EXHIBIT 10.1
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               AMENDMENT TO THE AMERICAN ONCOLOGY RESOURCES, INC.
                  1993 NON-EMPLOYEE DIRECTOR STOCK OPTION PLAN

     The Board of Directors of the Company adopted the American Oncology
Resources, Inc. 1993 Non-Employee Director Stock Option Plan (the "Plan") in
June 1993 and the Company's Stockholders approved the Plan in February 1994.
Subject to the provisions of the Plan, the Board retained the right to amend the
Plan.  On March 22, 1996, the Board determined that the Plan be amended as
follows, subject to, and to be effective upon, approval by the Company's
Stockholders.  At the annual meeting of Stockholders on May 9, 1996, the
Stockholders of the Company approved the Plan.  Capitalized terms not otherwise
defined in this First Amendment to the Plan have the meanings assigned thereto
in the Plan.

The Plan is hereby amended as follows:

A.   The definition of "Eligible Director" in Section II(a)(9) of the Plan is
hereby amended to read in its entirety as follows:

          (9)  "Eligible Director" means a person who as of any applicable date
               (i) is a member of the Board, (ii) is not an officer of the
               Company or any subsidiary of the Company and (iii) is not a full-
               time employee of the Company or any of its subsidiaries.

B.   Section III of the Plan is hereby amended to read in its entirety as
follows:

          III.  GRANTS OF STOCK OPTIONS; OPTION PRICE; VESTING SCHEDULE

          (a) Options will be granted only to individuals who are Eligible
          Directors of the Company. On the date of each annual meeting of
          stockholders of the Company after January 1, 1996, each Eligible
          Director elected at such annual meeting shall receive, without the
          exercise of the discretion of any person or persons, an option to
          purchase 1,000 shares.  All Options granted under the Plan shall be at
          the Option price set forth in the following subsection (b), shall be
          subject to adjustment as provided in Section VII and to the terms and
          conditions set forth in Section VIII and shall vest in the manner set
          forth in the following subsection (c).  All options granted under the
          Plan shall be evidenced by a written option agreement.

          (b) The purchase price of Shares issued under each Option shall be the
          Fair Market Value of Shares subject to the Option on the date the
          Option is granted.

 
          (c) Except to the extent otherwise provided herein, each Option
          granted under subsection (a) above shall vest and be exercisable as to
          all of the Shares covered thereby six months after the effective date
          of the grant of such Option.

C.   Section VII(b) of the Plan is hereby amended to read in its entirety as
follows:

          (b) If the Company shall effect a subdivision or consolidation of
          shares or other capital readjustment, the payment of a stock dividend,
          or other increase or reduction of the number of shares of Common Stock
          outstanding, without receiving compensation therefor in money,
          services or property, then (a) the number and per share price of
          shares of Common Stock to be granted pursuant to annual grants in
          subsection III(a) hereof shall be appropriately adjusted in such a
          manner as to entitle a Participant to receive options to purchase the
          same total number of shares as he would have received had he or she
          been granted such option immediately prior to the event requiring the
          adjustment; (b) the number and per share price of shares of Common
          Stock subject to outstanding Stock Options hereunder shall be
          appropriately adjusted in such a manner as to entitle a Participant to
          receive upon exercise of a Stock Option, for the same aggregate cash
          consideration, the same total number of shares as he would have
          received had he or she exercised his or her Stock Option in full
          immediately prior to the event requiring the adjustment; and (c) the
          number of shares then reserved for issuance under the Plan shall be
          adjusted by substituting for the total number of shares of Common
          Stock then reserved that number of shares of Common Stock that would
          have been received by the owner of an equal number of outstanding
          shares of Common Stock as the result of the event requiring the
          adjustment.