SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                -----------------

                                    FORM 8-K

                                 CURRENT REPORT

                       Pursuant to Section 13 or 15(d) of
                       the Securities Exchange Act of 1934

                Date of Report (Date of earliest event reported):

                                 October 1, 1999

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                                  EPITOPE, INC.
               (Exact name of Registrant as specified in charter)

                                     Oregon
                 (State or other jurisdiction of incorporation)

                                     1-10492
                              (Commission File No.)

                                   93-0779127
                        (IRS Employer Identification No.)

      8505 S.W. Creekside Place
          Beaverton, Oregon                                     97008
(Address of principal executive offices)                      (Zip Code)

               Registrant's telephone number, including area code:

                                 (503) 641-6115





Item 5.     Other Events.

On October 1, 1999, Epitope, Inc. (the "Company") announced that John W. Morgan,
its  President  and Chief  Executive  Officer,  had  notified the Company of his
resignation.  The Company's Chief Financial Officer,  Charles E. Bergeron,  will
serve as Interim  President  after Mr.  Morgan  leaves the Company and until the
Company  selects a permanent  successor.  Mr. Morgan will remain on the board of
directors.


A copy of a press release  announcing the changes is filed as an exhibit to this
report.


Item 7.     Financial Statements, Pro Forma Financial Information and Exhibits.

            (a)   Not applicable.

            (b)   Not applicable.

            (c)   Exhibits.

The  exhibits  filed  herewith  are listed in the exhibit  index  following  the
signature page of this report.






                                   SIGNATURES

Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
Registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.

                                  EPITOPE, INC.


Dated:  October 1, 1999             By: /s/ Charles E. Bergeron
                                    Charles E. Bergeron
                                    Chief Financial Officer




                                  EXHIBIT INDEX

99 Press release dated October 1, 1999.