CONFIDENTIAL INFORMATION OMITTED AND FILED SEPARATELY
                    WITH SECURITIES AND EXCHANGE COMMISSION
                         ASTERISKS DENOTE SUCH OMISSION

                                                                   EXHIBIT 10.45


                             DATE: DECEMBER 20, 2002





                             ELAN CORPORATION, PLC.

                                       AND

                            PAR PHARMACEUTICAL, INC.





                              TERMINATION AGREEMENT
                                   RELATING TO
                    DEVELOPMENT, LICENCE AND SUPPLY AGREEMENT
                             DATED 11 DECEMBER 2001





CONTROLLED RELEASE ET AL. / NOMINATED COMPOUNDS


                             Exhibit 10.45 - Page 1

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THIS TERMINATION AGREEMENT is made  December 20, 2002

BETWEEN:

(1)      ELAN CORPORATION, PLC., a public limited company incorporated under the
         laws of  Ireland  and having its  registered  office at Lincoln  House,
         Lincoln Place, Dublin 2, Ireland ("ELAN"); and

(2)      PAR  PHARMACEUTICAL,  INC., a company  organized  under the laws of New
         Jersey,  with offices at One Ram Ridge Road,  Spring  Valley,  New York
         10977, United States of America ("PAR")





RECITALS:

(A)      Elan and Par entered into a development,  licence and supply  agreement
         dated 11 December 2001 (the "ORIGINAL AGREEMENT").

(B)      Pursuant  to  the  Original   Agreement,   the  parties   selected  for
         development the Compound ********** and Elan has subsequently conducted
         development work to apply the Elan Technology to such Compound.

(C)      Elan and Par now wish to terminate the Original Agreement, on the terms
         and conditions set out in this Termination Agreement.

NOW IT IS HEREBY AGREED AS FOLLOWS in  consideration  of the premises and mutual
covenants promises herein contained:


1.       DEFINITIONS AND INTERPRETATION
         ------------------------------
Except where expressly provided to the contrary in this Termination Agreement:

1.1.     all capitalised terms used in this Termination Agreement shall have the
         same meanings as are assigned thereto in the Original Agreement; and

1.2.     "TERMINATION DATE" shall mean December 20, 2002.

2.       TERMINATION
         -----------

2.1.     The  Original  Agreement  is hereby  terminated  with  effect  from the
         Termination Date.

2.2.     For the avoidance of doubt:

         2.2.1    the license  granted by Elan to Par to import,  use, offer for
                  sale  and  sell  the  Products  in  the  Territory  is  hereby
                  terminated with effect from the Termination Date;

         2.2.2    development  work in respect  of the  Compound  **********  is
                  hereby abandoned;

         2.2.3    Elan shall remain the owner of the Elan Intellectual Property;

         2.2.4    no further Compounds will be selected for development; and

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         2.2.5    Par's  obligation  not to develop,  market or sell a Competing
                  Product is hereby  terminated with effect from the Termination
                  Date.

3.       EXISTING RIGHTS
         ---------------

Except as expressly provided to the contrary in this Termination Agreement, each
of the parties  hereby  waives all and any claims it may have  against any other
party as at the date hereof in respect of any breach of the Original Agreement.

4.       SURVIVAL
         --------

Termination of the Original Agreement shall be without prejudice to:

4.1.      the provisions of the Original Agreement relating to  confidentiality,
          which shall accordingly survive until the 7th (seventh) anniversary of
          the Termination Date, and provisions ancillary thereto; or

4.2.      any other agreement between Elan and Par.

5.        FINANCIAL PROVISIONS
          --------------------

Within five business  days of the  Termination  Date,  Par shall pay to Elan the
non-refundable  sum of US$ 651,797 (o United  States  dollars),  being the total
amount  outstanding  in  respect of  development  work up to and  including  the
Termination  Date and being in complete  satisfaction  of all amounts payable to
Elan in  respect  of  development  or  otherwise  pursuant  to the  terms of the
Original  Agreement.  Such payment  shall be made by bank  transfer  without any
deduction, set off or withholding whatsoever.

6. PATENT OPINION.
- -----------------

Elan  shall have not right to,  and shall  not,  rely on any  opinion of Frommer
Lawrence & Haug LLP in respect of any  intellectual  property matters related to
**********.

6.       FURTHER ASSURANCE
         -----------------

At the  request of any of the  parties,  each other  party  shall (and shall use
reasonable  efforts to procure that any other  necessary  persons shall) execute
and perform all such  documents,  acts and things as may  reasonably be required
subsequent  to the  execution of this  Termination  Agreement for assuring to or
vesting in the requesting party the full benefit of the terms hereof.

7.       COUNTERPARTS
         ------------

This Termination  Agreement may be signed in any number of counterparts with the
same  effect  as if the  signatures  to  each  counterpart  were  upon a  single
instrument,  and all such  counterparts  together shall be deemed an original of
this Termination Agreement.

8.       GOVERNING LAW AND JURISDICTION
         ------------------------------

This  Termination  Agreement  shall be  governed by the laws of the State of New
York,  excluding  its  conflict of laws  rules.  Any  dispute  arising  shall be
disposed of in the same manner as a dispute under the Original Agreement.

IN WITNESS WHEREOF the parties hereto have executed this Termination Agreement.

                             Exhibit 10.45 - Page 3



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SIGNED                                      SIGNED

By: /s/ Alex Nesbitt                        By:  /s/ Scott Tarriff
   --------------------------------------        -------------------------------
   For and on behalf of                          for and on behalf of
   ELAN CORPORATION, PLC.                        PAR PHARMACEUTICAL, INC.

                             Exhibit 10.45 - Page 4