EXHIBIT 99.21

              CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS 

     We consent to the incorporation by reference in the Registration
Statements, (Form S-3 No. 333-45539) pertaining to Premier Laser Systems, Inc.
for the registration of 1,144,916 shares of its Class A Common Stock and 28,290
Class B Warrants, (Form S-3 No. 333-04219) pertaining to Premier Laser Systems,
Inc. for the registration of 9,156,243 shares of its Class A Common Stock and
2,005,873 Class B Warrants, (Form S-4 No. 333-29573) pertaining to Premier Laser
Systems, Inc. for the registration of 1,990,250 shares of its Class A Common
Stock and options to purchase 165,250 shares of its Class A Common Stock, (Form
S-8 No. 333-01680) pertaining to the 1995 Stock Option Plan of Premier Laser
Systems, Inc., (Form S-8 No. 333-27151) pertaining to the February 1996 Stock
Option Plan of Premier Laser Systems, Inc., (Form S-8 No. 333-29497) pertaining
to the 1997 Stock Option Plan of Premier Laser Systems, Inc., of our reports
dated October 21, 1997, except for Note 10 as to which the date is November 18,
1997, and October 11, 1996, except for Note 10 as to which the date is November
21, 1996, with respect to the financial statements of Ophthalmic Imaging Systems
included in its Annual Reports (Form 10-KSB) for the years ended August 31, 1997
and 1996, respectively, and included in the Current Report on Form 8-K of
Premier Laser Systems, Inc. dated February 25, 1997, filed with the Securities
and Exchange Commission.


                                            ERNST & YOUNG LLP


Sacramento, California 
March 4, 1998