EXHIBIT 21 ST. JUDE MEDICAL, INC. SUBSIDIARIES OF THE REGISTRANT St. Jude Medical, Inc. Wholly Owned Subsidiaries: o Pacesetter, Inc. - Sylmar, California, Scottsdale, Arizona, and Maven, South Carolina (Delaware corporation) (doing business as St. Jude Medical Cardiac Rhythm Management Division) o St. Jude Medical S.C., Inc. - St. Paul, Minnesota (Minnesota corporation) - Lifeline Medical Systems, Inc. (Illinois corporation) (wholly owned subsidiary of St. Jude Medical S.C., Inc.) o St. Jude Medical Sales Corporation - St. Paul, Minnesota (Barbados corporation) o St. Jude Medical Europe, Inc. - St. Paul, Minnesota (Delaware corporation) - Brussels, Belgium branch o St. Jude Medical Canada, Inc. - Mississauga, Ontario and St. Hyacinthe, Quebec (Ontario, Canada corporation) o 151703 Canada, Inc. - St. Paul, Minnesota (Ontario, Canada corporation) o St. Jude Medical (Hong Kong) Limited - Kowloon, Hong Kong (Hong Kong corporation) - Shanghai and Beijing, China representative offices - Korean and Taiwan branch offices - Mumbai, New Delhi, Calcutta and Chennai, India branch offices o St. Jude Medical, Inc., Cardiac Assist Division - St. Paul, Minnesota (Delaware corporation) (Assets of St. Jude Medical, Inc., Cardiac Assist Division sold to Bard 1/19/96) o St. Jude Medical Australia Pty., Ltd. - Sydney Australia (Australian corporation) o St. Jude Medical Brasil, Ltda. - Sao Paulo and Belo Horizonte, Brazil (Brazilian corporation) - Telectronics Medica, Ltda. - Sao Paulo, Brazil (Brazilian corporation) o Medical Telectronics, Ltd. - Auckland, New Zealand (New Zealand corporation) o St. Jude Medical, Daig Division, Inc.- Minnetonka, Minnesota (Minnesota corporation) (formerly known as Daig Corporation) o St. Jude Medical Colombia, Ltda. (Bogota, Colombia) (Colombian corporation) o St. Jude Medical ATG, Inc. - Maple Grove, Minnesota (Minnesota corporation) (formerly known as St. Jude Medical Cardiovascular Group, Inc.) o SJM International, Inc. - St. Paul, Minnesota (Delaware corporation) (formerly known as SJM Europe, Inc.) - Tokyo, Japan branch 1 SJM International Inc. Wholly Owned Subsidiaries o St. Jude Medical Puerto Rico, Inc. - Caguas, Puerto Rico (Delaware corporation) - St. Jude Medical Puerto Rico Holding, B.V. (Netherlands corporation) (wholly owned subsidiary of St. Jude Medical Puerto Rico, Inc.) - St. Jude Medical Japan KK (Japanese corporation) (wholly owned subsidiary of St. Jude Medical Puerto Rico Holding, B.V.) - St. Jude Medical Nederland B.V. (Netherlands corporation) (wholly owned subsidiary of St. Jude Medical Puerto Rico Holding, B.V.) - Telectronics B.V. (Netherlands corporation) (wholly owned subsidiary of St. Jude Medical Nederland B.V.) - St. Jude Medical Netherlands Distribution AB (Swedish corporation headquartered in the Netherlands) (wholly owned subsidiary of St. Jude Medical Puerto Rico Holding, B.V.) - St. Jude Medical Puerto Rico B.V. (Netherlands corporation) (wholly owned subsidiary of St. Jude Medical Netherlands Distribution AB) - Puerto Rico branch of St. Jude Medical Puerto Rico B.V. - St. Jude Medical Coordination Center (Belgium branch of St. Jude Medical Netherlands Distribution AB) o St. Jude Medical AB (Swedish corporation) (formerly known as Pacesetter AB) o St. Jude Medical Sweden AB (Swedish corporation) o St. Jude Medical Danmark A/S (Danish corporation) - Telectronics Scandinavia Aps (Danish corporation) (wholly owned subsidiary of St. Jude Medical Danmark A/S) o St. Jude Medical Pacesetter Sales AB (Swedish corporation) o St. Jude Medical (Portugal) - Distribuicao de Produtos Medicos, Lda. (Portuguese corporation) o St. Jude Medical Export Ges.m.b.H. (Austrian corporation) o St. Jude Medical Medizintechnik Ges.m.b.H. (Austrian corporation) o St. Jude Medical Italia S.p.A. (Italian corporation) o N.V. St. Jude Medical Belgium, S.A. (Belgian corporation) - Portugal branch o St. Jude Medical Espana, S.A. (Spanish corporation) o St. Jude Medical France S.A. (French corporation) o St. Jude Medical Finland O/y (Finnish corporation) o St. Jude Medical Sp.zo.o. (Polish corporation) o St. Jude Medical GmbH (German corporation) o St. Jude Medical UK Limited (United Kingdom corporation) o St. Jude Medical AG (Swiss corporation) 2