EXHIBIT 12.1 STATEMENT REGARDING COMPUTATION OF RATIOS US ONCOLOGY, INC. COMPUTATION OF RATIO OF EARNINGS TO FIXED CHARGES 2001 2000 1999 1998 1997 Net income (loss) per the Consolidated Statement of Operations $46,316 $(72,643) $48,155 $59,981 $15,635 ======= ======== ======= ======= ======= Fixed charges $44,126 $ 46,735 $38,303 $27,529 $21,768 ======= ======== ======= ======= ======= Ratio of earnings to fixed charges 1.0 1.3 2.2 0.7 ======= ======== ======= ======= ======= Amount by which fixed charges exceed earnings 119,378 ======= ======== ======= ======= ======= Detail of Fixed Charges Interest charges per the Consolidated Statement of Operations $22,511 $ 26,809 $22,288 $15,908 $12,474 Add: Amortization of debt expense 1,185 701 471 Portion of rental expense representative of interest factor (1) 20,430 19,225 15,544 11,621 9,294 ------- -------- ------- ------- ------- $44,126 $ 46,735 $38,303 $27,529 $21,768 ======= ======== ======= ======= ======= - ----------- (1) Interest factor based on management's estimates and approximates one-third of rental expense. US ONCOLOGY, INC. COMPUTATION OF RATIO OF ADJUSTED EARNINGS TO FIXED CHARGES 2001 2000 1999 1998 1997 Net income (loss) per the Consolidated Statement of Operations $ 46,316 $(72,643) $ 48,155 $ 59,981 $15,635 Minority interest (1,997) (944) (634) (540) (437) Income taxes 28,388 (35,047) 32,229 36,184 11,593 Fixed charges 44,126 46,735 38,303 27,529 21,768 Unusual items: - - - - - Bad debt expense 10,198 37,841 Impairment, restructuring and other charges 5,868 201,846 29,014 Gain on investment in common stock (27,566) (14,431) -------- -------- -------- -------- ------- Adjusted earnings $122,701 $122,579 $132,636 $123,154 $86,400 ======== ======== ======== ======== ======= Fixed charges $ 44,126 $ 46,735 $ 38,303 $ 27,529 $21,768 ======== ======== ======== ======== ======= Ratio of adjusted earnings to fixed charges 2.78 2.62 3.46 4.47 3.97 ======== ======== ======== ======== ======= Detail of Fixed Charges Interest charges per the Consolidated Statement of Operations $ 22,511 $ 26,809 $ 22,288 $ 15,908 $12,474 Add: Amortization of debt expense 1,185 701 471 Portion of rental expense representative of interest factor (1) 20,430 19,225 15,544 11,621 9,294 -------- -------- -------- -------- ------- $ 44,126 $ 46,735 $ 38,303 $ 27,529 $21,768 ======== ======== ======== ======== ======= (1) Interest factor based on management's estimates and approximates one-third of rental expense.