Prospectus Supplement No. 1, dated November 30, 2001, Rule 424(c) to Prospectus, dated October 29, 2000. File No. 333-47032 ALLIANCE PHARMACEUTICAL CORP. SHARES OF COMMON STOCK This prospectus supplement relates to the public offering of shares of our common stock by the selling shareholders named in the Selling Shareholder Table in the prospectus referred to above. The shares are all issuable upon conversion of our debentures, dated August 22, 2000, referred to in the Selling Shareholder Table. The number of shares covered by the prospectus (and set forth in the table below) has been adjusted to reflect a change in the number of shares issuable upon conversion of the debentures due to: (i) a one-for-five reverse split of our common stock that became effective October 18, 2001; and (ii) a decrease in the debenture conversion price caused by an anti-dilution provision in the debentures being triggered. Pursuant to the anti-dilution provision, the conversion price of the debentures has been adjusted from $13.32 per share to $3.38 per share. The Selling Shareholder Table in the prospectus referred to above is hereby amended to reflect the sale of debentures by certain selling shareholders formerly listed in the Selling Shareholder Table and the change in the beneficial ownership of our shares by the listed shareholders. The debenture representing the right to purchase 58,108 shares of common stock owned by Narragansett I, LP and the debenture representing the right to purchase 77,027 shares of common stock owned by Narragansett Offshore, Ltd., two of the selling shareholders, have been transferred and re-dated October 30, 2001. The transfers are reflected in the following table: Number of shares of Common Number of Shares of Stock to be Acquisition of Common Stock Offered by Number of Shares of Common Stock Selling Beneficially Owned this Common Stock Beneficially Offered by this Shareholders Before Offering (1) Prospectus (3) Owned After the Offering Prospectus --------------- ----------- ------------------------ ---------- Number Percentage(2) Number Percentage(2) ------ ---------- ------ ---------- SDS Merchant 812,793 4.6% 404,677 408,116(4) 2.3% Represents common Fund, stock underlying L.P. four-year, 5% subordinated convertible debenture, dated October 30, 2001 ("10/30 Debentures"). Castle Creek 516,538 2.9% 77,823 438,715(5) 2.5% 10/30 Debenture Healthcare Investors, LLC CC LifeScience, 223,217 1.3% 77,823 145,394(6) * 10/30 Debenture Ltd. * Indicates ownership of less than 1% of outstanding shares. (1) Includes the shares of common stock underlying the 10/30 Debentures and being offered by this prospectus. (2) Based on 17,747,092 shares of our common stock outstanding as of November 30, 2001, which number assumes the sale of all the shares of common stock registered under this prospectus to persons who are not affiliates of the selling shareholders. (3) Includes the number of shares of common stock that could be issued as payment of interest on the 10/30 Debentures for a period of one year, commencing October 30, 2001. (4) Represents shares of common stock underlying a four-year, 5% subordinated convertible debenture, dated August 22, 2000, convertible at $3.38 per share, shares of common stock underlying a warrant, dated October 30, 2001, exercisable at $4.06 per share and shares of common stock acquired October 30 and November 30, 2001. (5) Represents shares of common stock underlying a four-year, 5% subordinated convertible debenture, dated August 22, 2000, convertible at $3.38 per share, shares of common stock underlying a warrant, dated October 30, 2001, exercisable at $4.06 per share and shares of common stock acquired October 30 and November 30, 2001. (6) Represents shares of common stock underlying a warrant, dated October 30, 2001, exercisable at $4.06 per share and shares of common stock acquired October 30 and November 30, 2001.