UNITED STATES

                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                                  SCHEDULE 14A

                PROXY STATEMENT PURSUANT TO SECTION 14(A) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

            Filed by the Registrant [X]

            Filed by a Party other than the Registrant [ ]

            Check the appropriate box:

            [X] Preliminary Proxy Statement

            [ ] Confidential, for Use of the Commission Only (as permitted by
                Rule 14a-6(e)(2))

            [ ] Definitive Proxy Statement

            [ ] Definitive Additional Materials

            [ ] Soliciting Material Pursuant to Section 240.14a-12

                                 PROTALEX, INC.

                (Name of Registrant as Specified In Its Charter)

    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

      [X]   No fee required

      [ ]   Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and
            0-11.

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                  applies:

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                  computed pursuant to Exchange Act Rule 0-11 (set forth the
                  amount on which the filing fee is calculated and state how it
                  was determined):

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      [ ]   Fee paid previously with preliminary materials

      [ ]   Check box if any part of the fee is offset as provided by Exchange
            Act Rule 0-11 (a) (2) and identify the filing for which the
            offsetting fee was paid previously. Identify the previous filing by
            registration statement number, or the Form or Schedule and the date
            of its filing.

            1)    Amount Previously Paid:

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                                 PROTALEX, INC.

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

                         TO BE HELD ON OCTOBER 25, 2005

                      TO THE STOCKHOLDERS OF PROTALEX, INC.

You are cordially invited to attend the 2005 Annual Meeting of Stockholders of
Protalex, Inc., which will be held at the Hyatt Regency Princeton, 102 Carnegie
Center Princeton, NJ 08540, (609) 987-1234, on Tuesday, October 25, 2005 at 9:30
a.m., to consider and act upon the following matters:

      1)    AMENDMENT TO THE PROTALEX, INC. AMENDED CERTIFICATE OF INCORPORATION
            ("CERTIFICATE OF INCORPORATION") TO INCREASE THE NUMBER OF
            AUTHORIZED SHARES OF THE COMPANY'S COMMON STOCK. To approve an
            amendment to the Certificate of Incorporation increasing the
            authorized number of shares of Common Stock from 40,000,000 shares
            to 100,000,000 shares;

      2)    AMENDMENT TO THE PROTALEX, INC. 2003 STOCK OPTION PLAN. To approve
            an increase in the authorized number of shares under the Protalex,
            Inc. 2003 Stock Option Plan from 1,500,000 shares to 4,500,000
            shares;

      3)    ELECTION OF DIRECTORS. To elect Directors of the Company as more
            fully described in the attached Proxy Statement to serve until the
            next Annual Meeting of Stockholders or until their respective
            successors are elected and qualified;

      4)    RATIFICATION OF INDEPENDENT AUDITORS. To ratify the appointment of
            Grant Thornton, LLP as the independent auditors for the Company for
            the fiscal year ending May 31, 2006; and

      5)    To transact such other business as may properly come before the
            Annual Meeting and any adjournment or postponement thereof.

The record date for the determination of the stockholders entitled to vote at
the meeting or at any adjournment thereof is the close of business on September
30, 2005. A list of stockholders entitled to vote at the Annual Meeting will be
open to the examination of any stockholder, for any purpose germane to the
meeting, at the location of the Annual Meeting on October 25, 2005, and during
ordinary business hours for ten days prior to the meeting at our principal
offices located at 145 Union Square Drive, New Hope, PA 18938.

It is important that your shares be represented at the meeting regardless of the
number of shares you hold. Whether or not you expect to attend the meeting in
person, please complete, date, sign and return the accompanying proxy in the
enclosed envelope to ensure the presence of a quorum at the Annual Meeting. If
you do attend the meeting, you may, if you prefer, revoke your proxy and vote
your shares in person.

Your Board of Directors recommends that you vote in favor of the proposals
outlined in the Proxy Statement. Please refer to the Proxy Statement for
detailed information on each of the proposals.

By Order of the Board of Directors

By: /s/ Steven H. Kane
- ----------------------

Steven H. Kane
President and Chief Executive Officer
145 Union Square Drive
New Hope, PA 18938

                                     - 2 -


                  WE URGE STOCKHOLDERS TO MARK, SIGN AND RETURN

                      PROMPTLY THE ACCOMPANYING PROXY CARD

                                 PROTALEX, INC.

                             145 Union Square Drive

                               New Hope, PA 18938

                          -----------------------------

                                 PROXY STATEMENT

                     FOR THE ANNUAL MEETING OF STOCKHOLDERS

                         TO BE HELD ON OCTOBER 25, 2005

      The accompanying proxy is solicited by the Board of Directors (the
"Board") of Protalex, Inc., a Delaware corporation (referred to throughout this
Proxy Statement as "Protalex" or "Company" or "we" or "our") for use at the
Annual Meeting of Stockholders to be held on October 25, 2005, at 9:30 a.m.
local time, and at any adjournment thereof, for the purposes set forth in the
accompanying Notice of Annual Meeting.

      The Annual Meeting will be held at the Hyatt Regency Princeton, 102
Carnegie Center Princeton, NJ 08540, (609) 987-1234. The date of this Proxy
Statement is September 16, 2005, the approximate date on which this Proxy
Statement and the accompanying form of proxy were first sent or given to
stockholders.

WHY HAVE I RECEIVED THOSE MATERIALS?

      The accompanying proxy, being mailed to stockholders on or about September
23, 2005, is solicited by the Board of Protalex in connection with our Annual
Meeting of Stockholders that will take place on October 25, 2005. You are
cordially invited to attend the Annual Meeting and are requested to vote on the
proposals described in this Proxy Statement.

WHO IS ENTITLED TO VOTE AT THE ANNUAL MEETING?

      Holders of common stock ("Common Stock") of Protalex, as of the close of
business on September 16, 2005 will be entitled to vote at the Annual Meeting.
On September 16, 2005, there were 19,433,221 shares of common stock outstanding
and entitled to vote.

HOW DO I VOTE MY SHARES AT THE ANNUAL MEETING?

      If you are a "record" stockholder of Common Stock (that is, if you hold
Common Stock in your own name in Protalex's stock records maintained by our
transfer agent, Wachovia Bank, N.A.), you may complete and sign the accompanying
proxy card and return it to Protalex or deliver it in person.

      "Street name" stockholders of Common Stock (that is, stockholders who hold
Common Stock through a broker or other nominee) who wish to vote at the Annual
Meeting will need to obtain a proxy form from the institution that holds their
shares and to follow the voting instructions on such form.

                                     - 3 -


WHAT DOES IT MEAN IF I RECEIVE MORE THAN ONE PROXY?

      It means you have multiple accounts with brokers and/or our transfer
agent. Please vote all of these shares. We recommend that you contact your
broker to consolidate as many accounts as possible under the same name and
address.

CAN I CHANGE MY VOTE AFTER I RETURN MY PROXY CARD?

      Yes. After you have submitted a proxy, you may change your vote at any
time before the proxy is exercised by submitting a written notice of revocation
or a proxy bearing a later date or by voting in person at the Annual Meeting.

HOW MANY VOTES AM I ENTITLED TO?

      Each share of Common Stock is entitled to one vote.

WHAT CONSTITUTES A QUORUM FOR PURPOSES OF THE ANNUAL MEETING?

      The presence at the Annual Meeting in person or by proxy of the holders of
a majority of the voting power of all outstanding shares of Common Stock
entitled to vote shall constitute a quorum for the transaction of business.
Proxies marked as abstaining (including proxies containing broker non-votes) on
any matter to be acted upon by stockholders will be treated as present at the
meeting for purposes of determining a quorum but will not be counted as votes
cast on such matters.

WHAT VOTE IS REQUIRED TO APPROVE EACH ITEM?

      Each item to be voted upon at the Annual Meeting, other than the election
of directors, requires the affirmative vote of a majority of the shares
represented in person or by proxy and entitled to vote on the matter for
approval. This means that the votes "FOR" the matter must exceed the votes
"AGAINST" the matter, Directors shall be elected by a plurality of the votes of
the shares present in person or by proxy at and entitled to vote on the election
of directors.

      A properly executed proxy marked "ABSTAIN" with respect to any matter will
not be voted, although it will be counted for purposes of determining whether
there is a quorum. Accordingly, an abstention on any such matter will have the
effect of a negative vote on such matter. If you hold your shares in "street
name" through a broker or other nominee, shares represented by "broker
non-votes" will be counted in determining whether there is a quorum but will not
be counted as votes cast on such matters.

      Also, due to contractual obligations of the Company, the consent of
vSpring SBIC, L.P. is required for the approval of proposals 1 and 2.

WHAT INFORMATION DO I NEED TO ATTEND THE ANNUAL MEETING?

      You will need an admission ticket to attend the Annual Meeting. If you are
a record stockholder, an admission ticket is included with this mailing and is
attached to the proxy card. If you are a street name stockholder, the stub of
your voting instruction form is your admission ticket. If you arrive at the
Annual Meeting without an admission ticket, we will admit you if we are able to
verify that you are a Protalex stockholder.

HOW DOES THE BOARD RECOMMEND THAT I VOTE MY SHARES?

      Unless you give other instructions on your proxy card, the persons named
as proxy holders on the proxy card will vote in accordance with the
recommendations of the Board. The Board's recommendation is set forth together
with the description of each item in this Proxy Statement. In summary, the Board
recommends a vote:

      -     FOR the approval of the amendments to the Company's Certificate of
            Incorporation as set forth on page 5;

      -     FOR the approval of the amendments to the Company's 2003 Stock
            Option Plan as set forth on page 6;

                                     - 4 -


      -     FOR the Directors' proposal to elect the nominated Directors set
            forth on page 9; and

      -     FOR the ratification of the Directors' selection of auditors as set
            forth on page 11.

      With respect to any other matter that properly comes before the Annual
Meeting, the proxy holders will vote as recommended by the Board or, if no
recommendation is given, in their own discretion in the best interests of
Protalex. At the date this Proxy Statement went to press, the Board had no
knowledge of any business other than that described herein that would be
presented for consideration at the Annual Meeting.

WHO WILL BEAR THE EXPENSE OF SOLICITING PROXIES?

      Protalex will bear the cost of soliciting proxies in the form enclosed. In
addition to the solicitation by mail, proxies may be solicited personally or by
telephone, facsimile or electronic transmission by our employees. Our employees
will not receive any additional compensation for participating in proxy
solicitation. We may reimburse brokers holding Common Stock in their names or in
the names of their nominees for their expenses in sending proxy materials to the
beneficial owners of such Common Stock.

IS THERE ANY INFORMATION THAT I SHOULD KNOW ABOUT FUTURE ANNUAL MEETINGS?

      Stockholder Proposals

      Any stockholder who intends to present a proposal at the 2006 Annual
Meeting of Stockholders (the "2006 Annual Meeting") must deliver the proposal to
our Corporate Secretary at 145 Union Square Drive, New Hope, PA 18938, not later
than June 3, 2006, if the proposal is submitted for inclusion in our proxy
materials for that meeting pursuant to Rule 14A-8 under the Securities Exchange
Act of 1934. If a stockholder proposal is received after June 3, 2006, we may
vote in our discretion as to that proposal all of the shares for which we have
received proxies for the 2006 Annual Meeting.

                                       I.

                                   PROPOSALS

                                   PROPOSAL 1.

       AMENDMENT OF THE COMPANY'S CERTIFICATE OF INCORPORATION TO INCREASE
                           THE AUTHORIZED COMMON STOCK

      The Board of Directors has adopted a resolution proposing and declaring
the advisability of amending the Company's Certificate of Incorporation to
increase the number of shares of Common Stock that the Company is authorized to
issue from 40,000,000 shares to 100,000,000 shares. The Board of Directors
directed that this proposed amendment be considered at the Annual Meeting of
Stockholders on October 25, 2005. The Board believes this capital structure more
appropriately reflects the present and future needs of the Company. The
authorization of an additional 60,000,000 shares of Common Stock would give the
Board of Directors the express authority, without further action of the
Stockholders, to issue such shares of Common Stock from time to time as the
Board deems necessary. A copy of the text of this proposed amendment to the
Certificate of Incorporation of the Company is set forth in full as APPENDIX A
attached to this Proxy Statement and is hereby incorporated herein by this
reference; provided, however, that the text of the amendment is subject to
change as may be required by the Delaware Secretary of State.

PURPOSES AND EFFECTS OF THE AMENDMENT TO INCREASE THE AUTHORIZED NUMBER OF
SHARES OF COMMON STOCK

NEED FOR ADDITIONAL FINANCING AND FLEXIBILITY

      The proposed increase in the authorized number of shares of Common Stock
will allow the Company to reserve an additional number of shares sufficient to
provide flexibility for the future. In particular, the Company may require
additional funding in 2006 and beyond for its operations and will therefore need
the increased number of authorized shares to raise additional equity. In
addition, the additional authorized shares may be used in the future for any
other proper corporate purpose approved by the Board, including corporate
mergers or acquisitions, an increase in the number of shares reserved under the
Company's stock option plans, stock dividends or splits, or other corporate
purposes. At present, the Company has no plans, agreements or understandings for
the issuance of additional shares of capital stock other than pursuant to the
2003 Stock Option Plan, upon exercise of outstanding options and warrants or
options granted hereafter under the 2003 Stock Option Plan. No further action or
authorization by the Stockholders would be necessary prior to the issuance of
additional shares unless applicable laws or regulations require such approval.

                                     - 5 -


      The Board of Directors believes the increase in the authorized shares is
necessary to provide the Company with the flexibility to act in the future with
respect to financings, acquisitions and other corporate purposes without the
delay and expense associated with obtaining special stockholder approval each
time an opportunity requiring the issuance of shares may arise.

EFFECTS OF THE AMENDMENT

      Each additional share of Common Stock authorized by the amendment to the
Certificate of Incorporation would have the same rights and privileges as each
share of Common Stock currently authorized or outstanding.

      An issuance of additional shares by the Company could have an effect on
the potential realizable value of a stockholder's investment. In the absence of
a proportionate increase in the Company's earnings and book value, an increase
in the aggregate number of outstanding shares of the Company caused by the
issuance of the additional shares would dilute the earnings per share and could
dilute the book value per share of all outstanding shares of the Company's
capital stock. If such factors were reflected in the price per share of Common
Stock, the potential realizable value of a stockholder's investment could be
adversely affected.

VOTE REQUIRED

      The approval of the amendment of the Certificate of Incorporation
increasing the authorized number of shares of Common Stock requires the
affirmative vote of a majority of the shares of Common Stock represented in
person or by proxy at the Annual Meeting and entitled to vote thereon.

          THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR APPROVAL OF THE
                       PROPOSED AMENDMENT OF THE COMPANY'S
          CERTIFICATE OF INCORPORATION INCREASING THE AUTHORIZED NUMBER
                            OF SHARES OF COMMON STOCK

                                   PROPOSAL 2.

         APPROVAL OF AMENDMENTS TO THE COMPANY'S 2003 STOCK OPTION PLAN

Subject to ratification by the stockholders, the Board of Directors has adopted
and approved certain amendments (the "Amendments") to, and a restatement of, the
Protalex, Inc. 2003 Stock Option Plan (the "2003 Plan"). The following summary
of the 2003 Plan below includes the Amendments and is qualified in its entirety
by reference to the complete text.

In general, the Amendments were adopted to

      -     Increase the number of shares of Common Stock available for issuance
            from 1,500,000 shares to 4,500,000 shares;

      -     Increase the individual per-employee limit from 200,000 shares per
            calendar year to 500,000 shares per calendar year;

      -     Provide that all nonstatutory stock options will be granted at no
            less than 100% of the fair market value of the underlying shares on
            the date of grant;

      -     Prohibit the reduction in price of any stock options granted under
            the Plan;

      -     Clarify the maximum number of shares of Common Stock that may be
            granted as incentive stock options;

      -     Clarify certain adjustment provisions within the Plan;

      -     Eliminate the prohibition on acceleration of vesting of stock
            options, in the event such acceleration would cause an excess
            parachute payment.

A copy of the proposed amended and restated Protalex, Inc. 2003 Stock Option
Plan is attached to this Proxy Statement as Appendix B.

DESCRIPTION OF THE AMENDED AND RESTATED 2003 PLAN

      General

      The purpose of the 2003 Plan is to increase stockholder value and to
advance the interests of the Company by furnishing economic incentives designed
to attract, retain and motivate employees of the Company. The 2003 Plan is
administered by a committee (the "Committee") of the Company's Board of
Directors. The Committee may grant options under the 2003 Plan to employees
(including employees who are officers and directors of the Company) and
directors of the Company as well as consultants, advisors and other independent
contractors who provide services to the Company.

                                     - 6 -


      The maximum number of shares of Common Stock which may be issued under the
2003 Plan is 4,500,000 shares subject to adjustment in the event of a merger,
recapitalization or other corporate restructuring. This number represents
approximately 23.2% of the outstanding shares of the Company's Common Stock on
the Record Date. The maximum number of shares subject to stock options which may
be granted to an employee during any calendar year is 500,000. As of August 23,
2005, 1,166,429 shares have been issued under or are covered by outstanding
stock options granted pursuant to the 2003 Plan, prior to its amendment.

      The number of shares available under the Plan, the maximum number that may
be granted to any employee during a calendar year, and the number of shares
covered by outstanding awards are subject to adjustment in the event of stock
splits, dividends and similar events. In addition, the plan contains adjustment
provisions in the event of various corporate transactions.

      Description of Stock Options

      The Committee may grant incentive and nonstatutory stock options to
eligible plan participants to purchase shares of Common Stock from the Company.
The 2003 Plan confers on the Committee discretion, with respect to any such
stock option, to determine the number and purchase price of the shares subject
to the option, whether the option is an incentive stock option or a nonstatutory
stock option, the term of each option, the manner of exercise and the time or
times during its term when the option becomes exercisable. However, the purchase
price of an option may not be less than 100% of the fair market value of the
Common Stock covered by the option on the date of grant, or 110% of the fair
market value of the Common Stock in the case of an incentive stock option
granted to a holder of more than 10% of the Company's Common Stock.

      In general, the stock options granted under the plan terminate in the
event of a "Capital Transaction", as defined in the plan, unless the stock
options are assumed by the successor corporation. However, prior to the Capital
Transaction, the stock options vest and become exercisable for a limited period
of time, which provision may have an anti-takeover effect.

      Transferability of Options

      Options granted under the 2003 Plan are non-transferable during the
recipient's lifetime, and may be transferred only in the event of the holder's
death, by will or the laws of descent and distribution.

      Amendment of the 2003 Plan

      The Board of Directors may amend, suspend or discontinue the 2003 Plan at
any time. Certain amendments require stockholder approval, including amendments
which would materially increase benefits accruing to participants, increase the
number of securities issuable under the 2003 Plan, or change the requirements
for eligibility under the 2003 Plan. The Amendments require stockholder
approval.

TERMINATION OF PLAN AND DILUTION

      The 2003 Plan will terminate on October 28, 2013, unless sooner terminated
by the Board. No options may be granted after termination of the 2003 Plan,
although Options outstanding at the time of termination will continue to be
exercisable in accordance with their terms. The issuance of shares of Common
Stock upon the exercise of options granted under the 2003 Plan will dilute the
voting power of the current stockholders. The extent of dilution will depend on
the number of options exercised and the difference between the option exercise
price and the market price for the Common Stock at the time of exercise.

FEDERAL INCOME TAX CONSEQUENCES

      The following discussion sets forth certain United States federal income
tax considerations in connection with the 2003 Plan. These tax considerations
are stated in general terms and are based on the Internal Revenue Code of 1986
in its current form and current judicial and administrative interpretations
thereof. This discussion does not address state or local tax considerations with
respect to the 2003 Plan. Moreover, the tax considerations relevant to the 2003
Plan may vary depending on a holder's participant status.

      Nonstatutory Stock Options. When a nonstatutory stock option is granted, a
participant should not recognize taxable income. When a nonstatutory stock
option granted pursuant to the 2003 Plan is exercised, the plan participant will
recognize ordinary income measured by the difference between the aggregate
purchase price of the shares of Common Stock as to which the option is exercised
and the aggregate fair market value of shares of the Common Stock on the
exercise date, and the Company will be entitled to a deduction in the year the
option is exercised equal to the amount the plan participant is required to
treat as ordinary income.

                                     - 7 -


      If the exercise price of a nonstatutory stock option is paid by surrender
of previously-owned shares, no income, gain or loss will be recognized by the
optionee on the receipt of shares equal in value on the date of exercise to the
shares delivered in payment of the exercise price. The fair market value of the
remainder of the shares received upon exercise of the nonstatutory stock option,
determined as of the date of exercise, less the amount of cash, if any, paid
upon exercise will be treated as compensation income received by the optionee on
the date of exercise of the stock option.

      Incentive Stock Options. Options that qualify as incentive stock options
are entitled to special tax treatment. When an incentive stock option is
granted, a participant should not recognize taxable income. Under existing
federal income tax law, if shares purchased pursuant to the exercise of such an
option are not disposed of by the optionee within either two years from the date
of granting of the option or one year after the transfer of the shares to the
optionee, whichever is longer, (that is, the optionee does not make a
"Disqualifying Disposition") then (i) no income will be recognized by the
optionee upon the exercise of the option; (ii) any gain or loss will be
recognized by the optionee only upon sale of the shares and, assuming the shares
constitute a capital asset of the optionee, will be treated as long-term capital
gain or loss; (iii) the optionee's basis in the shares purchased will be equal
to the amount of cash paid for such shares; and (iv) the Company will not be
entitled to a federal income tax deduction in connection with the grant or
exercise of the option. However, the positive difference between the option
price and the fair market value of the shares acquired upon exercise of an
incentive stock option will be treated as an "item of tax preference" for
purposes of the alternative minimum tax. In addition, incentive stock options
exercised more than three months after retirement are treated as nonstatutory
stock options, with the tax consequences described above.

      If the optionee disposes of the shares acquired by exercise of an
incentive stock option before the expiration of the holding period described
above, (that is, the optionee makes a Disqualifying Disposition of the shares)
the optionee must recognize as ordinary income in the year of that disposition
an amount equal to the excess of the fair market value of the shares on the date
of exercise (or, if less, the selling price of the shares) and the optionee's
basis in the shares. Any additional gain will be taxable as a capital gain and
any loss as a capital loss, which will be long-term or short-term depending on
whether the shares were held for more than one year. In addition, the Company
will be entitled to a deduction equal to the amount the employee is required to
recognize as ordinary income.

      Under proposed regulations, special rules apply in determining the
compensation income recognized upon a disqualifying disposition if the option
price of the incentive stock option is paid with shares of common stock. If
shares of common stock received upon the prior exercise of an incentive stock
option are transferred in payment of the option price of an incentive stock
option within either of the two or one-year periods referred to above, the
transfer will be considered a "disqualifying disposition" of the shares
transferred, but, under proposed regulations, only compensation income
determined as stated above, and no capital gain or loss, will be recognized.

NEW PLAN BENEFITS

      Awards have been granted under the 2003 Plan. No decisions have been made
as of the date of this Proxy Statement with regard to additional issuances under
the 2003 Plan, as amended pursuant to Proposal 2, with the exception of
scheduled grants to certain members of the Company's Board of Directors. The
table below sets forth the number of shares of the Company's common stock
underlying the grants of options that the Company can determine will be received
during the first twelve months following amendment of the 2003 Plan by members
of the Company's Board of Directors. No determination has been made with respect
to grants to other employees as a group. The options, if issued, will be granted
at the fair market value as of the date of grant.



                                                                                             DOLLAR     OPTIONS
                                         NAME AND POSITION                                  VALUE ($)   GRANTED
                                                                                                  
Steven H. Kane, President and Chief Executive Officer                                            0       25,000
Victor S. Sloan, MD, Senior Vice President and Chief Medical Officer                             0            0
Hector Alila, D.V.M., Ph.D., Senior Vice President of Drug Development                           0            0
Marc L. Rose, Vice President of Finance, Chief Financial Officer, Treasurer and Secretary        0            0
All Executive Officers, as a group                                                               0       25,000
All Directors who are not Executive Officers, as a group (5 persons)                             0      125,000
All Employees, including all officers who are not Executive Officers, as a group                 0            0


 THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS THAT YOU VOTE "FOR" THE APPROVAL
                   OF THE AMENDMENT OF 2003 STOCK OPTION PLAN.

                                     - 8 -


                                   PROPOSAL 3.

                              ELECTION OF DIRECTORS

      The Company's Board consists of seven directors, all of whom are up for
reelection at our 2005 Annual Meeting. Directors will be elected by the
affirmative vote of a plurality of the votes cast at the Annual Meeting.

      Unless authorization to do so is withheld, proxies received will be voted
FOR the nominees named on the next page. If any nominee should become
unavailable for election before the Annual Meeting, the proxies will be voted
for the election of such substitute nominee as the present Board may propose.
Each person nominated for election has agreed to serve if elected, and the Board
has no reason to believe that any nominee will be unable to serve.

INFORMATION WITH RESPECT TO NOMINEES AND CONTINUING DIRECTORS

The following table sets forth information as to persons who serve as our
Directors:



               NAME               AGE                POSITION AND OFFICES HELD WITH THE COMPANY
                               
G. Kirk Raab + #                   70     Chairman of the Board, Director and Director Nominee
Steven H. Kane +                   53     President, Chief Executive Officer, Director and Director Nominee
Carleton A. Holstrom * #           70     Director and Director Nominee
Eugene A. Bauer, MD                63     Director and Director Nominee
Thomas P. Stagnaro *               63     Director and Director Nominee
Dinesh Patel, Ph.D. *              55     Director and Director Nominee
Frank M. Dougherty + #             57     Director and Director Nominee


*     Member of the Audit Committee

#     Member of Compensation Committee

+     Member of the Nominating and Corporate Governance Committee

Set forth below is biographical information for each person nominated to serve
as a Director.

NOMINEES FOR ELECTION AT THIS ANNUAL MEETING

      G. Kirk Raab has served on the Company's Board of Directors since August
22, 2003. He is also the Chairman of the Board. Mr. Raab currently sits on the
Boards and serves as Chairman of Connetics Corporation, Applied Imaging Inc. and
BiPar Sciences, Inc. Connetics and Applied Imaging are publicly traded
companies. He also serves on the board of directors of Velos Medical
Informatics, Inc., TransOral Pharmaceuticals, Inc. and The National Foundation
for Science and Technology Medals. From February 1990 to July 1995, Mr. Raab
served as the President and Chief Executive Officer of Genentech. He originally
joined Genentech in February 1985, as President and Chief Operating Officer.
Prior to joining Genentech, Mr. Raab worked for Abbott Laboratories for 10
years, most recently as President, Chief Operating Officer and a director. Mr.
Raab served as the first Chairman of the Biotechnology Industry Organization and
the California Health Care Institute. Mr. Raab graduated from Colgate University
in 1959, and is a Trustee Emeritus. He is a member of Exeter College and was
elected to the Chancellor's Court of Benefactors of Oxford University in
September 2002. He is a former trustee of KQED, the San Francisco Ballet, the
San Francisco Symphony, UCSF Foundation and Golden Gate Planned Parenthood.

      Steven H. Kane has served on the Company's Board of Directors since
December 16, 2002. He is currently the President and Chief Executive Officer of
the Company. He has over 25 years experience in the health care industry. Most
recently, he was Vice President of North American Sales & Field Operations for
Aspect Medical. While at Aspect, he helped guide the company to a successful
initial public offering in January 2000. Prior to Aspect, Mr. Kane was Eastern
Area Vice President for Pyxis Corporation, where he was instrumental in
positioning the company for its successful initial public offering in 1992.
Pyxis later was acquired by

                                     - 9 -


Cardinal Health for $1 billion. Prior to that Mr. Kane worked in sales
management with Eli-Lilly and Becton Dickinson.

      Carleton A. Holstrom has served on the Company's Board of Directors since
October 26, 2004. From 1977 through 1987, Mr. Holstrom was the Chief Financial
Officer of Bear, Stearns & Co. and its successor, The Bear Stearns Companies,
Inc., and from 1987 to the present, he has been a Managing Director Emeritus.
From 1996 to 1997, Mr. Holstrom was the Chief Financial Officer of Scientific
Learning Corporation. From 1983 to the present, Mr. Holstrom has served on the
Board of Directors of Custodial Trust Company of Princeton, New Jersey, and,
from 1995 to the present has been a director of Scientific Learning Corporation
of Oakland, California. From 1989 through 1995, Mr. Holstrom served on the Board
of Governors of Rutgers University and was the Chair of the Board of Governors
from 1994 through 1995. From 1983 through 1995, Mr. Holstrom served on the Board
of Trustees of Rutgers University and was the Chair of that Board from 1998
through 1999. From 1995 through the present date, he has been an Emeritus Member
of the Rutgers University Board of Trustees. From 1977 through 2000, Mr.
Holstrom served on the Rutgers University Foundation Board of Overseers. He was
the Chair of the Board of Overseers from 1979 through 1981. From 2000 to the
present, he has served on the Rutgers University Foundation Board of Overseers
in an emeritus capacity. From 1994 until 2005, Mr. Holstrom served on the
University of Wisconsin at Madison College of Letters and Sciences Board of
Overseers. From 1989 through the present, he served on the University of
Wisconsin Foundation Board of Directors and was the Vice Chair of that
Foundation from 2000 through 2003.

      Eugene A. Bauer, MD, has served on the Company's Board of Directors since
February 15, 2005. Dr, Bauer is Chief Executive Officer of Neosil Incorporated,
a privately held biotechnology company. From 2002 to 2004 Dr. Bauer was a Senior
Client Partner with Korn/ Ferry International. Dr. Bauer served as Vice
President for the Stanford University Medical Center from 1997 to 2001, and as
Dean of the Stanford University School of Medicine from 1995 through 2001.
Dr.Bauer was a founder of Connetics. Since 1988 he has been Professor,
Department of Dermatology, Stanford University School of Medicine, and was Chief
of the Dermatology Service at Stanford University Hospital from 1988 to 1995.
From 1982 to 1988, he was a professor at Washington University School of
Medicine. Dr. Bauer has served as Chairman of two National Institutes of Health
study sections of the National Institute of Arthritis and Musculoskeletal and
Skin Diseases and has served on a board of scientific counselors for the
National Cancer Institute. Dr.Bauer also serves as a director of three private
companies and one non-profit Dermatological Organization. Dr. Bauer holds B.S.
and M.D. degrees from Northwestern University.

      Thomas P. Stagnaro has served on the Company's Board of Directors since
July 8, 2002. He is President and Chief Executive Officer of Americas Biotech
Distributor (ABD), which he founded in June 2004. Previously, Mr. Stagnaro was
President and Chief Executive Officer of Agile Therapeutics, a private company
focused on developing women's healthcare products from September 2000 to August
2004. Mr. Stagnaro also serves as a director on the board of INKINE
Pharmaceutical and Life Science Research Organization. Mr. Stagnaro formerly was
President and Chief Executive Officer of 3-Dimensional Pharmaceuticals and
Univax Biologics. Mr. Stagnaro began his career with Searle Laboratories and
held increasingly important positions during his 30 years in the pharmaceutical
industry. Mr. Stagnaro has raised over $200 million for three development stage
companies and took Univax Biologics public in 1972. Mr. Stagnaro holds three
patents and has published numerous articles.

      Dinesh Patel has served on the Company's Board of Directors since
September 18, 2003. Dr. Patel is a Managing Director and Founding Partner of
vSpring Capital, an early stage venture capital fund with $125 million under
management. Dr. Patel is also the Founder, Chairman, President & CEO of Ashni
Naturaceuticals, Inc. a company that specializes in the research, development
and marketing of clinically tested and patent-protected naturaceutical products.
In 1999, Dr. Patel co-founded and was the Chairman of Salus Therapeutics, Inc.,
a biotechnology company focused on the research and development of nucleic
acid-based therapeutics, including antisense and gene therapy drugs. In August
2003 publicly traded Genta, Inc acquired Salus for $30 million. From 1985
through 1999, Dr. Patel served as Co-founder, Chairman of the Board of
Directors, President & CEO, of Thera Tech, Inc., a Salt Lake City, Utah based
company, that has been a pioneer in the development and manufacture of
innovative drug delivery products. Under Dr. Patel's guidance, TheraTech
established strategic alliances with major pharmaceutical companies including
Eli Lilly, Pfizer, Proctor & Gamble, Roche, and SmithKline Beecham. TheraTech
went public in 1992 and became profitable in 1997. In January 1999, TheraTech
was acquired for approximately $350 million by Watson Pharmaceuticals, a
California based company. Dr. Patel has been the recipient of numerous awards,
including US Small Business Administration's Business Achiever Award, and
Scientific and Technology Award (State of Utah) and Entrepreneur of the Year
Award (Mountain West venture Group). Dr. Patel got his undergraduate degree from
India and his doctorate degree from University of Michigan. Dr. Patel is active
in the Indian and local community serving on several boards and as an active
donor for various charitable causes.

      Frank M. Dougherty has served on the Company's Board of Directors since
October 16, 2001, and served as the Company's Corporate Secretary from June 21,
2002 to December 16, 2002. From January 22, 2004 to April 13, 2005, Mr.
Dougherty served as the Corporate Secretary and Treasurer of the Company. Mr.
Dougherty is a practicing attorney and founder and owner of Frank M. Dougherty
P.C., a law firm in Albuquerque, New Mexico. Mr. Dougherty has practiced law
since 1982, and founded his current law firm in November 2001. Prior to becoming
a lawyer, Mr. Dougherty practiced as a CPA in Santa Fe, New Mexico. Mr.
Dougherty has

                                     - 10 -


an undergraduate degree in economics from the University of Colorado, a graduate
degree in accounting from the University of Arizona and a law degree from Texas
Tech University.

 THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS THAT YOU VOTE "FOR" THE ELECTION
  OF MESSRS. RAAB, KANE, HOLSTROM, DR. BAUER, MR. STAGNARO, DR. PATEL, AND MR.
                      DOUGHERTY, AS DIRECTORS OF PROTALEX.

                                   PROPOSAL 4.

                      RATIFICATION OF SELECTION OF AUDITORS

      The Board is seeking stockholder ratification of its selection of Grant
Thornton LLP to serve as Protalex's independent auditors for the fiscal year
ending May 31, 2006. Grant Thornton LLP served as our independent auditors for
the fiscal year ended May 31, 2003, May 31, 2004 and May 31, 2005.

      The auditor's reports on our consolidated financial statements for the
past two years did not contain an adverse opinion or disclaimer of opinion, nor
were they qualified or modified as to uncertainty, audit scope or accounting
principles. Their audit opinion on their 2004 and 2005 statements, dated July
23, 2004 and July 29, 2005, respectively, included a paragraph regarding the
Company's ability to continue as a going concern.

      During our two most recent fiscal years and through today, there were no
disagreements with Grant Thornton LLP on any matter of accounting principles or
practices, financial statement disclosure or auditing scope or procedure that,
if not resolved to Grant Thornton's satisfaction, would have caused them to make
reference to the subject matter in connection with their report on our
consolidated financial statements for such years.

      Grant Thornton LLP will be retained as our auditors for the fiscal year
ending May 31, 2006, if this proposal is approved by the holders of a majority
of the voting power of the shares represented and voting at the Annual Meeting.
If this proposal is not approved by the holders of a majority of the voting
power of the shares represented and voting at the Annual Meeting, the Board will
reconsider its selection of Grant Thornton LLP as its independent auditors for
the fiscal year ending May 31, 2006.

      During our two most recent fiscal years, and through September 30, 2005,
neither we nor anyone acting on our behalf consulted with Grant Thornton LLP
regarding the application of accounting principles to a specified transaction,
either completed or proposed, or the type of the audit opinion that might be
rendered on our financial statements, nor did we (or anyone acting on our
behalf) consult with Grant Thornton LLP regarding any other matter that was the
subject of a disagreement (as defined in Item 304(a)(1)(iv) of Regulation S-B
and the related instructions).

AUDIT FEES

      The aggregate fees paid to Grant Thornton LLP for professional services
rendered for the audit of the Company's annual financial statements for the
fiscal year ended May 31, 2004 and review of the financial statements included
in the Company's Form 10-Qs for the fiscal year ended May 31, 2004 totaled
$35,000. The aggregate fees paid to Grant Thornton LLP for professional services
rendered for the audit of the Company's annual financial statements for the
fiscal year ended May 31, 2005 and review of the financial statements included
in the Company's Form 10-Qs for the fiscal year ended May 31, 2005 totaled
$35,000.

AUDIT-RELATED FEES

      The Company paid no fees to Grant Thornton LLP for assurance and related
services related to the performance of their audit or review of the Company's
financial statements for the last two fiscal years that are included under the
previous heading "Audit Fees."

TAX FEES

      The Company paid no fees to Grant Thornton LLP for professional services
rendered for tax compliance, tax advice and tax planning for the fiscal years
ended May 31, 2004 and May 31, 2005.

ALL OTHER FEES

      Except as described above, no other fees were paid to Grant Thornton LLP
for any other services during the last two fiscal years.

                                     - 11 -


      We expect representatives of Grant Thornton LLP will attend the Annual
Meeting, and they will have the opportunity to make a statement if they desire
to do so, and will be available to respond to appropriate questions from
stockholders.

      THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS THAT YOU VOTE "FOR" THE
RATIFICATION OF GRANT THORNTON LLP AS AUDITORS OF PROTALEX FOR FISCAL YEAR ENDED
                                  MAY 31, 2006.

                                       II.

                    CORPORATE GOVERNANCE AND RELATED MATTERS

                BOARD OF DIRECTORS' MEETINGS, COMMITTEES AND FEES

      Our Board held a total of five meetings during the fiscal year ended May
31, 2005. All of our Directors attended more than 75% of the meetings of the
Board and meetings of committees of the Board on which they served. Among the
standing committees of the Board are the Audit Committee, the Compensation
Committee and the Nominating and Corporate Governance Committee. Under the
Company's Corporate Governance Guidelines, each director is expected to
regularly attend meetings of the Board and the Committees on which such director
sits, with the understanding that on occasion a director may be unable to attend
a meeting. Under a policy adopted by the Corporate Governance and Nominating
Committee in 2003, all directors are expected to make every reasonable effort to
attend the Annual Meeting of Stockholders.

AUDIT COMMITTEE

      The functions of the Audit Committee are described in detail below under
the heading "Report of the Audit Committee." The charter of the Audit Committee
is attached to this proxy statement as Appendix C and also is available on the
Investor Information section of the Company's website (www.protalex.com). The
Audit Committee met four times during fiscal 2005.

      The members of the Audit Committee are Messrs. Holstrom, Stagnaro and Dr.
Patel. As of May 31, 2005, the chair of the Audit Committee was Mr. Holstrom.
Mr. Holstrom is qualified as an audit committee financial expert within the
meaning of Securities and Exchange Commission ("SEC") regulations. In addition,
the Board has determined, in accordance with the listing standards of the NASDAQ
National Market,that Mr. Holstrom meets the standards of financial
sophistication set forth therein and that each other member of the audit
committee is able to read and understand fundamental financial statements.

      The Audit Committee meets with our management periodically to consider the
adequacy of our internal controls and the objectivity of our financial
reporting. The Audit Committee also meets with the independent auditors and with
our own appropriate financial personnel and internal auditors regarding these
matters. The independent auditors meet privately with the Audit Committee and
have unrestricted access to this committee. The Audit Committee recommends to
our Board the appointment of the independent auditors. The Audit Committee is
also responsible for the preapproval of any non-audit services provided to the
Company by the independent auditors, as described in more detail in the Audit
Committee Charter. The Audit Committee held four meetings during the fiscal year
ended May 31, 2005. See "Audit Committee Information--Report of Audit Committee"
on pages 13-14 for more information.

      All of the members of the Audit Committee are independent within the
meaning of SEC regulations, Rule 4200(a)(15) of the listing standards of the
NASDAQ National Market and the Company's Corporate Governance Guidelines.

COMPENSATION COMMITTEE

      The Compensation Committee annually reviews the performance and total
compensation package for the Company's executive officers, including the Chief
Executive Officer; considers the modification of existing compensation and
employee benefit programs, and the adoption of new plans; administers the terms
and provisions of the Company's equity compensation plans; and reviews the
compensation and benefits of non-employee directors. The charter of the
Compensation Committee is attached to the proxy statement as Appendix D and is
available on the Investor Information section of the Company's website
(www.protalex.com). The Compensation Committee met four times during fiscal
2005. All of the members of the Compensation Committee are independent within
the meaning of SEC regulations, the listing standards of the NASDAQ National
Market and the Company's Corporate Governance Guidelines.

                                     - 12 -


      The members of the Compensation Committee are Messrs. Raab, Holstrom, and
Dougherty. As of May 31, 2005, the chair of the Compensation Committee was Mr.
Raab. The functions of this committee include administering management incentive
compensation plans, establishing the compensation of officers and reviewing the
compensation of Directors. The Compensation Committee held four meetings during
the fiscal year ended May 31, 2005.

      None of our executive officers serves as a member of the Board of
Directors or compensation committee of an entity that has an executive officer
serving as a member of our Board or our Compensation Committee.

NOMINATING AND CORPORATE GOVERNANCE COMMITTEE

      The Corporate Governance and Nominating Committee is responsible for
developing and implementing policies and practices relating to corporate
governance, including reviewing and monitoring implementation of the Company's
Corporate Governance Guidelines. In addition, the Committee develops and reviews
background information on candidates for the Board and makes recommendations to
the Board regarding such candidates. The Committee also prepares and supervises
the Board's annual review of director independence and the Board's performance
evaluation. The charter of the Corporate Governance and Nominating Committee is
attached as Appendix E of the proxy statement and is available on the Investor
Information section of the Company's website (www.protalex.com). The Committee
met four times during fiscal 2005.

      The members of the Nominating and Corporate Governance Committee are
Messrs. Raab, Kane and Dougherty. All of the members of the Committee, except
Mr. Kane, are independent within the meaning of SEC regulations, the listing
standards of the NASDAQ National Market and the Company's Corporate Governance
Guidelines. Mr. Kane is not considered independent because he is the Company's
President and Chief Executive Officer. As of May 31, 2005, the chair of the
Nominating and Corporate Governance Committee was Mr. Dougherty. The functions
of this committee include recommending to our full Board nominees for election
as Directors. Prior to the establishment of the Nominating and Corporate
Governance Committee, its functions were performed by the entire Board. . The
Nominating and Corporate Governance Committee held four meetings during the
fiscal year ended May 31, 2005.

      Although there is no formal procedure for stockholders to recommend
nominees for the Board, the Nominating and Corporate Governance Committee will
consider such recommendations if received 120 days in advance of the Annual
Meeting of Stockholders. Such recommendations should be addressed to the
Nominating and Corporate Governance Committee at our address and provide all
information relating to such person that the stockholder desires to nominate
that is required to be disclosed in solicitation of proxies pursuant to
Regulation 14A under the Securities Exchange Act of 1934, as amended ("Exchange
Act").

DIRECTOR COMPENSATION

      Directors received stock-based compensation for their services as
directors during the fiscal year ended May 31, 2005. The Company issued 325,000
stock options to directors during such fiscal year, at exercise prices ranging
from $2.30 to $2.80.

      Directors do not receive separate meeting fees, but are reimbursed for
out-of-pocket expenses. We do not provide a retirement plan for our non-employee
Directors.

      The Company has an agreement with its Chairman to pay $12,500 per month as
a director fee. For the fiscal year ended May 31, 2005, the Company incurred
$150,000 for this director's fee.

      The Company has an agreement with Carleton A. Holstrom and Dr. Eugene
Bauer to pay each of them $1,667 per month on a quarterly basis payable in
arrears as a director fee. For the fiscal year ended May 31, 2005, the Company
incurred $18,337 for these directors' fees.

                           AUDIT COMMITTEE INFORMATION

REPORT OF AUDIT COMMITTEE

      The Audit Committee of the Company's Board of Directors is composed of
three independent directors and operates under a written charter adopted by the
Board that is designed to comply with rules adopted by the National Association
of Securities Dealers, Inc. A copy of the written charter is included as
APPENDIX C to this Proxy Statement. The current members of the Audit Committee
are Mr. Holstrom (chair), Dr. Patel and Mr. Stagnaro.

      Management is responsible for the preparation, presentation and integrity
of the Company's financial statements, accounting and financial reporting
principles, internal controls and procedures designed to ensure compliance with
accounting standards,

                                     - 13 -


applicable laws and regulations. The Company's independent public accountants
are responsible for performing an independent audit of the Company's
consolidated financial statements in accordance with generally accepted auditing
standards and issuing a report thereon. The Audit Committee's responsibility is
to monitor and oversee these processes, including the recommendation to the
Board of Directors of the selection of the Company's independent accountants.

      The Audit Committee members are not professional accountants or auditors,
and their functions are not intended to duplicate or to certify the activities
of management and the independent auditor, nor can the Audit Committee certify
that the independent auditor is "independent" under applicable rules. The Audit
Committee serves a Board-level oversight role, in which it provides advice,
counsel and direction to management and the auditors on the basis of the
information it receives, discussions with management and the auditors and the
experience of the Committee's members in business, financial and accounting
matters.

      In this context, the Audit Committee has met and held discussions with
management and the independent accountants, including meetings with the
independent accountants during which management was not present. Management
represented to the Audit Committee that the Company's financial statements were
prepared in accordance with generally accepted accounting principles, and the
Audit Committee has reviewed and discussed the consolidated financial statements
with management and the independent accountants. The Audit Committee discussed
with the independent accountants matters required to be discussed by Statement
on Auditing Standards No. 61 (Communication with Audit Committees).

      The Company's independent accountants also provided to the Audit Committee
the written disclosures required by Independence Standards Board Standard No. 1
(Independence Discussions with Audit Committees), and the Audit Committee
discussed with the independent accountants that firm's independence.

      Based upon the Audit Committee's discussion with management and the
independent accountants and the Audit Committee's review of the representation
of management and the report of the independent accountants to the Audit
Committee, the Audit Committee recommended that the Board of Directors include
the audited financial statements in the Company's Annual Report on Form 10-K for
the year ended May 31, 2005 as filed with the SEC.

                               Respectfully submitted
                               AUDIT COMMITTEE OF THE BOARD OF DIRECTORS
                                       Carleton A. Holstrom
                                       Dinesh Patel, Ph.D.
                                       Thomas P. Stagnaro

              CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS

      For the fiscal year ended May 31, 2005, the Company incurred $12,098 of
expenses related to air travel to a partnership principally owned by the Chief
Executive Officer of the Company.

      For the fiscal year ended, May 31, 2005, the Company incurred $12,515 of
expenses related to legal services to a firm, which employs one of the Company's
board members.

             SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

      Section 16(a) of the Securities Exchange Act of 1934, as amended, requires
certain of our executive officers, our Directors and persons who own more than
10% of a registered class of Protalex's equity securities to file initial
reports of ownership and changes in ownership with the SEC. Such executive
officers, directors and stockholders are required by SEC regulations to furnish
us with copies of all Section 16(a) forms they file. The Company is not aware of
any failure to timely file any report by any of its executive officers,
Directors or 10% stockholders during the fiscal year ended May 31, 2005, with
the exception of Mr. Dougherty and Dr. Arthur Bankhurst, a former member of the
Board of Director through October 26, 2004, each of whom filed one late
statement of change of beneficial ownership, each with respect to one
transaction.

                               EXECUTIVE OFFICERS

      The following individuals are executive officers of the Company who are
not also Directors:

      Victor S. Sloan, MD age 46 serves as the Company's Senior Vice President
and Chief Medical Officer since August 2005. From 1998 to August 2005, Dr. Sloan
was the Senior Director and Disease Area Section Head, Arthritis at Novartis
Pharmaceuticals Corporation since 1998.

                                     - 14 -


      Hector Alila, D.V.M., Ph.D., age 53 has served as the Company's Senior
Vice President of Drug Development since March 2004. From 1998 to 2003, Dr.
Alila was Vice President of Product Development at Cell Pathways (now merged
with OSI Pharmaceuticals, Inc.) in Horsham, Pennsylvania from 1998 to 2003. He
was responsible for the development of their two key products from preclinical
phases to NDA submission. From 1994 to 1998, Dr. Alila was the Director of
Preclinical Biology/Pharmacology at Gene-Medicine (now Valentis Inc.), The
Woodlands, Texas.

      Marc L. Rose, age 40, has served as the Company's Vice President of
Finance, Chief Financial Officer and Treasurer since November 2004 and in April
2005 Mr. Rose was elected Corporate Secretary. From March 2001 to November 2004,
Mr. Rose served as Vice President and Chief Financial Officer of the DentalEZ
Group, a privately held manufacturer of dental equipment and dental handpieces
located in Malvern, PA. From January 1998 to March 2001, Mr. Rose was Practice
Manager of Oracle Consulting Services for Oracle Corporation responsible for
designing and implementing Oracle financial and project applications. From
September 1990 to January 1998, Mr. Rose held several positions with the
controllership organization of Waste Management, Inc and from June 1988 to
September 1990, was an auditor with Ernst & Young in Philadelphia.

                                      III.

         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

      Set forth in the following table is the beneficial ownership of Common
Stock as of September 16, 2005, for our Directors, the executive officers listed
in the Summary Compensation Table, our Directors and executive officers as a
group and each person or entity known by us to beneficially own more than five
percent of the outstanding shares of our Common Stock.

      Beneficial ownership is determined in accordance with the rules of the
SEC. In computing the number of shares beneficially owned by a person or a group
and the percentage ownership of that person or group, shares of our Common Stock
issuable currently or within 60 days of September 16, 2005, upon exercise of
options or warrants held by that person or group are deemed outstanding. These
shares, however, are not deemed outstanding for computing the percentage
ownership of any other person. Except as indicated by footnote, and subject to
community property laws where applicable, the stockholders named in the table
below have sole voting and investment power with respect to all shares of Common
Stock shown as beneficially owned by them. Percentage ownership is based on
19,433,221 shares of Common Stock outstanding as of September 16, 2005, together
with applicable options and warrants for each stockholder. Unless otherwise
indicated, the address of each person listed below is in the care of Protalex,
Inc., 145 Union Square Drive, New Hope, PA 18938.



                                                                                              SHARES BENEFICIALLY OWNED
                                      NAME AND TITLE                                              NUMBER       PERCENT
                                                                                                         
G. Kirk Raab, Chairman of the Board and Director                                                  417,347(1)     2.1%
Steven H. Kane, President and Director                                                            970,095(2)     4.8%
Victor S. Sloan, MD, Senior Vice President and Chief Medical Officer                               40,000           *
Hector W. Alila, Senior Vice President, Drug Development                                          119,792(3)        *
Marc L. Rose, Vice President and Chief Financial Officer, Treasurer and Corporate Secretary        35,833(4)        *
Carleton A. Holstrom, Director                                                                    100,000(5)        *
John E. Doherty, Director                                                                       3,037,660(6)    13.5%
Frank M. Dougherty, Director                                                                      403,192(7)     2.0%
Eugene A. Bauer, M.D., Director                                                                   100,000(8)        *
Thomas Stagnaro, Director                                                                         269,500(9)     1.4%
vSpring SBIC, L.P.                                                                            12,584,587(10)    53.3%
Attn: Dinesh Patel
2795 E. Cottonwood Pkwy, Suite 360
Salt Lake City, UT 84121

Integral Capital Partners VI, L.P.                                                             1,687,500(11)     8.0%
Attn: Daniel McNally
3600 South Lake Drive
St. Francis, WI 53235


                                     - 15 -



                                                                                                          
SF Capital Partners Ltd.                                                                       1,588,235(12)     7.6%
Attn: Pamela K. Hagenah
3000 Sand Hill Road Big 3, Suite 240
Menlo Park, CA 94025

All officers and directors as a group (11 persons)                                            12,944,379(13)    66.6%


*     Indicates less than 1%.

(1)   Includes options to purchase 417,347 shares of Protalex common stock
      exercisable within 60 days of September 16, 2005.

(2)   Includes options to purchase 886,674 shares of Protalex common stock and
      warrants to purchase 7,778 shares of Protalex common stock exercisable
      within 60 days of September 16, 2005.

(3)   Includes options to purchase 69,792 shares of Protalex common stock
      exercisable within 60 days of September 16, 2005.

(4)   Includes options to purchase 20,833 shares of Protalex common stock
      exercisable within 60 days of September 16, 2005.

(5)   Includes options to purchase 100,000 shares of Protalex common stock
      exercisable within 60 days of September 16, 2005.

(6)   Includes options to purchase 85,000 shares of Protalex common stock
      exercisable within 60 days of September 16, 2005.

(7)   Includes options to purchase 65,000 shares of Protalex common stock
      exercisable within 60 days of September 16, 2005.

(8)   Includes options to purchase 100,000 shares of Protalex common stock
      exercisable within 60 days of September 16, 2005.

(9)   Includes options to purchase 269,500 shares of Protalex common stock
      exercisable within 60 days of September 16, 2005.

(10)  Includes warrants to purchase 1,047,255 shares of Protalex common stock
      exercisable within 60 days of September 16, 2005. vSpring SBIC, L.P. has
      entered into a Stockholders Agreement dated September 18, 2003 and amended
      on May 25, 2005 with G. Kirk Raab, Steven H. Kane, John E. Doherty, Frank
      M. Dougherty, Thomas P. Stagnaro, Marc L. Rose, Integral Capital Partners
      VI, L.P. and SF Capital Partners Ltd., pursuant to which each such party
      executed proxies appointing vSpring SPEC, L.P. as their proxy to vote all
      such respective shares (i) to fix and maintain the number of directors at
      seven (ii) to cause and maintain the election of a candidate designated by
      vSpring SBIC, L.P. on the Protalex board of directors. The proxy may not
      be exercised on any other matter, and each party may vote their shares on
      all other matters.

(11)  Includes warrants to purchase 437,500 shares of Protalex common stock
      exercisable within 60 days of September 16, 2005.

(12)  Includes warrants to purchase 411,765 shares of Protalex common stock
      exercisable within 60 days of September 16, 2005.

(13)  Includes options to purchase 2,014,146 shares of Protalex common stock and
      warrants to purchase 7,778 shares of Protalex common stock exercisable
      within 60 days of September 16, 2005.

                                       IV.

                  EXECUTIVE COMPENSATION AND OTHER INFORMATION

COMPENSATION PHILOSOPHY

      Protalex's compensation philosophy is that compensation should be designed
to support our primary objective of creating value for our stockholders. The
Compensation Committee believes that the following compensation strategies for
Protalex's executive officers, including the Chief Executive Officer (the
"CEO"), achieve this objective. This compensation philosophy is based on a base
salary, with opportunity for bonuses to reward outstanding performance and a
stock option program.

COMPENSATION PROGRAMS

      The following are summary descriptions of Protalex's compensation programs
for executive officers:

BASE SALARY

      Protalex generally establishes the base salary of each executive officer
based, among other factors, on the Board's assessment of that executive
officer's responsibilities, experience and performance. In addition, the Board
considers compensation levels in similarly sized companies in our industry.
Protalex's current philosophy is to pay base salaries sufficient to attract and
retain executives with a broad, proven track record of performance.

      The performance and base salary of each executive officer is reviewed
annually. An executive officer's level of responsibility is the primary factor
used in determining base salary. Individual performance and industry information
are also considered in

                                     - 16 -


determining any salary adjustment. The Board reviews and approves all executive
officer salary adjustments as recommended by the CEO. The Board reviews the
performance of the CEO and establishes his base salary.

EQUITY-BASED PROGRAM

      Our equity-based awards consist principally of stock options granted from
time to time. These options are granted in order to align management interests
with those of stockholders. The grants are based on various factors, including
competitive practice each executive officer's ability to contribute to our
future success and the other elements of such executive officer's compensation.

                              EMPLOYMENT CONTRACTS

      The Company has an employment agreement, effective as of December 16,
2002, with the Company's current President and Chief Executive Officer, Steven
H. Kane, whereby he was paid in stock totaling 8,334 shares per month from
January 2003 to June 2003. Thereafter, he was paid $12,500 per month through
December of 2003. Currently, he is paid at a rate of $27,083 per month. The
agreement calls for, and he was issued, options to purchase 863,242 shares of
Protalex common stock. The options vest over four years, at an exercise price of
$1.50. Vesting started his first day of employment, December 16, 2002, but the
first third of these options were not earned until after one year of employment.
The remaining options vest monthly over the remaining three years. The agreement
also set out two bonuses that were paid to Mr. Kane, grants an allowance for
health care benefits and states that the Company will pay all expenses relating
to the performance of Mr. Kane's duties as CEO.

      The Company has an employment agreement with Hector W. Alila, the
Company's current Senior Vice President of Drug Development, which was effective
as of March 1, 2004. Under the agreement, the Company granted Dr. Alila 50,000
shares of the Company's common stock, made a one time payment of $10,000 and
will pay a monthly salary of $14,167. Currently, he is paid at a rate of 16,250
per month. In addition, Dr. Alila was issued options to purchase 150,000 shares
of the Company's common stock. These options vest over four years at a rate of
1/48 per month starting on August 1, 2004, retroactive to March 1, 2004 and are
otherwise subject to the terms and conditions of the Company's 2003 Stock Option
Plan and its related agreements. Dr. Alila is eligible to participate in our
annual executive bonus plan, as well as in any life, health, accident,
disability, or hospitalization insurance plans, pension plans, or retirement
plans as our board of directors makes available to our executives as a group.
The agreement also provides for payment to Dr. Alila of up to 12 payments equal
to his monthly base salary in the event Dr. Alila is terminated without cause.

      Effective as of November 15, 2004, the Company entered into a letter
agreement with Marc L. Rose, which provides for a monthly salary of $13,750 and
a grant of options to acquire 100,000 shares of our common stock. These options
vest over four years at a rate of 1/48 per month starting on May 15, 2005,
retroactive to November 15, 2004, consistent with the provisions of the 2003
plan and have a 10-year term, subject to the terms of the 2003 plan. The letter
agreement also provides for an award of 15,000 restricted shares of our common
stock. Mr. Rose is eligible to participate in our annual executive bonus plan,
as well as in any life, health, accident, disability, or hospitalization
insurance plans, pension plans, or retirement plans as our board of directors
makes available to our executives as a group. The agreement also provides for
payment to Mr. Rose of up to 12 payments equal to his monthly base salary in the
event Mr. Rose is terminated without cause.

      Effective, August 23, 2005, the Company and Dr. Sloan entered into a
letter agreement, which provides for a monthly salary of $21,667.00 and a grant
of options to acquire 250,000 shares of the Company's common stock. These
options vest at a rate of 1/48 per month starting on January 23, 2006,
retroactive to August 23, 2005, have a 10-year term and are otherwise subject to
the terms and conditions of the Company's 2003 Stock Option Plan and its related
agreements. The letter agreement also provides for an award of 40,000 restricted
shares of the Company's common stock, as well as payment of specified relocation
expenses. Dr. Sloan is eligible to participate in the Company's annual executive
bonus plan, as well as in any life, health, accident, disability, or
hospitalization insurance plans, pension plans, or retirement plans as the
Company's Board of Directors makes available to the Company's executives as a
group. Either the Company or Dr. Sloan can terminate Dr. Sloan's employment at
any time, with or without cause, upon notice. If the Company terminates Dr.
Sloan without cause, he is entitled to one lump sum payment equal to his annual
base salary at the time of such termination.

                           SUMMARY COMPENSATION TABLE

      The following table sets forth the compensation we paid for services
rendered in all capacities during the last three fiscal years to our Chief
Executive Officer and our other four most highly compensated executive officers
who served as such at the end of the fiscal year ended May 31, 2004. In
accordance with the rules of the SEC, the compensation described in this table
does not include medical, group life insurance or ether benefits which are
available generally to our salaried employees.

                                     - 17 -




                                                                            ANNUAL COMPENSATION
                                                                                      OTHER ANNUAL   RESTRICTED STOCK
             NAME & PRINCIPAL POSITION                 YEAR     SALARY $    BONUS $   COMPENSATION       AWARDS $
                                                                                      
Steven H. Kane, President,                            2005      $281,350   $      0    $       0       $      0
Chief Executive Officer, and Director                 2004      $179,165   $176,576    $       0       $ 20,835(2)
                                                      2003(1)   $      0   $      0    $       0       $104,107(2)
Hector W. Alila, DVM, Ph.D, Senior Vice President,    2005      $180,417   $      0    $       0       $      0
Drug Development                                      2004(3)   $ 42,500   $      0    $       0       $107,500
Marc L. Rose. Vice President and Chief Financial      2005      $ 89,818   $      0    $       0       $ 38,250
Officer, Treasurer and Corporate Secretary            2004(4)   $      0   $      0    $       0       $      0


(1)   Mr. Kane was hired as the Company's President effective as of December 16,
      2002. Prior to that date, he was not employed, in any capacity, by the
      Company.

(2)   Mr. Kane received 41,668 shares of restricted stock through May 31, 2003.
      The value of this restricted stock received by Mr. Kane is computed using
      the closing price of Protalex common stock on May 31, 2003, which was
      $2.25. Mr. Kane received 8,334 shares of restricted stock on June 15,
      2003. The value of this stock was also computed using the closing price of
      Protalex common stock on May 31, 2003.

(3)   Dr. Alila was hired as the Company's Senior Vice President, Drug
      Development effective as of March 1, 2004. Prior to that date, he was not
      employed, in any capacity, by the Company.

(4)   Mr. Rose was hired as the Company's Vice President, Chief Financial
      Officer, Treasurer and Corporate Secretary effective as of November 15,
      2004. Prior to that date, he was not employed, in any capacity, by the
      Company.

               OPTION GRANTS IN THE FISCAL YEAR ENDED MAY 31, 2005

The following table sets forth information concerning the stock options granted
to each person named in the above "Summary Compensation Table" during the
Company's fiscal year ended May 31, 2005, and the exercise price of all such
options:

                      OPTION/SAR GRANTS IN LAST FISCAL YEAR

                                INDIVIDUAL GRANTS



                            NUMBER OF     PERCENT OF TOTAL
                           SECURITIES       OPTIONS/SARS
                           UNDERLYING        GRANTED TO
                          OPTIONS/SARS   EMPLOYEES IN FISCAL   EXERCISE OR BASE   MARKET PRICE ON
                           GRANTED (#)        YEAR (%)         PRICE ($/SHARE)     DATE OF GRANT
                                                                      
Steven H. Kane               175,000             23%                $2.55              $2.55
Hector W. Alila               50,000              7%                $2.55              $2.55
Marc L. Rose                 100,000             13%                $2.55              $2.55


      Aggregated Option Exercises in the Fiscal Year Ended May 31, 2005 and
Year-End Option Values.

      The following table sets forth information concerning the exercise of
stock options by each person named in the "Summary Compensation Table" during
the Company's fiscal year ended May 31, 2005, and the value of all exercisable
and unexercisable options at May 31, 2005:

                                     - 18 -




                          NUMBER OF SECURITIES UNDERLYING       VALUE OF UNEXERCISED IN THE MONEY
                          UNEXERCISED OPTIONS AT YEAR END              OPTIONS AT YEAR END
Name                      Exercisable       Unexercisable       Exercisable         Unexercisable
                                                                        
Steven H. Kane              682,163             531,079           $284,832             $196,789
Hector W. Alila              47,915             152,085           $      0             $      0
Marc L. Rose                 12,500              87,500           $      0             $      0


      The values of unexercised in-the-money options at year-end in the table
above were determined based on the fair market value as of May 31, 2005 minus
the per share exercise price multiplied by the number of shares.

                                  ANNUAL REPORT

      Our latest Annual Report on Form 10-KSB for the fiscal year ended May 31,
2005, as filed with the SEC, excluding exhibits, is being mailed to stockholders
with this Proxy Statement. We will furnish any exhibit to our Annual Report on
Form 10-KSB free of charge to any stockholder upon written request to the
Company at 145 Union Square Drive, New Hope, PA. The Annual Report is not
incorporated in, and is not a part of, this Proxy Statement and is not
proxy-soliciting material. You are encouraged to review the Annual Report
together with subsequent information filed by the Company with the SEC and other
publicly available information.

                                  OTHER MATTERS

      The Board does not know of any other matters that will be presented for
consideration at the Annual Meeting. If any other matters are properly brought
before the Annual Meeting or any adjournment thereof, the proxy holders named in
the accompanying proxy will have discretionary authority to vote all proxies in
accordance with their best judgment with respect to such matters.

                           STOCKHOLDER COMMUNICATIONS

      Stockholders may communicate with the Company's Board of Directors by
sending their communications to Protalex, Inc. Board of Directors, c/o Corporate
Secretary, 145 Union Square Drive, New Hope, PA 18938. The Corporate Governance
and Nominating Committee of the Board has approved a process for handling
letters received by the Company and addressed to independent members of the
Board. Under that process, the Corporate Secretary reviews all such
correspondence and regularly forwards to the Board a summary of all such
correspondence and copies of all correspondence that, in the opinion of the
Corporate Secretary, deals with the functions of the Board or its committees, or
that he otherwise determines requires their attention. Directors may at any time
review a log of all correspondence received by the Company that is addressed to
members of the Board and request copies of any such correspondence. Concerns
relating to accounting, internal controls or auditing matters are immediately
brought to the attention of the Company's internal audit department and handled
in accordance with procedures established by the Audit Committee with respect to
such matters.

New Hope, Pennsylvania      By Order of the Board of Directors

September 16, 2005

                            By:  /s/ Steven H. Kane
                                 Steven H. Kane
                                 President, Chief Executive Officer and Director

                                     - 19 -


                                 [Form of Proxy]

                                 PROTALEX, INC.

                             145 Union Square Drive

                                  New Hope, PA

                                 (215) 862-9720

                THIS PROXY IS SOLICITED BY THE BOARD OF DIRECTORS

               FOR USE AT THE 2005 ANNUAL MEETING OF STOCKHOLDERS

                               ON OCTOBER 25, 2005

      The shares of Common Stock you hold will be voted as you specify. By
signing this proxy, you revoke all prior proxies and appoint Steven H. Kane and
Marc L. Rose, and each of them, with full power of substitution, to vote your
shares on the matters shown below and any other matters which may come before
the Annual Meeting and all adjournments.

      This Proxy when properly executed will be voted as directed or, if no
direction is given, will be voted for Items 1, 2 and 3.

      The Board of Directors recommends a vote for Items 1, 2, 3 and 4.

      (1)   Amendment to the Protalex, Inc. Amended Certificate of Incorporation
            ("Certificate of Incorporation") to Increase the Number of
            Authorized Shares of the Company's Common Stock.

            FOR                 AGAINST              ABSTAIN

      (2)   Amendment to the Protalex, Inc. 2003 Stock Option Plan

            FOR                 AGAINST              ABSTAIN

      (3)   For the election of the following persons as Directors of Protalex
            to hold office until the 2006 Annual Meeting of Stockholders and
            until their respective successors are elected and qualified:

                                  G. Kirk Raab

                                 Steven H. Kane

                              Carleton A. Holstrom

                              Eugene A. Bauer, M.D

                               Thomas P. Stagnaro

                                  Dinesh Patel

                               Frank M. Dougherty

                                     - 20 -


FOR nominees listed above, except as         WITHHOLD AUTHORITY to vote for all
  indicated to the contrary below.                  nominees listed above.

  (INSTRUCTION: TO WITHHOLD AUTHORITY TO VOTE FOR A SINGLE NOMINEE, WRITE THAT
                  NOMINEE'S NAME IN THE SPACE PROVIDED BELOW.)

           ----------------------------------------------------------

      (4)   Ratification of Protalex's selection of Grant Thornton LLP as
            independent auditors for Protalex for fiscal year ending May 31,
            2006.

            FOR                 AGAINST              ABSTAIN

      (5)   In their discretion upon such other matters as may properly come
            before the meeting and any adjournments thereof.

            FOR                 AGAINST              ABSTAIN

The shares represented by this proxy will be voted as you have indicated above.
If no indication has been made, the shares represented by this proxy will be
voted for the above nominees and in favor of such proposals, and as said proxy
deems advisable on such other business as may properly come before this meeting.

Dated: __________________________, 2005

________________________________________________

(Signature)

________________________________________________

(Signature of joint owner or additional trustee)

Sign exactly as your name appears on your share certificate. When signing as
attorney, executer, administrator, trustee or guardian, please give full title.
If more than one trustee, all should sign. All joint owners should sign. If a
corporation, sign in full corporation name by president or other authorized
officer. If a partnership, sign in partnership name by authorized person.
Persons signing in a fiduciary capacity should indicate their full title in such
capacity.

    PLEASE MARK, SIGN, DATE AND RETURN THIS PROXY CARD PROMPTLY BY USING THE
                               ENCLOSED ENVELOPE.

                                     - 21 -


                                   APPENDIX A

                            CERTIFICATE OF AMENDMENT
                                       TO
                          CERTIFICATE OF INCORPORATION
                                       OF
                                 PROTALEX, INC.

      The undersigned, being the President and Secretary, respectively, of
PROTALEX, INC., a corporation existing under the laws of the State of Delaware,
do hereby certify as follows:

      1. The name of the Corporation is Protalex, Inc. (hereinafter referred to
as the "Corporation").

      2. The certificate of incorporation of the Corporation is hereby amended
by replacing Article V, in its entirety, with the following:

      "The aggregate number of shares which the Corporation shall have authority
to issue is One Hundred Million (100,000,000) shares of common stock, par value
$0.0001 per share."

      3. The amendment of the certificate of incorporation herein certified has
been duly adopted by the unanimous written consent of the Corporation's Board of
Directors and by the vote the Corporation's stockholders holding a majority of
the outstanding shares of common stock of the Corporation in accordance with the
provisions of Sections 141(f) and 242 of the General Corporation Law of the
State of Delaware.

      IN WITNESS WHEREOF, the Corporation has caused this Certificate of
Amendment of Certificate of Incorporation to be signed by the undersigned
officers of this Corporation, on this __ day of August, 2005.

                                       PROTALEX, INC.

                                       By:
                                           -------------------------------------
                                             Steven H. Kane, President

                                       By:
                                           -------------------------------------
                                             Marc L. Rose, Secretary

                                     - 22 -


                                   APPENDIX B

                                 PROTALEX, INC.
                             2003 STOCK OPTION PLAN

                    amended and restated as of July 29, 2005

      1. PURPOSE. This Stock Option Plan (the "Plan") is intended to serve as an
incentive to, and to encourage stock ownership by, certain eligible participants
rendering services to Protalex, Inc., a Delaware corporation (the
"Corporation"), and certain affiliates, as set forth below, so that they may
acquire or increase their proprietary interest in the Corporation and to
encourage them to remain in the service of the Corporation.

      2. ADMINISTRATION.

            2.1 Committee. The Plan shall be administered by the Board of
Directors of the Corporation (the "Board of Directors") or a committee of two or
more members appointed by the Board of Directors (the "Committee") who are
Non-Employee Directors as defined in Rule 16b-3 promulgated under Section 16 of
the Securities Exchange Act of 1934 and an outside director as defined in
Treasury Regulation Section 1.162-27(e)(3). If the Board of Directors does not
appoint a Committee, reference to the Committee herein below shall mean the
Board of Directors. If a Committee is appointed, it shall select one of its
members as Chairman and shall appoint a Secretary, who need not be a member of
the Committee. The Committee shall hold meetings at such times and places as it
may determine and minutes of such meetings shall be recorded. Acts by a majority
of the Committee in a meeting at which a quorum is present and acts approved in
writing by a majority of the members of the Committee shall be valid acts of the
Committee.

            2.2 Term. If the Board of Directors selects a Committee, the members
of the Committee shall serve on the Committee for the period of time determined
by the Board of Directors and shall be subject to removal by the Board of
Directors at any time. The Board of Directors may terminate the function of the
Committee at any time and resume all powers and authority previously delegated
to the Committee.

            2.3 Authority. The Committee shall have sole discretion and
authority to grant options under the Plan to eligible participants rendering
services to the Corporation or any "parent" or "subsidiary" of the Corporation,
as defined in Section 424 of the Internal Revenue Code of 1986, as amended (the
"Code") ("Parent or Subsidiary"), at such times, under such terms and in such
amounts as it may decide. For purposes of this Plan and any Stock Option
Agreement (as defined below), the term "Corporation" shall include any Parent or
Subsidiary, if applicable. Subject to the express provisions of the Plan, the
Committee shall have complete discretion and authority to interpret the Plan, to
prescribe, amend and rescind the rules and regulations relating to the Plan, to
determine the details and provisions of any Stock Option Agreement, to
accelerate any options granted under the Plan and to make all other
determinations necessary or advisable for the administration of the Plan.

            2.4 Type of Option. The Committee shall have full authority and
discretion to determine, and shall specify, whether the eligible individual will
be granted options intended to qualify as incentive options under Section 422 of
the Code ("Incentive Options") or options which are not intended to qualify
under Section 422 of the Code ("Non-Qualified Options"); provided, however, that
Incentive Options shall only be granted to employees of the Corporation, or a
Parent or Subsidiary thereof, and shall be subject to the special limitations
set forth herein attributable to Incentive Options.

            2.5 Interpretation. The interpretation and construction by the
Committee of any provisions of the Plan or of any option granted under the Plan
shall be final and binding on all parties having an interest in this Plan or any
option granted hereunder. No member of the Committee shall be liable for any
action or determination made in good faith with respect to the Plan or any
option granted under the Plan.

      3. ELIGIBILITY.

            3.1 General. All directors, officers, employees of and certain
persons rendering services to the Corporation, or any Parent or Subsidiary,
relative to the Corporation's, or any Parent's or Subsidiaries', management,
operation or development shall be eligible to receive options under the Plan.
The selection of recipients of options shall be within the sole and absolute
discretion of the Committee. No person shall be granted an option under this
Plan unless such person has executed the grant representation letter set forth
on Exhibit "A," as such Exhibit may be amended by the Committee from time to
time. No person shall be granted an Incentive Option under this Plan unless such
person is an employee of the Corporation, or a Parent or Subsidiary, on the date
of grant. No employee shall be granted more than 500,000 options in any one
calendar year period.

                                     - 23 -


            3.2 Termination of Eligibility.

                  3.2.1 If an optionee ceases to be employed by the Corporation,
or its Parent or Subsidiary, is no longer an officer or member of the Board of
Directors of the Corporation or no longer performs services for the Corporation,
or its Parent or Subsidiary for any reason (other than for "cause," as
hereinafter defined, or such optionee's death), any vested option granted
hereunder to such optionee shall expire three months after the date the
occurrence giving rise to such termination of eligibility (or 1 year in the
event an optionee is "disabled," as defined in Section 22(e)(3) of the Code) or
upon the date it expires by its terms, whichever is earlier. Any option that has
not vested in the optionee as of the date of such termination shall immediately
expire and shall be null and void. The Committee shall, in its sole and absolute
discretion, decide, using the provisions set forth in Treasury Regulations
Section 1.421-7(h), whether an authorized leave of absence or absence for
military or governmental service, or absence for any other reason, shall
constitute termination of eligibility for purposes of this Section.

                  3.2.2 If an optionee ceases to be employed by the Corporation,
or its Parent or Subsidiary, is no longer an officer or member of the Board of
Directors of the Corporation, or no longer performs services for the
Corporation, or its Parent or Subsidiary and such termination is as a result of
"cause," as hereinafter defined, then all options granted hereunder to such
optionee shall expire on the date of the occurrence giving rise to such
termination of eligibility or upon the date it expires by its terms, whichever
is earlier, and such optionee shall have no rights with respect to any
unexercised options. For purposes of this Plan, "cause" shall mean an optionee's
personal dishonesty, misconduct, breach of fiduciary duty, incompetence,
intentional failure to perform stated obligations, willful violation of any law,
rule, regulation or final cease and desist order, or any material breach of any
provision of this Plan, any Stock Option Agreement or any employment agreement.
The Board of Directors shall have complete discretion and authority to determine
whether the termination of the optionee is for cause.

            3.3 Death of Optionee and Transfer of Option. In the event an
optionee shall die, a vested option may be exercised (subject to the condition
that no option shall be exercisable after its expiration and only to the extent
that the optionee's right to exercise such option had accrued at the time of the
optionee's death) at any time within six months after the optionee's death by
the executors or administrators of the optionee or by any person or persons who
shall have acquired the option directly from the optionee by bequest or
inheritance. Any option that has not vested in the optionee as of the date of
death or termination of employment, whichever is earlier, shall immediately
expire and shall be null and void; provided however, that the Committee may
include in any option agreement a provision that the optionee's shares will
fully vest upon death of the optionee. No option shall be transferable by the
optionee other than by will or the laws of intestate succession.

            3.4 Limitation on Incentive Options. No person shall be granted any
Incentive Option to the extent that the aggregate fair market value of the Stock
(as defined below) to which such options are exercisable for the first time by
the optionee during any calendar year (under all plans of the Corporation as
determined under Section 422(d) of the Code) exceeds $100,000.

      4. IDENTIFICATION OF STOCK. The Stock, as defined herein, subject to the
options shall be shares of the Corporation's authorized but unissued or acquired
or reacquired common stock (the "Stock"). The aggregate number of shares subject
to outstanding options shall not exceed Four Million Five Hundred Thousand
(4,500,000) shares of Stock (subject to adjustment as provided in Section 6),
all of which may be granted as incentive stock options. If any option granted
hereunder shall expire or terminate for any reason without having been exercised
in full, the unpurchased shares subject thereto shall again be available for
purposes of this Plan.

      5. TERMS AND CONDITIONS OF OPTIONS. Any option granted pursuant to the
Plan shall be evidenced by an agreement ("Stock Option Agreement") in such form
as the Committee shall from time to time determine, which agreement shall comply
with and be subject to the following terms and conditions:

            5.1 Number of Shares. Each option shall state the number of shares
of Stock to which it pertains.

            5.2 Option Exercise Price. Each option shall state the option
exercise price, which shall be determined by the Committee; provided, however,
that (i) the exercise price of any option shall not be less than the fair market
value of the Stock, as determined by the Committee, on the date of grant of such
option and (ii) the exercise price of any Incentive Stock Option granted to any
person who owns more than 10% of the total combined voting power of all classes
of the Corporation's stock, as determined for purposes of Section 422 of the
Code, shall not be less than 110% of the fair market value of the Stock, as
determined by the Committee, on the date of grant of such option. The purchase
price of any option may not be reduced after grant, whether through amendment,
cancellation, replacement or otherwise.

            5.3 Term of Option. The term of an option granted hereunder shall be
determined by the Committee at the time of grant, but shall not exceed ten years
from the date of the grant. The term of any Incentive Option granted to an
employee who owns more than 10% of the total combined voting power of all
classes of the Corporation's stock, as determined for purposes of Section 422 of
the Code, shall in no event exceed five years from the date of grant. All
options shall be subject to early termination as set forth in this Plan. In no
event shall any option be exercisable after the expiration of its term.

                                     - 24 -


            5.4 Method of Exercise. An option shall be exercised by written
notice to the Corporation by the optionee (or successor in the event of death)
and execution by the optionee of an exercise representation letter in the form
set forth on Exhibit "B," as such Exhibit may be amended by the Committee from
time to time. Such written notice shall state the number of shares with respect
to which the option is being exercised and designate a time, during normal
business hours of the Corporation, for the delivery thereof ("Exercise Date"),
which time shall be at least 30 days after the giving of such notice unless an
earlier date shall have been mutually agreed upon. At the time specified in the
written notice, the Corporation shall deliver to the optionee at the principal
office of the Corporation, or such other appropriate place as may be determined
by the Committee, a certificate or certificates for such shares. Notwithstanding
the foregoing, the Corporation may postpone delivery of any certificate or
certificates after notice of exercise for such reasonable period as may be
required to comply with any applicable listing requirements of any securities
exchange. In the event an option shall be exercisable by any person other than
the optionee, the required notice under this Section shall be accompanied by
appropriate proof of the right of such person to exercise the option.

            5.5 Medium and Time of Payment. The option exercise price shall be
payable in full on or before the option Exercise Date by certified or bank
cashier's check.

            5.6 Fair Market Value. The fair market value of a share of Stock on
any relevant date shall be determined in accordance with the following
provisions:

                  5.6.1 If the Stock at the time is neither listed nor admitted
to trading on any stock exchange nor traded in the over-the-counter market, then
the fair market value shall be determined by the Committee after taking into
account such factors as the Committee shall deem appropriate.

                  5.6.2 If the Stock is not at the time listed or admitted to
trading on any stock exchange but is traded in the over-the-counter market, the
fair market value shall be the mean between the highest bid and lowest asked
prices (or, if such information is available, the closing selling price) of one
share of Stock on the date in question in the over-the-counter market, as such
prices are reported by the National Association of Securities Dealers through
its NASDAQ system or any successor system. If there are no reported bid and
asked prices (or closing selling price) for the Stock on the date in question,
then the mean between the highest bid and lowest asked prices (or the closing
selling price) on the last preceding date for which such quotations exist shall
be determinative of fair market value.

                  5.6.3 If the Stock is at the time listed or admitted to
trading on any stock exchange, then the fair market value shall be the closing
selling price of one share of Stock on the date in question on the stock
exchange determined by the Committee to be the primary market for the Stock, as
such price is officially quoted in the composite tape of transactions on such
exchange. If there is no sale of Stock on such exchange on the date in question,
then the fair market value shall be the closing selling price on the exchange on
the last preceding date for which such quotation exists.

            5.7 Rights as a Stockholder. An optionee or successor shall have no
rights as a stockholder with respect to any Stock underlying any option until
the date of the issuance to such optionee of a certificate for such Stock. No
adjustment shall be made for dividends (ordinary or extraordinary, whether in
cash, securities or other property) or distributions or other rights for which
the record date is prior to the date such Stock certificate is issued, except as
provided in Section 6.

            5.8 Modification, Extension and Renewal of Options. Subject to the
terms and conditions of the Plan, the Committee may modify, extend or renew
outstanding options granted under the Plan, or accept the surrender of
outstanding options (to the extent not exercised) and authorize the granting of
new options in substitution therefor.

            5.9 Vesting and Restrictions. The Committee shall have complete
authority and discretion to set the terms, conditions, restrictions, vesting
schedules and other provisions of any option in the applicable Stock Option
Agreement and shall have complete authority to require conditions and
restrictions on any Stock issued pursuant to this Plan; provided, however, that,
except with respect to options granted to officers or directors of the
Corporation, options granted pursuant to this Plan shall be exercisable or
"vest" at the rate of at least 25% per year over the 4-year period beginning on
the date the option is granted. Options granted to officers and directors shall
become exercisable or "vest," subject to reasonable conditions, at any time
during any period established by the Corporation.

            5.10 Other Provisions. The Stock Option Agreements shall contain
such other provisions, including without limitation, restrictions or conditions
upon the exercise of options, as the Committee shall deem advisable.

      6. ADJUSTMENTS UPON CHANGES IN CAPITALIZATION.

            6.1 Subdivision or Consolidation. Subject to any required action by
stockholders of the Corporation, the number of shares of Stock covered by each
outstanding option, and the exercise price thereof, the number of shares of
Common Stock which may be issued under the Plan but are not then subject to
outstanding stock options, and the maximum number of shares as to which stock
options may be granted and as to which shares may be awarded during any calendar
year under Section 3.1 shall be

                                     - 25 -


proportionately adjusted for any increase or decrease in the number of issued
shares of Stock of the Corporation resulting from a subdivision or consolidation
of shares, including, but not limited to, a stock split, reverse stock split,
recapitalization, continuation or reclassification, or the payment of a stock
dividend (but only on the Stock) or any other increase or decrease in the number
of such shares effected without receipt of consideration by the Corporation.

            If the outstanding shares of Stock shall be changed into or
exchangeable for a different number or kind of shares of stock or other
securities of the Corporation or another corporation, or cash or other property,
whether through reorganization, reclassification, recapitalization, stock
split-up, combination of shares, merger or consolidation, then there shall be
substituted for each share of Stock subject to any then outstanding option, and
for each share of Stock which may be issued under the Plan but which is not then
subject to any outstanding option, the number and kind of shares of stock or
other securities (and in the case of outstanding options, the cash or other
property) into which each outstanding share of the Stock shall be so changed or
for which each such share shall be exchangeable.

            In case of any adjustment or substitution as provided for in this
Section 6.1, the aggregate option price for all shares subject to each then
outstanding option, prior to such adjustment or substitution shall be the
aggregate option price for all shares of stock or other securities (including
any fraction), cash or other property to which such shares shall have been
adjusted or which shall have been substituted for such shares. Any new option or
exercise price per share or other unit shall be carried to at least three
decimal places with the last decimal place rounded upwards to the nearest whole
number.

            If the outstanding shares of the Stock shall be changed in value by
reason of any spin-off, split-off or split-up, or dividend in partial
liquidation, dividend in property other than cash, or extraordinary distribution
to stockholders of the Stock, the Committee shall make any adjustments to any
then outstanding stock option, which it determines are equitably required to
prevent dilution or enlargement of the rights of optionees which would otherwise
result from any such transaction.

            No adjustment or substitution provided for in this Section 6.1 shall
require the Corporation to issue or sell a fraction of a share or other
security. Accordingly, all fractional shares or other securities which result
from any such adjustment or substitution shall be eliminated and not carried
forward to any subsequent adjustment or substitution.

            If any such adjustment or substitution provided for in this Section
6.1 requires the approval of stockholders in order to enable the Corporation to
grant Incentive Stock Options, then no such adjustment or substitution shall be
made without the required stockholder approval. Notwithstanding the foregoing,
in the case of Incentive Stock Options, if the effect of any such adjustment or
substitution would be to cause the stock option to fail to continue to qualify
as an Incentive Stock Option or to cause a modification, extension or renewal of
such stock option within the meaning of Section 424 of the Code, the Committee
may elect that such adjustment or substitution not be made but rather shall use
reasonable efforts to effect such other adjustment of each then outstanding
stock option as the Committee, in its discretion, shall deem equitable and which
will not result in any disqualification, modification, extension or renewal
(within the meaning of Section 424 of the Code) of such Incentive Stock Option.

            6.2 Capital Transactions. Upon a sale or exchange of all or
substantially all of the assets of the Corporation, a merger or consolidation in
which the Corporation is not the surviving corporation, a merger, reorganization
or consolidation in which the Corporation is the surviving corporation and
stockholders of the Corporation exchange their stock for securities or property,
a liquidation of the Corporation or similar transaction, as determined by the
Committee ("Capital Transaction"), this Plan and each option issued under this
Plan, whether vested or unvested, shall terminate, unless such options are
assumed by a successor corporation in a merger or consolidation, immediately
prior to such Capital Transaction; provided, however, that if the outstanding
options will not be assumed by a successor corporation in a merger or
consolidation, subject to terms approved by the Committee, all optionees will
have the right, during the 15 days prior to such Capital Transaction, to
exercise all options. For purposes of this right of exercise prior to a Capital
Transaction in which the options will not be assumed, all options granted to the
optionees will be considered fully vested. The Corporation shall, subject to any
nondisclosure provisions, attempt to provide optionees at least 15 days notice
of the option termination date. The Committee may (but shall not be obligated
to) (i) accelerate the vesting of any option or (ii) apply the foregoing
provisions, including but not limited to termination of this Plan and any
options granted pursuant to the Plan, in the event there is a sale of 51% or
more of the stock of the Corporation in any two year period or a transaction
similar to a Capital Transaction.

            6.3 Adjustments. To the extent that the foregoing adjustments relate
to stock or securities of the Corporation, such adjustments shall be made by the
Committee, whose determination in that respect shall be final, binding and
conclusive.

            6.4 Ability to Adjust. The grant of an option pursuant to the Plan
shall not affect in any way the right or power of the Corporation to make
adjustments, reclassifications, reorganizations or changes of its capital or
business structure or to merge, consolidate, dissolve, liquidate, sell or
transfer all or any part of its business or assets.

            6.5 Notice of Adjustment. Whenever the Corporation shall take any
action resulting in any adjustment provided for in this Section, the Corporation
shall forthwith deliver notice of such action to each optionee, which notice
shall set forth the number of shares subject to the option and the exercise
price thereof resulting from such adjustment.

                                     - 26 -


            6.6 Limitation on Adjustments. Any adjustment, assumption or
substitution of an Incentive Option shall comply with Section 424 of the Code,
if applicable.

      7. NONASSIGNABILITY. Options granted under this Plan may not be sold,
pledged, assigned or transferred in any manner other than by will or by the laws
of intestate succession, and may be exercised during the lifetime of an optionee
only by such optionee. Any transfer in violation of this Section shall void such
option and any Stock Option Agreement entered into by the optionee and the
Corporation regarding such transferred option shall be void and have no further
force or effect. No option shall be pledged or hypothecated in any way, nor
shall any option be subject to execution, attachment or similar process.

      8. NO RIGHT OF EMPLOYMENT. Neither the grant nor exercise of any option
nor anything in this Plan shall impose upon the Corporation or any other
corporation any obligation to employ or continue to employ any optionee. The
right of the Corporation and any other corporation to terminate any employee
shall not be diminished or affected because an option has been granted to such
employee.

      9. TERM OF PLAN. This Plan is effective on the date the Plan is adopted by
the Board of Directors and options may be granted pursuant to the Plan from time
to time within a period of ten (10) years from such date, or the date of any
required stockholder approval required under the Plan, if earlier. Termination
of the Plan shall not affect any option theretofore granted.

      10. AMENDMENT OF THE PLAN. The Board of Directors of the Corporation may,
subject to any required stockholder approval, suspend, discontinue or terminate
the Plan, or revise or amend it in any respect whatsoever with respect to any
shares of Stock at that time not subject to options.

      11. APPLICATION OF FUNDS. The proceeds received by the Corporation from
the sale of Stock pursuant to options may be used for general corporate
purposes.

      12. RESERVATION OF SHARES. The Corporation, during the term of this Plan,
shall at all times reserve and keep available such number of shares of Stock as
shall be sufficient to satisfy the requirements of the Plan.

      13. NO OBLIGATION TO EXERCISE OPTION. The granting of an option shall not
impose any obligation upon the optionee to exercise such option.

      14. APPROVAL OF BOARD OF DIRECTORS AND STOCKHOLDERS. The Plan, as amended,
shall not take effect until approved by the Board of Directors of the
Corporation. This amended and restated Plan shall be approved by a vote of the
stockholders within 12 months from the date of approval by the Board of
Directors. In the event such stockholder vote is not obtained, all options
granted pursuant to the terms of the amended and restated Plan, whether vested
or unvested, shall be null and void.

      15. WITHHOLDING TAXES. Notwithstanding anything else to the contrary in
this Plan or any Stock Option Agreement, the exercise of any option shall be
conditioned upon payment by such optionee in cash, or other provisions
satisfactory to the Committee, of all local, state, federal or other withholding
taxes applicable, in the Committee's judgment, to the exercise or to later
disposition of shares acquired upon exercise of an option (including any
repurchase of an option or the Stock).

      16. SECURITIES LAWS COMPLIANCE. Notwithstanding anything contained herein,
the Corporation shall not be obligated to grant any option under this Plan or to
sell, issue or effect any transfer of any Stock unless (i) such grant, sale,
issuance or transfer is at such time effectively registered or exempt from
registration under the Securities Act of 1933, as amended (the "Act"), (ii) the
shares shall have been listed (or authorized for listing upon official notice of
issuance) upon each stock exchange, if any, on which the Stock may then be
listed and (iii) the grant, sale and/or issuance complies with all other
applicable laws, regulations, rules and orders which may then be in effect. As a
condition to exercise of any option, each optionee shall make such
representations as may be deemed appropriate by counsel to the Corporation for
the Corporation to use any available exemption from registration under the Act
or qualification under any applicable state securities law.

      17. RESTRICTIVE LEGENDS. The certificates representing the Stock issued
upon exercise of options granted pursuant to this Plan will bear any legends
required by applicable securities laws as determined by the Committee.

      18. NOTICES. Any notice to be given under the terms of the Plan shall be
addressed to the Corporation in care of its Secretary at its principal office,
and any notice to be given to an optionee shall be addressed to such optionee at
the address maintained by the Corporation for such person or at such other
address as the optionee may specify in writing to the Corporation.

      This amended and restated Plan, as adopted by the Board of Directors as of
July 29, 2005.

                                     - 27 -


                                     PROTALEX, INC., a Delaware corporation

                                     Signature:_________________________________

                                     Printed Name:______________________________

                                     Title:_____________________________________

                                     - 28 -


                                    EXHIBIT A

Date: ___________________, 200_

Protalex, Inc.
145 Union Square Drive
New Hope, PA  18938

Re: 2003 Stock Option Plan

To Whom It May Concern:

      This letter is delivered to Protalex, Inc., a Delaware corporation (the
"Corporation"), in connection with the grant to (the "Optionee") of an option
(the "Option") to purchase shares of common stock of the Corporation (the
"Stock") pursuant to the Protalex, Inc. 2003 Stock Option Plan, amended and
restated ________________, 2005 (the "Plan"). The Optionee understands that the
Corporation's receipt of this letter executed by the Optionee is a condition to
the Corporation's willingness to grant the Option to the Optionee.

      In addition, the Optionee makes the following representations and
warranties with the understanding that the Corporation will rely upon them.

      1. The Optionee acknowledges receipt of a copy of the Plan and Agreement.
The Optionee has carefully reviewed the Plan and Agreement.

      2. The Optionee acknowledges receipt of a prospectus regarding the Plan
which includes the information required by Section (a)(1) of Rule 428 under the
Securities Act of 1933.

      3. The Optionee understands and acknowledges that the Option and the Stock
are subject to the terms and conditions of the Plan.

      4. The Optionee understands and agrees that, at the time of exercise of
any part of the Option for Stock, the Optionee may be required to provide the
Corporation with additional representations, warranties and/or covenants similar
to those contained in this letter.

      5. The Optionee is a resident of the State of __________________.

      6. The Optionee will notify the Corporation immediately of any change in
the above information which occurs before the Option is exercised in full by the
Optionee.

      The foregoing representations and warranties are given on ______________,
200_ at ____________________ (city, state).

                                         OPTIONEE:

                                         Signature:_____________________________

                                         Printed Name:__________________________

                                     - 29 -


                                    EXHIBIT B

Address of Optionee: ________________________________________

________________________________________

________________________________________

________________________________________

Date: _________________, 200_

Protalex, Inc.
145 Union Square Drive
New Hope, PA  18938

Re: 2003 Stock Option Plan

To Whom It May Concern:

      I (the "Optionee") hereby exercise my right to purchase _______________
shares of common stock (the "Stock") of Protalex, Inc., a Delaware corporation
(the "Corporation"), pursuant to, and in accordance with, the Protalex, Inc.,
2003 Stock Option Plan, amended and restated ________________, 2005 (the "Plan")
and Stock Option Agreement (the "Agreement") dated ________________, 200_. As
provided in such Plan, I deliver herewith payment as set forth in Section 5.5 of
the Plan in the amount equal to the number of shares being purchased multiplied
by the price per share, as indicated in Section 1 of the Agreement. Please
deliver to me at my address as set forth above stock certificates representing
the subject shares registered in the following name(s):________________________.
I further request that the certificates be registered in the following form of
ownership (for example, as individual property, community property, separate
property, etc.):________________________________.

      The Optionee hereby represents and agrees as follows:

      1. The Optionee acknowledges receipt of a copy of the Plan and Agreement.
The Optionee has carefully reviewed the Plan and Agreement.

      2. The Optionee is a resident of the State of _______________.

      3 The Optionee represents and agrees that if the Optionee is an
"affiliate" (as defined in Rule 144 under the Securities Act of 1933) of the
Corporation at the time the Optionee desires to sell any of the Stock, the
Optionee will be subject to certain restrictions under, and will comply with all
of the requirements of, applicable federal and state securities laws.

      The foregoing representations and warranties are given on _______________,
200_ at ______________________(city, state).

                                        OPTIONEE:

                                        Signature:_____________________________

                                        Printed Name:__________________________

                                     - 30 -


                                   APPENDIX C

                         CHARTER OF THE AUDIT COMMITTEE

             As adopted by the Board of Directors on April 13, 2005

The charter of the Audit Committee (the "Committee") of the Board of Directors
(the "Board") of Protalex, Inc. (the "Company") is as follows, subject to
amendment by the Board from time to time:

ROLE

The role of the Committee is to act on behalf of the Board in fulfilling the
Board's oversight responsibility to the stockholders relating to the Company's
financial statements and accounting and financial reporting processes, and in
particular the quality and integrity of those processes, the systems of internal
control over financial reporting, the annual independent audit of the Company's
financial statements, the quality and integrity of the Company's financial
processes, statements and reports, and the qualifications, independence and
performance of the firm or firms of certified public accountants engaged as the
Company's independent outside auditors (the "Auditors").

MEMBERSHIP:

The Committee will be composed of at least three members of the Board. The
members of the Committee shall satisfy the independence and financial literacy
requirements of The NASDAQ Stock Market ("NASDAQ"), when, if and as required by
NASDAQ and when, if and as applicable to the Company and Committee members, as
in effect from time to time, including any exceptions permitted by these
requirements. At least one member shall satisfy the applicable NASDAQ financial
sophistication requirements, when, if and as applicable and in effect from time
to time. The members of the Committee and the Committee chair will be appointed
by and serve at the discretion of the Board. Vacancies occurring on the
Committee will be filled by the Board.

PRIMARY COMMITTEE RESPONSIBILITIES:

The Committee shall oversee the Company's financial reporting process on behalf
of the Board and shall have direct responsibility for the appointment,
compensation, evaluation, retention, termination, and oversight of the work of
the Auditors, who shall report directly to and be accountable to the Committee.
The Committee shall also report the results of its activities to the Board. The
Committee's functions and procedures should remain flexible to address changing
circumstances most effectively. To fulfill the Committee's role, the Committee
shall be charged with the following functions and processes, with the
understanding, however, that the Committee may supplement or (except as
otherwise required by applicable laws or rules) deviate from these activities as
appropriate under the circumstances:

      1.    To evaluate the performance of the Auditors, to assess their
            qualifications and to determine whether to retain or to terminate
            the existing Auditors or to appoint and engage new auditors for the
            ensuing year.

      2.    To determine and approve engagements of the Auditors, prior to
            commencement of such engagements, to perform all proposed audit,
            review and attest services, including the scope of and plans for the
            audit, the adequacy of staffing, and the compensation to be paid by
            the Company to the Auditors, which approval may be pursuant to
            preapproval policies and procedures established by the Committee
            consistent with applicable laws and rules, including the delegation
            of preapproval authority to one or more Committee members so long as
            any such preapproval decisions are presented to the full Committee
            at the next scheduled meeting.

      3.    To determine and approve engagements of the Auditors, prior to
            commencement of such engagements (unless in compliance with
            exceptions available under applicable laws and rules related to
            immaterial aggregate amounts of services), to perform any proposed
            permissible non-audit services, including the scope of the service
            and the compensation to be paid therefore, which approval may be
            pursuant to preapproval policies and procedures established by the
            Committee consistent with applicable laws and rules, including the
            delegation of preapproval authority to one or more Committee members
            so long as any such preapproval decisions are presented to the full
            Committee at the next scheduled meeting.

      4.    At least annually, to receive and review written statements from the
            Auditors delineating all relationships between the Auditors and the
            Company consistent with Independence Standards Board Standard No. 1,
            to consider and discuss with the Auditors any disclosed
            relationships and any compensation or services that could affect the
            Auditors' objectivity and independence, and to assess and otherwise
            take appropriate action to oversee the independence of the Auditors.

                                     - 31 -


      5.    To assist and interact with the Auditors in order that they may
            carry out their duties in the most efficient and cost-effective
            manner.

      6.    To evaluate the cooperation received by the Auditors during their
            audit examination, including their access to all requested records,
            data and information, and elicit the comments of management
            regarding the responsiveness of the independent auditors to the
            Company's needs.

      7.    To review with the management of the Company and the Auditors, upon
            completion of their audit, the financial statements proposed to be
            included in the Company's Annual Report on Form 10-KSB or any
            successor form thereto, including Form 10-K, and to recommend
            whether or not such financial statements should be so included. In
            the course of that review, to discuss with management and the
            Auditors the results of the annual audit, including the Auditors'
            assessment of the quality, not just acceptability, of accounting
            principles, the reasonableness of significant judgments and
            estimates (including material changes in estimates), any material
            audit adjustments proposed by the Auditors and adjustments proposed
            but not recorded, the adequacy of the disclosures in the financial
            statements and any other matters required to be communicated to the
            Committee by the Auditors under the standards of the Public Company
            accounting Oversight Board (United States), as appropriate.

      8.    To review the interim financial statements with the management of
            the Company and the Auditors, as appropriate, prior to public
            disclosure of quarterly financial information, if practicable, and
            in any event, prior to the filing of the Company's Quarterly Reports
            on Form 10-QSB or any successor form thereto, including Form 10-Q.
            In this review, the Committee shall discuss the results of this
            quarterly review and any other matters required to be communicated
            to the Committee by the independent auditors under the standards of
            the Public Company Accounting Oversight Board (United States), as
            appropriate..

      9.    To review and discuss with management and the Auditors, as
            appropriate, earnings press releases, which discussions may be
            general discussions of the type of information to be disclosed or
            the type of presentation to be made. The Chair of the Committee may
            represent the entire Committee for this purpose.

      10.   To review with management and the Auditors, as appropriate,
            significant issues that arise regarding accounting principles and
            financial statement presentation, including critical accounting
            policies and practices, alternative accounting policies available
            under GAAP related to material items discussed with management and
            any other significant reporting issues and judgments.

      11.   To review with the Auditors and, if appropriate, management, any
            management or internal control letter issued or, to the extent
            practicable, proposed to be issued by the Auditors and management's
            response, if any, to such letter, as well as any additional material
            written communications between the Auditors and management.

      12.   To review with the Auditors and management, as appropriate, any
            conflicts or disagreements between management and the Auditors
            regarding financial reporting, accounting practices or policies and
            to resolve any such conflicts regarding financial reporting.

      13.   To review with management and the Auditors, as appropriate, the
            scope, quality and effectiveness of internal control over financial
            reporting.

      14.   Periodically, to meet in separate sessions with the Auditors and
            management to discuss any matters that the Committee, the Auditors
            or management believe should be discussed privately with the
            Committee.

      15.   To establish procedures in compliance with applicable laws and rules
            and as determined to be appropriate by the Committee, for the
            receipt, retention and treatment of complaints received by the
            Company regarding accounting, internal accounting controls or
            auditing matters and for the confidential and anonymous submission
            by employees of concerns regarding questionable accounting or
            auditing matters.

      16.   To review and approve related-party transactions as required by
            NASDAQ rules, except to the extent that such matters are reviewed
            and approved by the Nominating and Corporate Governance Committee in
            accordance with its charter and NASDAQ rules.

                                     - 32 -


      17.   To review with counsel, the Auditors and management, as appropriate,
            any significant regulatory or other legal or accounting initiatives
            or matters that may have a material impact on the Company's
            financial statements, compliance programs and policies if, in the
            judgment of the Committee, such review is necessary or appropriate.

      18.   To prepare the Committee Report for inclusion in the Company's proxy
            statement for its annual meeting of stockholders.

      19.   To conduct such investigations as the Audit Committee deems to be
            appropriate and to retain such accounting, legal and other
            independent experts in connection with such investigations or
            otherwise to advise the Committee as the Committee deems to be
            appropriate.

      20.   To periodically review and discuss with management and the Auditors,
            as appropriate, the Company's major risk exposures and the steps
            management has taken to monitor and control such exposures.

      21.   To review and assess the adequacy of this charter annually and
            recommend any proposed changes to the Board for approval.

      22.   To periodically conduct a self-evaluation of the Committee's
            performance.

      23.   To perform such other functions and have such power as may be
            necessary or convenient in the efficient and lawful discharge of the
            foregoing.

It shall be the responsibility of management to prepare the Company's financial
statements and periodic reports and the responsibility of the Auditors to audit
those financial statements. These functions shall not be the responsibility of
the Committee, nor shall it be the Committee's responsibility to ensure that the
financial statements or periodic reports are complete and accurate, conform to
GAAP or otherwise comply with applicable laws.

COMMITTEE PROCESSES

      -     Meeting Frequency - The Committee shall hold such regular or special
            meetings as the Committee or its chair deems necessary or
            appropriate and shall meet at least four times per year.

      -     Resources and Authority - The Committee shall have authority to
            appoint, determine funding for, at the expense of the Company,
            retain and oversee the Auditors as set forth in Section 10A(m)(2) of
            the Securities Exchange Act of 1934, as amended, and the rules there
            under and otherwise to fulfill its responsibilities under this
            charter. The Committee shall have the authority to obtain and
            determine compensation for, at the expense of the Company, advice
            and assistance from internal or external independent legal,
            accounting, or other advisors and consultants, as it determines
            necessary or appropriate to carry out its duties. The Committee
            shall also have authority to pay, at the expense of the Company,
            ordinary administrative expenses that, as determined by the
            Committee, are necessary or appropriate in carrying out its duties.
            The Committee shall have full access to all books, records,
            facilities and personnel of the Company as deemed necessary or
            appropriate by any member of the Committee to discharge his or her
            responsibilities hereunder. The Committee shall have the authority
            to perform such other functions, and shall have such powers, as may
            be necessary or appropriate in the efficient and lawful discharge of
            its responsibilities hereunder.

      -     Reporting to the Board of Directors - The Committee, through the
            Committee chair, shall report to the Board of Directors with respect
            to material issues that arise regarding the quality or integrity of
            the Company's financial statements, the performance or independence
            of the Auditors or such other matters as the Committee deems
            appropriate from time to time or whenever it shall be called upon to
            do so.

                                     - 33 -


                                   APPENDIX D

                         COMPENSATION COMMITTEE CHARTER

             As adopted by the Board of Directors on April 13, 2005

The charter of the Compensation Committee (the "Committee") of the Board of
Directors (the "Board") of Protalex, Inc. (the "Company") is as follows, subject
to amendment by the Board from time to time:

ROLE

The role of the Committee is to act on behalf of the Board in fulfilling the
Board's responsibilities to oversee the Company's compensation policies, plans
and programs; to review and determine the compensation to be paid to the
Company's executive officers; and to review and recommend to the Board the
compensation to be paid to the Company's directors.

The Committee shall seek to maintain an overall compensation structure designed
to attract, retain and motivate management and other employees by providing
appropriate levels of risk and reward, in proportion to individual contribution
and performance. The Committee shall seek to establish appropriate incentives
for management to further the Company's long-term strategic plan and long-term
value as a going concern and to avoid undue emphasis on short-term market value.

MEMBERSHIP

The Committee shall consist of at least three Board members. At least two of the
members of the Committee shall satisfy the "outside director" standard within
the meaning of Section 162(m) of the Internal Revenue Code of 1986, as amended
from time to time (the "Code"). At least two of the members of the Committee
shall satisfy the "non-employee director" standard within the meaning of Section
16b-3 of the Securities Exchange Act of 1934, as amended from time to time (the
"Exchange Act"), unless grants to executive officers otherwise comply with the
requirements of Rule 16b-3. Each member shall satisfy the independence
requirements of the NASDAQ National Market ("NASDAQ") when, if and as required
by NASDAQ and when, if and as applicable to the Company and Committee Members,
as in effect from time to time, including any exceptions permitted by these
requirements.

The members of the Committee and the Committee chairperson shall be appointed by
the Board and serve at the discretion of the Board.

PRIMARY COMMITTEE RESPONSIBILITIES

The primary responsibilities of the Committee are set forth below. The Committee
may supplement and, except as otherwise required by applicable law or the
requirements of NASDAQ, deviate from these activities as appropriate under the
circumstances:

      -     Overall Compensation Strategy - The Committee shall review, modify
            (as needed) and approve the overall compensation strategy and
            policies for the Company, including:

            -     reviewing and approving corporate performance goals and
                  objectives relevant to the compensation of the Company's
                  executive officers and other senior management, as
                  appropriate;

            -     establishing policies with respect to cash compensation,
                  consistent with the objectives of linking compensation to
                  performance and establishing compensation levels sufficient to
                  attract, retain and motivate qualified employees;

            -     establishing policies with respect to equity compensation
                  arrangements with the objective of appropriately balancing the
                  perceived value of equity compensation and the dilutive and
                  other costs of that compensation to the Company; and

            -     reviewing and approving the terms of any employment
                  agreements, severance arrangements, change-of-control
                  protections and any other compensatory arrangements for the
                  Company's executive officers and other senior management, as
                  appropriate.

      The term "compensation," as used in this charter, shall include salary,
      long-term incentives, bonuses, perquisites, equity incentives, severance
      arrangements, retirement benefits and other related benefits and benefit
      plans.

      -     Compensation of Chief Executive Officer - The Committee, meeting in
            executive session, shall determine, in its sole discretion, the
            compensation and other terms of employment of the Company's Chief
            Executive Officer and shall evaluate the Chief Executive Officer's
            performance in light of relevant corporate performance goals and
            objectives, taking into account, among other things, the policies of
            the Committee and the Chief Executive Officer's performance in:

                                     - 34 -


      -     fostering a corporate culture that promotes the highest levels of
            integrity and the highest ethical standards;

      -     developing and executing the Company's long-term strategic plan and
            conducting the business of the Company in a manner appropriate to
            enhance long-term stockholder value;

      -     achieving any other corporate performance goals and objectives
            deemed relevant to the Chief Executive Officer as established by the
            Committee; and

      -     achieving the Chief Executive Officer's individual performance goals
            and objectives.

In determining the long-term incentive component of the Chief Executive
Officer's compensation, the Committee should seek to achieve an appropriate
level of risk and reward, taking into consideration the Company's performance
and relative stockholder return, the value of similar incentive awards given to
chief executive officers of comparable companies, the awards given to the
Company's Chief Executive Officer in past years, and such other criteria as the
Committee deems advisable.

      -     Compensation of Other Officers - With respect to Company's executive
            officers other than the Chief Executive Officer:

            -     The Chief Executive Officer shall recommend to the Committee
                  the cash compensation, equity-based compensation and other
                  terms of employment of each such officer.

The Committee shall have the responsibility and authority to make all
determinations with respect to the compensation of such officers, taking into
consideration the officer's performance, the Company's performance, market
levels of compensation for similar positions, and such other criteria as the
Committee deems advisable. The Chief Executive Officer may be present during
these deliberations, but may not vote.

      -     Compensation of Directors - The Committee shall recommend to the
            Board the type and amount of compensation to be paid or awarded to
            Board members, including consulting, retainer, Board meeting,
            committee and committee chair fees and stock option grants or
            awards.

      -     Administration of Benefit Plans - The Committee shall recommend to
            the Board the adoption, amendment and termination of the Company's
            stock option plans, stock appreciation rights plans, pension and
            profit sharing plans, incentive plans, stock bonus plans, stock
            purchase plans, bonus plans, deferred compensation plans and similar
            programs. The Committee shall have full power and authority to
            administer the Company's 2003 Stock Option Plan, and any other
            equity incentive plan explicitly delegated to the Committee by the
            Board after the date hereof (together, the "Delegated Equity
            Incentive Plans"), and in connection therewith shall have full power
            and authority to establish guidelines, interpret plan documents,
            select participants, approve grants and awards, and exercise such
            other power and authority as may be permitted or required under such
            Delegated Equity Incentive Plans.

      The Committee shall also have full power and authority to adopt and
      administer any of the Company's non-equity incentive plans, as maybe
      adopted for time to time, and other cash bonus plans. In connection
      therewith, the Committee shall have full power and authority to adopt plan
      documents, establish guidelines, interpret plan documents, select
      participants, approve awards, and exercise such other power and authority
      as may be permitted or required under such non-equity incentive plans.

      -     Other Compensation Matters - The Committee shall review and approve
            such other compensation matters as the Board or the Chief Executive
            Officer may wish to submit to the Committee.

      -     Committee Report - The Committee shall prepare and review the
            Committee report included in the Company's annual proxy statement in
            accordance with applicable rules and regulations of the SEC.

      -     Committee Self-Assessment - The Committee shall review, discuss and
            assess its own performance at least annually. The Committee shall
            also periodically review and assess the adequacy of this charter,
            including the Committee's role and responsibilities as outlined in
            this Charter, and shall recommend any proposed changes to the Board
            for its consideration.

COMMITTEE PROCESSES

      -     Meeting Frequency - The Committee shall hold such regular or special
            meetings as the Committee or its chair deems necessary or
            appropriate and shall meet at least annually.

      -     Resources and Authority - The Committee shall have full access to
            all books, records, facilities and personnel of the Company as
            deemed necessary or appropriate by any member of the Committee to
            discharge his or her responsibilities hereunder. The Committee shall
            have the authority to obtain, at the expense of the Company, advice
            and assistance from internal or external legal, accounting, or other
            advisors and consultants. In addition, the Committee shall have sole
            authority to retain and terminate any compensation consultant to
            assist in the evaluation of director, chief executive officer or
            senior executive compensation,

                                     - 35 -


            including sole authority to approve such consultant's reasonable
            fees and other retention terms, all at the Company's expense. Other
            reasonable expenditures for external resources that the Committee
            deems necessary or appropriate in the performance of its duties are
            permitted. The Committee shall have the authority to perform such
            other functions, and shall have such powers, as may be necessary or
            appropriate in the efficient and lawful discharge of its
            responsibilities hereunder.

      -     Reporting to the Board of Directors - The Committee, through the
            Committee chair, shall report all material activities of the
            Committee to the Board from time to time.

                                     - 36 -


                                   APPENDIX E

              NOMINATING AND CORPORATE GOVERNANCE COMMITTEE CHARTER

             As adopted by the Board of Directors on April 13, 2005

The role and responsibilities of the Nominating and Corporate Governance
Committee (the "Committee") of Protalex, Inc. (the "Company") are as follows,
subject to amendment by the Company's Board of Directors (the "Board") from time
to time:

ROLE

The Committee's roles are (1) to oversee the Director nomination process; (2) to
administer and oversee all aspects of the Company's corporate governance
functions on behalf of the Board, including making recommendations to the Board
regarding corporate governance issues; and (3) to make other recommendations to
the Board regarding affairs relating to the directors of the Company.

MEMBERSHIP

Committee membership shall consist of at least three Board members. The members
of the Committee and the Committee chairperson shall be appointed by the Board.

PRIMARY COMMITTEE RESPONSIBILITIES

The primary Committee responsibilities are:

      -     Director Nominations - The Committee, in consultation with the
            Chairman and the Chief Executive Officer, has the primary
            responsibility for identifying, evaluating, reviewing and
            recommending qualified candidates to serve on the Board. The
            selection of nominees for Director to be presented to the
            stockholders for election or reelection, and the selection of new
            Directors to fill vacancies and newly created directorships on the
            Board, are made by the majority of the independent members of the
            Board based on the recommendations of the Committee.

      -     Board Committee Nominations - The Committee, in consultation with
            the Chairman and the Chief Executive Officer, and after considering
            the wishes of the individual Directors, recommends to the entire
            Board annually the chairmanship and membership of each committee.

      -     Director Change of Position - The Committee is responsible for
            reviewing and making a recommendation to the Board regarding the
            continued service of a Director in the event (i) an employee
            Director's employment with the Company is terminated for any reason
            or (ii) a non-employee Director changes his/her primary job
            responsibility from that held at the time such Director was most
            recently elected to the Board.

      -     Performance Assessment - The Committee shall establish a process for
            the periodic review and assessment of the performance of the Board
            and Board committees, seeking input from senior management, the
            other committees, the full Board and others.

      -     Independence Determinations - The Committee will consider and assess
            periodically the independence of directors, including determining
            which members are independent of management as defined by NASDAQ,
            and whether the members of the standing committees of the Board meet
            the independence requirements of NASDAQ when and as applicable to
            such committees.

      -     Director Education - The Committee will evaluate the need and, if
            necessary, develop and institute a plan or program for the
            continuing education of directors.

      -     Corporate Governance - The Committee may develop a set of corporate
            governance principles applicable to the Company to be adopted by the
            Board, and periodically review and assess these principles and their
            application and recommend any changes deemed appropriate to the
            Board for its consideration. When applicable, the Committee will
            review and make recommendations to the Board regarding proposals
            submitted by stockholders that relate to corporate governance
            matters.

      -     Code of Ethics - The Committee will review with management and the
            Board the adequacy of, and monitor compliance with, the Company's
            Code of Ethics (the "Code of Ethics").

                                     - 37 -


      -     Special Committees - From time to time, when applicable, the
            Committee will evaluate the need for and recommend to the Board the
            establishment of such special committees as may be desirable or
            necessary in order to address ethical, legal, business or other
            matters that may arise.

      -     Information Processes - Oversee and review the processes and
            procedures used by the Company to provide accurate, relevant and
            appropriately detailed information to the Board and its committees
            on a timely basis.

      -     Public Affairs. The Committee will oversee the Company's policies
            and practices regarding philanthropic and political activities.

      -     Committee Self Assessment and Charter. The Committee will
            periodically review, discuss and assess the performance of the
            Committee as well as the Committee's role and responsibilities,
            seeking input from senior management, the full Board and others and
            recommend any changes to the Board. The Committee shall review, as
            it deems necessary, the Committee Charter and shall recommend any
            proposed changes for approval by the full Board

      -     Additional Duties. The Committee may also undertake such additional
            activities within the scope of its primary functions as the
            Committee may from time to time determine.

COMMITTEE PROCESSES

      -     Meeting Frequency. The Committee should meet as frequently as
            considered necessary by the Committee or the chairperson, and shall
            meet at least annually.

      -     Resources - The Committee shall be authorized to access such
            internal and, in consultation with senior management, external
            resources as the Committee deems necessary or appropriate to fulfill
            its defined responsibilities. Expenditures for external resources
            that are expected to be material and outside the ordinary course of
            the Committee's practices shall be recommended by the Committee for
            the approval of the full Board. The Committee shall have the
            authority to perform such other functions, and shall have such
            powers, as may be necessary or appropriate in the efficient and
            lawful discharge of its responsibilities hereunder.

      -     Reporting to the Board of Directors - The Committee, through the
            Committee chairperson, shall report all material activities of the
            Committee to the Board from time to time. The Committee shall report
            annually to the Board on the independence of Directors, as
            determined by the Board from time to time.

      -     Delegation - The Committee may delegate any of its responsibilities,
            powers and authority to one or more subcommittees of the Committee.

                                     - 38 -