Registration Statement No. 333-00077
                                    Filed pursuant to Rule 424(b)(3)
                                    under the Securities Act of 1933
       
       
       
       Rider to Prospectus dated January 22, 1996
       Relating to Shares being sold by Selling 
       Stockholders
       
       
                         U.S. BIOSCIENCE, INC.
                             Common Stock
       
       Effective the close of business April 22, 1996, U.S. Bioscience,
       Inc. effected a 1-for-2 reverse stock split of its Common Stock,
       reducing by 50% the number of outstanding shares of Common Stock. 
       In connection with the reverse stock split, the par value of the
       Common Stock was changed from $.005 per share to $.01 per share.