Exhibit 10.31
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AMENDMENT N0. 1
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TO
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KIRIN-AMGEN, INC./AMGEN
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G-CSF EUROPEAN LICENSE AGREEMENT
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THIS AMENDMENT N0. 1 ("Amendment No. 1") TO THAT CERTAIN KIRIN-AMGEN,
INC./AMGEN G-CSF EUROPEAN LICENSE AGREEMENT ("License Agreement"), is made and
entered into this 1st day of June, 1987, by and between AMGEN INC., a Delaware
corporation ("Amgen"), and KIRIN-AMGEN, INC., a California corporation
("Corporation").
R E C I T A L S
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A. Amgen and Corporation have previously executed that certain License
Agreement regarding G-CSF.
B. The parties desire to incorporate certain definitional changes into
the License Agreement.
NOW, THEREFORE, it is agreed as follows:
1. Article I at pages 2-3 of the License Agreement is hereby amended as
follows:
"ARTICLE I
DEFINITIONS
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1.01 Incorporation by Reference. Unless otherwise defined
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herein, capitalized terms shall have the meanings specified
in that certain Company Shareholders' Agreement dated May 11,
1984, as amended ("Shareholders' Agreement"), and in that
certain Research, Development, Technology Disclosure and
License Agreement: PPO effective as of July 1, 1985 ("PPO
Agreement").
1.04 G-CSF Products. "G-CSF Products" shall mean any
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product, method or system for human pharmaceutical use which
contains G-CSF as its single primary element.
1.05 G-CSF Technology. "G-CSF Technology" shall mean all G-
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CSF technical information whether tangible or intangible,
including any and all data, pre-clinical and clinical
results, techniques, discoveries, inventions, ideas,
processes, know-how, patents, inventor's certificates, trade
secrets and other proprietary information, and any physical,
chemical or biological material (including cell lines) and
any replication of any part of any such material.
1.08 G-CSF. "G-CSF" shall mean a glycosylated or
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nonglycosylated molecule consisting of the linear array of
amino acids attached as Exhibit "A" hereto or any variation
thereof consisting of additions, deletions or substitutions
of up to ten amino acids, and shall include the definition of
PPO as set forth in the PPO Agreement."
2. Except to the extent as provided herein, the provisions of
the License Agreement, as amended, are hereby ratified and confirmed
in all respects.
IN WITNESS WHEREOF, the undersigned have caused this Amendment No. 1 to
be executed as of the first day written above .
AMGEN INC., a Delaware
corporation
By /s/ George B. Rathmann
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George B. Rathmann, President
"Amgen"
KIRIN-AMGEN, INC., a
California corporation
By /s/ Y. Yamamoto
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Yashushi Yamamoto, Chairman
"Corporation"
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G-CSF
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A Amino acids [23-30] Lys Ile Gln Gly Asp Gly Ala Ala
mRNA AAG AUC CAG GGC GAU GGC GCA GCG
Probes [24-23 mers] TTC TAC GTC CCT CTA CCT GGT CG
B -12 -10
ELU TRP HIS SER ALA LEU TRP THR VAL GLN GLU ALA THR PRO LEU
CIG TGG CAC AGI GIA CIC TGG ACR GIG CAG GAA GCC ACC CCC CIG
10
ALY PRO ALA SER SER LEU PRO GLN SER PHE LEU LEU LYS CYS LEU
GGC CCT GCC AGC TCC CTG CCC CAG AGC TTC CTG CTC AAG TGC TTA
20 30 phe
ALU GLN VAL ARG LYS ILE GLN GLY ASP GLY ALA ALA LEU GLN GLN
GAG CAA GTG AGG AAG ATC CAG GGC GAT GGC GCA GCG CTC CAG GAG
gly
LYS LEU CYS ALA THR TYR LYS LEU CYS HIS PRO GLU GLU LEU VAL
AAG CTG TGT GCC ACC TAC AAG CTG TGT CAC CCC GAG GAG CTG GTG
50 60
LEU LEU GLY HIS SER LEU GLY ILE PRO TRP ALA PRO LEU SER SER
CTG CTC GGA CAC TCT CTG GGC ATC CCC TGG GCT CCC CTG AGC AGC
70
CYS PRO SER GLN ALA LEU GLN LEU ALA GLY CYS LEU SER GLN LEU
TGC CCC AGC CAG GCC CTG CAG CTG GCA GGC TGC TTG AGC CAA CTC
80 90
HIS SER GLY LEU PHE LEU TYR GLN GLY LEU LEU GLN ALA LEU GLN
CAT AGC GGC CTT TTC CTC TAC CAG GGG CTC CTG CAG GCC CTG GAA
100
GLY ILE SER PRO GLU LEU GLY PRO THR LEU ASP THR LEU GLN LEU
GGG ATC TCC CCC GAG TTG GGT CCC ACC TTG GAC ACA CTG CAG CTG
110 120
ASP VAL ALA ASP PHE ALA THR THR ILE TRP GLN GLN MET GLU GLU
GAC GTC GCC GAC TTT GCC ACC ACC ATC TGG CAG CAG ATG GAA GAA
130
LEU GLY MET ALA PRO ALA LEU GLN PRO THR GLN GLY ALA MET PRO
CTG GGA ATG GCC CCT GCC CTG CAG CCC ACC CAG GGT GCC ATG CCG
140 150
ALA PHE ALA SER ALA PHE GLN ARG ARG ALA GLY GLY VAL LEU VAL
GCC TTC GCC TCT GCT TTC CAG CGC CGG GCA GGA GGG GTC CTG GTT
160
ALA SER HIS LEU GLN SER PHE LEU GLU VAL SER TYR ARG VAL LEU
GCC TCC CAT CTG CAG AGC TTC CTG GAG GTG TCG TAC CGC GTT CTA
170 174
ARG HIS LEU ALA GLN PRO OP
CGC CAC CTT GCC CAG CCC TGA GCCAAGCCCTCCCCATCCCATGTATTTATCT
CTATTTAATATTTATGTCTATTTAAGCCTCATATTTAAAGACAGGGAAGAGCAGAACGG
AGCCCCAGGCCTCTGTGTCCTTCCCTGCATTTCTGAGTTTCATTCTCCTGCCTGTAGCA
GTGAGAAAAAGCTCCTGTCCTCCCATCCCCTGGACTGGGAGGTAGATAGGTAAATACCA
AGTATTTATTACTATGACTGCTCCCCAGCCCTGGCTCTGCAATGGGCACTGGGATGAGC
CGCTGTGAGCCCCTGGTCCTGAGGGTCCCCACCTGGGACCCTTGAGAGTATCAGGTCTC
CCACGTGGGAGACAAGAAATCCCTGTTTAATATTTAAACAGCAGTGTTCCCCATCTGGG
TCCTTGCACCCCTCACTCTGGCCTCAGCCGACTGCACAGCGGCCCCTGCATCCCCTTGG
CTGTGAGGCCCCTGGACAAGCAGAGGTGGCCAGAGCTGGGAGGCATGGCCCTGGGGTCC
CACGAATTTGCTGGGGAATCTCGTTTTTCTTCTTAAGACTTTTGGGACATGGTTTGACT
CCCGAACATCACCGACGTGTCTCCTGTTTTTCTGGGTGGCCTCGGGACACCTGCCCTGC
CCCCACGAGGGTCAGGACTGTGACTCTTTTTAGGGCTAGGCAGGTGCCTGGACATTTGC
CTTGCTGGACGGGGACTGGGGATGTGGGAGGGAGCAGACAGGAGGAATCATGTCAGGCC
TGTGTGTGAAAGGAAGCTCCACTGTCACCCTCCACCTCTTCACCCCCCACTCACCAGTG
TCCCCTCCACTGTCACATTGTAACTGAACTTCAGGATAATAAAGTGTTTGCCTCCAA
EXHIBIT "A"