[Form of Notice -- Technology Transfer Warrants]

                           NOTICE TO WARRANTHOLDERS


THE  WARRANTS  REFERRED TO BELOW AND THE SHARES OF COMMON STOCK  UNDERLYING  THE
WARRANTS HAVE NOT BEEN REGISTERED FOR ISSUANCE TO THE  WARRANTHOLDERS  UNDER THE
SECURITIES ACT OF 1933, AS AMENDED ("1933 ACT"),  AND MAY NOT BE OFFERED,  SOLD,
PLEDGED,  OR OTHERWISE  TRANSFERRED AND THE WARRANTS MAY NOT BE EXERCISED UNLESS
THE TRANSACTION IS REGISTERED UNDER THE 1933 ACT AND APPLICABLE STATE SECURITIES
LAWS OR UNLESS AN EXEMPTION  FROM  REGISTRATION  IS AVAILABLE  AND THE ISSUER IS
FURNISHED  A  SATISFACTORY  OPINION OF  COUNSEL  THAT SUCH  REGISTRATION  IS NOT
REQUIRED.


[Name and Address of Warrantholder]


            Reference is made to the warrants  ("Warrants")  to purchase  common
stock,  no  par  value  ("Common  Stock"),  of  Epitope,  Inc.  (the  "Company")
originally  issued by the  Company on August 1, 1993,  and the  related  Warrant
Agreements ("Warrant Agreements") dated as of the same date containing the terms
of the Warrants.  Capitalized  terms used and not otherwise  defined herein have
the same meanings as in the Warrant Agreements.

            The Expiration  Date for the Warrants,  as previously  extended,  is
September 30, 1997. The Company hereby further extends the Expiration Date until
September 30, 2000.

            The  Company  intends  to  effect  a  spin-off  of  Agritope,   Inc.
("Agritope") by making a dividend  distribution (the "Distribution") of Agritope
common stock to the  Company's  shareholders.  Subject to and effective ten days
after  occurrence of the  Distribution,  the Company will permit exercise of the
Warrants  at a reduced  exercise  price per share  equal to 110  percent  of the
average  closing  price of the Common  Stock on The Nasdaq  Stock Market for the
five  consecutive  trading days beginning on the date of the  Distribution.  The
Company waives payment of the additional Cash Purchase Consideration  referenced
in the Warrant Agreements.

            Warrantholders  will  not  receive  Agritope  common  stock  in  the
Distribution  with  respect to shares of Common  Stock  issued upon  exercise of
Warrants after the record date for the Distribution.

            Please attach a copy of this notice to your Warrant Agreement.

Dated:  September 12, 1997.

                    EPITOPE, INC.



                    By-------------------------------------------------------
                         Executive Vice President and Chief Financial Officer









THESE WARRANTS AND THE SHARES OF COMMON STOCK UNDERLYING THESE WARRANTS HAVE NOT
BEEN REGISTERED  UNDER THE SECURITIES ACT OF 1933, AS AMENDED ("1933 ACT"),  AND
MAY NOT BE OFFERED,  SOLD,  PLEDGED,  OR OTHERWISE  TRANSFERRED  UNLESS THEY ARE
REGISTERED  UNDER THE 1933 ACT AND APPLICABLE STATE SECURITIES LAWS OR UNLESS AN
EXEMPTION  FROM  REGISTRATION  IS  AVAILABLE  AND  THE  ISSUER  IS  FURNISHED  A
SATISFACTORY OPINION OF COUNSEL THAT SUCH REGISTRATION IS NOT REQUIRED.

COMMON STOCK  PURCHASED  PURSUANT TO THE  EXERCISE OF THESE  WARRANTS MAY NOT BE
SOLD OR OTHERWISE  TRANSFERRED  OR DISPOSED OF FOR A PERIOD OF 60 DAYS AFTER THE
DATE OF PURCHASE OF SUCH COMMON STOCK.


                 VOID AFTER 5 P.M., UNITED STATES PACIFIC TIME,
                              ON SEPTEMBER 30, 2000
                    OR SUCH EARLIER DATE AS SPECIFIED HEREIN

                        WARRANTS TO PURCHASE COMMON STOCK

Warrant No. _______________
                            _______________ Warrants


                                 EPITOPE, INC.

                              THIS CERTIFIES THAT

                            [Name of Warrantholder]

or registered  assigns is the registered holder of the number of Warrants (each,
a  "Warrant,"  and  collectively,  "Warrants")  set forth  above.  Each  Warrant
represented by this certificate for Warrants ("Warrant  Agreement") entitles the
registered holder thereof (the "Warrantholder") to purchase from Epitope,  Inc.,
a corporation  incorporated  under the laws of the state of Oregon  ("Company"),
United States of America  ("U.S."),  one fully paid and  nonassessable  share of
common stock, no par value, of the Company  ("Common  Stock") upon  presentation
and  surrender  of this  Warrant  Agreement  with the  accompanying  Election to
Exercise  Warrants duly  completed,  at any time prior to 5 P.M.,  U.S.  Pacific
time, on the Expiration Date (as defined in Section 2), at the corporate offices
of the Company at 8505 S.W. Creekside Place, Beaverton, Oregon 97008, or at such
other  address  as may be  specified  by  the  Company  pursuant  to  Section  ,
accompanied  by  payment  of the  Exercise  Price (as  defined  herein)  and any
applicable taxes,  either in cash in U.S. funds or by certified or official bank
check in U.S.  funds  payable to the order of the  Company.  These  Warrants are
issued  pursuant  to a  1993  Technology  Transfer  Warrant  Issuance  Agreement
("Issuance  Agreement")  among the Company and the Investors  described  therein
dated as of June 15, 1993.

   Section 1.  Exercise  Price.  Each  Warrant  entitles  the  Warrantholder  to
purchase  one share of Common  Stock for U.S.  $_____  (the  "Exercise  Price"),
subject to adjustment as provided herein.

   Section 2. Expiration. All Warrants not theretofore exercised shall expire at
5  p.m.,  U.S.  Pacific  time,  on the  earlier  of  the  following  dates  (the
"Expiration  Date"):  (a) September 30, 2000, and (b) the expiration of 120 days
after the first  period of 20  consecutive  trading days during which period the
average of the high and low sales prices of the Common Stock on The Nasdaq Stock
Market,  or any other  exchange  or national  market  system on which the Common
Stock is then traded, is at least $30.00.




                                      - 1 -





   Section 3. Adjustments of Number and Kind of Shares  Purchasable and Exercise
Price.  The number and kind of securities  or other  property  purchasable  upon
exercise of a Warrant shall be subject to adjustment  from time to time upon the
occurrence, after the date hereof, of the following events:

        3.1 If the outstanding  shares of the Company's Common Stock are divided
   into a greater  number of shares or a dividend in Common Stock is paid on the
   Common  Stock,  the number of shares of Common Stock  issuable on exercise of
   the Warrants  shall be  proportionately  increased and the Exercise  Price in
   effect  immediately  prior to such  subdivision or at the record date of such
   dividend shall,  simultaneously with the effectiveness of such subdivision or
   immediately  after  the  record  date of such  dividend,  be  proportionately
   reduced;  and,  conversely,  if the  outstanding  shares of Common  Stock are
   combined  into a smaller  number of shares  of Common  Stock,  the  number of
   shares of Common  Stock  issuable  upon  exercise  of the  Warrants  shall be
   proportionately reduced and the Exercise Price in effect immediately prior to
   such  combination  shall,  simultaneously  with  the  effectiveness  of  such
   combination,  be  proportionately  increased.  The increases  and  reductions
   provided  for in this  subsection  3.1 shall be made with the intent  and, as
   nearly as  practicable,  the effect that neither the  percentage of the total
   equity of the Company  issuable on  exercise  of the  Warrants  nor the price
   payable for such percentage upon such exercise shall be affected by any event
   described in this subsection 3.1.

        3.2 No  adjustment  of the Exercise  Price will be made if the amount of
   the  adjustment  is less  than  U.S.  $.01 per  share,  but in that  case any
   adjustment  that  would  otherwise  be  required  to be made will be  carried
   forward and will be made at the time of and together with the next adjustment
   of the Exercise Price which,  together with any adjustment  carried  forward,
   amounts to U.S. $.01 per share or more.

        3.3 In case of any change in the  Common  Stock of the  Company  through
   merger, consolidation, reclassification,  reorganization, partial or complete
   liquidation,  or other  change in the capital  structure  of the Company (not
   including a  combination  of shares or the issuance of  additional  shares of
   Common  Stock by the Company by stock split or stock  dividend),  then,  as a
   condition of the change in the capital  structure  of the Company,  provision
   shall be made so that the  holder  of this  Warrant  Agreement  will have the
   right  thereafter  to receive  upon the exercise of the Warrants the kind and
   amount of shares  of stock or other  securities  or  property  to which  such
   holder  would  have  been  entitled  if,  immediately  prior to such  merger,
   consolidation, reclassification,  reorganization,  recapitalization, or other
   change in the capital structure, such holder had held the number of shares of
   Common Stock  issuable upon the exercise of the  Warrants.  In any such case,
   appropriate adjustment shall be made in the application of the provisions set
   forth  herein  with  respect  to the rights and  interest  thereafter  of the
   Warrantholder,  to the  end  that  the  provisions  set  forth  herein  shall
   thereafter be applicable,  as nearly as reasonably may be, in relation to any
   shares of stock or other property thereafter deliverable upon the exercise of
   the Warrants. The Company will not permit any change in its capital structure
   to occur unless the issuer of the shares of stock or other  securities  to be
   received by the holder of this Warrant Agreement,  if not the Company, agrees
   to be bound by and comply with the provisions of this Warrant Agreement.

        3.4 When any  adjustment  is required to be made in the number of shares
   of Common Stock, other securities,  or property  purchasable upon exercise of
   the Warrants,  the Company shall promptly  determine the new number of shares
   or other securities or property purchasable upon exercise of the Warrants and
   (a) prepare and retain on file a statement  describing in  reasonable  detail
   the method used in  arriving at the new number of shares or other  securities
   or property purchasable upon exercise of the Warrants and (b) cause a copy of
   such  statement  to be mailed to the  Warrantholder  within  thirty (30) days
   after the date when the event giving rise to the adjustment occurred.

        3.5 No fractional  shares of Common Stock or other  securities  shall be
   issued in connection with the exercise of any Warrants, but the Company shall
   pay, in lieu of fractional  shares,  a cash payment  therefor on the basis of
   the closing price on a national  securities  exchange on the day  immediately
   prior to exercise or, if the Common Stock or other  securities are not traded
   on a national securities exchange



                                      - 2 -





   on such day, on the basis of the fair market value  thereof as  determined by
   the  board  of  directors  of  the  Company,  which  determination  shall  be
   conclusive.

        3.6 Notwithstanding  anything herein to the contrary,  there shall be no
   adjustment  made  hereunder on account of the sale and issuance of the shares
   of  Common  Stock  or  other  securities  purchasable  upon  exercise  of the
   Warrants.

   Section 4. Rights of Warrantholder as Shareholder.  No holder of this Warrant
Agreement shall, as such, be entitled to vote, receive  dividends,  or be deemed
the holder of Common  Stock or any other  securities  of the Company that may at
any time be issuable on the exercise hereof for any purpose whatever,  nor shall
anything contained herein be construed to confer upon the holder of this Warrant
Agreement,  as such,  any of the rights of a  shareholder  of the Company or any
right to vote for the  election of  directors  or upon any matter  submitted  to
shareholders at any meeting thereof or give or withhold consent to any corporate
action (whether upon any matter submitted to shareholders at any meeting thereof
or otherwise)  including,  without limitation,  giving or withholding consent to
any  merger,  recapitalization,  issuance of stock,  reclassification  of stock,
exchange of stock, change of stock to par value, consolidation or conveyance, or
to receive  notice of meetings or other  actions  affecting  shareholders  or to
receive dividends or subscription rights or other distributions.

   Section 5.  Payment of Certain  Taxes and Charges.  The Company  shall not be
required to issue or deliver any certificate for shares of Common Stock or other
securities upon the exercise of Warrants  evidenced by this Warrant Agreement or
to register the transfer of the Warrants  evidenced  hereby until any applicable
transfer tax and any other taxes or governmental charges that the Company may be
required by law to collect in respect of such  exercise  or transfer  shall have
been paid, such tax being payable by the holder of this Warrant Agreement at the
time of surrender for exercise or transfer.

   Section 6. Registration. The Company has prepared a registration statement on
Form S-3 (the  "Registration  Statement") under the 1933 Act with respect to the
resale by the  Warrantholder  of the shares of Common  Stock  issued or issuable
upon  exercise of this Warrant  Agreement  (the  "Warrant  Shares").  As soon as
practicable  after  the  original  issue  date of this  Warrant  Agreement  (the
"Original Issue Date"),  the Company shall file the Registration  Statement with
the U.S.  Securities  and Exchange  Commission and shall use its best efforts to
cause  the  Registration  Statement  to become  effective  under the 1933 Act as
promptly as practicable after the Original Issue Date as provided for in, and in
accordance with, the terms and conditions of the Issuance Agreement.

   Section 7.  Transfer and Exchange.

        7.1 Transfer.  This Warrant  Agreement is  transferable  on the registry
   books of the Company subject to the restrictions on the first page hereof and
   in Section  7.4. The Company may deem and treat the person or entity in whose
   name this  Warrant  Agreement  is  registered  as the  absolute  owner hereof
   (notwithstanding  any notation of ownership or other writing  thereon made by
   anyone other than the Company)  for all  purposes  whatever,  and the Company
   shall not be affected by any notice to the contrary.

        7.2 Exchange.  Subject to the provisions of Section and the restrictions
   on the first page hereof,  this  Warrant  Agreement  is  exchangeable  at the
   principal  office of the Company for Warrant  Agreements to purchase the same
   aggregate number of shares of Common Stock as are purchasable hereunder, each
   new Warrant  Agreement  to  represent  the right to  purchase  such number of
   shares as the Warrantholder shall designate at the time of such exchange.

        7.3  Securities Act of 1933. The  Warrantholder,  by acceptance  hereof,
   agrees that this Warrant  Agreement  and the shares of Common Stock issued or
   issuable upon  exercise of this Warrant  Agreement may not be offered or sold
   except in  compliance  with the 1933 Act. The  Warrantholder  consents to the
   Company's  making a notation on its records and on the  certificates  for any
   shares of Common Stock issued upon exercise hereof in order to implement such
   restriction on transferability.




                                      - 3 -




        7.4 Minimum Warrant Agreement Amount.  Notwithstanding the provisions of
   Section  7.1 and  Section  , the  Company  shall not be  required  to issue a
   Warrant  Agreement  for  Warrants  covering  less than 1,000 shares of Common
   Stock,  except in the case of a partial exercise by the Warrantholder of this
   Warrant  Agreement  that leaves  Warrants  exercisable  to purchase less than
   1,000  shares  that are to remain  registered  in the name of the  exercising
   Warrantholder,  and any subsequent partial exercise, transfer, or exchange of
   such Warrant Agreement.

        7.5 No  Transfer of Common  Stock for 60 Days.  Common  Stock  purchased
   pursuant  to the  exercise  of these  Warrants  may not be sold or  otherwise
   transferred or disposed of for a period of 60 days after the date of purchase
   of such Common Stock.

   Section 8. Holdback Agreement. The Warrantholder, if requested by the Company
and an  underwriter  of the  Company's  securities,  shall  agree not to sell or
otherwise  transfer or dispose of any Warrants or Warrant Shares for a specified
period  of time  (not to  exceed  90 days)  following  the  effective  date of a
registration  statement  pursuant  to which  the  Company  proposes  to sell its
securities  to the  public  generally;  provided,  however,  that all  executive
officers and directors of the Company enter into similar agreements.

   Section 9. Notices. Any notice,  request, or other communication  required or
permitted  hereunder  shall be in writing  and shall be deemed to have been duly
given if delivered  personally or by certified  mail,  postage  prepaid,  return
receipt requested,  to: (a) the Company at 8505 S.W. Creekside Place, Beaverton,
Oregon 97008, Attn:  Secretary,  with a copy to Miller,  Nash,  Wiener,  Hager &
Carlsen,  3500 U.S.  Bancorp  Tower,  111 S.W.  Fifth Avenue,  Portland,  Oregon
97204-3699,  Attn: Erich W. Merrill,  Jr. and (b) to the  Warrantholders  at the
addresses set forth in the registry books of the Company  referred to in Section
7.1. Any notice,  request,  or other communication given by certified mail shall
be deemed  given 10 days after the mailing  date;  notices,  requests,  or other
communications given in any other manner shall be deemed given when received.

   Section  10.  Amendment.  This  Warrant  Agreement  may  be  amended  or  its
provisions waived only by an instrument in writing signed by the Company and the
Warrantholder as provided in the Issuance Agreement.

   Section 11. Law Governing.  This Warrant  Agreement  shall be governed by and
construed in  accordance  with the laws of the state of Oregon,  without  giving
effect to choice of laws principles thereof.

   Dated as of _______________.

                                      EPITOPE, INC.


                                      By----------------------------------------







                                      - 4 -






                          ELECTION TO EXERCISE WARRANT


To: Epitope, Inc.
    8505 S.W. Creekside Place
    Beaverton, Oregon  97008

        The  undersigned  hereby  exercises  the within  Warrant  Agreement  for
________ shares of the Common Stock of Epitope,  Inc.  ("Warrant  Shares"),  and
tenders payment herewith in the amount of U.S. $_________ in accordance with the
terms thereof.

THE WARRANTS MAY NOT BE EXERCISED UNLESS THE TRANSACTION IS REGISTERED UNDER THE
1933 ACT AND  APPLICABLE  STATE  SECURITIES  LAWS OR  UNLESS AN  EXEMPTION  FROM
REGISTRATION IS AVAILABLE AND THE ISSUER IS FURNISHED A SATISFACTORY  OPINION OF
COUNSEL THAT SUCH REGISTRATION IS NOT REQUIRED.

THE  UNDERSIGNED  HEREBY AGREES NOT TO SELL OR OTHERWISE  TRANSFER OR DISPOSE OF
THE WARRANT SHARES FOR A PERIOD ENDING 60 DAYS AFTER THE DATE OF PURCHASE OF THE
WARRANT SHARES.

   Please  deliver  the  certificate  and  a  new  Warrant   Agreement  for  the
unexercised Warrants, if any, to:

                  ------------------------------------
                  ------------------------------------
                  ------------------------------------


                            Warrantholder:--------------------------------------


                            By--------------------------------------------------
                               Title:

                            [Name of  Warrantholder  must be  identical  to name
                            shown  in  the   registry   books  of  the  Company;
                            signature  must be guaranteed by a bank or brokerage
                            firm doing business in the United States.]

Dated:  -------------, 199--.

Warrantholder:   -------------------------------------
Address:   -------------------------------------------
           -------------------------------------------
           -------------------------------------------






                              FORM OF ASSIGNMENT


        FOR VALUE  RECEIVED,  the undersigned  registered  owner of this Warrant
Agreement hereby sells,  assigns,  and transfers to the Assignee(s)  named below
all of the rights of the undersigned under the Warrant  Agreement,  with respect
to Warrants for the number of shares of Common Stock set forth below:


Name of Assignee            Address                             No. of Shares*
- ----------------            -------                             --------------







   *Please note that the minimum denomination in which Warrant Agreements may be
issued is 1,000 shares of Common Stock.

        The  undersigned  agrees  to  furnish  to the  Company  upon  request  a
satisfactory  opinion of counsel to the effect that the transfer requested above
is exempt from the  Securities  Act of 1933, as amended,  and  applicable  state
securities laws.

   Dated: --------------, 19---.

                            Warrantholder:  ------------------------------------



                            By--------------------------------------------------
                              Title:


                            [Name of  Warrantholder  must be  identical  to name
                            shown  in  the   registry   books  of  the  Company;
                            signature  must be guaranteed by a bank or brokerage
                            firm doing business in the United States.]




                                      - 6 -