EXHIBIT 32.1

                            CERTIFICATION PURSUANT TO
                             18 U.S.C. SECTION 1350,
                             AS ADOPTED PURSUANT TO
                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report of Neose Technologies, Inc. (the
"COMPANY") on Form 10-Q for the fiscal quarter ending September 30, 2005 as
filed with the Securities and Exchange Commission on the date hereof (the
"REPORT"), I, C. Boyd Clarke, President, Chief Executive Officer and Chairman of
the Company, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to
Section 906 of the Sarbanes-Oxley Act of 2002, that:

         (1) The Report fully complies with the requirements of section 13(a) or
15(d) of the Securities Exchange Act of 1934; and

         (2) The information contained in the Report fairly presents, in all
material respects, the financial condition and results of operations of the
Company.



/s/ C. Boyd Clarke
- --------------------------------------------
C. Boyd Clarke
President, Chief Executive Officer and Chairman


Date:    November 2, 2005