Exhibit 10.2
                                AMENDMENT TO THE
                           NAPRO BIOTHERAPEUTICS, INC.
                             1993 STOCK OPTION PLAN

         1.       Plan Sponsor:  NaPro BioTherapeutics, Inc.

         2.       Amendment of Plan:  The following  Amendment to the NaPro
BioTherapeutics,  Inc.  1993  Stock Option Plan (the "Plan") is adopted,
effective December 16, 2000:

         Section 9 of the Plan regarding Exercise Price and Consideration shall
         be amended by adding at the end thereof the following new subsection
         (e):

                  (e) Notwithstanding anything in the Plan to the contrary,
         effective December 16, 2000, unless approved by the holders of a
         majority of the shares present and entitled to vote at a duly convened
         meeting of the Company's shareholders, the Board shall not grant any
         Option with an exercise price that is less than 100% of the fair market
         value per Share on the date of grant or reduce the exercise price of
         any Option granted under the Plan.

         3.       Terms and Conditions of Plan.  Except for the above
amendments,  all terms and conditions of the Plan are unamended and shall remain
in full force and effect.

         4.       Execution.   The Plan sponsor  has executed this Amendment as
of the 11th day of December, 2000.

            NAPRO BIOTHERAPEUTICS, INC.
            Plan Sponsor
            By:      /s/ Gordon Link
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            Title:   VP, Chief Financial Officer
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