ARONEX PHARMACEUTICALS, INC.
                                                                    EXHIBIT 11.1
                                                                    ------------
             Statement Regarding Computation of Per Share Earnings

The following reflects the information used in calculating the number of shares 
in the computation of net loss per share for each of the periods set forth in 
the Statements of Operations. 
 
 
                                                           Average                    Loss
                        Days                               Shares                      Per
        Shares      Outstanding  Shares X Days           Outstanding       Loss       Share
                                                                        
YEAR ENDED DECEMBER 31, 1996:
        10,380,056      1           10,380,056                                       
        10,390,003     10          103,900,030
        10,409,608      4           41,638,432
        10,418,676      2           20,837,352
        10,478,786      1           10,478,786
        10,046,458      3           30,139,374
        10,598,792      1           10,598,792
        10,678,561      2           21,357,122
        10,680,653      1           10,680,653
        10,680,903      3           32,042,709
        10,710,132      4           42,840,528
        10,718,504      6           64,311,024
        10,727,170      4           42,908,680
        10,728,565      1           10,728,565
        10,729,263      1           10,729,263
        10,729,394      7           75,105,758
        10,731,487     19          203,898,253
        10,742,559      7           75,197,913
        10,771,115      2           21,542,230
        10,775,477      2           21,550,954
        10,776,991      4           43,107,964
        10,784,842      1           10,784,842
        10,812,921      1           10,812,921
        10,832,546      2           21,665,092
        10,847,725      3           32,543,175
        10,848,023      5           54,240,115
        10,849,767      7           75,948,369
        10,851,626      3           32,554,878
        10,858,605      1           10,858,605
        10,862,095      2           21,724,190
        10,962,004      1           10,962,004
        10,962,593      4           43,850,372
        10,965,241      2           21,930,482
        10,965,939      1           10,965,939
        10,967,993      6           65,807,958
        10,927,354      5           54,636,770
        10,997,354      2           21,994,708
        10,978,310      7           76,848,170
        10,983,980      4           43,935,920
        10,989,215      1           10,989,215
        13,992,587      1           13,992,587
        13,996,077      1           13,996,077
        13,996,949      6           83,981,694
        14,446,949      1           14,446,949
        14,453,492      5           72,267,460
        14,456,109      5           72,280,545
        14,465,806      1           14,465,806
        14,472,786      2           28,945,572
        14,473,658      1           14,473,658
        14,478,658      3           43,435,974
        14,481,500      1           14,481,500
        14,483,680      3           43,451,040
        14,484,059      1           14,484,059
        14,485,899      2           28,971,798
        14,488,079      3           43,464,237
        14,526,802      3           43,580,406
        14,526,802     23          334,116,446
        14,531,016      1           14,531,016
        14,543,516     20          290,870,320
        14,543,736      1           14,543,736
        14,544,318     18          261,797,724
        14,545,238      2           29,090,476
        14,545,321      7          101,817,247
        14,555,018     14          203,770,252
        14,556,217      5           72,781,085
        14,557,089      8          116,456,712
        14,563,193     17          247,574,281
        14,568,375      3           43,705,125
        14,569,375      7          101,985,625
        14,570,954      3           43,712,862
        14,579,548      4           58,318,192
        14,582,198      1           14,582,198
        14,583,853      3           43,751,559
        14,584,853      3           43,754,559
        14,586,353     14          204,208,942
        14,595,950     10          145,959,500
        14,596,513     11          160,561,643
        14,597,247      8          116,777,976
                      365        4,762,415,001  /365      13,047,712   (8,030,000)   (0.62)
 
                                  Page 1 of 2



                         ARONEX PHARMACEUTICALS, INC.
                                                                    EXHIBIT 11.1
                                                                    ------------
             STATEMENT REGARDING COMPUTATION OF PER SHARE EARNINGS

The following reflects the information used in calculating the number of shares
in the computation of net loss per share for each of the periods set forth in 
the Statements of Operations.
                                                   Average               Loss
                         Days                       Shares                Per
              Shares  Outstanding  Shares X Days  Outstanding   Loss     Share
                      
YEAR ENDED DECEMBER 31, 1995:

              5,202,476    2      10,404,952         
              5,214,976    2      10,429,952
              5,221,604   82     428,171,528
              5,232,463   57     298,250,391
              5,233,599   41     214,577,559                  
              5,233,978   18      94,211,604
              5,235,493   51     267,010,143
              9,128,929   20     182,578,580
              9,136,184   34     310,630,256
              9,200,154    3      27,600,462
              9,201,669    2      18,403,338
              9,202,805   12     110,433,660
              9,216,760    1       9,216,760
              9,217,843    6      55,307,058
              9,260,401    3      27,781,203
              9,274,343    5      46,371,715
              9,316,912    2      18,633,824
              9,857,533    5      49,287,665
              9,887,531    5      49,437,655
              9,899,311    2      19,798,622
              9,900,249    2      19,800,498
              9,902,749    4      39,610,996
              9,969,021    2      19,938,042
              9,981,786    3      29,945,358
             10,380,056    1      10,380,056
                          365  2,368,211,877 /365 6,488,252 (17,429,000) (2.69)

YEAR ENDED DECEMBER 31, 1994:

              5,121,202   12      61,454,424  
              5,124,331   33     169,102,923
              5,130,013   91     466,831,183
              5,131,149   39     200,114,811
              5,136,199   17      87,315,383
              5,136,313   60     308,178,780
              5,202,476  113     587,879,788
                         365   1,880,877,292 /365 5,153,088  (9,052,000) (1.76)

                                  Page 2 of 2