UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                    FORM 8-K
                                 CURRENT REPORT

                     Pursuant to Section 13 or 15 (d) of the
                         Securities Exchange Act of 1934

                                 August 14, 2007
                                 ---------------
                Date of report (Date of earliest event reported)

                     RMK Multi-Sector High Income Fund, Inc.
                     ---------------------------------------
             (Exact name of registrant as specified in its charter)

          Maryland                       001-32719           20-4048379
- --------------------------          ---------------------    -------------------
(State or other jurisdiction       (Commission file number)  (IRS Employer
of incorporation or organization)                            Identification No.)

     Morgan Keegan Tower, Fifty North Front Street, Memphis, Tennessee 38103
     -----------------------------------------------------------------------
                    (Address of Principal Executive Offices)

Registrant's telephone number, including area code:      (901) 524-4100
                                                   ---------------------------

Check  the  appropriate  box  below  if the  Form  8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

/_/   Written  communication  pursuant to Rule 425 under the  Securities Act (17
      CFR 230.425).

/_/   Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
      240.14a-12).

/_/   Pre-commencement  communications  pursuant  to  Rule  14d-2(b)  under  the
      Exchange Act (17 CFR 240.14d-2(b)).

/_/   Pre-commencement  communications  pursuant  to  Rule  13e-4(c)  under  the
      Exchange Act (17 CFR 240.13e-4(c)).




ITEM 7.01 REGULATION FD DISCLOSURE.
          ------------------------

     An  independent  valuation  consultant  has  been  retained  to  assist  in
determining the fair value of certain  portfolio  securities of RMK Multi-Sector
High Income Fund, Inc. (the "Fund"). Recent instability in the markets for fixed
income securities, particularly mortgage-backed and asset-backed securities, has
made it more  difficult  to  obtain  realistic  values  for  some of the  Fund's
portfolio  securities.  In the absence of reliable market quotations,  portfolio
securities  are valued by the Fund's  investment  adviser at their "fair  value"
under procedures established and monitored by the Fund's Board of Directors. The
"fair value" of securities may be difficult to determine and thus judgment plays
a greater role in this valuation  process.  Fair valuation  procedures have been
used to value a  substantial  portion  of the assets of the Fund with input from
the valuation  consultant  and these  valuations  are reflected in the daily net
asset value of the Fund's shares.

     This  information is furnished  pursuant to Item 7.01 of Form 8-K and shall
not be deemed to be "filed"  for the  purposes  of Section 18 of the  Securities
Exchange Act of 1934 or otherwise  subject to the  liabilities  of that Section,
unless we specifically incorporate it by reference in a document filed under the
Securities  Act of 1933 or the  Securities  Exchange Act of 1934. By filing this
report on Form 8-K and furnishing this information,  the Fund makes no admission
as to the  materiality of any  information in this report that is required to be
disclosed solely by reason of Regulation FD.



                                   SIGNATURES

     Pursuant to the  requirements of the Securities Act of 1934, the Registrant
has duly  caused  this  report  to be signed  on its  behalf by the  undersigned
hereunto duly authorized.





   Date:  August 14, 2007                RMK MULTI-SECTOR HIGH INCOME FUND, INC.


                                           By: /s/ Charles D. Maxwell
                                               ---------------------------------
                                               Charles D. Maxwell
                                               Secretary and Assistant Treasurer