POWER OF ATTORNEY


            KNOW ALL MEN BY THESE  PRESENTS  that each  person  whose  signature
appears below  constitutes and appoints  Robert D. Thompson,  Richard D. Hooper,
and  Jack  E.  Jerrett,   and  each  of  them,   his  or  her  true  and  lawful
attorneys-in-fact and agents, with full power of substitution and resubstitution
for the undersigned and in the undersigned's  name, place, and stead, in any and
all capacities,  to sign the Annual Report on Form 10-K of OraSure Technologies,
Inc., for its fiscal year ended December 31, 2000, and any and all amendments to
the report and to file the same, with all exhibits thereto,  and other documents
in connection therewith,  with the Securities and Exchange Commission,  granting
unto  said  attorneys-in-fact  and  agents,  and each of them,  full  power  and
authority to do and perform each and every act and thing requisite and necessary
to be done,  as fully to all intents and  purposes as the  undersigned  might or
could  do  in  person,   hereby   ratifying   and   confirming   all  that  said
attorneys-in-fact  and  agents  or each of them or  their or his  substitute  or
substitutes may lawfully do or cause to be done by virtue hereof.

            IN WITNESS  WHEREOF,  this Power of Attorney  has been signed by the
undersigned effective as of February 1, 2000.


                                                /s/ Michael G. Bolton
                                                ---------------------------
                                                Signature


                                                Michael G. Bolton
                                                ---------------------------
                                                Print Name


                               POWER OF ATTORNEY

          KNOW  ALL MEN BY THESE  PRESENTS  that  each  person  whose  signature
appears below  constitutes and appoints  Robert D. Thompson,  Richard D. Hooper,
and  Jack  E.  Jerrett,   and  each  of  them,   his  or  her  true  and  lawful
attorneys-in-fact and agents, with full power of substitution and resubstitution
for the undersigned and in the undersigned's  name, place, and stead, in any and
all capacities,  to sign the Annual Report on Form 10-K of OraSure Technologies,
Inc., for its fiscal year ended December 31, 2000, and any and all amendments to
the report and to file the same, with all exhibits thereto,  and other documents
in connection therewith,  with the Securities and Exchange Commission,  granting
unto  said  attorneys-in-fact  and  agents,  and each of them,  full  power  and
authority to do and perform each and every act and thing requisite and necessary
to be done,  as fully to all intents and  purposes as the  undersigned  might or
could  do  in  person,   hereby   ratifying   and   confirming   all  that  said
attorneys-in-fact  and  agents  or each of them or  their or his  substitute  or
substitutes may lawfully do or cause to be done by virtue hereof.

            IN WITNESS  WHEREOF,  this Power of Attorney  has been signed by the
undersigned effective as of February 1, 2000.


                                                /s/ William W. Crouse
                                                ---------------------------
                                                Signature


                                                William W. Crouse
                                                ---------------------------
                                                Print Name


                               POWER OF ATTORNEY

          KNOW  ALL MEN BY THESE  PRESENTS  that  each  person  whose  signature
appears below  constitutes and appoints  Robert D. Thompson,  Richard D. Hooper,
and  Jack  E.  Jerrett,   and  each  of  them,   his  or  her  true  and  lawful
attorneys-in-fact and agents, with full power of substitution and resubstitution
for the undersigned and in the undersigned's  name, place, and stead, in any and
all capacities,  to sign the Annual Report on Form 10-K of OraSure Technologies,
Inc., for its fiscal year ended December 31, 2000, and any and all amendments to
the report and to file the same, with all exhibits thereto,  and other documents
in connection therewith,  with the Securities and Exchange Commission,  granting
unto  said  attorneys-in-fact  and  agents,  and each of them,  full  power  and
authority to do and perform each and every act and thing requisite and necessary
to be done,  as fully to all intents and  purposes as the  undersigned  might or
could  do  in  person,   hereby   ratifying   and   confirming   all  that  said
attorneys-in-fact  and  agents  or each of them or  their or his  substitute  or
substitutes may lawfully do or cause to be done by virtue hereof.

            IN WITNESS  WHEREOF,  this Power of Attorney  has been signed by the
undersigned effective as of February 1, 2000.


                                                /s/ Michael J. Gausling
                                                ---------------------------
                                                Signature


                                                Michael J. Gausling
                                                ---------------------------
                                                Print Name


                               POWER OF ATTORNEY

          KNOW  ALL MEN BY THESE  PRESENTS  that  each  person  whose  signature
appears below  constitutes and appoints  Robert D. Thompson,  Richard D. Hooper,
and  Jack  E.  Jerrett,   and  each  of  them,   his  or  her  true  and  lawful
attorneys-in-fact and agents, with full power of substitution and resubstitution
for the undersigned and in the undersigned's  name, place, and stead, in any and
all capacities,  to sign the Annual Report on Form 10-K of OraSure Technologies,
Inc., for its fiscal year ended December 31, 2000, and any and all amendments to
the report and to file the same, with all exhibits thereto,  and other documents
in connection therewith,  with the Securities and Exchange Commission,  granting
unto  said  attorneys-in-fact  and  agents,  and each of them,  full  power  and
authority to do and perform each and every act and thing requisite and necessary
to be done,  as fully to all intents and  purposes as the  undersigned  might or
could  do  in  person,   hereby   ratifying   and   confirming   all  that  said
attorneys-in-fact  and  agents  or each of them or  their or his  substitute  or
substitutes may lawfully do or cause to be done by virtue hereof.

            IN WITNESS  WHEREOF,  this Power of Attorney  has been signed by the
undersigned effective as of February 1, 2000.


                                                /s/ Frank G. Hausmann Jr.
                                                ---------------------------
                                                Signature


                                                Frank G. Hausmann Jr.
                                                ---------------------------
                                                Print Name



                               POWER OF ATTORNEY

          KNOW  ALL MEN BY THESE  PRESENTS  that  each  person  whose  signature
appears below  constitutes and appoints  Robert D. Thompson,  Richard D. Hooper,
and  Jack  E.  Jerrett,   and  each  of  them,   his  or  her  true  and  lawful
attorneys-in-fact and agents, with full power of substitution and resubstitution
for the undersigned and in the undersigned's  name, place, and stead, in any and
all capacities,  to sign the Annual Report on Form 10-K of OraSure Technologies,
Inc., for its fiscal year ended December 31, 2000, and any and all amendments to
the report and to file the same, with all exhibits thereto,  and other documents
in connection therewith,  with the Securities and Exchange Commission,  granting
unto  said  attorneys-in-fact  and  agents,  and each of them,  full  power  and
authority to do and perform each and every act and thing requisite and necessary
to be done,  as fully to all intents and  purposes as the  undersigned  might or
could  do  in  person,   hereby   ratifying   and   confirming   all  that  said
attorneys-in-fact  and  agents  or each of them or  their or his  substitute  or
substitutes may lawfully do or cause to be done by virtue hereof.

            IN WITNESS  WHEREOF,  this Power of Attorney  has been signed by the
undersigned effective as of February 1, 2000.


                                                /s/ Roger L. Pringle
                                                ---------------------------
                                                Signature


                                                Roger L. Pringle
                                                ---------------------------
                                                Print Name


                                POWER OF ATTORNEY

          KNOW  ALL MEN BY THESE  PRESENTS  that  each  person  whose  signature
appears below  constitutes and appoints  Robert D. Thompson,  Richard D. Hooper,
and  Jack  E.  Jerrett,   and  each  of  them,   his  or  her  true  and  lawful
attorneys-in-fact and agents, with full power of substitution and resubstitution
for the undersigned and in the undersigned's  name, place, and stead, in any and
all capacities,  to sign the Annual Report on Form 10-K of OraSure Technologies,
Inc., for its fiscal year ended December 31, 2000, and any and all amendments to
the report and to file the same, with all exhibits thereto,  and other documents
in connection therewith,  with the Securities and Exchange Commission,  granting
unto  said  attorneys-in-fact  and  agents,  and each of them,  full  power  and
authority to do and perform each and every act and thing requisite and necessary
to be done,  as fully to all intents and  purposes as the  undersigned  might or
could  do  in  person,   hereby   ratifying   and   confirming   all  that  said
attorneys-in-fact  and  agents  or each of them or  their or his  substitute  or
substitutes may lawfully do or cause to be done by virtue hereof.

            IN WITNESS  WHEREOF,  this Power of Attorney  has been signed by the
undersigned effective as of February 1, 2000.


                                                /s/ Robert D. Thompson
                                                ---------------------------
                                                Signature


                                                Robert D. Thompson
                                                ---------------------------
                                                Print Name