EXHIBIT 5

                        [Letterhead of Latham & Watkins]



                                 March 7, 2001

Amgen Inc.
One Amgen Center Drive
Thousand Oaks, California  91320-1789

          Re:  Amgen Inc.
               Common Stock, par value $.0001 per share
               Registration on Form S-8
               -------------------------------------------

Ladies and Gentlemen:

          At your request, we have examined the Registration Statement on
Form S-8 (the "Registration Statement"), which you intend to file with the
Securities and Exchange Commission in connection with the registration under the
Securities Act of 1933, as amended, of an aggregate of 5,000,000 shares of
Common Stock, par value $0.0001 per share (the "Shares"), to be sold by Amgen
Inc. (the "Company") under the Amended and Restated 1997 Special Non-Officer
Equity Incentive Plan (the "Plan"). We are familiar with the proceedings
undertaken in connection with the authorization and proposed issuance and sale
of the Shares. Additionally, we have examined such questions of law and fact as
we have considered necessary or appropriate for purposes of this opinion.

          Based upon the foregoing, we are of the opinion that the Shares have
been duly authorized, and upon the issuance of Shares under the terms of the
Plan and delivery and payment therefor of legal consideration in excess of the
aggregate par value of the Shares issued, such Shares will be validly issued,
fully paid and nonassessable.

          We consent to your filing this opinion as an exhibit to the
Registration Statement.

                                   Very truly yours,


                                   /s/ Latham & Watkins