K&L | GATES                       Kirkpatrick & Lockhart Preston Gates Ellis LLP
                                  1601 K Street NW
                                  Washington, DC  20006-1600

                                  T 202.778.9000            www.klgates.com

                                  Alan C. Porter
                                  202.778.9186 direct dial
                                  202.778.9100 fax
                                  alan.porter@klgates.com



                                   May 2, 2008


VIA EDGAR
---------

U.S. Securities and Exchange Commission
100 F Street, NE
Washington, DC 20549

   Re:   Preliminary Proxy Statement for RMK Multi-Sector High Income Fund, Inc.
         -----------------------------------------------------------------------
         (File No. 811-21833)
         --------------------

Ladies and Gentlemen:

     On behalf of RMK  Multi-Sector  High Income  Fund,  Inc.  (the  "Company"),
transmitted  herewith for filing  pursuant to Rule 14a-6(a) under the Securities
Exchange Act of 1934, as amended,  are the  preliminary  proxy statement and the
forms of proxy to be used in connection  with the special and annual meetings of
shareholders  of the  Company  scheduled  to be  held  on  July  11,  2008  (the
"Meetings").  The proxy materials for the Meetings  consist of a letter from the
president of the Company, the notice of the meetings,  the proxy statement,  and
the forms of proxy.

     The  Company's  Meetings  are being held  jointly  with  special and annual
meetings of RMK  Advantage  Income Fund,  Inc.  (File No.  811-21631),  RMK High
Income Fund, Inc. (File No. 811-21332) and RMK Strategic Income Fund, Inc. (File
No.  811-21487),  which today have also filed proxy materials  relating to their
respective  shareholder  meetings.  Because  the  proxy  materials  filed by the
Company are substantially identical to those filed by these other RMK closed-end
funds,  the staqff  need only  review  one of the  referenced  filings.  We will
consider any comments  conveyed by the staff as being applicable to all filings,
unless the context requires otherwise.

     We  anticipate   that   definitive   proxy  materials  will  be  mailed  to
shareholders beginning on or after May 12, 2008.

     If you have any  questions  or comments  regarding  the  foregoing,  please
contact me at (202) 778-9186, or Mitra Shakeri at (202) 778-9024.



                                   Sincerely,

                                   /s/ Alan C. Porter

                                   Alan C. Porter


Enclosures