bid and asked
prices for a share of Common Stock on the relevant valuation date as reported in
The Wall Street  Journal (or, if not so reported,  as otherwise  reported by the
National  Association  of Securities  Dealers  Automated  Quotations  ("NASDAQ")
System),  as  applicable  or, if there is no trading  on such date,  on the next
trading  date.  In the event  shares of Common Stock are listed on a national or
regional securities exchange or traded through NASDAQ/NMS, the Fair Market Value
of a share of  Common  Stock  shall be the  closing  price for a share of Common
Stock on the exchange or on  NASDAQ/NMS,  as reported in The Wall Street Journal
on the relevant  valuation  date, or if there is no trading on that date, on the
next trading date.

            Section 9.   Adjustments.
                         -----------

            (1)  Subject to required  action by the  stockholders,  if any,  the
number of Shares as to which  Options  may be  Awarded  under  this Plan and the
number of Shares  subject to  outstanding  Options and the option prices thereof
shall be adjusted  proportionately for any increase or decrease in the number of
outstanding  shares of Common Stock of the Company  resulting from stock splits,
reverse stock splits, stock dividends, reclassifications and recapitalizations.

            (2) No fractional  Shares shall be issuable on account of any action
aforesaid,  and the aggregate number of Shares into which Shares then covered by
the Option,  when

                                      -16-


changed  as the result of such  action,  shall be reduced to the number of whole
Shares  resulting from such action,  unless the Board,  in its sole  discretion,
shall determine to issue scrip certificates in respect to any fractional Shares,
which scrip certificates,  in such event, shall be in a form and have such terms
and conditions as the Board in its discretion shall prescribe.

            Section 10.    Rights as a Stockholder.
                           -----------------------

            The Optionee  shall have no rights as a  stockholder  of the Company
and shall not have the right to vote nor receive  dividends  with respect to any
Shares  subject  to an  Option  until  such  Option  has  been  exercised  and a
certificate  with respect to the Shares  purchased  upon such  exercise has been
issued to him.

            Section 11.   Time of Awarding Options.
                          ------------------------

            The date of Award of an Option shall, for all purposes,  be the date
on which the Board makes the determination  Awarding such Option.  Notice of the
determination  shall be given to each  Employee  to whom an Option is so Awarded
within a reasonable time after the date of such Award.

            Section 12.   Modification, Extension and Renewal of Option.
                          ---------------------------------------------

            Subject  to the terms  and  conditions  of the  Plan,  the Board may
modify,  extend or renew an Option, or accept the surrender of an Option (to the
extent  not  theretofore  exercised).  Notwithstanding  the  foregoing,  (a)  no
modification  of an Option which  adversely  affects the Optionee  shall be made
without the consent of the  Optionee,  and (b) no Incentive  Stock Option may be
modified,  extended or renewed if such  action  would cause it to cease to be an
"incentive stock option" within the meaning of Section 422 of the Code.

            Section 13.  Purchase for Investment and Other Restrictions.
                         ----------------------------------------------

                                      -17-


            The  issuance  of  Shares  on the  exercise  of an  Option  shall be
conditioned  on  obtaining   such   appropriate   representations,   warranties,
restrictions and agreements of the Optionee as set forth in the applicable Stock
Purchase Agreement.  Among other representations,  warranties,  restrictions and
agreements,  the Optionee shall  represent and agree that the purchase of Shares
under the applicable  Option  Agreement shall be for investment,  and not with a
view to the public resale or distribution thereof,  unless the Shares subject to
the Option are  registered  under the Securities Act and the transfer or sale of
such Shares  complies  with all other  laws,  rules and  regulations  applicable
thereto. Unless the Shares are registered under the Securities Act, the Optionee
shall  acknowledge  that the Shares  purchased on exercise of the Option are not
registered under the Securities Act and may not be sold or otherwise transferred
unless the Shares have been  registered  under the  Securities Act in connection
with the sale or other transfer  thereof,  or that counsel  satisfactory  to the
Company has issued an opinion satisfactory to the Company that the sale or other
transfer of such Shares is exempt from  registration  under the Securities  Act,
and unless  said sale or  transfer is in  compliance  with all other  applicable
laws,  rules  and  regulations,  including  all  applicable  federal  and  state
securities laws, rules and regulations.  Additionally,  the Shares,  when issued
upon the exercise of an Option, shall be subject to other transfer restrictions,
rights of first refusal and rights of repurchase as set forth in or incorporated
by reference into the  applicable  Stock Purchase  Agreement.  The  certificates
representing the Shares shall contain the following legend:

            THE SHARES  REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED
            UNDER THE SECURITIES ACT OF 1933, AS AMENDED OR ANY APPLICABLE STATE
            SECURITIES  LAWS. THESE SHARES HAVE

                                      -18-


            NOT BEEN ACQUIRED WITH A VIEW TO DISTRIBUTION OR RESALE, AND MAY NOT
            BE SOLD, ASSIGNED,  EXCHANGED,  MORTGAGED,  PLEDGED, HYPOTHECATED OR
            OTHERWISE  TRANSFERRED  OR DISPOSED OF, BY GIFT OR OTHERWISE,  OR IN
            ANY WAY ENCUMBERED WITHOUT AN EFFECTIVE  REGISTRATION  STATEMENT FOR
            SUCH SHARES UNDER THE  SECURITIES  ACT OF 1933, AS AMENDED,  AND ANY
            APPLICABLE  STATE  SECURITIES  LAWS,  OR A  SATISFACTORY  OPINION OF
            COUNSEL SATISFACTORY TO ORASURE TECHNOLOGIES, INC. THAT REGISTRATION
            IS NOT REQUIRED UNDER SUCH ACT AND UNDER APPLICABLE STATE SECURITIES
            LAWS.  MOREOVER,  THE SHARES  REPRESENTED  BY THIS  CERTIFICATE  ARE
            SUBJECT  TO AND  RESTRICTED  BY THE  PROVISIONS  OF A CERTAIN  STOCK
            PURCHASE AND RESTRICTION  AGREEMENT  BETWEEN  ORASURE  TECHNOLOGIES,
            INC.  AND  THE  STOCKHOLDER,  A COPY  OF  WHICH  AGREEMENT  WILL  BE
            FURNISHED BY ORASURE  TECHNOLOGIES,  INC.  UPON WRITTEN  REQUEST AND
            WITHOUT  CHARGE,  AND ALL OF THE  PROVISIONS  OF SUCH  AGREEMENT ARE
            INCORPORATED BY REFERENCE IN THIS CERTIFICATE.

            Section 14.   Transferability.
                          ---------------

            No Option shall be assignable or transferable otherwise than by will
or by the laws of descent and distribution. During the lifetime of the Optionee,
his  Options  shall be  exercisable

                                      -19-


only by him, or, in the event of his legal incapacity or Disability by his legal
guardian or representative.

            Section 15.   Other Provisions.
                          ----------------

            The Option  Agreement and Stock Purchase  Agreement may contain such
other  provisions as the Board in its discretion  deems  advisable and which are
not  inconsistent  with  the  provisions  of  this  Plan,   including,   without
limitation,  restrictions  upon or  conditions  precedent to the exercise of the
Option.
            Section 16.   Power of Board in Case of Change in Control.
                          -------------------------------------------

            Notwithstanding  anything  to the  contrary  set  forth in this Plan
(with the exception of Section 31 hereof),  in the event of a Change in Control,
the Board  shall have the  right,  in its sole  discretion,  to  accelerate  the
vesting and  exercisability  of all  unmatured  Options  and/or to  establish an
earlier date for the expiration of the exercise of an Option  (notwithstanding a
later  expiration  of  exercisability  set  forth in an  Option  Agreement).  In
addition,  in the event of a Change in Control of the  Company,  the Board shall
have the right,  in its sole  discretion,  subject to and  conditioned  upon the
consummation of the transactions  which result in the Change in Control,  to (1)
arrange for the successor  company (or other entity) to assume all of the rights
and  obligations  of the Company under this Plan; or (2) terminate this Plan and
(a) to pay to all  Optionees  cash with respect to those Options that are vested
as of the date of such consummation in an amount equal to the difference between
the  exercise  price  and the  Fair  Market  Value of a Share  of  Common  Stock
(determined as of the date the Plan is  terminated)  multiplied by the number of
Options that are vested as of the date of the  consummation of the  transactions
which result in the Change in Control  which are held by the Optionee as of such
date, or (b) to arrange

                                      -20-


for the  exchange of all Options  for  options to purchase  common  stock in the
successor  corporation,  or (c) to distribute to each Optionee other property in
an amount equal to and in the same form as the Optionee would have received from
the  successor  corporation  if the  Optionee  had owned the  Shares  subject to
Options that are vested as of the date of the  consummation of the  transactions
which result in the Change in Control rather than the Option at the time of such
consummation.  The form of payment or distribution  to the Optionee  pursuant to
this Section shall be determined by the Board in its sole discretion.

            Section 17.   Amendment of the Plan.
                          ---------------------
            Insofar as permitted by law and the Plan, the Board may from time to
time  suspend,  terminate or  discontinue  the Plan or revise or amend it in any
respect  whatsoever  with  respect to any  Shares at the time not  subject to an
Option;  provided,  however, that without approval of the stockholders,  no such
revision  or  amendment  may  change  the  aggregate  number of Shares for which
Options  may be  Awarded  hereunder,  change  the  designation  of the  class of
Employees eligible to receive Options or decrease the price at which Options may
be Awarded.

            Any other  provision  of this Section 17  notwithstanding  (with the
exception of Section 31 hereof),  the Board  specifically is authorized to adopt
any  amendment  to this Plan deemed by the Board to be necessary or advisable to
assure that the  Incentive  Stock  Options or the  non-qualified  stock  Options
available under the Plan continue to be treated as such, respectively, under all
applicable laws.

            Section 18.   Application of Funds.
                          --------------------

            The  proceeds  received  by the  Company  from  the  sale of  Shares
pursuant  to the  exercise  of  Options  shall  be used  for  general  corporate
purposes.


                                      -21-


            Section 19.   No Obligation to Exercise Option.
                          --------------------------------

            The  Awarding  of an  Option  shall  impose no  obligation  upon the
Optionee to exercise such Option.

            Section 20.   Approval of Stockholders.
                          ------------------------

            This Plan shall  become  effective on the date that it is adopted by
the Board;  provided,  however,  that it shall become limited to a non-qualified
stock  option  plan if it is not  approved  by the  holders of a majority of the
Company's outstanding voting stock within one year (365 days) of its adoption by
the Board.  The Board may Award Options  hereunder prior to approval of the Plan
or any material amendments thereto by the holders of a majority of the Company's
outstanding voting stock; provided, however, that any and all Options so Awarded
automatically shall be converted into non-qualified stock options if the Plan is
not  approved by such  stockholders  within 365 days of its adoption or material
amendment.

            Section 21.   Conditions Upon Issuance of Shares.
                          ----------------------------------

            (1) Options Awarded under the Plan are conditioned upon  the Company
obtaining any required permit or order from appropriate  governmental  agencies,
authorizing  the  Company to issue such  Options  and Shares  issuable  upon the
exercise thereof.

            (2) Shares shall not be issued pursuant to the exercise of an Option
unless the  exercise of such Option and the issuance and delivery of such Shares
pursuant  thereto shall comply with all relevant  provisions of law,  including,
without  limitation,  the  Securities  Act,  the  Exchange  Act,  the  rules and
regulations promulgated  thereunder,  and the requirements of any stock exchange
upon which the Shares  may then be listed,  and shall be further  subject to the
approval of counsel for the Company with respect to such compliance.

                                      -22-


            (3) As a  condition  to the  exercise  of an Option,  the Board  may
require the person  exercising such Option to execute an agreement with,  and/or
may require the person exercising such Option to make any representation  and/or
warranty  to, the Company as may be, in the  judgment of counsel to the Company,
required  under  applicable  law or  regulation,  including but not limited to a
representation  and  warranty  that the  Shares  are  being  purchased  only for
investment and without any present  intention to sell or distribute  such Shares
if, in the  opinion  of  counsel  for the  Company,  such a  representation  and
warranty is appropriate under any of the aforementioned  relevant  provisions of
law.

            Section 22.   Reservation of Shares.
                          ---------------------

            The  Company,  during  the term of this  Plan,  shall  at all  times
reserve  and keep  available  such  number of Shares as shall be  sufficient  to
satisfy the requirements of the Plan.

            The  Company,  during  the  term of this  Plan,  shall  use its best
efforts to seek to obtain from  appropriate  regulatory  agencies any  requisite
authorization  in order to issue  and sell  such  number  of  Shares as shall be
sufficient to satisfy the requirements of the Plan. The inability of the Company
to obtain from any such  regulatory  agency  having  jurisdiction  the requisite
authorization(s)  deemed by the Company's counsel to be necessary for the lawful
issuance and sale of any Shares  hereunder,  or the  inability of the Company to
confirm to its  satisfaction  that any issuance and sale of any Shares hereunder
will meet  applicable  legal  requirements,  shall  relieve  the  Company of any
liability  in  respect to the  failure to issue or sell such  Shares as to which
such requisite authority shall not have been obtained.

            Section 23.   Stock Option and Stock Purchase Agreements.
                          ------------------------------------------

                                      -23-


            Options  shall be  evidenced by an  Option Agreement in such form or
forms as the Board  shall  approve  from time to time.  Upon the  exercise of an
Option,  the  Optionee  shall sign and deliver to the  Company a Stock  Purchase
Agreement in such form or forms as the Board shall approve from time to time.

            Section 24.   Taxes, Fees, Expenses and Withholding of Taxes.
                          ----------------------------------------------

            (1) The Company shall pay all original issue and transfer taxes (but
not income taxes,  if any) with respect to the Award of Options and/or the issue
and transfer of Shares pursuant to the exercise thereof,  and all other fees and
expenses necessarily incurred by the Company in connection  therewith,  and will
from time to time use its best  efforts to comply with all laws and  regulations
which, in the opinion of counsel for the Company, shall be applicable thereto.

            (b) The  Award of  Options  hereunder  and the  issuance  of  Shares
pursuant to the exercise thereof is conditioned  upon the Company's  reservation
of the  right to  withhold  in  accordance  with any  applicable  law,  from any
compensation or other amounts payable to the Optionee,  any taxes required to be
withheld under federal,  state or local law as a result of the Award or exercise
of such Option or the sale of the Shares  issued upon exercise  thereof.  To the
extent that  compensation or other amounts,  if any,  payable to the Optionee is
insufficient  to pay any taxes  required to be so withheld,  the Company may, in
its sole discretion,  require the Optionee (or such other person entitled herein
to exercise the Option),  as a condition of the exercise of an Option, to pay in
cash to the  Company  an  amount  sufficient  to  cover  such tax  liability  or
otherwise to make  adequate  provision  for the  Company's  satisfaction  of its
withholding obligations under federal, state and local law.

                                      -24-


            Section 25.   Notices.
                          -------

            Any notice to be given to the Company  pursuant to the provisions of
this Plan shall be  addressed to the Company in care of its  Secretary  (or such
other person as the Company may  designate  from time to time) at its  principal
executive  office,  and any notice to be given to an Optionee shall be delivered
personally  or addressed to him or her at the address  given  beneath his or her
signature  on his or her  Option  Agreement,  or at such  other  address as such
Optionee or his or her  permitted  transferee  (upon the transfer of the Shares)
may  hereafter  designate  in writing to the  Company.  Any such notice shall be
deemed  duly  given  when  enclosed  in a properly  sealed  envelope  or wrapper
addressed as  aforesaid,  registered or certified,  and  deposited,  postage and
registry or  certification  fee prepaid,  in a post office or branch post office
regularly  maintained  by the  United  States  Postal  Service.  It shall be the
obligation  of each  Optionee  and  each  permitted  transferee  holding  Shares
purchased upon exercise of an Option to provide the Secretary of the Company, by
letter  mailed as  provided  herein,  with  written  notice of his or her direct
mailing address.

            Section 26.   No Enlargement of Employee Rights.
                          ---------------------------------

            This Plan is purely  voluntary on the part of the  Company,  and the
continuance of the Plan shall not be deemed to constitute a contract between the
Company and any  Employee,  or to be  consideration  for or a  condition  of the
employment or service of any Employee.  Nothing  contained in this Plan shall be
deemed to give any Employee the right to be retained in the employ or service of
the  Company,  its Parent,  any  Subsidiary  or a successor  corporation,  or to
interfere with the right of the Company or any such  corporation to discharge or
retire any Employee  thereof at any time. No Employee shall have any right to or
interest  in Options  authorized  hereunder  prior to the Award  thereof to such
Employee,  and upon such Award he shall have only such rights and  interests  as
are expressly provided herein, subject, however, to all applicable provisions of
the Company's Certificate of Incorporation, as the same may be amended from time
to time.

            Section 27.   Information to Optionees.
                          ------------------------

            The Company,  upon  request,  shall provide  without  charge to each
Optionee  copies of such  annual and  periodic  reports as are  provided  by the
Company to its stockholders generally.

            Section 28.   Availability of Plan.
                          --------------------

            A copy of this  Plan  shall be  delivered  to the  Secretary  of the
Company  and  shall be shown by him to any  eligible  person  making  reasonable
inquiry concerning it.

                                      -25-


            Section 29.   Invalid Provisions.
                          ------------------

            In the event that any  provision of this Plan is found to be invalid
or  otherwise  unenforceable  under  any  applicable  law,  such  invalidity  or
unenforceability  shall not be  construed  as  rendering  any  other  provisions
contained  herein as invalid  or  unenforceable,  and all such other  provisions
shall be given full force and effect to the same extent as though the invalid or
unenforceable provision was not contained herein.

            Section 30.   Applicable Law.
                          --------------

            This Plan shall be governed by and construed in accordance  with the
laws of the State of Delaware.

            Section 31.   Board Action.
                          ------------

            Notwithstanding anything to the contrary set forth in this Plan, any
and all actions of the Board or Committee, as the case may be, taken under or in
connection   with  this  Plan  and  any  agreements,   instruments,   documents,
certificates or other writings entered into,  executed,  granted,  issued and/or
delivered  pursuant to the terms hereof,  shall be subject to and limited by any
and all votes, consents,  approvals,  waivers or other actions of all or certain
stockholders  of the  Company  or other  persons  required  pursuant  to (i) the
Company's  Certificate  of  Incorporation  (as the  same may be  amended  and/or
restated  from  time to time),  (ii) the  Company's  Bylaws  (as the same may be
amended and/or restated from time to time), and (iii) any agreement, instrument,
document or writing now or hereafter existing,  between or among the Company and
its  stockholders  or other  persons  (as the same may be  amended  from time to
time).

           ADOPTION AND APPROVAL OF PLAN Date Plan adopted by Board:

                       Date Plan approved by Stockholders:

                             Effective Date of Plan:


                                      -26-