EXHIBIT 16 Andersen Arthur Andersen LLP Suite 1300 711 Louisiana Houston, Texas 77002-2786 Tel-713-237-2323 Fax-713-237-2786 www.andersen.com May 23, 2002 Office of the Chief Accountant Securities and Exchange Commission 450 Fifth Street, N.W. Washington, D.C. 20549 Dear Sir/Madam: We have read Item 4 included in the Form 8-K dated May 23, 2002 of Tanox, Inc. to be filed with the Securities and Exchange Commission and are in agreement with the statements contained therein. Very truly yours, Arthur Andersen LLP Copy to: Ms. Nancy T. Chang, President and CEO, Tanox, Inc.