ARONEX PHARMACEUTICALS, INC. EXHIBIT 11.1 ------------ Statement Regarding Computation of Per Share Earnings The following reflects the information used in calculating the number of shares in the computation of net loss per share for each of the periods set forth in the Statements of Operations. Average Loss Days Shares Per Shares Outstanding Shares X Days Outstanding Loss Share YEAR ENDED DECEMBER 31, 1996: 10,380,056 1 10,380,056 10,390,003 10 103,900,030 10,409,608 4 41,638,432 10,418,676 2 20,837,352 10,478,786 1 10,478,786 10,046,458 3 30,139,374 10,598,792 1 10,598,792 10,678,561 2 21,357,122 10,680,653 1 10,680,653 10,680,903 3 32,042,709 10,710,132 4 42,840,528 10,718,504 6 64,311,024 10,727,170 4 42,908,680 10,728,565 1 10,728,565 10,729,263 1 10,729,263 10,729,394 7 75,105,758 10,731,487 19 203,898,253 10,742,559 7 75,197,913 10,771,115 2 21,542,230 10,775,477 2 21,550,954 10,776,991 4 43,107,964 10,784,842 1 10,784,842 10,812,921 1 10,812,921 10,832,546 2 21,665,092 10,847,725 3 32,543,175 10,848,023 5 54,240,115 10,849,767 7 75,948,369 10,851,626 3 32,554,878 10,858,605 1 10,858,605 10,862,095 2 21,724,190 10,962,004 1 10,962,004 10,962,593 4 43,850,372 10,965,241 2 21,930,482 10,965,939 1 10,965,939 10,967,993 6 65,807,958 10,927,354 5 54,636,770 10,997,354 2 21,994,708 10,978,310 7 76,848,170 10,983,980 4 43,935,920 10,989,215 1 10,989,215 13,992,587 1 13,992,587 13,996,077 1 13,996,077 13,996,949 6 83,981,694 14,446,949 1 14,446,949 14,453,492 5 72,267,460 14,456,109 5 72,280,545 14,465,806 1 14,465,806 14,472,786 2 28,945,572 14,473,658 1 14,473,658 14,478,658 3 43,435,974 14,481,500 1 14,481,500 14,483,680 3 43,451,040 14,484,059 1 14,484,059 14,485,899 2 28,971,798 14,488,079 3 43,464,237 14,526,802 3 43,580,406 14,526,802 23 334,116,446 14,531,016 1 14,531,016 14,543,516 20 290,870,320 14,543,736 1 14,543,736 14,544,318 18 261,797,724 14,545,238 2 29,090,476 14,545,321 7 101,817,247 14,555,018 14 203,770,252 14,556,217 5 72,781,085 14,557,089 8 116,456,712 14,563,193 17 247,574,281 14,568,375 3 43,705,125 14,569,375 7 101,985,625 14,570,954 3 43,712,862 14,579,548 4 58,318,192 14,582,198 1 14,582,198 14,583,853 3 43,751,559 14,584,853 3 43,754,559 14,586,353 14 204,208,942 14,595,950 10 145,959,500 14,596,513 11 160,561,643 14,597,247 8 116,777,976 365 4,762,415,001 /365 13,047,712 (8,030,000) (0.62) Page 1 of 2 ARONEX PHARMACEUTICALS, INC. EXHIBIT 11.1 ------------ STATEMENT REGARDING COMPUTATION OF PER SHARE EARNINGS The following reflects the information used in calculating the number of shares in the computation of net loss per share for each of the periods set forth in the Statements of Operations. Average Loss Days Shares Per Shares Outstanding Shares X Days Outstanding Loss Share YEAR ENDED DECEMBER 31, 1995: 5,202,476 2 10,404,952 5,214,976 2 10,429,952 5,221,604 82 428,171,528 5,232,463 57 298,250,391 5,233,599 41 214,577,559 5,233,978 18 94,211,604 5,235,493 51 267,010,143 9,128,929 20 182,578,580 9,136,184 34 310,630,256 9,200,154 3 27,600,462 9,201,669 2 18,403,338 9,202,805 12 110,433,660 9,216,760 1 9,216,760 9,217,843 6 55,307,058 9,260,401 3 27,781,203 9,274,343 5 46,371,715 9,316,912 2 18,633,824 9,857,533 5 49,287,665 9,887,531 5 49,437,655 9,899,311 2 19,798,622 9,900,249 2 19,800,498 9,902,749 4 39,610,996 9,969,021 2 19,938,042 9,981,786 3 29,945,358 10,380,056 1 10,380,056 365 2,368,211,877 /365 6,488,252 (17,429,000) (2.69) YEAR ENDED DECEMBER 31, 1994: 5,121,202 12 61,454,424 5,124,331 33 169,102,923 5,130,013 91 466,831,183 5,131,149 39 200,114,811 5,136,199 17 87,315,383 5,136,313 60 308,178,780 5,202,476 113 587,879,788 365 1,880,877,292 /365 5,153,088 (9,052,000) (1.76) Page 2 of 2