EXHIBIT 10.1
 
                                 ZONAGEN, INC.

                 1996 NONEMPLOYEE DIRECTORS' STOCK OPTION PLAN

                            I. PURPOSE OF THE PLAN



     The ZONAGEN, INC. 1996 NONEMPLOYEE DIRECTORS' STOCK OPTION PLAN (the
"Plan") is intended to promote the interests of ZONAGEN, INC., a Delaware
corporation (the "Company"), and its stockholders by helping to award and retain
highly-qualified independent directors and allowing them to develop a sense of
proprietorship and personal involvement in the development and financial success
of the Company. Accordingly, the Company shall grant to directors of the Company
who are not employees or consultants of the Company or any of its subsidiaries
("Nonemployee Directors") the option ("Option") to purchase shares of the common
stock of the Company ("Stock"), as hereinafter set forth.  Options granted under
the Plan shall be options which do not constitute incentive stock options,
within the meaning of section 422(b) of the Internal Revenue Code of 1986, as
amended.

                            II.  OPTION AGREEMENTS

     Each Option shall be evidenced by a written agreement in the form attached
to the Plan.


                         III.  ELIGIBILITY OF OPTIONEE



     Options may be granted only to individuals who are Nonemployee Directors of
the Company.  Each Nonemployee Director who is in office on the effective date
of this Plan shall receive, on such date, an Option exercisable for 25,000
shares of Stock.  Each nonemployee Director who is elected to the Board of
Directors of the Company (the "Board") for the first time after the effective
date of the Plan shall receive, as of the date of his or her election and
without the exercise of the discretion of any person or persons, an Option
exercisable for 25,000 shares of Stock (subject to adjustment in the same manner
as provided in Paragraph VII hereof with respect to shares of Stock subject to
Options then outstanding).   As of the date of the annual meeting of the
stockholders of the Company in each year that the Plan is in effect as provided
in Paragraph VI hereof, each Nonemployee Director then in office who is not then
entitled to receive an Option pursuant to the preceding sentence shall receive,
without the exercise of the discretion of any person or persons, an Option
exercisable for 2,500 shares of Stock (subject to adjustment in the same manner
as provided in Paragraph VII hereof with respect to shares of Stock subject to
Options then outstanding).  If, as of any date that the Plan is in effect, there
are not sufficient shares of Stock available under the Plan to allow for the
grant to each Nonemployee Director of an Option for the number of shares
provided herein, each Nonemployee Director shall receive an Option for his or
her pro-rata share of the total number of shares of Stock then available under
the Plan.  All Options granted under the Plan shall be at the Option price set
forth in Paragraph V hereof and shall be subject to adjustment as provided in
Paragraph VII hereof.


                        IV.  SHARES SUBJECT TO THE PLAN

     The aggregate number of shares which may be issued under Options granted
under the Plan shall not exceed 400,000 shares of Stock.  Such shares may
consist of authorized but unissued shares of Stock or previously issued shares
of Stock acquired by the Company.  Any of such shares which remain unissued and
which are not subject to outstanding Options at the termination of the Plan
shall cease to be subject to the Plan, but, until termination of the Plan, the
Company shall at all times make available a sufficient number of shares to meet
the 

 
requirements of the Plan.  Should any Option hereunder expire or terminate
prior to its exercise in full, the shares theretofore subject to such Option
which may be issued under the Plan shall be subject to adjustment in the same
manner as provided in Paragraph VII hereof with respect to shares of Stock
subject to Options then outstanding.  Exercise of an Option shall result in a
decrease in the number of shares of Stock which may thereafter be available,
both for purposes of the Plan and for sale to any one individual, by the number
of shares as to which the Option is exercised.


                               V.  OPTION PRICE

     The purchase price of Stock issued under each Option shall be the fair
market value of Stock subject to the Option as of the date the Option is
granted.  For all purposes under the Plan, the fair market value of a share of
Stock on a particular date shall be equal to the last sales price of the Stock
(i) reported by the Nasdaq Stock Market on that date or (ii) if the Stock is
listed on a national stock exchange, reported on the stock exchange composite
tape on that date; or, in either case, if no prices are reported on that date,
on the last preceding date on which such prices of the Stock are so reported.
If the Stock is traded over the counter at the time a determination of its fair
market value is required to be made hereunder, its fair market value shall be
deemed to be equal to the average between the reported high and low or closing
bid and asked prices of Stock on the most recent date on which Stock was
publicly traded.  In the event Stock is not publicly traded at the time a
determination of its value is required to be made hereunder, the determination
of its fair market value shall be made by the Board in such manner as it deems
appropriate.


                               VI.  TERM OF PLAN

     The Plan shall be effective on the date the Plan is approved the Board,
provided that the Plan shall be subject to approval by  the stockholders of the
Company at the first annual meeting of the Company's stockholders following the
effective date of the Plan.  Except with respect to Options then outstanding, if
not sooner terminated under the provisions of Paragraph VIII, the Plan shall
terminate upon and no further Options shall be granted after the expiration of
ten years from the date the Plan is approved by the Board.


                   VII.  RECAPITALIZATION OR REORGANIZATION

     A.  The existence of the Plan and the Options granted hereunder shall not
affect in any way the right or power of the Board or the stockholders of the
Company to make or authorize any adjustment, recapitalization, reorganization,
or other change in the Company's capital structure or its business, any merger
or consolidation of the Company, any issue of debt or equity securities, the
dissolution or liquidation of the Company or any sale, lease, exchange or other
disposition of all or any part of its assets or business or any other corporate
act or proceeding.

     B.  The shares with respect to which Options may be granted are shares of
Stock as presently constituted, but if, and whenever, prior to the expiration of
an Option theretofore granted, the Company shall effect a subdivision or
consolidation of shares of Stock or the payment of a stock dividend on Stock
without receipt of consideration by the Company, the number of shares of Stock
with respect to which such Option may thereafter be exercised (i) in the event
of an increase in the number of outstanding shares shall be proportionately
increased, and the purchase price per share shall be proportionately reduced,
and (ii) in the event of a reduction in the number of outstanding shares shall
be proportionately reduced, and the purchase price per share shall be
proportionately increased.

                                      -2-

 
     C.  If the Company recapitalizes, reclassifies its capital stock, or
otherwise changes its capital structure (a "recapitalization"), the number and
class of shares of Stock covered by an Option theretofore granted shall be
adjusted so that such Option shall thereafter cover the number and class of
shares of stock and securities to which the optionee would have been entitled
pursuant to the terms of the recapitalization if, immediately prior to the
recapitalization, the optionee had been the holder of record of the number of
shares of Stock then covered by such Option.

     D.  Any adjustment provided for in Subparagraph (B) or (C) above shall be
subject to any required stockholder action.

     E.  Except as hereinbefore expressly provided, the issuance by the Company
of shares of stock of any class or securities convertible into shares of stock
of any class, for cash, property, labor or services, upon direct sale, upon the
exercise of rights or warrants to subscribe therefor, or upon conversion of
shares or obligations of the Company convertible into such shares or other
securities, and in any case whether or not for fair value, shall not affect, and
no adjustment by reason thereof shall be made with respect to, the number of
shares of Stock subject to Options theretofore granted or the purchase price per
share.

                  VIII.  AMENDMENT OR TERMINATION OF THE PLAN

     The Board in its discretion may terminate the Plan at any time with respect
to any shares for which Options have not theretofore been granted.  The Board
shall have the right to alter or amend the Plan or any part thereof from time to
time; provided, that no change in any Option theretofore granted may be made
which would impair the rights of the optionee without the consent of such
optionee and provided, further, that the Board may not make any alteration or
amendment which would materially increase the benefits accruing to participants
under the Plan, increase the aggregate number of shares which may be issued
pursuant to the provisions of the Plan, change the class of individuals eligible
to receive Options under the Plan or extend the term of the Plan, without the
approval of the stockholders of the Company.


                             IX.  SECURITIES LAWS

     A.  The Company shall not be obligated to issue any Stock pursuant to any
Options granted under the Plan at any time when the offering of the shares
covered by such Option have not been registered under the Securities Act of
1933, as amended, and such other state and federal laws, rules or regulations as
the Company deems applicable and, in the opinion of legal counsel for the
Company, there is no exemption from the registration requirements of such laws,
rules or regulations available for the offering and sale of such shares.

     B.  It is intended that the Plan and any grant of an Option made to a
person subject to Section 16 of the Securities Exchange Act of 1934, as amended
(the "1934 Act"), meet all of the requirements of Rule 16b-3, as currently in
effect or as hereinafter modified or amended ("Rule 16b-3"), promulgated under
the 1934 Act.  If any provision of the Plan or any such Option would disqualify
the Plan or such Option under, or would otherwise not comply with, Rule 16b-3,
such provision or Option shall be construed or deemed amended to conform to Rule
16b-3.

                                      -3-

 
                 NONEMPLOYEE DIRECTOR'S STOCK OPTION AGREEMENT
                                (INITIAL GRANT)


     AGREEMENT made as of the _____ day of __________, 19_____, between ZONAGEN,
INC., a Delaware corporation (the "Company"), and ____________________
("Director").



     To carry out the purposes of the ZONAGEN, INC. 1996 NONEMPLOYEE DIRECTORS'
STOCK OPTION PLAN (the "Plan"), by affording Director the opportunity to
purchase shares of common stock of the Company ("Stock"), and in consideration
of the mutual agreements and other matters set forth herein and in the Plan, the
Company and Director hereby agree as follows:


     1.  GRANT OF OPTION.  The Company hereby irrevocably grants the Director
the right and option ("Option") to purchase all or any part of an aggregate of
_______ shares of Stock, on the terms and conditions set forth herein and in the
Plan, which Plan is incorporated herein by reference as a part of this
Agreement.  This Option shall not be treated as an incentive stock option within
the meaning of section 422(b) of the Internal Revenue Code of 1986, as amended
(the "Code").

     2.  PURCHASE PRICE.  The purchase price of Stock purchased pursuant to the
exercise of this Option shall be $________ per share, which has been determined
to be not less than the fair market value of the Stock at the date of grant of
this Option.  For all purposes of this Agreement, fair market value of Stock
shall be determined in accordance with the provisions of the Plan.

     3.  EXERCISE OF OPTION.  Subject to the earlier expiration of this Option
as herein provided, this Option may be exercised, by written notice to the
Company at its principal executive offices addressed to the attention of Chief
Executive Officer, at any time and from time to time after the date of grant
hereof, but, except as otherwise provided below, this Option shall not be
exercisable for more than a percentage of the aggregate number of shares offered
by this Option determined by the number of full years from the first day of the
calendar month coincident with or next following the date of grant hereof to the
date of such exercise, in accordance with the following schedule:

 
                                                  Percentage of Shares
          Number of Full Years                   That May Be Purchased
 
 
Less than 1 year..............................          0.00%

1 year but less than 2 years..................         20.00%
 
2 years but less than 3 years.................         40.00%
 
3 years but less than 4 years.................         60.00%
 
4 years but less than 5 years.................         80.00%

5 years or more...............................        100.00%


     Notwithstanding the foregoing, if (i) the Company shall not be the
surviving entity in any merger, consolidation or other reorganization (or
survives only as a subsidiary of an entity other than a previously wholly-owned
subsidiary of the Company), (ii) the Company sells, leases or exchanges or
agrees to sell, lease or exchange all or substantially all of its assets to any
other person or entity (other than a wholly-owned subsidiary of the Company),
(iii) the Company is to be dissolved and liquidated, (iv) any person or entity,
including a "group" as contemplated by Section 13(d)(3) of the Securities
Exchange Act of 1934, acquires or gains ownership or control (including, without
limitation, power to vote) of more than 50% of the outstanding shares of the
Company's voting stock (based upon voting power), or (v) as a result of or in
connection with a contested election of directors, the persons who were
directors of the Company before such election shall cease to constitute a
majority of the Board of Directors of the Company (each such event is referred
to herein as a "Corporate Change"), then effective as of the earlier of (1) the
date of approval by the stockholders of the 

 
Company of such merger, consolidation, reorganization, sale, lease or exchange
of assets or dissolution or such election of directors or (2) the date of such
Corporate Change, this Option shall be exercisable in full.

     This Option and all rights granted hereunder are not transferable by
Director other than by will or the laws of descent and distribution or pursuant
to a qualified domestic relations order as defined by the Code or Title 1 of the
Employee Retirement Income Security Act of 1974, as amended, or the rules
thereunder, and may be exercised during Director's lifetime only by Director or
Director's guardian or legal representative.  This Option may be exercised only
while Director remains a member of the Board of Directors of the Company (the
"Board") and will terminate and cease to be exercisable upon Director's
termination of membership on the Board, except that:

          (a) If Director's membership on the Board terminates by reason of
     disability, this Option may be exercised in full by Director (or Director's
     estate or the person who acquires this Option by will or the laws of
     descent and distribution or otherwise by reason of the death of Director)
     at any time during the period of one year following such termination.

          (b) If Director dies while a member of the Board, Director's estate,
     or the person who acquires this Option by will or the laws of descent and
     distribution or otherwise by reason of the death of Director, may exercise
     this Option in full at any time during the period of one year following the
     date of Director's death.

          (c) If Director's membership on the Board terminates for any reason
     other than as described in (a) or (b) above, this Option may be exercised
     by Director at any time during the period of three months following such
     termination, or by Director's estate (or the person who acquires this
     Option by will or the laws of descent and distribution or otherwise by
     reason of the death of Director) during a period of one year following
     Director's death if Director dies during such three month period, but in
     each case only as to the number of shares Director was entitled to purchase
     hereunder upon exercise of this Option as of the date Director's membership
     on the Board so terminates.

     This Option shall not be exercisable in any event after the expiration of
ten years from the date of grant hereof.  The purchase price of shares as to
which this Option is exercised shall be paid in full at the time of exercise (A)
in cash (including check, bank draft or money order payable to the order of the
Company), (B) by delivering to the Company shares of Stock having a fair market
value equal to the purchase price, or (C) any combination of cash or Stock. No
fraction of a share of Stock shall be issued by the Company upon exercise of an
Option or accepted by the Company in payment of the purchase price thereof;
rather, Director shall provide a cash payment for such amount as is necessary to
effect the issuance and acceptance of only whole shares of Stock. Unless and
until a certificate or certificates representing such shares shall have been
issued by the Company to Director, Director (or the person permitted to exercise
this Option in the event of Director's death) shall not be or have any of the
rights or privileges of a stockholder of the Company with respect to shares
acquirable upon an exercise of this Option.

     4.  WITHHOLDING OF TAX.  To the extent that the exercise of this Option or
the disposition of shares of Stock acquired by exercise of this Option results
in compensation income to Director for federal or state income tax purposes,
Director shall deliver to the Company at the time of such exercise or
disposition such amount of money or shares of Stock as the Company may require
to meet its obligation under applicable tax laws or regulations, and, if
Director fails to do so, the Company is authorized to withhold from any cash or
Stock renumeration then or thereafter payable to Director any tax required to be
withheld by reason of such resulting compensation income.  Upon an exercise of
this Option, the Company is further authorized in its discretion to satisfy any
such withholding requirement out of any cash or shares of Stock distributable to
Director upon such exercise.

     5.  STATUS OF STOCK.  The Company intends to register for issuance under
the Securities Act of 1933, as amended (the "Act"), the shares of Stock
acquirable upon exercise of this Option, and to keep such registration effective
throughout the period this Option is exercisable.  In the absence of such
effective registration or an available exemption from registration under the
Act, issuance of shares of Stock acquirable upon exercise of this Option will be
delayed until registration of such shares is effective or an exemption from
registration under the Act is available.  The Company 

                                      -2-

 
intends to use its best efforts to ensure that no such delay will occur. In the
event exemption from registration under the Act is available upon an exercise of
this Option, Director (or the person permitted to exercise this Option in the
event of Director's death or incapacity), if requested by the Company to do so,
will execute and deliver to the Company in writing an agreement containing such
provisions as the Company may require to assure compliance with applicable
securities laws.

     Director agrees that the shares of Stock which Director may acquire by
exercising this Option will not be sold or otherwise disposed of in any manner
which would constitute a violation of any applicable federal or state securities
laws.  Director also agrees (i) that the certificates representing the shares of
Stock purchased under this Option may bear such legend or legends as the Company
deems appropriate in order to assure compliance with applicable securities laws,
(ii) that the Company may refuse to register the transfer of the shares of Stock
purchased under this Option on the stock transfer records of the Company if such
proposed transfer would in the opinion of counsel satisfactory to the Company
constitute a violation of any applicable securities law and (iii) that the
Company may give related instructions to its transfer agent, if any, to stop
registration of the transfer of the shares of Stock purchased under this Option.

     6.  BINDING EFFECT.  This Agreement shall be binding upon and inure to the
benefit of any successors to the Company and all persons lawfully claiming under
Director.

     7.  GOVERNING LAW.  This Agreement shall be governed by, and construed in
accordance with, the laws of the State of Delaware.

     IN WITNESS WHEREOF, the Company has caused this Agreement to be duly
executed by its officer thereunto duly authorized, and Director has executed
this Agreement, all as of the day and year first above written.

                              ZONAGEN, INC.


                              By:_______________________________________

                              DIRECTOR

                              __________________________________________

                                      -3-

 
                 NONEMPLOYEE DIRECTOR'S STOCK OPTION AGREEMENT
                                (ANNUAL GRANT)

     AGREEMENT made as of the _____ day of __________, 19_____, between ZONAGEN,
INC., a Delaware corporation (the "Company"), and ____________________
("Director").

     To carry out the purposes of the ZONAGEN, INC. 1996 NONEMPLOYEE DIRECTORS'
STOCK OPTION PLAN (the "Plan"), by affording Director the opportunity to
purchase shares of common stock of the Company ("Stock"), and in consideration
of the mutual agreements and other matters set forth herein and in the Plan, the
Company and Director hereby agree as follows:

     1.  GRANT OF OPTION.  The Company hereby irrevocably grants the Director
the right and option ("Option") to purchase all or any part of an aggregate of
_______ shares of Stock, on the terms and conditions set forth herein and in the
Plan, which Plan is incorporated herein by reference as a part of this
Agreement.  This Option shall not be treated as an incentive stock option within
the meaning of section 422(b) of the Internal Revenue Code of 1986, as amended
(the "Code").

     2.  PURCHASE PRICE.  The purchase price of Stock purchased pursuant to the
exercise of this Option shall be $________ per share, which has been determined
to be not less than the fair market value of the Stock at the date of grant of
this Option.  For all purposes of this Agreement, fair market value of Stock
shall be determined in accordance with the provisions of the Plan.

     3.  EXERCISE OF OPTION.  Subject to the earlier expiration of this Option
as herein provided, this Option may be exercised, by written notice to the
Company at its principal executive offices addressed to the attention of Chief
Executive Officer, at any time and from time to time after the date of grant
hereof, but, except as otherwise provided below, this Option shall not be
exercisable for more than a percentage of the aggregate number of shares offered
by this Option determined by the number of full calendar months from the first
day of the calendar month coincident with or next following the date of grant
hereof to the date of such exercise, in accordance with the following schedule:

 
                                                          Percentage of Shares
       Number of Full Calendar Months                     That May Be Purchased
                                                              
 
                                                              
Less than 1 month.......................................            0.00%     
                                                                              
1 month but less than 2 months..........................            8.33%     
                                                                              
2 months but less than 3 months.........................           16.67%     
                                                                              
3 months but less than 4 months.........................           25.00%      
                                                                              
4 months but less than 5 months.........................           33.33%    
                                                                              
5 months but less than 6 months.........................           41.67%    
                                                                              
6 months but less than 7 months.........................           50.00%    
                                                                              
7 months but less than 8 months.........................           58.33%    
                                                                              
8 months but less than 9 months.........................           66.67%    
                                                                              
9 months but less than 10 months........................           75.00%     

                                      -4-

 
10 months but less than 11 months.......................           83.33%
                                                                              
11 months but less than 12 months.......................           91.67%
                                                                              
12 months or more.......................................          100.00%
                                                                                

     Notwithstanding the foregoing, if (i) the Company shall not be the
surviving entity in any merger, consolidation or other reorganization (or
survives only as a subsidiary of an entity other than a previously wholly-owned
subsidiary of the Company), (ii) the Company sells, leases or exchanges or
agrees to sell, lease or exchange all or substantially all of its assets to any
other person or entity (other than a wholly-owned subsidiary of the Company),
(iii) the Company is to be dissolved and liquidated, (iv) any person or entity,
including a "group" as contemplated by Section 13(d)(3) of the Securities
Exchange Act of 1934, acquires or gains ownership or control (including, without
limitation, power to vote) of more than 50% of the outstanding shares of the
Company's voting stock (based upon voting power), or (v) as a result of or in
connection with a contested election of directors, the persons who were
directors of the Company before such election shall cease to constitute a
majority of the Board of Directors of the Company (each such event is referred
to herein as a "Corporate Change"), then effective as of the earlier of (1) the
date of approval by the stockholders of the Company of such merger,
consolidation, reorganization, sale, lease or exchange of assets or dissolution
or such election of directors or (2) the date of such Corporate Change, this
Option shall be exercisable in full.

     This Option and all rights granted hereunder are not transferable by
Director other than by will or the laws of descent and distribution or pursuant
to a qualified domestic relations order as defined by the Code or Title 1 of the
Employee Retirement Income Security Act of 1974, as amended, or the rules
thereunder, and may be exercised during Director's lifetime only by Director or
Director's guardian or legal representative.  This Option may be exercised only
while Director remains a member of the Board of Directors of the Company (the
"Board") and will terminate and cease to be exercisable upon Director's
termination of membership on the Board, except that:

          (a) If Director's membership on the Board terminates by reason of
     disability, this Option may be exercised in full by Director (or Director's
     estate or the person who acquires this Option by will or the laws of
     descent and distribution or otherwise by reason of the death of Director)
     at any time during the period of one year following such termination.

          (b) If Director dies while a member of the Board, Director's estate,
     or the person who acquires this Option by will or the laws of descent and
     distribution or otherwise by reason of the death of Director, may exercise
     this Option in full at any time during the period of one year following the
     date of Director's death.

          (c) If Director's membership on the Board terminates for any reason
     other than as described in (a) or (b) above, this Option may be exercised
     by Director at any time during the period of three months following such
     termination, or by Director's estate (or the person who acquires this
     Option by will or the laws of descent and distribution or otherwise by
     reason of the death of Director) during a period of one year following
     Director's death if Director dies during such three month period, but in
     each case only as to the number of shares Director was entitled to purchase
     hereunder upon exercise of this Option as of the date Director's membership
     on the Board so terminates.

     This Option shall not be exercisable in any event after the expiration of
ten years from the date of grant hereof.  The purchase price of shares as to
which this Option is exercised shall be paid in full at the time of exercise (A)
in cash (including check, bank draft or money order payable to the order of the
Company), (B) by delivering to the Company shares of Stock having a fair market
value equal to the purchase price, or (C) any combination of cash or Stock. No
fraction of a share of Stock shall be issued by the Company upon exercise of an
Option or accepted by the Company in payment of the purchase price thereof;
rather, Director shall provide a cash payment for such amount as is necessary to
effect the issuance and acceptance of only whole shares of Stock. Unless and
until a certificate or certificates representing such shares shall have been
issued by the Company to Director, Director (or the person permitted to 

                                      -5-

 
exercise this Option in the event of Director's death) shall not be or have any
of the rights or privileges of a stockholder of the Company with respect to
shares acquirable upon an exercise of this Option.

     4.  WITHHOLDING OF TAX.  To the extent that the exercise of this Option or
the disposition of shares of Stock acquired by exercise of this Option results
in compensation income to Director for federal or state income tax purposes,
Director shall deliver to the Company at the time of such exercise or
disposition such amount of money or shares of Stock as the Company may require
to meet its obligation under applicable tax laws or regulations, and, if
Director fails to do so, the Company is authorized to withhold from any cash or
Stock renumeration then or thereafter payable to Director any tax required to be
withheld by reason of such resulting compensation income.  Upon an exercise of
this Option, the Company is further authorized in its discretion to satisfy any
such withholding requirement out of any cash or shares of Stock distributable to
Director upon such exercise.

     5.  STATUS OF STOCK.  The Company intends to register for issuance under
the Securities Act of 1933, as amended (the "Act"), the shares of Stock
acquirable upon exercise of this Option, and to keep such registration effective
throughout the period this Option is exercisable.  In the absence of such
effective registration or an available exemption from registration under the
Act, issuance of shares of Stock acquirable upon exercise of this Option will be
delayed until registration of such shares is effective or an exemption from
registration under the Act is available.  The Company intends to use its best
efforts to ensure that no such delay will occur.  In the event exemption from
registration under the Act is available upon an exercise of this Option,
Director (or the person permitted to exercise this Option in the event of
Director's death or incapacity), if requested by the Company to do so, will
execute and deliver to the Company in writing an agreement containing such
provisions as the Company may require to assure compliance with applicable
securities laws.

     Director agrees that the shares of Stock which Director may acquire by
exercising this Option will not be sold or otherwise disposed of in any manner
which would constitute a violation of any applicable federal or state securities
laws.  Director also agrees (i) that the certificates representing the shares of
Stock purchased under this Option may bear such legend or legends as the Company
deems appropriate in order to assure compliance with applicable securities laws,
(ii) that the Company may refuse to register the transfer of the shares of Stock
purchased under this Option on the stock transfer records of the Company if such
proposed transfer would in the opinion of counsel satisfactory to the Company
constitute a violation of any applicable securities law and (iii) that the
Company may give related instructions to its transfer agent, if any, to stop
registration of the transfer of the shares of Stock purchased under this Option.

     6.  BINDING EFFECT.  This Agreement shall be binding upon and inure to the
benefit of any successors to the Company and all persons lawfully claiming under
Director.

     7.  GOVERNING LAW.  This Agreement shall be governed by, and construed in
accordance with, the laws of the State of Delaware.

     IN WITNESS WHEREOF, the Company has caused this Agreement to be duly
executed by its officer thereunto duly authorized, and Director has executed
this Agreement, all as of the day and year first above written.

                              ZONAGEN, INC.

                              By:_______________________________________


                              DIRECTOR

                              __________________________________________

                                      -6-