EXHIBIT 10.54
 
                                   AGREEMENT
                                   ---------

     This Agreement, made and entered into this ________ day of 
____________________ ("Agreement"), is by and between Texas Biotechnology 
Corporation, a Delaware corporation ("Company"), and ____________________ 
("Indemnitee"):

     WHEREAS, highly competent persons are becoming more reluctant to serve 
publicly-held corporations as directors or in other capacities unless they are 
provided with adequate protection through insurance or adequate indemnification 
against inordinate risks or claims and actions against them arising out of their
service to, and activities on behalf of, the corporation; and

     WHEREAS, the current impracticability of obtaining adequate insurance and 
the uncertainties relating to indemnification have increased the difficulty of 
attracting and retaining such persons;

     WHEREAS, the Board of Directors of the Company (the "Board") has determined
that the inability to attract and retain such persons is detrimental to the best
interests of the Company's stockholders and that the Company should act to 
assure such persons that there will be increased certainty of such protection in
the future; and

     WHEREAS, it is reasonable, prudent and necessary for the Company 
contractually to obligate itself to indemnify such persons to the fullest extent
permitted by applicable law so that they will serve or continue to serve the 
Company free from undue concern that they will not be so indemnified;

     WHEREAS, Indemnitee is willing to serve, continue to serve and to take on 
additional service for or on behalf of the Company on the condition that he be 
so indemnified; and

     NOW, THEREFORE, in consideration of the premises and the covenants 
contained herein, the Company and Indemnitee do hereby covenant and agree as 
follows:

     Section 1. Services by Indemnitee. Indemnitee agrees to serve as 
______________ of the Company. Indemnitee may at any time and for any reason 
resign from such position (subject to any other contractual obligation or any 
obligation imposed by operation of law), in which event the Company shall have 
no obligation under this Agreement to continue Indemnitee in any such position.

     Section 2. Indemnification - General. The Company shall indemnify, and 
advance Expenses (as hereinafter defined), to Indemnitee as provided in this 
Agreement and to the fullest extent permitted by applicable law in effect on the
date hereof and to such greater extent as applicable law may thereafter from 
time to time permit. The rights of Indemnitee provided under


 
the preceding sentence shall include, but shall not be limited to, the rights 
set forth in the other Sections of this Agreement.

     Section 3. Proceedings Other Than Proceedings by or in the Right of the 
Company. Indemnitee shall be entitled to the rights of indemnification provided 
in this Section 3 if, by reason of his Corporate Status (as hereinafter defined)
or by reason of anything done or not done by Indemnitee in any such capacity, he
is, or is threatened to be made, a party to any threatened, pending, or 
completed Proceeding (as hereinafter defined), other than a Proceeding by or in 
the right of the Company. Pursuant to this Section 3, Indemnitee shall be 
indemnified to the full extent of the law against Expenses, judgments, 
penalties, fines and amounts paid in settlement (including all interest, 
assessments, and other charges paid or payable in connection with or in respect 
of such expenses, judgments, fines, penalties or amounts paid in settlement) 
actually and reasonably incurred by him or on his behalf in connection with such
Proceeding or any claim, issue or matter therein, if he acted in good faith and 
in a manner he reasonably believed to be in or not opposed to the best interests
of the Company, and, with respect to any criminal Proceeding, had no reasonable 
cause to believe his conduct was unlawful.

     Section 4. Proceedings by or in the Right of the Company. Indemnitee shall 
be entitled to the rights of indemnification provided in this Section 4 if, by 
reason of his Corporate Status, he is, or is threatened to be made, a party to 
any threatened, pending or completed Proceeding brought by or in the right of 
the Company to procure a judgment in its favor. Pursuant to this Section, 
Indemnitee shall be indemnified to the full extent of the law against Expenses 
actually and reasonably incurred by him or on his behalf in connection with such
Proceeding if he acted in good faith and in a manner he reasonably believed to 
be in or not opposed to the best interests of the Company. Notwithstanding the 
foregoing, no indemnification against such Expenses shall be made in respect of 
any claim, issue or matter in such Proceeding as to which Indemnitee shall have 
been adjudged to be liable to the Company if applicable law prohibits such 
indemnification; provided, however, that, if applicable law so permits, 
indemnification against Expenses shall nevertheless be made by the Company in 
such event if and only to the extent that the Court of Chancery of the State of 
Delaware, or the court in which such Proceeding shall have been brought or is 
pending, shall determine.

     Section 5. Indemnification for Expenses of a Party Who is Wholly or Partly 
Successful. Notwithstanding any other provision of this Agreement, to the extent
that Indemnitee is, by reason of his Corporate Status, a party to and is 
successful, on the merits or otherwise, in any Proceeding, he shall be 
indemnified against all Expenses actually and reasonably incurred by him or on 
his behalf in connection therewith. If Indemnitee is not wholly successful in 
such Proceeding but is successful, on the merits or otherwise, as to one or more
but less than all claims, issues or matters in such Proceeding, the Company 
shall indemnify Indemnitee against all Expenses actually and reasonably incurred
by him or on his behalf in connection with each successfully resolved claim, 
issue or matter. For purposes of this Section and without limitation, the 
termination of any claim, issue or matter in such a Proceeding by dismissal, 
with or without prejudice, shall be deemed to be a successful result as to such 
claim, issue or matter.

                                       2

 
     Section 6. Indemnification for Expenses of a Witness. Notwithstanding any 
other provision of this Agreement, to the extent that Indemnitee is, by reason 
of his Corporate Status, a witness in any Proceeding, he shall be indemnified 
against all Expenses actually and reasonably incurred by him or on his behalf in
connection therewith.

     Section 7. Advancement of Expenses. The Company shall advance all 
reasonable Expenses incurred by or on behalf of Indemnitee in connection with 
any Proceeding within two days after the receipt by the Company of a statement 
or statements from Indemnitee requesting such advance or advances from time to 
time, whether prior to or after final disposition of such Proceeding. Such 
statement or statements shall reasonably evidence the Expenses incurred by 
Indemnitee and shall include or be preceded or accompanied by an undertaking by 
or on behalf of Indemnitee to repay any Expenses advanced if it shall ultimately
be determined that Indemnitee is not entitled to be indemnified against such 
Expenses; provided, however, that Indemnitee shall not be required to reimburse 
Company for any advancement of Expenses until a final judicial determination is 
made (as to which all rights of appeal have been exhausted or lapsed).

     Section 8. Procedure for Determination of Entitlement to Indemnification.

             (a) To obtain indemnification under this Agreement, Indemnitee 
shall submit to the Company a written request, including therein or therewith 
such documentation and information as is reasonably available to Indemnitee and
is reasonably necessary to determine whether and to what extent Indemnitee is 
entitled to indemnification. The Secretary of the Company shall, promptly upon 
receipt of such a request for indemnification, advise the Board of Directors in 
writing that Indemnitee has requested indemnification.

             (b) Upon written request by Indemnitee for indemnification pursuant
to the first sentence of Section 8(a) hereof, a determination, if required by 
applicable law, with respect to Indemnitee's entitlement thereto shall be made 
in the specific case: (i) if a Change in Control (as hereinafter defined) shall 
have occurred, by Independent Counsel (as hereinafter defined) (unless 
Indemnitee shall request that such determination be made by the Board of 
Directors or the stockholders, in which case by the person or persons or in the 
manner provided for in clauses (ii) or (iii) of this Section 8(b)) in a written 
opinion to the Board of Directors, a copy of which shall be delivered to 
Indemnitee; (ii) if a Change of Control shall not have occurred, (A) by the 
Board of Directors by a majority vote of a quorum consisting of Disinterested 
Directors (as hereinafter defined), or (B) if a quorum of the Board of Directors
consisting of Disinterested Directors is not obtainable or, even if obtainable, 
such quorum of Disinterested Directors so directs, by Independent Counsel in a 
written opinion to the Board of Directors, a copy of which shall be delivered to
Indemnitee or (C) if so directed by the Board of Directors, by the stockholders 
of the Company; or (iii) as provided in Section 9(b) of this Agreement; and, if 
it is so determined that Indemnitee is entitled to Indemnification, payment to
Indemnitee shall be made within ten (10) days after such determination. 
Indemnitee shall cooperate with the person, persons or entity making such 
determination with respect to Indemnitee's entitlement to indemnification, 
including

                                       3


providing to such person, persons or entity upon reasonable advance request any 
documentation or information which is not privileged or otherwise protected from
disclosure and which is reasonably available to Indemnitee and reasonably 
necessary to such determination. Any costs or expenses (including attorneys, 
fees and disbursements) incurred by Indemnitee in so cooperating with the 
person, persons or entity making such determination shall be borne by the 
Company (irrespective of the determination as to Indemnitee's entitlement to 
indemnification) and the Company hereby indemnifies and agrees to hold 
Indemnitee harmless therefrom.

        (c) In the event the determination of entitlement to indemnification is 
to be made by Independent Counsel pursuant to Section 8(b) hereof, the 
Independent Counsel shall be selected as provided in this Section 8(c). If a 
Change of Control shall not have occurred, the Independent Counsel shall be 
selected by the Board of Directors, and the Company shall give written notice to
Indemnitee advising him of the identity of the Independent Counsel so selected. 
If a Change of Control shall have occurred, the Independent Counsel shall be 
selected by Indemnitee (unless Indemnitee shall request that such selection be 
made by the Board of Directors, in which event the preceding sentence shall 
apply), and Indemnitee shall give written notice to the Company advising it of 
the identity of the Independent Counsel so selected. In either event, Indemnitee
or the Company, as the case may be, may, within 7 days after such written notice
of selection shall have been given, deliver to the Company or to Indemnitee, as 
the case may be, a written objection to such selection. Such objection may be 
asserted only on the ground that the Independent Counsel so selected does not 
meet the requirements of "Independent Counsel" as defined in Section 17 of this 
Agreement, and the objection shall set forth with particularity the factual 
basis of such assertion. If such written objection is made, the Independent 
Counsel so selected may not serve as Independent Counsel unless and until a 
court has determined that such objection is without merit. If, within 20 days 
after submission by Indemnitee of a written request for indemnification pursuant
to Section 8(a) hereof, no Independent Counsel shall have been selected without 
objection, either the Company or Indemnitee may petition the Court of Chancery 
of the State of Delaware or other court of competent jurisdiction for 
resolution of any objection which shall have been made by the Company or 
Indemnitee to the other's selection of Independent Counsel and/or for the 
appointment as Independent Counsel of a person selected by the Court or by such 
other person as the Court shall designate, and the person with respect to whom 
an objection is so resolved or the person so appointed shall act as Independent 
Counsel under Section 8(b) hereof. The Company shall pay any and all reasonable 
fees and expenses of Independent Counsel incurred by such Independent Counsel in
connection with acting pursuant to Section 8(b) hereof, and the Company shall 
pay all reasonable fees and expenses incident to the procedures of this Section 
8(c), regardless of the manner in which such Independent Counsel was selected or
appointed.  Upon the due commencement of any judicial proceeding or arbitration 
pursuant to Section 10(a)(iii) of this Agreement, Independent Counsel shall be 
discharged and relieved of any further responsibility in such capacity (subject 
to the applicable standards of professional conduct then prevailing).

                                       4

 

    Section 9.  Presumptions and Effect of Certain Proceedings.

        (a) In making a determination with respect to entitlement to
indemnification hereunder, the person or persons or entity making such
determination shall presume that Indemnitee is entitled to indemnification under
this Agreement if Indemnitee has submitted a request for indemnification in
accordance with Section 8(a) of this Agreement, and the Company shall have the
burden of proof to overcome that presumption in connection with the making by
any person, persons or entity of any determination contrary to that presumption.

        (b) If the person, persons or entity empowered or selected under Section
8 of this Agreement to determine whether Indemnitee is entitled to 
indemnification shall not have made a determination within 60 days after receipt
by the Company of the request therefor, the requisite determination of 
entitlement to indemnification shall be deemed to have been made and Indemnitee
shall be entitled to such indemnification, absent (i) a misstatement by
Indemnitee of a material fact, or an omission of a material fact necessary to
make Indemnitee's statement not materially misleading, in connection with the
request for indemnification, or (ii) a prohibition of such indemnification under
applicable law; provided, however, that such 60-day period may be extended for a
reasonable time, not to exceed an additional 30 days, if the person, persons or
entity making the determination with respect to entitlement to indemnification
in good faith requires such additional time for the obtaining or evaluating of
documentation and/or information relating thereto; and provided, further, that
the foregoing provisions of this Section 9(b) shall not apply (i) if the
determination of entitlement to indemnification is to be made by the
stockholders pursuant to Section 8(b) of this Agreement and if (A) within 15
days after receipt by the Company of the request for such determination the
Board of Directors has resolved to submit such determination to the stockholders
for their consideration at an annual meeting thereof to be held within 75 days
after such receipt and such determination is made thereat, or (B) a special
meeting of stockholders is called within 15 days after such receipt for the
purpose of making such determination, such meeting is held for such purpose
within 60 days after having been so called and such determination is made
thereat, or (ii) if the determination of entitlement to indemnification is to be
made by Independent Counsel pursuant to Section 8(b) of this Agreement.

        (c) The termination of any Proceeding or of any claim, issue or matter 
therein, by judgment, order, settlement or conviction, or upon a plea of nolo 
contendere or its equivalent, shall not (except as otherwise expressly provided 
in this Agreement) of itself adversely affect the right of Indemnitee to 
indemnification or create a presumption that Indemnitee did not act in good 
faith and in a manner which he reasonably believed to be in or not opposed to 
the best interests of the Company or, with respect to any criminal Proceeding, 
that Indemnitee had reasonable cause to believe that his conduct was unlawful.
    
    Section 10.  Remedies of Indemnitee.
        
        (a) In the event that (i) a determination is made pursuant to Section 8 
of this Agreement that Indemnitee is not entitled to indemnification under this 
Agreement, or (ii)

                                       5


 
advancement of Expenses is not timely made pursuant to Section 7 of this 
Agreement, or (iii) the determination of entitlement to indemnification is to be
made by Independent Counsel pursuant to Section 8(b) of this Agreement and such 
determination shall not have been made and delivered in a written opinion within
90 days after receipt by the Company of the request for indemnification, or (iv)
payment of indemnification is not made pursuant to Section 6 of this Agreement 
within ten (10) days after receipt by the Company of a written request therefor,
or (v) payment of indemnification is not made within ten (10) days after a 
determination has been made that Indemnitee is entitled to indemnification or 
such determination is deemed to have been made pursuant to Sections 8 or 9 of 
this Agreement, Indemnitee shall be entitled to an adjudication in an 
appropriate court of the State of Delaware, or in any other court of competent 
jurisdiction, of his entitlement to such indemnification or advancement of 
Expenses, and Company hereby consents to service of process and to appear in any
such proceeding. Alternatively, Indemnitee, at his option, may seek an award in 
arbitration to be conducted by a single arbitrator pursuant to the rules of the 
American Arbitration Association. Indemnitee shall commence such proceeding 
seeking an adjudication or an award in arbitration within 180 days following the
date on which Indemnitee first has the right to commence such proceeding 
pursuant to this Section 10(a); provided, however, that the foregoing clause 
shall not apply in respect of a proceeding brought by an Indemnitee to enforce 
his rights under Section 5 of the Agreement.

             (b) In the event that a determination shall have been made pursuant
to Section 8 of this Agreement that Indemnitee is not entitled to 
indemnification, any judicial proceeding or arbitration commenced pursuant to 
this Section 10 shall be conducted in all respects as a de novo trial, or 
arbitration, on the merits and Indemnitee shall not be prejudiced by reason of 
that adverse determination. If a Change of Control shall have occurred, in any 
judicial proceeding or arbitration commenced pursuant to this Section 10 the 
Company shall have the burden of proving that Indemnitee is not entitled to 
indemnification or advancement of Expenses, as the case may be.

             (c) If a determination shall have been made or deemed to have been 
made pursuant to Section 8 or 9 of this Agreement that Indemnitee is entitled to
indemnification, the Company shall be bound by such determination in any 
judicial proceeding or arbitration commenced pursuant to this Section 10, absent
(i) a misstatement by Indemnitee of a material fact, or an omission of a 
material fact necessary to make Indemnitee's statement not materially 
misleading, in connection with the request for indemnification, or (ii) a 
prohibition of such indemnification under applicable law.

             (d) The Company shall be precluded from asserting in any judicial 
proceeding or arbitration commenced pursuant to this Section 10 that the 
procedures and presumptions of this Agreement are not valid, binding and 
enforceable and shall stipulate in any such court or before any such arbitrator 
that the Company is bound by all the provisions of this Agreement.

             (e) In the event that Indemnitee, pursuant to this Section 10, 
seeks a judicial adjudication of or an award in arbitration to enforce his 
rights under, or to recover damages for 

                                       6

 
breach of, this Agreement, Indemnitee shall be entitled to recover from the 
Company, and shall be indemnified by the Company against, any and all expenses 
(of the types described in the definition of Expenses in Section 17 of this 
Agreement) actually and reasonably incurred by him in such judicial adjudication
or arbitration, but only if he prevails therein. If it shall be determined in 
said judicial adjudication or arbitration that Indemnitee is entitled to receive
part but not all of the indemnification or advancement of expenses sought, the 
expenses incurred by Indemnitee in connection with such judicial adjudication or
arbitration shall be appropriately prorated.

     Section 11.  Non-Exclusivity; Insurance; Subrogation; No Duplicate
Payments.

             (a) The rights of indemnification and to receive advancement of 
Expenses as provided by this Agreement shall not be deemed exclusive of any 
other rights to which Indemnitee may at any time be entitled under applicable 
law, the Certificate of Incorporation, the By-Laws, any agreement, a vote of 
stockholders or a resolution of directors, or otherwise. No amendment, 
alteration or repeal of this Agreement or any provision hereof shall be 
effective as to any Indemnitee with respect to any action taken or omitted by 
such Indemnitee in his Corporate Status prior to such amendment, alteration or 
repeal.

             (b) To the extent that the Company maintains an insurance policy or
policies providing liability insurance for directors, officers, employees, 
agents or fiduciaries of the Company or of any other corporation, partnership, 
joint venture, trust, employee benefit plan or other enterprise, which such 
person serves at the request of the Company, Indemnitee shall be covered by such
policy or policies in accordance with its or their terms to the maximum extent 
of the coverage available for any such director, officer, employee or agent 
under such policy or policies.

             (c) In the event of any payment under this Agreement, the Company 
shall be subrogated to the extent of such payment to all of the rights of 
recovery of Indemnitee, who shall execute all papers required and take all 
action necessary to secure such rights, including execution of such documents as
are necessary to enable the Company to bring suit to enforce such rights.

             (d) The Company shall not be liable under this Agreement to make 
any payment of amounts otherwise indemnifiable hereunder if and to the extent 
that Indemnitee has otherwise actually received such payment under any insurance
policy, contract, agreement or otherwise.

     Section 12. Binding Effect; Survival of Rights. This Agreement shall be 
binding upon and inure to the benefit of and be enforceable by the parties and 
their respective successors, assigns (including any direct or indirect 
successors by purchase, merger, consolidation or otherwise to all or 
substantially all of the business and/or assets of the Company), spouses, heirs,
executors, administrators, and personal and legal representatives. The Company 
shall require and cause any successor (whether direct or indirect by purchase, 
merger, consolidation or otherwise) to all, substantially all or a substantial 
part, of the business and/or assets of the Company, by

                                       7

 
written agreement in form and substance satisfactory to the Indemnitee, 
expressly to assume and agree to perform this Agreement in the same manner and 
to the same extent that the Company would be required to perform if no such 
succession had taken place. This Agreement shall continue in effect regardless 
of whether Indemnitee continues to serve as an officer or director of the 
Company or of any other enterprise at the Company's request.

     Section 13. Limitations Period. No legal action shall be brought and no 
cause of action shall be asserted by or in the right of the Company or any 
affiliate of the Company against Indemnitee, Indemnitee's spouse, heirs, 
executors or personal or legal representatives after the expiration of two years
from the date of accrual of such cause of action, and any claim or cause of 
action of the Company or its affiliate shall be extinguished and deemed released
unless asserted by the timely filing of a legal action within such two year 
period; provided, however, that if any shorter period of limitations is 
otherwise applicable to any such cause of action such shorter period shall 
govern.

     Section 14. Severability. If any provision of this Agreement shall be held 
to be invalid, illegal or unenforceable for any reason whatsoever: (a) the 
validity, legality and enforceability of the remaining provisions of this 
Agreement (including without limitation, each portion of any Section of this 
Agreement containing any such provision held to be invalid, illegal or 
unenforceable, that is not itself invalid, illegal or unenforceable) shall not 
in any way be affected or impaired thereby; and (b) to the fullest extent 
possible, the provisions of this Agreement (including, without limitation, each 
portion of any Section of this Agreement containing any such provision held to 
be invalid, illegal or unenforceable, that is not itself invalid, illegal or 
unenforceable) shall be construed so as to give effect to the intent manifested 
by the provision held invalid, illegal or unenforceable.

     Section 15. Exception to Right of Indemnification or Advancement of 
Expenses. Notwithstanding any other provision of this Agreement, Indemnitee 
shall not be entitled to indemnification or advancement of Expenses under this 
Agreement with respect to any Proceeding, or any claim therein, brought or made 
by him against the Company or the Individual Indemnitors, unless the Company has
joined in or consented to the initiation of such Proceeding.

     Section 16. Identical Counterparts. This Agreement may be executed in one 
or more counterparts, each of which shall for all purposes be deemed to be an 
original but all of which together shall constitute one and the same Agreement. 
Only one such counterpart signed by the party against whom enforceability is 
sought needs to be produced to evidence the existence of this Agreement.

     Section 17. Headings. The headings of the paragraphs of this Agreement are 
inserted for convenience only and shall not be deemed to constitute part of this
Agreement or to affect the construction thereof.

     Section 18. Definitions. For purposes of this Agreement:

                                       8

 
             (a) "Change in Control" means a change in control of the Company
occurring after the Effective Date of a nature that would be required to be
reported in response to item 6(e) of Schedule 14A of Regulation 14A (or in
response to any similar item on any similar schedule or form) promulgated under
the Securities Exchange Act of 1934 (the "Act"), whether or not the Company is
then subject to such reporting requirement; provided, however, that, without
limitation, such a Change in Control shall be deemed to have occurred if after
the Effective Date (i) any "person" (as such term is used in Section 13(d) and
14(d) of the Act) is or becomes the "beneficial owner" (as defined in Rule 13d-3
under the Act), directly or indirectly, of securities of the Company
representing 10% or more of the combined voting power of the Company's then
outstanding securities without the prior approval of at least two-thirds of the
members of the Board of Directors in office immediately prior to such person
attaining such percentage interest; (ii) the Company is a party to a merger,
consolidation, sale of assets or other reorganization, or a proxy contest, as a
consequence of which members of the Board of Directors in office immediately
prior to such transaction or event constitute less than a majority of the Board
of Directors thereafter; or (iii) during any period of two consecutive years,
individuals who at the beginning of such period constituted the Board of
Directors (including for this purpose any new director whose election or
nomination for election by the Company's stockholders was approved by a vote of
at least two-thirds of the directors then still in office who were directors at
the beginning of such period) cease for any reason to constitute at least a
majority of the Board of Directors.

             (b) "Corporate Status" describes the status of a person who is or 
was a director, officer, employee, agent or fiduciary of the Company or of any 
other corporation, partnership, joint venture, trust, employee benefit plan or 
other enterprise which such person is or was serving at the request of the 
Company.

             (c) "Disinterested Director" means a director of the Company who is
not and was not a party to the Proceeding in respect of which indemnification is
sought by Indemnitee.

             (d) "Effective Date" means the date of this Agreement.

             (e) "Expenses" shall include all reasonable attorneys' fees, 
retainers, court costs, transcript costs, fees of experts, witness fees, travel 
expenses, duplicating costs, printing and binding costs, telephone charges, 
postage, delivery service fees, and all other disbursements or expenses paid or 
incurred in connection with prosecuting, defending, preparing to prosecute or 
defend, investigating, or being or preparing to be a witness in a Proceeding, 
including on appeal.

             (f) "Independent Counsel" means a law firm, or a member of a law 
firm, that is experienced in matters of corporation law and neither presently 
is, nor in the past five years has been, retained to represent: (i) the Company 
or Indemnitee in any matter material to either such party, or (ii) any other 
party to the Proceeding giving rise to a claim for indemnification hereunder. 
Notwithstanding the foregoing, the term "Independent Counsel" shall not include 
any 

                                       9

 
person who, under the applicable standards of professional conduct then 
prevailing, would have a conflict of interest in representing either the Company
or Indemnitee in an action to determine Indemnitee's rights under this 
Agreement.

             (g) "Proceeding" includes any action, suit, arbitration, alternate 
dispute resolution mechanism, administrative hearing, inquiry or investigation, 
whether civil, criminal, administrative or other (whether instituted by the 
Company or any other party), or any inquiry or investigation that Indemnitee in 
good faith believes might lead to the institution of any such action, suit, or 
proceeding, whether civil, criminal, administrative, investigative, or other; 
Notwithstanding the foregoing, the term "Proceeding" shall not include any 
action, suit, arbitration, alternate dispute resolution mechanism, 
administrative hearing, or any inquiry or investigation initiated by an 
Indemnitee pursuant to Section 10 of this Agreement to enforce his rights under 
this Agreement.

     Section 19. Modification and Waiver. No supplement, modification or 
amendment of this Agreement shall be binding unless executed in writing by both 
of the parties hereto. No waiver of any of the provision of this Agreement shall
be deemed or shall constitute a waiver of any other provision hereof (whether or
not similar) nor shall such waiver constitute a continuing waiver.

     Section 20. Notice by Indemnitee. Indemnitee agrees promptly to notify the 
Company in writing upon being served with any summons, citation, subpoena, 
complaint, indictment, information or other document relating to any Proceeding 
or matter which may be subject to indemnification or advancement of Expenses 
covered hereunder.

     Section 21. Notices. All notices, requests, demands and other 
communications hereunder shall be in writing and shall be deemed to have been 
duly given if (i) delivered by hand and receipted for by the party to whom said 
notice or other communication shall have been directed, or (ii) mailed by 
certified or registered mail with postage prepaid, on the third business day 
after the date on which it is so mailed:

             (a)  If to Indemnitee, to:

                         ____________________________________________
                         ____________________________________________
                         ____________________________________________

             (b)  If to the Company, to:

                          Texas Biotechnology Corporation
                          7000 Fannin, Suite 1920
                          Houston, Texas 77030

                                      10

 
or to such other address as may have been furnished to Indemnitee by the Company
or to the Company by Indemnitee, as the case may be.

     Section 22. Governing Law. The parties agree that this Agreement shall be 
governed by, and construed and enforced in accordance with, the laws of the 
State of Delaware.

     Section 23. Miscellaneous. Use of the masculine pronoun shall be deemed to 
include usage of the feminine pronoun where appropriate.

     IN WITNESS WHEREOF, the parties hereto have executed this Agreement on the 
day and year first above written.

                                       TEXAS BIOTECHNOLOGY CORPORATION

                                       By: 
                                          ----------------------------------

                                       Indemnitee
                                       
                                       -------------------------------------

                                      11