1 Supplemental Proxy Materials filed pursuant to Rule 14a-2 under the Securities Exchange Act of 1934 [TSENG LETTERHEAD] October 15, 1998 Dear Tseng Labs, Inc. Stockholder: You are cordially invited to attend a 30 minute luncheon presentation by the Cell Pathways, Inc. management team with respect to the Cell Pathways/Tseng transaction and the business of Cell Pathways at the following locations: City Date and Time Location Call - ---- -------------- --------- ----- San Francisco Wednesday, Salomon Smith Barney Helen Kim October 21 39th fl. 415-955-1605 12:30 p.m. 555 California Street Chicago Friday, Salomon Smith Barney Kathy Boyer October 23 87th fl. 312-419-3627 12:15 p.m. Sears Tower New York City Tuesday, The Omni Berkshire Stacey Alosa October 27 Hotel 212-723-7297 12:00 p.m. Carnegie Room 21 East 52nd St. Philadelphia Thursday, The Pyramid Club Bill Freeman October 29 52nd fl. 215-854-6034 12:00 p.m. Mellon Bank Center 1735 Market St. You should have already received proxy materials with respect to the November 3 special meeting of stockholders of Tseng Labs, Inc. to consider the proposed transaction with Cell Pathways. Additional proxy materials/prospectuses will be available at these presentations. Representatives from Salomon Smith Barney, BancBoston Robertson Stephens, and Cell Pathways will be available to answer any questions. Please call the appropriate person listed above to reserve space. As described in the proxy materials previously sent to you, Cell Pathways is a pharmaceutical company focused on the development and commercialization of products to prevent and treat cancer. The proposed transaction is intended to provide substantial funding for the programs of Cell Pathways. In the transaction, the new Cell Pathways will issue its common stock to the stockholders of both Tseng Labs and Cell Pathways in exchange for all the stock they now own in their respective companies, with the exchange ratio as specified in the Reogranization Agreement. Stockholder meetings to approve the transaction will be held on November 2 (Cell Pathways) and November 3 (Tseng). The common stock of the new Cell Pathways is expected to commence trading on the NASDAQ National Market assuming approval of the transaction at such stockholders' meetings. We look forward to your attendance at any of the presentations listed above. Sincerely, Sincerely, /s/ Robert J. Towarnicki /s/ John J. Gibbons - ------------------------ -------------------- Robert J. Towarnicki John J. Gibbons Chief Executive Officer Chairman of the Board of Directors Cell Pathways, Inc. Tseng Labs, Inc.