[Form of Notice -- 1991 Warrants]

                            NOTICE TO WARRANTHOLDERS


THE  WARRANTS  REFERRED TO BELOW AND THE SHARES OF COMMON STOCK  UNDERLYING  THE
WARRANTS HAVE NOT BEEN REGISTERED FOR ISSUANCE TO THE  WARRANTHOLDERS  UNDER THE
UNITED STATES  SECURITIES ACT OF 1933, AS AMENDED  ("1933 ACT"),  AND MAY NOT BE
OFFERED,  SOLD,  TRANSFERRED,  PLEDGED, OR OTHERWISE DISPOSED OF, IN WHOLE OR IN
PART, DIRECTLY OR INDIRECTLY, IN THE UNITED STATES OR TO A U. S. PERSON (AS SUCH
TERMS ARE DEFINED IN  REGULATION S UNDER THE 1933 ACT),  NOR MAY THE WARRANTS BE
EXERCISED IN THE UNITED STATES OR BY OR ON BEHALF OF A U. S. PERSON,  UNLESS (i)
THE TRANSACTION IS REGISTERED  UNDER THE 1933 ACT AND ANY APPLICABLE  SECURITIES
LAWS OF ANY STATE,  TERRITORY OR POSSESSION OF THE UNITED STATES OR THE DISTRICT
OF COLUMBIA ("STATE ACT"), OR (ii) AN EXEMPTION FROM REGISTRATION UNDER THE 1933
ACT OR ANY  APPLICABLE  STATE ACT IS  AVAILABLE  AND THE ISSUER HAS  RECEIVED AN
OPINION OF COUNSEL TO SUCH EFFECT REASONABLY SATISFACTORY TO IT.

[Name and Address of Warrantholder]

            Reference is made to the warrants  ("Warrants")  to purchase  common
stock,  no  par  value  ("Common  Stock"),  of  Epitope,  Inc.  (the  "Company")
originally  issued by the Company on September 26, 1991, and the related Warrant
Agreements ("Warrant Agreements") dated as of the same date containing the terms
of the Warrants.  Capitalized  terms used and not otherwise  defined herein have
the same meanings as in the Warrant Agreements.

            The Expiration  Date for the Warrants,  as previously  extended,  is
September 30, 1997. The Company hereby further extends the Expiration Date until
September 30, 2000.

            The  Company  intends  to  effect  a  spin-off  of  Agritope,   Inc.
("Agritope") by making a dividend  distribution (the "Distribution") of Agritope
common stock to the  Company's  shareholders.  Subject to and effective ten days
after  occurrence of the  Distribution,  the Company will permit exercise of the
Warrants  at a reduced  exercise  price per share  equal to 110  percent  of the
average  closing  price of the Common  Stock on The Nasdaq  Stock Market for the
five consecutive trading days beginning on the date of the Distribution.

            Warrantholders  will  not  receive  Agritope  common  stock  in  the
Distribution  with  respect to shares of Common  Stock  issued upon  exercise of
Warrants after the record date for the Distribution.

            Please attach a copy of this notice to your Warrant Agreement.


Dated:  September 12, 1997.


                                    EPITOPE, INC.


                                    By:-----------------------------------------
                                    Executive Vice President and Chief
                                    Financial Officer









THESE WARRANTS AND THE SHARES OF COMMON STOCK  UNDERLYING THESE WARRANTS MAY NOT
BE OFFERED, SOLD, TRANSFERRED,  PLEDGED OR OTHERWISE DISPOSED OF, IN WHOLE OR IN
PART, DIRECTLY OR INDIRECTLY,  IN THE UNITED STATES OR TO A U.S. PERSON (AS SUCH
TERMS ARE DEFINED IN REGULATION S UNDER THE  SECURITIES ACT OF 1933, AS AMENDED,
OF THE UNITED  STATES OF AMERICA (THE "1933  ACT")),  NOR MAY THESE  WARRANTS BE
EXERCISED IN THE UNITED STATES OR BY OR ON BEHALF OF A U.S.  PERSON,  UNLESS (i)
THE TRANSACTION IS REGISTERED  UNDER THE 1933 ACT AND ANY APPLICABLE  SECURITIES
LAWS OF ANY STATE,  TERRITORY OR  POSSESSION  OF THE UNITED STATES OF AMERICA OR
THE DISTRICT OF COLUMBIA  ("STATE ACT"), OR (ii) AN EXEMPTION FROM  REGISTRATION
UNDER THE 1933 ACT OR ANY  APPLICABLE  STATE ACT IS AVAILABLE AND THE ISSUER HAS
RECEIVED AN OPINION OF COUNSEL TO SUCH EFFECT REASONABLY SATISFACTORY TO IT.


             VOID AFTER 5 P.M., PACIFIC TIME, ON SEPTEMBER 30, 2000,
                        WARRANTS TO PURCHASE COMMON STOCK

Warrant No. ___                  ___ Warrants


                                 EPITOPE, INC.

                              THIS CERTIFIES THAT

                            [Name of warrantholder]

or  registered  assigns,  is the  registered  holder of the  number of  Warrants
("Warrants")  set forth  above.  Each Warrant  entitles the holder  thereof (the
"Warrantholder")  to purchase  from Epitope,  Inc., a  corporation  incorporated
under the laws of the state of Oregon ("Company"), United States of America, one
fully paid and nonassessable share of common stock, no par value, of the Company
("Common Stock") upon  presentation and surrender of this Warrant Agreement with
the instructions for the registration and delivery of Common Stock filled in, at
any time prior to 5 P.M.,  Pacific time, on September 30, 2000, at the corporate
offices of the Company at 8505 S.W.  Creekside Place,  Beaverton,  Oregon 97008,
United  States of America,  or at such other  address as may be specified by the
Company  pursuant to Section ,  accompanied by payment of the Exercise Price (as
defined  herein) and any  applicable  taxes,  either in cash or by  certified or
official bank check,  payable in lawful money of the United States of America to
the order of the Company.

      Section 1. Exercise  Price.  Each Warrant  entitles the  Warrantholder  to
purchase one share of Common  Stock for U.S.  $______  (the  "Exercise  Price"),
subject to adjustment as provided herein.

      Section 2. Expiration. All Warrants not theretofore exercised shall expire
at 5 p.m., Pacific time, on September 30, 2000 (the "Expiration Date").

      Section  3.  Adjustments  of  Number  and Kind of Shares  Purchasable  and
Exercise Price. The number and kind of securities or other property  purchasable
upon exercise of a Warrant shall be subject to adjustment from time to time upon
the occurrence, after the date hereof, of the following events:

            3.1 If the  outstanding  shares of the  Company's  Common  Stock are
      divided into a greater  number of shares or a dividend in stock is paid on
      the  Common  Stock,  the  number of shares of  Common  Stock  issuable  on
      exercise  of the  Warrants  shall  be  proportionately  increased  and the
      Exercise Price in effect  immediately  prior to such subdivision or at the
      record date of such dividend shall,  simultaneously with the effectiveness
      of such subdivision or immediately after the record date of such dividend,
      be proportionately reduced; and, conversely,  if the outstanding shares of
      Common Stock are combined into a smaller number of shares of Common Stock,
      the



                                      - 1 -






      number of shares of Common Stock  issuable  upon  exercise of the Warrants
      shall  be  proportionately  reduced  and  the  Exercise  Price  in  effect
      immediately  prior  to such  combination  shall,  simultaneously  with the
      effectiveness  of such  combination,  be  proportionately  increased.  The
      increases and reductions provided for in this subsection 3.1 shall be made
      with the intent and, as nearly as practicable, the effect that neither the
      percentage of the total equity of the Company  issuable on exercise of the
      Warrants  nor the price  payable for such  percentage  upon such  exercise
      shall be affected by any event described in this subsection 3.1.

            3.2 No adjustment  of the Exercise  Price will be made if the amount
      of the  adjustment  is less than one cent per share,  but in that case any
      adjustment  that would  otherwise  be  required to be made will be carried
      forward  and  will be  made at the  time of and  together  with  the  next
      adjustment  of the Exercise  Price  which,  together  with any  adjustment
      carried forward, amounts to one cent per share or more.

            3.3 In case of any change in the Common Stock of the Company through
      merger,  consolidation,   reclassification,   reorganization,  partial  or
      complete  liquidation,  or other  change in the capital  structure  of the
      Company  (not  including  a  combination  of  shares  or the  issuance  of
      additional  shares of Common  Stock by the Company by stock split or stock
      dividend),  then, as a condition of the change in the capital structure of
      the  Company,  provision  shall be made so that the holder of this Warrant
      Agreement  will have the right  thereafter to receive upon the exercise of
      the Warrants the kind and amount of shares of stock or other securities or
      property to which such holder  would have been  entitled  if,  immediately
      prior to such  merger,  consolidation,  reclassification,  reorganization,
      recapitalization,  or other change in the capital  structure,  such holder
      had held the number of shares of Common Stock  issuable  upon the exercise
      of the Warrants. In any such case, appropriate adjustment shall be made in
      the  application  of the  provisions  set forth herein with respect to the
      rights and interest  thereafter of the Warrantholder,  to the end that the
      provisions set forth herein shall  thereafter be applicable,  as nearly as
      reasonably  may be, in relation  to any shares of stock or other  property
      thereafter deliverable upon the exercise of the Warrants. The Company will
      not permit any change in its capital  structure to occur unless the issuer
      of the shares of stock or other securities to be received by the holder of
      this  Warrant  Agreement,  if not the  Company,  agrees to be bound by and
      comply with the provisions of this Warrant Agreement.

            3.4 When any  adjustment  is  required  to be made in the  number of
      shares of Common Stock, other securities, or the property purchasable upon
      exercise of the  Warrants,  the Company shall  promptly  determine the new
      number of shares or other securities or property purchasable upon exercise
      of the Warrants and (i) prepare and retain on file a statement  describing
      in  reasonable  detail the method  used in  arriving  at the new number of
      shares or other  securities or property  purchasable  upon exercise of the
      Warrants  and (ii)  cause a copy of such  statement  to be  mailed  to the
      Warrantholder within thirty (30) days after the date when the event giving
      rise to the adjustment occurred.

            3.5 No fractional shares of Common Stock or other securities will be
      issued in connection  with the exercise of any  Warrants,  but the Company
      shall pay, in lieu of fractional  shares,  a cash payment  therefor on the
      basis of the closing  price on a national  securities  exchange on the day
      immediately  prior to exercise or if the Common Stock or other  securities
      are not traded on a national securities exchange on such day, on the basis
      of the fair market value  thereof as  determined by the board of directors
      of the Company, which determination shall be conclusive.

            3.6 Notwithstanding  anything herein to the contrary, there shall be
      no  adjustment  made  hereunder on account of the sale and issuance of the
      shares of Common Stock or other  securities  purchasable  upon exercise of
      the Warrants.




                                      - 2 -





      Section  4.  Rights of  Warrantholder  as  Shareholder.  No holder of this
Warrant Agreement shall, as such, be entitled to vote, receive dividends,  or be
deemed the holder of Common  Stock or any other  securities  of the Company that
may at any time be issuable on the exercise hereof for any purpose whatever, nor
shall anything  contained  herein be construed to confer upon the holder of this
Warrant Agreement, as such, any of the rights of a shareholder of the Company or
any right to vote for the election of directors or upon any matter  submitted to
shareholders at any meeting thereof or give or withhold consent to any corporate
action (whether upon any matter submitted to shareholders at any meeting thereof
or otherwise)  including,  without limitation,  giving or withholding consent to
any  merger,  recapitalization,  issuance of stock,  reclassification  of stock,
change  of par  value  or  change  of stock to no par  value,  consolidation  or
conveyance,  or to  receive  notice  of  meetings  or  other  actions  affecting
shareholders  or  to  receive   dividends  or   subscription   rights  or  other
distributions.

      Section 5. Payment of Certain Taxes and Charges.  The Company shall not be
required to issue or deliver any certificate for shares of Common Stock or other
securities upon the exercise of Warrants  evidenced by this Warrant Agreement or
to register the transfer of the Warrants  evidenced  hereby until any applicable
transfer tax and any other taxes or governmental charges that the Company may be
required by law to collect in respect of such  exercise  or transfer  shall have
been paid, such tax being payable by the holder of this Warrant Agreement at the
time of surrender for exercise or transfer.

      Section 6.  Registration.

            6.1 Registration Statement.  The Company has prepared a registration
      statement on Form S-3 (the  "Registration  Statement")  under the 1933 Act
      with respect to transfer by the  Warrantholder  of the Warrants covered by
      this Warrant  Agreement and the re-sale by the Warrantholder of the shares
      of Common Stock issued or issuable upon exercise of this Warrant Agreement
      (the "Warrant  Shares").  A soon as  practicable  after the original issue
      date of this Warrant  Agreement (the "Original  Issue Date"),  the Company
      shall file the  Registration  Statement with the United States  Securities
      and  Exchange  Commission  and  shall  use its best  efforts  to cause the
      Registration  Statement to become effective under the 1933 Act as promptly
      as  practicable  after the Original  Issue Date. If required by applicable
      law,  the  Company  shall  furnish  to  the  initial   Warrantholder  such
      reasonable  number of  copies  of a  prospectus,  in  conformity  with the
      requirements  of the 1933 Act, and any amendments or  supplements  thereto
      and such other documents as such  Warrantholder may reasonably  request in
      order to facilitate  the  disposition  of the Warrants and Warrant  Shares
      (the  "Securities")  after the  Registration  Statement  has been declared
      effective.  The  Company  shall use  reasonable  efforts (i) to notify the
      initial  Warrantholder  when a prospectus  relating to the  Securities  is
      required to be  delivered  under the 1933 Act,  (ii) to notify the initial
      Warrantholder  of the  happening  of any  event as a result  of which  the
      prospectus  included  in the  Registration  Statement,  as then in effect,
      includes  an  untrue  statement  of a  material  fact or  omits to state a
      material  fact  required  to be stated  therein or  necessary  to make the
      statements  therein not misleading in the light of the circumstances  then
      existing, (iii) to promptly file such amendments and supplements as may be
      required  on account of such  event,  and (iv) to use its best  efforts to
      cause each such amendment and supplement to become effective.  The initial
      Warrantholder  shall not effect sales of the  Securities  after receipt of
      notice from the Company that any such  amendment or supplement is required
      on account of any such event,  until the amendment or  supplement  becomes
      effective.  The Company's obligations under this Section shall expire five
      years after the  Original  Issue Date or on any earlier  date by which the
      initial  Warrantholder  has sold the  Securities or on and after which the
      initial  Warrantholder may sell the Securities without  registration under
      the 1933 Act.

            6.2 Warrantholder Information.  It shall be a condition precedent to
      the obligations of the Company to take any action pursuant to this Section
      that Warrantholder shall furnish to the Company such information regarding
      itself,  the  Securities,  and the intended  method of  disposition of the
      Securities as the Company shall reasonably request.




                                      - 3 -






            6.3  Expenses of  Registration.  The Company  shall pay all expenses
      (other than  underwriting  discounts and  commissions,  transfer taxes, if
      any, and fees and disbursements of counsel to the Warrantholder)  incurred
      in connection with the Registration Statement.

      Section 7.  Transfer and Exchange.

            7.1 Transfer. This Warrant Agreement is transferable on the registry
      books of the Company subject to the  restrictions on the first page hereof
      and in Section . The  Company  may deem and treat the person in whose name
      this  Warrant  Agreement  is  registered  as  the  absolute  owner  hereof
      (notwithstanding  any notation of ownership or other writing  thereon made
      by anyone  other than the  Company)  for all  purposes  whatever,  and the
      Company shall not be affected by any notice to the contrary.

            7.2  Exchange.  Subject to the  provisions of Section , this Warrant
      Agreement  is  exchangeable  at the  principal  office of the  Company for
      Warrant  Agreements  to purchase  the same  aggregate  number of shares of
      Common Stock as are purchasable  hereunder,  each new Warrant Agreement to
      represent the right to purchase such number of shares as the Warrantholder
      shall designate at the time of such exchange.

            7.3 Securities Act of 1933. The Warrantholder, by acceptance hereof,
      agrees that this Warrant  Agreement  and the shares of Common Stock issued
      or issuable upon exercise of this Warrant  Agreement may not be offered or
      sold except in compliance with the 1933 Act. The Warrantholder consents to
      the Company's making a notation on its records and on the certificates for
      any  shares  of  Common  Stock  issued  upon  exercise  hereof in order to
      implement such restriction on transferability.

            7.4 Minimum Warrant Agreement Amount. Notwithstanding the provisions
      of Section 7.1 and Section 7.2, the Company shall not be required to issue
      a Warrant Agreement for Warrants covering less than 1,000 shares of Common
      Stock,  except in the case of a partial  exercise by the  Warrantholder of
      this Warrant  Agreement that leaves Warrants  exercisable to purchase less
      than  1,000  shares  that  are to  remain  registered  in the  name of the
      exercising Warrantholder,  and any subsequent partial exercise,  transfer,
      or exchange of such Warrant Agreement.

      Section 8.  Lockup  Agreement.  The  Warrantholder,  if  requested  by the
Company and an underwriter of the Company's securities,  shall agree not to sell
or otherwise transfer or dispose of any Warrant Shares for a specified period of
time (not to exceed 90 days)  following  the  effective  date of a  registration
statement  pursuant to which the Company  proposes to sell its securities to the
public generally;  provided,  however, that all executive officers and directors
of the Company enter into similar agreements.

      Section 9. Notices. All notices and other communications given pursuant to
this  Warrant  Agreement  shall be in writing.  Notices to the Company  shall be
deemed  to  have  been  given  when  received  by the  Company.  Notices  to the
Warrantholder  shall be deemed to have been given when personally  delivered or,
if mailed, upon deposit in the United States mails,  postage prepaid,  addressed
at the address  provided to the Company and set forth in the Company's  registry
books.  Notices  mailed to the  Warrantholder  shall be sent via  airmail if the
Warrantholder's  address is outside  the United  States.  Notices to the Company
should be addressed as follows:

                  Epitope, Inc.
                  8505 S.W. Creekside Place
                  Beaverton, Oregon  97008
                  Attention:  President

            With a copy (which shall not constitute notice) to:



                                      - 4 -






                  Miller, Nash, Wiener, Hager & Carlsen LLP
                  3500 U. S. Bancorp Tower
                  111 S.W. Fifth Avenue
                  Portland, Oregon  97204
                  Attention:  Erich W. Merrill, Jr.

Such  addresses  for  notices may be changed by any party by notice to the other
party pursuant to this Section 9.

      Section 10.  Amendment.  This Warrant  Agreement may be amended only by an
instrument in writing signed by the Company and the Warrantholder.

      Section 11. Law Governing.  This Warrant  Agreement shall be construed and
enforced  in  accordance  with and  governed by the laws of the state of Oregon,
United States of America,  applicable to contracts to be performed in such state
between residents thereof,  without regard to the conflicts of law provisions of
such state.

      Dated as of ------------------.

                                    EPITOPE, INC.


                                    By------------------------------------------

                                    Attest:


                                    By------------------------------------------





                                      - 5 -








                          ELECTION TO EXERCISE WARRANT

      [NOTE:  Unless the Warrant Shares have been registered  under the 1933 Act
      or are exempt  from  registration  thereunder,  this  Election to Exercise
      Warrant  must be  executed,  and the  Warrant  Shares  must be  delivered,
      outside of the United States of America, its territories and possessions.]

To:   Epitope, Inc.
      8505 Creekside Place
      Beaverton, Oregon  97008
      United States of America

            The undersigned  hereby  exercises the within Warrant  Agreement for
________  shares of the Common  Stock of  Epitope,  Inc.,  and  tenders  payment
herewith in the amount of U.S. $_________ in accordance with the terms thereof.

            The undersigned hereby certifies that (mark one of the two responses
below):

            ___   (i) It is the  sole  beneficial  owner of the  Warrants  being
                  exercised, (ii) it is not a U.S. person, within the meaning of
                  Regulation S promulgated  by the United States  Securities and
                  Exchange  Commission  pursuant to the  Securities  Act of 1933
                  ("1933 Act"), and (iii) it is not exercising  Warrants for the
                  benefit of any U.S. person.

                                     --OR--

            ___   The  securities  to be delivered  upon exercise of the Warrant
                  ("Warrant  Shares") have been registered under the 1933 Act or
                  are exempt from registration thereunder and Epitope, Inc., has
                  been  provided  with a  written  opinion  of  counsel  to that
                  effect.  [A legal opinion  regarding the  registration  of the
                  Warrant  Shares  will be  obtained  at the expense of Epitope,
                  Inc., by its designated  legal counsel upon notice of exercise
                  of the  Warrant  Agreement  by the  Warrantholder  at any time
                  after the effective date of a registration  statement covering
                  the  Warrant  Shares;  any other  legal  opinion  shall be the
                  responsibility of the Warrantholder.]

      Please  deliver  the  certificate  and a new  Warrant  Agreement  for  the
unexercised Warrants, if any, to:

                        ------------------------------------
                        ------------------------------------
                        ------------------------------------

                                          --------------------------------------
                                          Name and Title:

Dated:  ---------------, 199--

Warrantholder: --------------------------------
Address:       --------------------------------
               --------------------------------
               --------------------------------






                               FORM OF ASSIGNMENT

      [NOTE:  Unless the Warrants have been registered under the 1933 Act or are
      exempt from registration thereunder, this Assignment must be executed, and
      the re-issued Warrants must be delivered,  outside of the United States of
      America, its territories and possessions.]



      FOR VALUE  RECEIVED,  the  undersigned  registered  owner of this  Warrant
Agreement hereby sells,  assigns, and transfers unto the Assignee(s) named below
all of the rights of the undersigned under the Warrant  Agreement,  with respect
to Warrants for the number of shares of Common Stock set forth below:


Name of Assignee                    Address                     No. of Shares*
- ----------------                    -------                     --------------








      *Please note that the minimum denomination in which Warrant Agreements may
be issued is 1,000 shares of Common Stock.



      Dated: --------------, 19--.

                                    Warrantholder:------------------------------



                                    By------------------------------------------
                                       Title:

                                    [Name of warrantholder  must be identical to
                                    name  shown  in the  registry  books  of the
                                    Company;  signature  must be guaranteed by a
                                    bank or brokerage firm doing business in the
                                    United States.]