SCHEDULE 14A
                                 (Rule 14a-101)

                     INFORMATION REQUIRED IN PROXY STATEMENT

                            SCHEDULE 14A INFORMATION

           PROXY STATEMENT PURSUANT TO SECTION 14(A) OF THE SECURITIES
                      EXCHANGE ACT OF 1934 (AMENDMENT NO. )

     Filed by the Registrant |X|
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     |_| Preliminary Proxy Statement                |_|  Confidential, for Use
                                                         of the Commission Only
                                                         (as permitted by
                                                         Rule 14a-6(e)(2))
     |X| Definitive Proxy Statement
     |_| Definitive Additional Materials
     |_| Soliciting Material Under Rule 14a-12

                        COLLAGENEX PHARMACEUTICALS, INC.
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified in Its Charter)

- --------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

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                        COLLAGENEX PHARMACEUTICALS, INC.
                               41 University Drive
                                Newtown, PA 18940



                                                April 15, 2002

To Our Stockholders:

       You  are  cordially   invited  to  attend  the  2002  Annual  Meeting  of
Stockholders of CollaGenex  Pharmaceuticals,  Inc. at 8:30 A.M.,  local time, on
Thursday,  May 9, 2002, at the Philadelphia Airport Marriott Hotel, One Arrivals
Road, Philadelphia, Pennsylvania.

       The Notice of Meeting and Proxy Statement on the following pages describe
the matters to be presented at the meeting.

       It is important that your shares be represented at this meeting to assure
the presence of a quorum. Whether or not you plan to attend the meeting, we hope
that you will have your stock represented by signing,  dating and returning your
proxy in the enclosed envelope, as soon as possible. Your stock will be voted in
accordance with the instructions you have given in your proxy.

       Thank you for your continued support.


                                                Sincerely,

                                                /s/ Brian M. Gallagher

                                                Brian M. Gallagher, Ph.D.
                                                Chairman, President and
                                                Chief Executive Officer


                        COLLAGENEX PHARMACEUTICALS, INC.
                               41 University Drive
                                Newtown, PA 18940


                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                             To Be Held May 9, 2002


       The Annual Meeting of Stockholders of COLLAGENEX PHARMACEUTICALS, INC., a
Delaware  corporation,  will be held at the Philadelphia Airport Marriott Hotel,
One Arrivals Road, Philadelphia, Pennsylvania, on Thursday, May 9, 2002, at 8:30
A.M., local time, for the following purposes:

(1)    To elect  seven  directors  to serve  until the next  Annual  Meeting  of
       Stockholders and until their  respective  successors shall have been duly
       elected and qualified;

(2)    To amend our 1996 Stock  Option  Plan to increase  the maximum  aggregate
       number of shares of common stock  available for issuance  thereunder from
       2,000,000 to 2,500,000 shares and to reserve an additional 500,000 shares
       of our common stock for issuance in connection  with awards granted under
       the 1996 Stock Option Plan;

(3)    To ratify the appointment of KPMG LLP as our independent auditors for the
       year ending December 31, 2002; and

(4)    To transact  such other  business as may properly  come before the Annual
       Meeting or any adjournment or adjournments thereof.

       Holders of our common stock and Series D preferred stock of record at the
close of business on April 4, 2002 are  entitled to notice of and to vote at the
Annual Meeting,  or any adjournment or adjournments  thereof. A complete list of
such  stockholders  will be open to the  examination  of any  stockholder at our
principal executive offices at 41 University Drive, Newtown, Pennsylvania 18940,
during  ordinary  business  hours,  for a period of 10 days  prior to the Annual
Meeting as well as on the day of the Annual  Meeting.  The Annual Meeting may be
adjourned  from time to time without  notice other than by  announcement  at the
Annual Meeting.

       IT IS IMPORTANT THAT YOUR SHARES BE REPRESENTED  REGARDLESS OF THE NUMBER
OF SHARES YOU MAY HOLD. WHETHER OR NOT YOU PLAN TO ATTEND THE MEETING IN PERSON,
PLEASE  COMPLETE,  DATE AND SIGN THE ENCLOSED PROXY CARD AND MAIL IT PROMPTLY IN
THE ENCLOSED RETURN ENVELOPE.  THE PROMPT RETURN OF PROXIES WILL ENSURE A QUORUM
AND SAVE US THE  EXPENSE OF FURTHER  SOLICITATION.  EACH  PROXY  GRANTED  MAY BE
REVOKED BY THE STOCKHOLDER APPOINTING SUCH PROXY AT ANY TIME BEFORE IT IS VOTED.
IF YOU RECEIVE MORE THAN ONE PROXY CARD BECAUSE  YOUR SHARES ARE  REGISTERED  IN
DIFFERENT NAMES OR ADDRESSES, EACH SUCH PROXY CARD SHOULD BE SIGNED AND RETURNED
TO ASSURE THAT ALL OF YOUR SHARES WILL BE VOTED.


                                        By Order of the Board of Directors

                                        /s/ Nancy C. Broadbent

                                        Nancy C. Broadbent
                                             Secretary


Newtown, Pennsylvania
April 15, 2002

            OUR 2001 ANNUAL REPORT ACCOMPANIES THIS PROXY STATEMENT.


                        COLLAGENEX PHARMACEUTICALS, INC.
                               41 University Drive
                                Newtown, PA 18940


                 -----------------------------------------------

                                 PROXY STATEMENT

                 -----------------------------------------------

       This Proxy Statement is furnished in connection with the  solicitation by
the Board of Directors of CollaGenex Pharmaceuticals,  Inc. (also referred to in
this Proxy Statement as the "Company,"  "CollaGenex,"  "we," or "us") of proxies
to be voted at our Annual Meeting of Stockholders to be held on Thursday, May 9,
2002  at  the   Philadelphia   Airport   Marriott  Hotel,   One  Arrivals  Road,
Philadelphia,   PA  at  8:30  a.m.,  local  time,  and  at  any  adjournment  or
adjournments thereof.  Holders of record of our common stock, $.01 par value per
share, and Series D cumulative  convertible  preferred stock, $.01 par value per
share,  as of the close of business on April 4, 2002, will be entitled to notice
of and to  vote  at the  Annual  Meeting  and any  adjournment  or  adjournments
thereof.  As of that date,  there  were  11,116,769  shares of our common  stock
issued and  outstanding  and entitled to vote and 200,000 shares of our Series D
preferred  stock issued and  outstanding  and  entitled to vote.  Such shares of
Series D  preferred  stock were,  as of such date,  convertible  into  2,017,861
shares of common  stock.  Except for the proposal to elect the Series D Director
(as  hereinafter  defined),  as set forth  below,  each share of common stock is
entitled  to one  vote  on any  matter  presented  at the  Annual  Meeting.  The
aggregate number of common stock votes entitled to be cast at the Annual Meeting
is 13,127,880,  including the 2,017,861 shares underlying the Series D preferred
stock to be voted on an as converted  to common stock basis.  The holders of all
classes of stock will vote as a single class for all proposals generally, except
that the holders of Series D preferred  stock will also vote as a separate class
for the proposal to elect the Series D Director.

       If proxies in the accompanying  form are properly  executed and returned,
the shares of common stock and Series D preferred stock represented thereby will
be voted in the manner specified therein. If not otherwise specified, the shares
of common stock and Series D preferred stock  represented by the proxies will be
voted (i) FOR, as applicable,  the election of the seven nominees named below as
directors,  (ii) FOR a proposal to amend our 1996 Stock  Option Plan to increase
the maximum  number of shares of common stock  available for issuance  under the
1996 Stock  Option Plan from  2,000,000  to  2,500,000  shares and to reserve an
additional  500,000  shares of our common stock for issuance in connection  with
awards granted under the 1996 Stock Option Plan,  (iii) FOR the  ratification of
the  appointment  of KPMG LLP as our  independent  auditors  for the year ending
December  31,  2002,  and (iv) in the  discretion  of the  persons  named in the
enclosed form of proxy,  on any other  proposals  which may properly come before
the Annual Meeting or any adjournment or adjournments  thereof.  Any stockholder
who has  submitted  a proxy  may  revoke it at any time  before it is voted,  by
written  notice  addressed to and received by the  Secretary of the Company,  by
submitting a duly executed  proxy bearing a later date or by electing to vote in
person at the Annual  Meeting.  The mere  presence at the Annual  Meeting of the
person appointing a proxy does not, however, revoke the appointment.

       The presence,  in person or by proxy,  of holders of shares of our common
stock,  including the shares of common stock  underlying  the Series D preferred
stock to be voted on an as converted to common  stock  basis,  in the  aggregate
having a  majority  of the votes  entitled  to be cast by the  holders of common
stock at the Annual  Meeting,  shall  constitute  a quorum  with  respect to all
matters  except for the  election of the Series D  Director.  The  presence,  in
person or by proxy,  of holders of shares of Series D preferred  stock  having a
majority  of the votes  entitled to be cast by the holders of Series D preferred
stock at the  Annual  Meeting  shall  constitute  a quorum  with  respect to the
election  of the Series D  Director.  The  affirmative  vote by the holders of a
plurality of the shares of common stock  represented at the Annual Meeting,  but
not including the shares of common stock underlying the Series D preferred stock
to be voted on an as  converted  to common  stock  basis,  is  required  for the
election of  directors  other than the Series D  Director,  provided a quorum of
such  stockholders is present in person or by proxy. The affirmative vote by the
holders of a majority of the shares of Series D preferred  stock is required for
the election of the Series D Director.  All actions  proposed  herein other than
the election of directors may be taken upon the affirmative vote of stockholders
possessing a majority of the requisite  voting power  represented  at the Annual
Meeting, provided a quorum is present in person or by proxy.





       Abstentions  are included in the shares present at the Annual Meeting for
purposes of determining  whether a quorum is present,  and are counted as a vote
against for  purposes of  determining  whether a proposal  is  approved.  Broker
non-votes  (when  shares  are  represented  at the  Annual  Meeting  by a  proxy
specifically conferring only limited authority to vote on certain matters and no
authority to vote on other  matters) are  included in the  determination  of the
number of shares  represented  at the Annual Meeting for purposes of determining
whether a quorum is present  but are not counted  for  purposes  of  determining
whether a proposal has been approved and thus have no effect on the outcome.

       This Proxy  Statement,  together with the related  proxy cards,  is being
mailed to our  stockholders  on or about April 15,  2002.  The Annual  Report to
Stockholders  of the Company for the year ended  December  31,  2001,  including
financial statements,  is being mailed together with this Proxy Statement to all
stockholders  of record  as of April 4,  2002.  In  addition,  we have  provided
brokers,  dealers,  banks,  voting trustees and their nominees,  at our expense,
with  additional  copies of the Annual Report so that such record  holders could
supply such materials to beneficial owners as of April 4, 2002.




                                       -2-


                              ELECTION OF DIRECTORS

       At the Annual  Meeting,  seven  directors are to be elected (which number
shall  constitute  our entire Board of  Directors) to hold office until the 2003
Annual  Meeting  of  Stockholders  and until  their  successors  shall have been
elected and  qualified.  The holders of common  stock,  voting as a class,  will
elect six directors. The holders of Series D preferred stock, voting as a class,
will elect one director  (referred  to in this proxy  statement as the "Series D
Director").

       It is the intention of the persons named in the enclosed form of proxy to
vote the stock represented thereby, unless otherwise specified in the proxy, for
the  election as  directors of the persons  whose names and  biographies  appear
below. All such persons are, at present,  members of our Board of Directors.  In
the event any of the nominees should become  unavailable or unable to serve as a
director,  it is  intended  that  votes  will be cast for a  substitute  nominee
designated  by our Board of  Directors.  The Board of Directors has no reason to
believe that the nominees named will be unable to serve if elected.  Each of the
nominees has  consented to being named in this Proxy  Statement  and to serve if
elected.

       The current members of our Board of Directors,  who are also nominees for
election to our Board of Directors, are as follows:


COMMON STOCK DIRECTORS:
- ----------------------

                                       SERVED AS A    POSITION(S) WITH
NAME                           AGE   DIRECTOR SINCE   THE COMPANY
- -----                          ---   --------------   ------------

Brian M. Gallagher, Ph.D ....  54         1994        President, Chief Executive
                                                      Officer and Chairman of
                                                      the Board

Peter R. Barnett, D.M.D......  50         1997        Director

Robert C. Black..............  59         1999        Director

James E. Daverman............  52         1995        Director

Robert J. Easton.............  57         1993        Director

W. James O'Shea..............  52         2000        Director

SERIES D PREFERRED STOCK DIRECTOR:
- ----------------------------------
                                       SERVED AS A    POSITION(S) WITH
NAME                           AGE   DIRECTOR SINCE   THE COMPANY
- -----                          ---   --------------   -----------

Stephen A. Kaplan............  43         1999        Director

       The principal occupations and business experience,  for at least the past
five years, of each nominee are as follows:

       Dr. Gallagher joined  CollaGenex  in April  1994 as  President  and Chief
Executive  Officer,  and has been a member of our Board of Directors since 1994.
On March  10,  2000,  Dr.  Gallagher  was  appointed  Chairman  of the  Board of
Directors.   From  1988  until  April  1994,  Dr.   Gallagher  was  employed  by
Bristol-Myers Squibb Company and its predecessor, Squibb Corporation, in various
executive positions including strategic planning, worldwide product and business
development  and marketing.  From 1991 until April 1994, Dr.  Gallagher was Vice
President   and   General   Manager  of  Squibb   Diagnostics   in  the  imaging
pharmaceutical  division. Prior to 1991, Dr. Gallagher served for ten years with
E.I.  DuPont  de  Nemours  &  Co.  in  a  variety  of  pharmaceutical  research,
development, marketing and business management positions.




                                       -3-


       Dr.  Barnett has been a member of our Board of Directors  since  February
1997. Dr. Barnett currently serves as an independent health care consultant. Dr.
Barnett was  formerly  President,  Chief  Executive  Officer and a member of the
Board of Directors of  HealthASPex,  Inc., a claims  technology  firm, from June
2000 to September  2001. He was also  President and Chief  Operating  Officer of
United Dental Care,  Inc., a managed dental  benefits  firm,  where he served in
such  capacity  from  January  1995 until May 2000.  From August 1994 to January
1995, Dr. Barnett was Executive  Director of Prudential DMO, and from March 1993
to August  1994,  he served as an  independent  consultant  in the managed  care
field.  From January 1985 to March 1993, Dr. Barnett was a Senior Vice President
with Pearle Vision, Inc.

       Mr.  Black has been a member of our Board of  Directors  since  September
1999. He was President of the Zeneca  Pharmaceuticals  Division of  AstraZeneca,
Inc., a  pharmaceutical  company,  until his  retirement in June 1999. He joined
AstraZeneca,  Inc. in 1965 as a  pharmaceutical  sales  representative  and held
numerous positions of increasing  responsibility in sales and marketing prior to
becoming President of the Zeneca Pharmaceuticals Division in 1991.

       Mr.  Daverman has been a member of our Board of Directors  since November
1995. He is a managing general partner of Marquette Partners,  a venture capital
investment  company  which he founded in 1987.  Mr.  Daverman  is  President  of
Marquette  Management  Partners,  LLC, the general partner of Marquette  Venture
Partners,  L.P.  and a general  partner of MG II, L.P.,  the general  partner of
Marquette  Venture  Partners  II, L.P.  and MVP II  Affiliates  Fund,  L.P.  Mr.
Daverman is a member of the Board of Directors of  Endocardial  Solutions,  Inc.
and  numerous  privately  held  companies,  for many of which he  serves  on the
compensation committee.

       Mr.  Easton has been a member of our Board of  Directors  since  November
1993. He currently serves as Chairman of Easton  Associates,  a consulting firm,
and has held this position since May 2000. He was formerly  Managing Director of
IBM Healthcare  Consulting,  Inc., a major health care consulting firm, where he
served in such capacity from 1981 to May 2000. Mr. Easton is a former  President
of the Biomedical Marketing Association. Mr. Easton is a member of the Boards of
Directors  of  eXegenics,  Inc.  (formerly  Cytoclonal  Pharmaceuticals,  Inc.),
Cepheid, Inc., and several privately held companies.

       Mr.  O'Shea has been a member of our Board of Directors  since  September
2000. He currently serves as President and Chief Operating  Officer of Sepracor,
Inc., a position he has held since  October 1999.  Formerly,  he was Senior Vice
President of AstraZeneca,  Inc., a pharmaceutical  company, from 1975 to October
1999.

       Mr.  Kaplan has been a member of our Board of Directors  since  September
1999.  He is a principal and portfolio  manager of Oaktree  Capital  Management,
LLC, which is the general partner of OCM Principal  Opportunities  Fund, L.P., a
venture  capital fund. He has held such  positions  since June 1995 and November
1993,  respectively.  From November 1993 to May 1995 he was Managing Director of
Trust  Company  of The West.  Mr.  Kaplan  serves as a  director  of Forest  Oil
Corporation and General Maritime Corporation, as well as numerous privately held
companies.

       Pursuant to the terms of our Certificate of Designation,  Preferences and
Rights of Series D  Cumulative  Convertible  Preferred  Stock,  as amended,  the
holders of the Series D  preferred  stock,  acting as a single  class,  have the
right to designate and elect one member of our Board of  Directors.  The holders
of the Series D preferred  stock have exercised  such right by  designating  Mr.
Kaplan to serve as a member of our Board of Directors.

       All  directors  will  hold  office  until  the  next  annual  meeting  of
stockholders  and until  their  successors  shall  have been  duly  elected  and
qualified.  None of our directors are related to any other director or to any of
our executive officers.

       THE BOARD OF DIRECTORS RECOMMENDS THAT STOCKHOLDERS,  AS APPLICABLE, VOTE
FOR EACH OF THE  NOMINEES FOR THE BOARD OF  DIRECTORS.  PLEASE NOTE THAT PROXIES
CANNOT BE VOTED FOR A GREATER NUMBER OF PERSONS THAN THE NOMINEES NAMED ABOVE.



                                       -4-


COMMITTEES AND MEETINGS OF THE BOARD

       Our Board of Directors  currently consists of Brian M. Gallagher,  Ph.D.,
who serves as Chairman,  Peter R.  Barnett,  D.M.D.,  Robert C. Black,  James E.
Daverman,  Robert J. Easton, W. James O' Shea and Stephen A. Kaplan. Our By-Laws
currently  provide that the total number of  directors  comprising  our Board of
Directors shall be such number as is fixed by our Board of Directors,  but in no
event less than one.  Pursuant to the terms of our  Certificate of  Designation,
Preferences and Rights of Series D Cumulative  Convertible  Preferred  Stock, as
amended, our Board of Directors shall consist of not less than five and not more
than nine directors.  Our Board of Directors has provided that our full Board of
Directors shall be comprised of nine directors.  Although we have nominated, and
are only seeking to elect, seven members to our Board of Directors at this time,
we are actively recruiting potential  candidates for these two vacancies.  These
two vacancies may be filled by the vote or written  consent of a majority of our
directors  elected by the holders of record of our common stock, and shall serve
until the next annual meeting of  stockholders,  unless earlier  removed or such
directors resign.  Proxies may not be voted for a greater number of persons than
such number of nominees  named in this Proxy  Statement and on the  accompanying
proxy.

       There were six  meetings  of the Board of  Directors  during  2001.  Each
incumbent director attended at least 75% of the aggregate of all meetings of the
Board of  Directors  held during the period in which he served as a director and
the total number of meetings held by the committee on which he served during the
period, if applicable.

       There are  currently  three  committees  of the Board of  Directors:  the
Compensation Committee; the Nominating Committee; and the Audit Committee.

The Compensation Committee of the Board of Directors

       The Compensation  Committee  currently  consists of W. James O'Shea,  who
serves as  Chairman,  Robert C. Black and  Robert J.  Easton.  The  Compensation
Committee  was  established  in March 1996 and held two  meetings  in 2001.  The
primary   responsibilities  of  the  Compensation  Committee  include  approving
salaries and incentive compensation for our executive officers and administering
our stock option plan.

The Nominating Committee of the Board of Directors

       The  Nominating  Committee  currently  consists of Robert C.  Black,  who
serves as  Chairman,  Peter R.  Barnett and Stephen A.  Kaplan.  The  Nominating
Committee  was  established  in March 2000 and held four  meetings in 2001.  The
primary  responsibility of the Nominating  Committee is reviewing and nominating
candidates for election to the Board of Directors. The Nominating Committee will
consider  nominees for the Board of Directors  suggested by  stockholders  whose
names are submitted in writing to the Nominating Committee in care of the office
of the Corporate Secretary of the Company.

The Audit Committee of the Board of Directors

       The Audit Committee  currently consists of James E. Daverman,  who serves
as Chairman,  Robert J. Easton and Stephen A. Kaplan.  The Audit  Committee  was
established  in March  1996 and  currently  acts  under a  charter  adopted  and
approved on May 8, 2000.  The Audit  Committee  held four meetings in 2001.  The
primary  responsibilities  of the Audit  Committee  include:  (i) evaluating and
recommending  to the  Board  of  Directors  the  engagement  of our  independent
auditors;  (ii)  reviewing the results and scope of the audit and other services
provided by our independent  auditors;  and (iii) monitoring on a periodic basis
our internal  controls.  Such  responsibilities  are more fully set forth in the
Audit Committee  Charter adopted by us on May 8, 2000, a copy of which was filed
as an Appendix to our proxy  statement  filed with the  Securities  and Exchange
Commission on April 18, 2001.

       Each  Audit  Committee  Member is an  independent  member of the Board of
Directors  as  defined  in  Rule  4200(a)(14)  of the  National  Association  of
Securities Dealers' listing standards.  As an independent  director of our Board
of Directors,  each Audit Committee  Member is not an officer or employee of the
Company  or our  subsidiaries  or does not  have a  relationship  which,  in the
opinion  of our  Board  of  Directors,  would  interfere  with the  exercise  of
independent judgement in carrying out the responsibilities of a director.


                                       -5-


COMPENSATION OF DIRECTORS

       During 2001, Brian M. Gallagher,  Ph.D. was not paid any compensation for
his  services as  Chairman of the Board.  Robert J.  Easton,  Peter R.  Barnett,
Robert C. Black and W. James  O'Shea  each  receive  $1,500 per meeting for each
meeting of the Board of  Directors  attended.  No other  directors  receive cash
compensation for services on the Board of Directors. We provide reimbursement to
directors for  reasonable  and necessary  expenses  incurred in connection  with
attendance at meetings of the Board of Directors and other Company business.

       From  time-to-time,  members of the Board of Directors  have been granted
options to purchase  shares of our common  stock.  See  "SECURITY  OWNERSHIP  OF
CERTAIN BENEFICIAL OWNERS AND MANAGEMENT."

       Pursuant to our 1996  Non-Employee  Director Stock Option Plan,  each new
non-employee  director is  automatically  granted an option to  purchase  25,000
shares of common stock, at an exercise price per share equal to the then current
fair market value per share.  All such options become  exercisable in five equal
annual installments  commencing one year after the date of grant,  provided that
the optionee then remains a director.  The right to exercise annual installments
of options under the Non-Employee Plan will be reduced  proportionately based on
the  optionee's  actual  attendance at meetings of the Board of Directors if the
optionee  fails to attend at least 75% of the meetings of the Board of Directors
held in any calendar year.

REPORT OF THE AUDIT COMMITTEE

March 25, 2002

To the Board of Directors of CollaGenex Pharmaceuticals, Inc.:

We have reviewed and discussed with management the Company's  audited  financial
statements as of and for the year ended December 31, 2001.

Management  is  responsible  for the Company's  internal  controls and financial
reporting  process.  The  Company's  independent  auditors are  responsible  for
performing  an  independent  audit  of the  Company's  financial  statements  in
accordance with accounting  standards generally accepted in the United States of
America and to issue a report on those financial statements. As appropriate, the
Audit  Committee  reviews  and  evaluates,  and  discusses  with  the  Company's
management,  internal  accounting,  financial  and  auditing  personnel  and the
independent auditors, the following:

o      the plan for, and the independent  auditors' report on, each audit of the
       Company's financial statements;
o      the Company's  financial  disclosure  documents,  including all financial
       statements and reports filed with the Securities and Exchange  Commission
       or sent to stockholders;
o      management's selection, application and disclosure of critical accounting
       policies;
o      changes in the Company's accounting  practices,  principles,  controls or
       methodologies;
o      significant developments or changes in accounting rules applicable to the
       Company; and
o      the adequacy of the Company's internal controls and accounting, financial
       and auditing personnel.

We have discussed with the Company's  independent  auditors the matters required
to be discussed by Statement on Auditing  Standards No. 61,  Communication  with
Audit Committees,  as amended,  by the Auditing  Standards Board of the American
Institute  of  Certified  Public  Accountants  ("SAS 61").  SAS 61 requires  the
Company's  independent  auditors to discuss with the Company's Audit  Committee,
among other things, the following:

o      methods to account for significant unusual transactions;
o      the  effect  of  significant  accounting  policies  in  controversial  or
       emerging  areas for which  there is a lack of  authoritative  guidance or
       consensus;
o      the process used by  management  in  formulating  particularly  sensitive
       accounting  estimates  and  the  basis  for  the  auditor's   conclusions
       regarding the reasonableness of those estimates; and
o      disagreements   with   management  over  the  application  of  accounting
       principles,  the  basis for  management's  accounting  estimates  and the
       disclosures in the financial statements.


                                       -6-


We have received,  reviewed and discussed the written disclosures and the letter
from  the  independent  auditors  required  by  Independence   Standard  No.  1,
Independence Discussions with Audit Committees,  as amended, by the Independence
Standards  Board  ("Independence  Standards  Board  Standard  No. 1"),  and have
discussed with the auditors the auditors'  independence.  Independence Standards
Board  Standard  No. 1 requires  auditors  annually  to  disclose in writing all
relationships  that in the  auditor's  professional  opinion  may be  reasonably
thought to bear on  independence,  confirm  their  independence  and engage in a
discussion of independence.

We have  considered  whether the non audit services  provided by the independent
auditors, as set forth in the section of the Company's proxy statement entitled,
"Independent  Auditor's Fees and Other Matters," are compatible with maintaining
the public accountants' independence.

Based on the reviews and  discussions  referred to above,  we  recommend  to the
Board of Directors that the financial  statements  referred to above be included
in the  Company's  Annual  Report on Form 10-K for the year ended  December  31,
2001.

James E.  Daverman
Audit Committee Chairman

Robert J. Easton
Audit Committee Member

Stephen A. Kaplan
Audit Committee Member

INDEPENDENT AUDITORS' FEES AND OTHER MATTERS

       The  following  table  presents  fees  for  professional  audit  services
rendered by KPMG LLP for the audit of our annual  financial  statements  for the
year ended December 31, 2001,  and fees for other services  rendered by KPMG LLP
for the year ended December 31, 2001:

FEE                                               AMOUNT
- ---                                               ------
Audit Fees
(excluding audit related services)(1)....         $89,000
                                                  =======
Financial Information Systems Design and
Implementation(2)........................         $     0
                                                  =======
All Other Fees:
   Audit Related Fees(3).................         $62,500

   Other Non-Audit Services(4)...........         $19,600
                                                  -------

   Total                                          $82,100
                                                  =======

(1)    Such amount includes  professional  services  rendered in connection with
       the audit of our  consolidated  financial  statements for the most recent
       fiscal  year and the  reviews  of the  condensed  consolidated  financial
       statements  included in each of our Quarterly Reports on Form 10-Q during
       the fiscal year ended December 31, 2001.

(2)    KPMG  LLP  did  not  provide  any  professional  services  to us  or  our
       affiliates for the fiscal year ended December 31, 2001 in connection with
       financial information systems design or implementation,  the operation of
       our information system or the management of our local area network.

                                       -7-


(3)    Such amount consists  principally of services rendered in connection with
       reviewing  registration  statements  and  issuing  consents,   addressing
       Securities and Exchange  Commission  comment letters,  reviewing  related
       amendments  to our Annual  Report on Form  10-K,  auditing  of  financial
       statements of employee benefit plans and certain accounting consultation.

(4)    Other non-audit related fees consisted of tax compliance services.


                                       -8-


                               EXECUTIVE OFFICERS

     The following table identifies our current executive officers:



                                                   CAPACITIES IN                 IN CURRENT
NAME                                        AGE    WHICH SERVED                  POSITION SINCE
- ----                                        ---    -------------                 --------------
                                                                        

Brian M. Gallagher, Ph.D............        54     President, Chief Executive    April 1994
                                                   Officer and Chairman of       (Director since November
                                                   the Board                     1994 and Chairman since
                                                                                 March 2000)

Robert A. Ashley(1).................        44     Senior Vice President         January 1999
                                                                                 (Vice President,
                                                                                 Commercial Development
                                                                                 since September 1994)

Nancy C. Broadbent(2)...............        46     Chief Financial Officer,      March 1996
                                                   Treasurer and Secretary

Jeffrey S. Day (3)..................        38     Vice President, Dermatology   October 2001

Douglas C. Gehrig(4)................        57     Vice President, Sales         June 1997

David P. Pfeiffer(5)................        39     Senior Vice President,        December 2000
                                                   Sales and Marketing           (Vice President,
                                                                                 Marketing since June
                                                                                 1997)

Michael Romanowicz, D.M.D., R.Ph.(6)..      42     Vice President of             January 2002
                                                   Professional Affairs and      (Senior Director of
                                                   Managed Care                  Professional Affairs and
                                                                                 Managed Care since
                                                                                 November 1999)


(1)    Mr.  Ashley  joined  CollaGenex  in  September  1994 as  Vice  President,
       Commercial  Development.  He was  promoted  to Senior Vice  President  in
       January  1999.  From  1989  until  September  1994,  he was  employed  by
       Bristol-Myers Squibb Company and its predecessor,  Squibb Corporation, in
       various positions including product development,  commercial and business
       development and, most recently,  as Director,  Business Development where
       he was  responsible for the worldwide  product and market  development of
       several new drugs.  From 1979 to 1989, Mr. Ashley held various  positions
       at Amersham  International (UK) Ltd.,  including  research,  development,
       manufacturing,  sales  and  marketing  positions,  as well  as  worldwide
       product development and product launch positions.

(2)    Ms. Broadbent joined CollaGenex in March 1996 as Chief Financial Officer,
       Treasurer  and  Secretary.  From  October  1994  until  March  1996,  Ms.
       Broadbent  served as Senior Vice President,  Chief Financial  Officer and
       director of Human Genome Sciences,  Inc., a pharmaceuticals company. From
       January  1993 to October  1994,  she served as Vice  President  and Chief
       Financial Officer of Cangene,  Inc., a  biopharmaceutical  company.  From
       January  1992  through   December  1992,  Ms.   Broadbent  served  as  an
       independent financial  consultant.  From March 1990 to December 1991, she
       was  employed by Baring  Brothers & Co.,  Inc.,  initially as Senior Vice
       President and then as Executive  Director,  Corporate  Finance.  Prior to
       that, Ms. Broadbent served for nine years in corporate  finance positions
       with Salomon Brothers, Inc. and PaineWebber Incorporated.

                                       -9-


(3)    Mr. Day joined CollaGenex in October 2001 as Vice President, Dermatology.
       From March  2001 to October  2001,  he served as  President  of Rx Pharma
       Pharmaceuticals,  Inc., a privately-held  dermatology sales and marketing
       company. From January 1996 to February 2001, he was Director of Trade and
       Commercial  Development  with  Ferndale  Laboratories,  Inc. From 1994 to
       1996,  Mr. Day was employed  with Ciba Vision  Ophthalmics  as a National
       Accounts  Manager,  and from 1992 to 1994, he was employed with Allergan,
       Inc. as a Regional Accounts  Manager.  Mr. Day has approximately 14 years
       of  experience  in  the  dermatology  industry,  including  senior  level
       positions in sales, marketing and business development.

(4)    Mr. Gehrig joined CollaGenex in June 1997 as Vice President,  Sales. From
       September  1991 until June 1997,  he was employed by the  Musculoskeletal
       Transplant Foundation,  most recently as Vice President,  Hospital Sales.
       From January 1990 until  September 1991, Mr. Gehrig was Director of Sales
       for the Consumer  Product  Division of Warner Lambert.  Prior to that, he
       served  for 19 years in various  sales,  marketing  and sales  management
       positions with Johnson & Johnson.

(5)    Mr. Pfeiffer joined CollaGenex in June 1997 as Vice President, Marketing.
       He was promoted to Senior Vice President, Sales and Marketing in December
       2000.  From  September  1995  until  June 1997,  Mr.  Pfeiffer  served as
       Director  of  Marketing,   Health  Management  Services,  for  SmithKline
       Beecham. From May 1994 to September 1995, he served as Director,  Disease
       Management Services of Stuart Disease Management  Services, a division of
       Zeneca Pharmaceuticals.  From October 1991 to May 1994 he was employed in
       various product management positions with Zeneca  Pharmaceuticals  Group.
       From July 1988 to October  1991,  he held various  marketing  and product
       management positions with the Lederle  Laboratories  Division of American
       Cyanamid.

(6)    Dr.  Romanowicz  joined CollaGenex in November 1999 as Senior Director of
       Professional Affairs and Managed Care. He was promoted in January 2002 to
       his  current  position  of Vice  President  of  Professional  Affairs and
       Managed Care.  From October 1997 to November 1999, he was employed by The
       GMR Group, a pharmaceutical  consulting and marketing company, in various
       positions  including Vice President of Clinical Services.  From September
       1992  to  September  1997,  he  was  employed  in  various  managed  care
       capacities with Independence Blue Cross, a health care insurer.

       None of our executive officers are related to any other executive officer
or to any of our directors.  Our executive  officers are elected annually by the
Board of  Directors  and serve  until  their  successors  are duly  elected  and
qualified.

SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

       Section  16(a)  of the  Securities  Exchange  Act of  1934,  as  amended,
requires our directors, officers and stockholders who beneficially own more than
10% of any class of our equity securities  registered  pursuant to Section 12 of
the Exchange Act to file initial  reports of ownership and reports of changes in
ownership with respect to our equity securities with the Securities and Exchange
Commission.  All reporting  persons are required by the  Securities and Exchange
Commission's  regulations  to furnish us with  copies of all  reports  that such
reporting persons file with the Securities and Exchange  Commission  pursuant to
Section 16(a).

       Based solely on our review of the copies of such forms received by us and
upon written  representations of our reporting persons received by us, except as
described  below,  each such reporting  person has filed all of their respective
reports  pursuant  to Section  16(a) on a timely  basis.  Jeffrey  S. Day,  Vice
President,  Dermatology,  failed  to  timely  file  a  Form  3  relating  to his
commencement of employment in such position with us on October 10, 2001. Mr. Day
subsequently  filed such Form 3 with the Securities  and Exchange  Commission on
January 14, 2002.


                                       -10-


                             EXECUTIVE COMPENSATION

SUMMARY OF COMPENSATION IN FISCAL 2001, 2000 AND 1999

       The  following   Summary   Compensation   Table  sets  forth  information
concerning  compensation for services in all capacities awarded to, earned by or
paid to each person who served as our Chief Executive Officer at any time during
2001 and each other of our executive  officers whose aggregate cash compensation
exceeded  $100,000  at the end of 2001  (collectively  referred to as the "Named
Executives") during the years ended December 31, 2001, 2000 and 1999.




                          SUMMARY COMPENSATION TABLE(1)
- -----------------------------------------------------------------------------------------------------------
                                                                                          LONG-TERM
                                                                                        COMPENSATION
                                                 ANNUAL COMPENSATION                       AWARDS
                                          -----------------------------------------------------------------
                                                                                          SECURITIES
                                                                                          UNDERLYING
 NAME AND PRINCIPAL POSITION       YEAR           SALARY                BONUS              OPTIONS
                                                   ($)                   ($)                 (#)
           (a)                     (b)             (c)                   (d)(3)              (g)
- -----------------------------------------------------------------------------------------------------------

                                                                                

Brian M. Gallagher, Ph.D.(2)....   2001           315,000               131,615             100,000
     President, Chief Executive    2000           300,000                35,615              95,000
     Officer and Chairman of the   1999           268,000               137,917              75,000
     Board

Robert A. Ashley................   2001           225,000                93,908              80,000
     Senior Vice President         2000           215,000                29,708              40,000
                                   1999           190,000                64,117              35,000

Nancy C. Broadbent..............   2001           210,000                87,881              50,000
     Chief Financial Officer,      2000           200,000                 3,881              25,000
     Treasurer and Secretary       1999           186,000                53,717              25,000

Douglas C. Gehrig...............   2001           200,000                82,712              50,000
     Vice President, Sales         2000           190,000                27,912              40,000
                                   1999           157,000                53,505              25,000

David F. Pfeiffer ..............   2001           225,000                93,812              80,000
     Senior Vice President,        2000           210,000                29,012              50,000
     Sales and Marketing           1999           157,000                94,408              25,000

- -----------

(1)    The costs of  certain  benefits  are not  included  because  they did not
       exceed, in the case of each Named Executive, the lesser of $50,000 or 10%
       of the total annual salary and bonus reported in the above table.

(2)    In November  1994,  Dr.  Gallagher  purchased  125,000  shares of the our
       restricted  common stock at $0.335 per share. Such shares were subject to
       the Company's right of first refusal, pursuant to which we were permitted
       to buy such shares back from Dr.  Gallagher  at $0.335 per share,  if Dr.
       Gallagher was terminated for cause,  and at the then current market value
       per share,  if he was terminated  for any other reason.  On May 11, 1999,
       the Board of  Directors  unanimously  voted to remove  the right of first
       refusal  restriction  from the 125,000 shares.  At December 31, 2001, Dr.
       Gallagher  held all of such  shares,  with a year-end  value of  $970,625
       based on the value of the common stock as of such date ($8.10 per share),
       less the  purchase  price  per share  paid for such  shares  ($0.335  per
       share).

(3)    Such bonus  amounts for each Named  Executive  for fiscal  years 2000 and
       1999 have been  restated to reflect,  among other  things,  the amount of
       bonus  earned  by  each  such  Named  Executive  in  those  fiscal  years
       notwithstanding  the fact  that  such  bonus  may have  been  paid in the
       subsequent year.


                                       -11-


Option Grants in 2001

       The following table sets forth information  concerning  individual grants
of stock options made during 2001 to each of the Named Executives.




                        OPTION GRANTS IN LAST FISCAL YEAR

- -------------------------------------------------------------------------------------------------------------------
                                INDIVIDUAL GRANTS

- -------------------------------------------------------------------------------------------------------------------
                                                                                          POTENTIAL REALIZABLE
                                                  PERCENT OF                                   VALUE AT
                                   NUMBER OF        TOTAL                                 ASSUMED ANNUAL RATES
                                   SECURITIES      OPTIONS                                      OF STOCK
                                   UNDERLYING     GRANTED TO   EXERCISE                   PRICE APPRECIATION FOR
                                    OPTIONS       EMPLOYEES     OR BASE                          OPTION
                                    GRANTED       IN FISCAL     PRICE      EXPIRATION           TERM (2)
             NAME                     (#)          YEAR (1)     ($/Sh)       DATE          5%($)      10%($)
              (a)                     (b)            (c)         (d)          (e)           (f)        (g)
- ------------------------------------------------------------------------------------------------------------------
                                                                                   

Brian M. Gallagher, Ph.D.....       100,000         17.54%      5.1875       2/27/11      326,239    826,754

Robert A. Ashley.............        80,000         14.03%      5.1875       2/27/11      260,991    661,403

Nancy C. Broadbent...........        50,000          8.77%      5.1875       2/27/11      163,120    413,377

Douglas C. Gehrig............        50,000          8.77%      5.1875       2/27/11      163,120    413,377

David F. Pfeiffer............        80,000         14.03%      5.1875       2/27/11      260,991    661,403

- -----------

(1)    Based on an  aggregate of 570,100  options  granted to employees in 2001,
       including options granted to Named Executives.

(2)    Based on a grant date fair market value of $5.1875 per share.


                                       -12-


Aggregated Option Exercises in 2001 and Year End Option Values

       The following  table sets forth  information  concerning each exercise of
options  during 2001 by each of the Named  Executives  and the year end value of
unexercised in-the-money options.



                 AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR
                        AND FISCAL YEAR END OPTION VALUES

- ---------------------------------------------------------------------------------------------------------------------

                                                                 NUMBER OF
                                                                 SECURITIES           VALUE OF
                                                                 UNDERLYING          UNEXERCISED
                                                                 UNEXERCISED         IN-THE-MONEY
                                                                  OPTIONS AT          OPTIONS AT
                                  SHARES                           FISCAL               FISCAL
                                 ACQUIRED                         YEAR-END             YEAR-END
                                    ON           VALUE               (#)                 ($)(1)
                                 EXERCISE       REALIZED         EXERCISABLE/        EXERCISABLE/
           Name                    (#)            ($)            UNEXERCISABLE       UNEXERCISABLE
           (a)                     (b)            (c)                (d)                  (e)
- ---------------------------------------------------------------------------------------------------------------------
                                                                       
Brian M. Gallagher, Ph.D.......     --           --          254,000 / 241,000     874,740 / 288,460

Robert A. Ashley...............     --           --          110,500 / 132,000     333,092 / 204,868

Nancy C. Broadbent.............     --           --            75,000 / 90,000     148,370 / 134,980

Douglas L. Gehrig..............     --           --           100,000 / 95,000      51,320 / 131,280

David F. Pfeiffer..............     --           --          108,000 / 127,000      68,792 / 201,168

- ----------

(1)    Based on a year end fair market value of the underlying  securities equal
       to $8.10 per share, less the exercise price payable for such shares.

EMPLOYMENT   CONTRACTS,   TERMINATION   OF  EMPLOYMENT   AND   CHANGE-IN-CONTROL
ARRANGEMENTS

       We have executed  indemnification  agreements  with each of our executive
officers  and  directors  pursuant  to which we have  agreed to  indemnify  such
parties to the full extent permitted by law, subject to certain  exceptions,  if
any such party  becomes  subject to an action  because such party is a director,
officer,  employee, agent or fiduciary of the Company. In general, our employees
are covered by confidentiality agreements.

       In addition,  each of Dr.  Gallagher,  Ms. Broadbent and Messrs.  Ashley,
Gehrig,  and Pfeiffer have agreed that during the term of his or her  employment
and for a period of two years  thereafter,  such  person  will not  directly  or
indirectly provide services to or for any business engaged in research regarding
the  development,   manufacture,  testing,  marketing  or  sale  of  collagenase
inhibiting drugs for application in periodontal disease or any other application
which, during the period of such person's employment with us, is either marketed
or in advanced clinical development by us.



                                       -13-


COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

       The  Compensation  Committee  currently  consists  of,  and  during  2001
consisted  of, W.  James  O'Shea,  who serves as  Chairman,  Robert C. Black and
Robert J.  Easton.  There are no,  and during  2001 there were no,  Compensation
Committee interlocks.

       As of March 15, 2002, Mr. Easton, in his individual capacity, held 25,532
shares of our common stock.  Such shares of common stock include those shares of
common stock which were previously  issued by us upon conversion of our Series A
preferred  stock,  Series  B  preferred  stock  and  Series  C  preferred  stock
previously held by Mr. Easton.  As of March 15, 2002, Mr. Easton also held 2,000
shares of our Series D preferred stock which were convertible into 20,179 shares
of our common stock as of such date.

       In September 1995, we entered into a registration  rights  agreement with
each of the then  holders  of our  Series A,  Series B and  Series C  redeemable
preferred stock pursuant to which we have granted certain registration rights to
such stockholders.  Pursuant to such registration rights agreement,  at any time
beginning  six months after June 20,  1996,  the  effective  date of our initial
public  offering,  the holders of at least a majority of the common stock issued
upon the conversion of the Series A, Series B and Series C redeemable  preferred
stock (referred to collectively as the "Registrable Securities") have the right,
subject to certain  restrictions set forth in the registration rights agreement,
to require that we register the Registrable Securities requested by such holders
at our expense (on no more than two occasions) on either a Form S-1, Form S-2 or
Form S-3 Registration Statement under the Securities Act of 1933, as amended. We
are not,  however,  required to register any Registrable  Securities unless such
shares represent at least 10% of our outstanding  shares of common stock, or, if
less than 10%, if the anticipated aggregate offering price exceeds $1,000,000.

       The holders of Registrable Securities also have the right to an unlimited
number of  registrations  on Form S -3 under the Securities  Act, as of 1933, as
amended. We are not, however,  required to effect such a registration unless the
requesting holders reasonably  anticipate having an aggregate  disposition price
of at least $500,000.

       Also  pursuant  to the  registration  rights  agreement,  if, at any time
during the  seven-year  period  commencing on the effective  date of our initial
public  offering,  we propose to  register  any of our  common  stock  under the
Securities Act of 1933, as amended,  for sale to the public,  the holders of the
Registrable  Securities  have  unlimited  piggyback  registration  rights at our
expense,  subject to certain  restrictions set forth in the registration  rights
agreement.

       Also in  September  1995,  we  granted  to the then  holders of Series A,
Series B and Series C redeemable  preferred  stock certain rights to participate
in certain future offerings undertaken by us. Such rights to participate require
that,  with certain  exceptions  including,  but not limited to, an underwritten
public  offering,  any time we propose to issue,  sell or  exchange,  or reserve
therefor,  any  securities,  we  must  first  offer  to  sell  to  each  of  the
pre-conversion  holders of Series A, Series B and Series C redeemable  preferred
stock their respective pro rata share of such securities at a price and on terms
identical to the price and terms of the securities  proposed to be issued,  sold
or exchanged in the applicable offering.

       In May 1999,  we  entered  into a  Stockholder  and  Registration  Rights
Agreement  with each of the holders of our Series D preferred  stock pursuant to
which,  among other things, we registered on a Registration  Statement on a Form
S-3,  all of the shares of our common  stock  underlying  the shares of Series D
preferred stock then issued and  outstanding.  The Stockholder and  Registration
Rights Agreement further obligates us to register,  on a Registration  Statement
on Form S-3, all of the shares of common stock issued as dividends on the Series
D preferred  stock to the holders  thereof  within a  reasonable  period of time
after each such dividend  payment is made. We are obligated to keep current each
such Registration  Statement on Form S-3 until such time as all of the shares of
common stock  registered  thereunder have been sold or are otherwise exempt from
registration.

       The holders of at least a majority of the Series D  preferred  stock also
have the right, subject to certain  restrictions,  to require us to register the
shares  of  common  stock  underlying  their  Series  D  preferred  stock  on  a
Registration  Statement  on  Form  S-1  at our  expense  (on no  more  than  two
occasions). Also, pursuant to the Stockholder and Registration Rights Agreement,
if we propose to register  any of our  securities  under the  Securities  Act of
1933, as amended,  for sale to the public, the holders of the Series D preferred
stock have certain piggyback  registration  rights with respect to the shares of
common stock underlying their Series D preferred stock at our


                                       -14-


expense, subject to certain restrictions.  In addition, if we grant registration
rights to the holders of any of our securities  that are more favorable than the
registration  rights  granted  under the  Stockholder  and  Registration  Rights
Agreement,  then the holders of the Series D preferred  stock shall be deemed to
have been granted such superior  registration rights as well with respect to the
shares of common stock underlying their Series D preferred stock.  Also pursuant
to the terms of the Stockholder and Registration  Rights Agreement,  the holders
of Series D preferred stock have certain rights of first refusal with respect to
certain stock issuances by us, beginning twelve months after the date of initial
issuance of the Series D preferred stock.



                                       -15-


PERFORMANCE GRAPH

       The following graph compares the cumulative total  stockholder  return on
our common stock with the cumulative  total return on the Nasdaq Composite Index
and the Nasdaq  Pharmaceutical  Index  (capitalization  weighted) for the period
beginning  on January  1, 1997 and ending on the last day of our last  completed
fiscal year.

                 COMPARISON OF CUMULATIVE TOTAL RETURN(1)(2)(3)

              Among CollaGenex, the Nasdaq Composite Index and the
                           Nasdaq Pharmaceutical Index
                            (Capitalization Weighted)












                     [THE FOLLOWING TABLE WAS REPRESENTED AS
                     A LINE GRAPH IN THE PRINTED MATERIALS]

















                Base
   Company/    Period
    Index      January   June   December   June    December   June    December   June   December   June   December
    Name         1997    1997     1997     1998      1998     1999     1999      2000     2000     2001     2001
- -----------    -------  ------  --------  -------  --------  -------  --------  ------  --------  ------  --------
                                                                           

CGPI.......    $100.00  $147.60  $153.75  $106.15  $118.45   $123.00  $307.50   $115.38  $45.39   $100.86   $99.63

NASDAQ.....    $100.00  $111.90  $122.48  $147.28  $172.68   $211.79  $320.83   $313.18  $192.98  $169.78  $153.12

NASDAQ
PHAR.......    $100.00  $102.13  $103.05  $104.36  $130.81   $146.41  $246.64   $336.22  $307.65  $283.02  $262.19

- -----------

(1)    Graph assumes $100  invested on January 1, 1997 in our common stock,  the
       Nasdaq   Composite   Index   and   the   Nasdaq    Pharmaceutical   Index
       (capitalization weighted).

(2)    Total return assumes reinvestment of dividends.

(3)    Year ended December 31.


                                       -16-


COMPENSATION COMMITTEE REPORT ON EXECUTIVE COMPENSATION

       The Compensation Committee has furnished the following report:

       The Compensation Committee is comprised of three non-employee  directors.
The  Compensation  Committee  recommends,  and the Board  approves,  all matters
relating to executive compensation, including setting and administering policies
governing executive salaries, bonuses (if any) and stock option awards (if any).
The  Compensation  Committee meets twice annually to set performance  objectives
for the Chief Executive Officer and to determine the annual  compensation of the
CEO  and  our  other  senior  executives.  The  CEO is not  present  during  the
discussion of his compensation.

EXECUTIVE COMPENSATION POLICY

       The  goal of our  executive  compensation  policy  is to  ensure  that an
appropriate  relationship exists between executive compensation and the creation
of stockholder value, while at the same time attracting and retaining  qualified
senior management. In order to continually attract and retain highly experienced
executives,   our  compensation   packages  for  senior  executives  are  highly
competitive  with  those paid to  executives  of other  emerging  pharmaceutical
companies.

COMPENSATION MIX

       Our executive  compensation  packages generally include three components:
base salary, a discretionary annual cash bonus and stock options.

BASE SALARY

       The  Compensation  Committee  seeks to establish  base  salaries for each
position  and  level of  responsibility  which  are  competitive  with  those of
executive officers at other emerging pharmaceutical companies.

DISCRETIONARY CASH BONUS

       The Compensation  Committee  believes that discretionary cash bonuses are
important to motivate and reward executive officers.  However,  cash bonuses are
not  guaranteed.  Annual cash bonuses are awarded to  executives  based on their
achievements  against a stated list of objectives  developed at the beginning of
each year by senior management and the Compensation  Committee.  Such objectives
are reviewed and approved by the Board of Directors.

STOCK OPTIONS

       Stock option grants are designed to align the long term  interests of our
executives with those of our stockholders by rewarding executives for increasing
stockholder value. All executive officers are awarded option grants upon joining
the  Company  which  are   competitive   with  those  at   comparable   emerging
pharmaceutical  companies.  In addition,  the  Compensation  Committee may award
additional  stock option grants  annually.  When  granting  stock  options,  the
Compensation  Committee considers the recommendation of our CEO and the relative
performance and contributions of each officer compared to that of other officers
within the Company  with  similar  levels of  responsibility.  The  Compensation
Committee has in the past  granted,  and may continue to grant from time to time
in the future,  options to our executive  officers  containing target milestones
with respect to the trading  price of our common stock and  accelerated  vesting
upon the achievement of such milestones.

COMPENSATION OF THE CHIEF EXECUTIVE OFFICER

       In establishing Dr. Gallagher's  compensation  package,  the Compensation
Committee  seeks  to  maintain  a level of total  current  compensation  that is
competitive  with  that paid to chief  executive  officers  of other  comparable
emerging   pharmaceutical   companies.  In  addition,  in  order  to  align  Dr.
Gallagher's  interests with the interests of our stockholders,  the Compensation
Committee  attempts  to make a  substantial  portion  of the  value of his total
compensation dependent on the appreciation of our stock price.


                                       -17-


       Dr.  Gallagher's  performance is evaluated  annually by the  Compensation
Committee  against a stated  list of  short,  medium  and long  term  objectives
developed  by the  Compensation  Committee  at the  beginning  of each  year and
approved by the Board of Directors.  Based on his achievements relating to these
objectives,  the Compensation Committee  recommended,  and the Board approved, a
bonus to Dr.  Gallagher  of  $131,615  for  2001,  which was paid in 2002 and an
increase in base salary from $315,000 to $324,450 effective January 1, 2002.

TAX CONSIDERATIONS

       Section  162(m)  of the  Internal  Revenue  Code  of  1986,  as  amended,
generally disallows a tax deduction to public companies for certain compensation
in excess of $1 million paid to the company's CEO and the four other most highly
compensated  executive  officers.  Certain  compensation,   including  qualified
performance-based  compensation,  will not be subject to the deduction  limit if
certain  requirements are met. The Compensation  Committee reviews the potential
effect  of  Section  162(m)  periodically  and uses its  judgment  to  authorize
compensation  payments  that may be subject  to the limit when the  Compensation
Committee  believes such payments are  appropriate  and in the best interests of
the Company and our  stockholders,  after  taking  into  consideration  changing
business conditions and the performance of our employees.

                                       Compensation Committee Members:

                                       W. James O'Shea, Chairman
                                       Robert C. Black, Member
                                       Robert J. Easton, Member


                                       -18-


         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

       There were, as of March 15, 2002, approximately 116 holders of record and
approximately  3,500 beneficial holders of our common stock. The following table
sets forth certain  information,  as of March 15, 2002, with respect to holdings
of our common stock by (i) each person known by us to be the beneficial owner of
more than 5% of the total number of shares of the common stock outstanding as of
such date,  based on currently  available  Schedules  13D and 13G filed with the
SEC,  (ii)  each of our  directors  (which  includes  all  nominees)  and  Named
Executives, and (iii) all directors and officers as a group.



                                                     AMOUNT AND NATURE OF           PERCENT
NAME AND ADDRESS OF BENEFICIAL OWNER(1)              BENEFICIAL OWNERSHIP(1)        OF CLASS(2)
- ------------------------------------                 --------------------           --------
                                                                                

(i)    Certain Beneficial Owners:

Oaktree Capital Management, LLC
OCM Principal Opportunities Fund, L.P.
333 South Grand Avenue, 28th Floor
Los Angeles, California 90071.......................      2,321,982(3)                18.0%

Perseus-Soros BioPharmaceutical Fund, L.P.
c/o Soros Fund Management LLC
888 Seventh Avenue, 29th Floor
New York, NY  10106 ................................      1,266,668(4)                11.1%

Marquette Venture Partners II, L.P.
and MVP II Affiliates Fund, L.P.
520 Lake Cook Road, Suite 450
Deerfield, Illinois 60015...........................      1,023,464(5)                 9.1%

Ashford Capital Management, Inc.
P.O. Box 4172
Wilmington, Delaware 19807..........................        791,366(6)                 7.1%

(ii)   Directors (which includes all nominees) and
       Named Executives:

Brian M. Gallagher, Ph.D............................        458,000(7)                 4.0%
Robert A. Ashley....................................        184,100(8)                 1.6%
Nancy C. Broadbent..................................        153,000(9)                 1.4%
Douglas C. Gehrig...................................        132,320(10)                1.2%
David F. Pfeiffer...................................        150,500(11)                1.3%
Peter R. Barnett, D.M.D.............................         27,000(12)                   *
Robert Black........................................         10,000(13)                   *
James E. Daverman...................................      1,103,464(14)                9.8%
Robert J. Easton....................................         75,161(15)                   *
Stephen Kaplan......................................      2,334,982(16)               18.0%
W. James O'Shea.....................................          5,000(17)                   *

(iii)  All Directors and executive officers as a
       group (13 persons)...........................      4,661,027(18)               33.4%

- -----------

*      Less than 1%

                                       -19-


(1)    Except  as set  forth in the  footnotes  to this  table  and  subject  to
       applicable  community property law, the persons and entities named in the
       table have sole voting and investment power with respect to all shares.

(2)    Applicable percentage of ownership for each holder is based on 11,110,019
       shares of common stock  outstanding  on March 15,  2002,  plus any common
       stock  equivalents  and presently  exercisable  stock options or warrants
       held by each such  holder,  and  options  or  warrants  held by each such
       holder which will become exercisable within 60 days after March 15, 2002.

(3)    Includes 1,785,805 shares of common stock issuable upon the conversion of
       177,000  shares of the Series D preferred  stock held thereby and 561,177
       shares of common  stock  issued in payment of  dividends  on the Series D
       preferred stock.

(4)    Includes 266,668 shares of common stock underlying  warrants which are or
       may be exercisable as of March 15, 2002 or 60 days after such date.

(5)    Includes  an  aggregate  of  1,019,775  shares of common  stock  owned by
       Marquette  Venture  Partners II, L.P.  (which  includes  98,089 shares of
       common stock issuable upon the conversion of 9,722 shares of the Series D
       preferred  stock held  thereby,  30,826  shares of common stock issued in
       payment of dividends on such Series D preferred  stock and 890,860 shares
       of common stock otherwise held thereby), and an aggregate of 3,689 shares
       of common  stock owned by MVP II  Affiliates  Fund,  L.P (which  includes
       2,805 shares of common stock  issuable upon the  conversion of 278 shares
       of the Series D preferred  stock held  thereby,  and 884 shares of common
       stock issued in payment of dividends on such Series D preferred stock).

(6)    Includes 200,000 shares of common stock registered in the name of Ashford
       Capital Partners, LP and 200,000 shares of common stock registered in the
       name of Anvil Investment  Associates,  LP. Also includes 53,333 shares of
       common stock underlying warrants held by Ashford Capital Partners, LP and
       53,333  shares  of  common  stock  underlying   warrants  held  by  Anvil
       Investment  Associates,  LP, which are or may be  exercisable as of March
       15, 2002 or 60 days after such date.  Theodore H. Ashford is Chairman and
       CEO of Ashford  Capital  Management,  Inc.,  the  Advisor to the  general
       partners of Ashford Capital Partners, LP and Anvil Investment Associates,
       LP and,  as  such,  has the  power to vote or  direct  the vote of and to
       dispose  of or direct  the  disposition  of the  shares  owned by Ashford
       Capital  Partners,  LP and Anvil Investment  Associates,  LP. Mr. Ashford
       expressly disclaims beneficial ownership of such shares, except as to his
       proportionate   interest  in  Ashford  Capital  Partners,  LP  and  Anvil
       Investment Associates, LP.

(7)    Includes 333,000 shares of common stock  underlying  options which are or
       may be exercisable as of March 15, 2002 or 60 days after such date.

(8)    Includes 151,500 shares of common stock  underlying  options which are or
       may be exercisable as of March 15, 2002 or 60 days after such date.

(9)    Includes 105,000 shares of common stock  underlying  options which are or
       may be exercisable as of March 15, 2002 or 60 days after such date.  Also
       includes  2,000  shares  of  common  stock  held  as  custodian  for  Ms.
       Broadbent's minor child, 1,000 shares of common stock held in the name of
       Ms.  Broadbent's spouse and 1,000 shares of common stock held in the name
       of Ms. Broadbent's parent who resides with Ms. Broadbent.

(10)   Includes 127,000 shares of common stock  underlying  options which are or
       may be exercisable as of March 15, 2002 or 60 days after such date.

(11)   Includes  143,000  shares of common stock  underlying  options  which are
       exercisable as of March 15, 2002 or 60 days after such date.

(12)   Includes  25,000  shares of common  stock  underlying  options  which are
       exercisable as of March 15, 2002 or 60 days after such date.

                                       -20-


(13)   Includes  10,000  shares of common  stock  underlying  options  which are
       exercisable as of March 15, 2002 or 60 days after such date.

(14)   James E. Daverman is President of Marquette Management Partners, LLC, the
       general partner of Marquette Venture Partners, L.P. and a general partner
       of MG II, L.P.,  the general  partner of Marquette  Venture  Partners II,
       L.P. and MVP II Affiliates Fund, L.P. and, as such, has the power to vote
       or direct the vote of and to dispose of or direct the  disposition of the
       shares owned by Marquette Venture Partners II, L.P. and MVP II Affiliates
       Fund, L.P. Mr. Daverman expressly disclaims  beneficial ownership of such
       shares,  except as to his  proportionate  interest in  Marquette  Venture
       Partners II, L.P. and MVP II Affiliates Fund, L.P. Includes 25,000 shares
       of common stock underlying  options which are exercisable as of March 15,
       2002 or 60 days  after  such  date and  55,000  shares  of  common  stock
       otherwise held by Mr. Daverman, individually.

(15)   Includes  25,000  shares of common  stock  underlying  options  which are
       exercisable  as of  March  15,  2002 or 60 days  after  such  date.  Also
       includes  20,179 shares of common stock  issuable upon the  conversion of
       2,000 shares of the Series D preferred stock held by Mr. Easton and 6,343
       shares of common  stock  issued in payment of  dividends on such Series D
       preferred stock.  Also includes 19,189 shares of common stock held by Mr.
       Easton,  individually,  and 4,450  shares of common stock held as trustee
       for the Rachel Easton Charitable Trust.

(16)   Stephen Kaplan is a principal of OCM Principal  Opportunities  Fund, L.P.
       and, as such,  has the power to vote or direct the vote of and to dispose
       of or  direct  the  disposition  of the  shares  owned  by OCM  Principal
       Opportunities  Fund,  L.P.  Mr.  Kaplan  expressly  disclaims  beneficial
       ownership of such shares, except as to his proportionate  interest in OCM
       Principal  Opportunities Fund, L.P. Includes 3,000 shares of common stock
       held by Mr. Kaplan in his individual capacity and 10,000 shares of common
       stock underlying options which are exercisable as of March 15, 2002 or 60
       days after such date.

(17)   Includes  5,000  shares  of common  stock  underlying  options  which are
       exercisable as of March 15, 2002 or 60 days after such date.

(18)   See Notes 7 through 17.


                                      -21-


SERIES D PREFERRED STOCK

       There  were,  as of March 15,  2002,  6 holders of record of our Series D
preferred stock. The following table sets forth certain information, as of March
15,  2002,  with respect to the  beneficial  ownership of our Series D preferred
stock by (i) each person known by us to be the beneficial  owner of more than 5%
of the total number of shares of Series D preferred stock outstanding as of such
date,  (ii)  each of our  directors  (which  includes  all  nominees)  and Named
Executives who  beneficially  own shares of Series D preferred  stock, and (iii)
all directors and officers as a group.



                                                           AMOUNT AND NATURE OF         PERCENT
NAME AND ADDRESS OF BENEFICIAL OWNER(1)                    BENEFICIAL OWNERSHIP(1)      OF CLASS(2)
- ------------------------------------                       ---------------------        --------
                                                                                      
(i)    Certain Beneficial Owners:
OCM Principal Opportunities Fund, L.P..................         177,000(3)                  88.5%
Richard A. Horstmann...................................          10,000(4)                   5.0%
Marquette Venture Partners II, L.P. and
   MVP II Affiliates Fund, L.P.........................          10,000(5)                   5.0%
(ii)   Directors (which includes all nominees) and
       Named Executives:
Robert J. Easton.......................................           2,000(6)                   1.0%
Stephen Kaplan.........................................         177,000(7)                  88.5%
(iii)  All Directors and officers as a
       group (13 persons)..............................         189,000(5)(6)(7)            94.5%

- -----------

(1)    Except  as set  forth in the  footnotes  to this  table  and  subject  to
       applicable  community property law, the persons and entities named in the
       table have sole voting and investment power with respect to all shares.

(2)    Applicable percentage of ownership is based on 200,000 shares of Series D
       preferred stock outstanding on March 15, 2002.

(3)    Such shares of Series D preferred  stock are  convertible  into 1,785,805
       shares of common stock.

(4)    Such  shares of Series D preferred  stock are  convertible  into  100,893
       shares of common stock.

(5)    Of such  shares of Series D  preferred  stock,  9,722  shares are held by
       Marquette  Venture  Partners  II, L.P.  and are  convertible  into 98,089
       shares of common stock. Also, of such shares of Series D preferred stock,
       278 shares are held by MVP II Affiliates  Fund,  L.P. and are convertible
       into 2,805 shares of common stock.

(6)    Such  shares of Series D  preferred  stock are  convertible  into  20,179
       shares of common stock.

(7)    Stephen Kaplan is a principal of OCM Principal  Opportunities  Fund, L.P.
       and, as such,  has the power to vote or direct the vote of and to dispose
       of or  direct  the  disposition  of the  shares  owned  by OCM  Principal
       Opportunities  Fund,  L.P.  Mr.  Kaplan  expressly  disclaims  beneficial
       ownership of such shares, except as to his proportionate  interest in OCM
       Principal Opportunities Fund, L.P.



                                       -22-


                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

       For transactions and information  relating to certain registration rights
and rights to participate in certain future offerings  undertaken by us, for Mr.
Easton,  who  currently  serves,  and  during  2001  served,  as a member of our
Compensation  Committee,  please  see  "EXECUTIVE  COMPENSATION  -  Compensation
Committee Interlocks and Insider Participation."

       James E.  Daverman,  a member of our board of  directors,  is a  managing
general partner of Marquette  Venture  Partners,  a venture  capital  investment
company  which he founded in 1987.  Additionally,  Mr.  Daverman is President of
Marquette  Management  Partners,  LLC, the general partner of Marquette  Venture
Partners,  L.P.  and a general  partner of MG II, L.P.,  the general  partner of
Marquette  Venture  Partners  II, L.P. and MVP II  Affiliates  Fund,  L.P.  Both
Marquette  Venture Partners II, L.P. and MVP II Affiliates Fund, L.P. are, as of
March 15, 2002, holders of 921,686 and 884 shares,  respectively,  of our common
stock.  Such  shares  include  those  shares  of our  common  stock  which  were
previously issued by us upon conversion of our Series A preferred stock,  Series
B preferred stock and Series C preferred  stock  previously held by each entity.
Such  entities are entitled,  therefore,  to identical  registration  rights and
rights to  participate  in future  offerings  undertaken by us as is Mr. Easton,
with respect to such shares of our common stock.

       As of March 15, 2002: (i) Marquette  Venture Partners II, L.P. and MVP II
Affiliates  Fund,  L.P.  held an  aggregate  of 10,000  shares  of our  Series D
preferred stock which were  convertible  into 100,894 shares of our common stock
as of such date; and (ii) OCM Principal Opportunities Fund, L.P., with which Mr.
Kaplan, a member of our board of directors, is affiliated,  held an aggregate of
177,000  shares of our Series D  preferred  stock  which were  convertible  into
1,785,805 shares of our common stock. Such entities are entitled,  therefore, to
identical  registration  rights and rights to  participate  in future  offerings
undertaken  by us as is Mr.  Easton,  with  respect  to such  shares of Series D
preferred stock.

                         1996 STOCK OPTION PLAN PROPOSAL

       The 1996 Stock  Option  Plan was  adopted by the Board of  Directors  and
approved by our stockholders on March 22, 1996 and March 29, 1996, respectively.
Those eligible to receive stock option grants or stock purchase rights under the
1996 Stock Option Plan include our  employees,  directors and  consultants.  The
1996 Stock Option Plan was adopted to

o      attract  and  retain  the  best  available  personnel  for  positions  of
       substantial responsibility;

o      provide  additional  incentives  to  employees,  members  of the Board of
       Directors and consultants of the Company and our subsidiaries; and

o      promote the success of our business.

       Currently  there  are  2,000,000  shares  of common  stock  reserved  for
issuance upon the exercise of options and/or stock purchase rights granted under
the 1996 Stock Option Plan.

       The 1996 Stock Option Plan is administered by the Compensation Committee,
which is  comprised  solely of outside  directors.  The  Compensation  Committee
determines, among other things, the

o      nature of the options to be granted;

o      persons, or grantees, who are to receive options;

o      number of shares to be subject to each option;

o      exercise price of the options; and

o      vesting schedule of the options.

                                       -23-


       The 1996 Stock Option Plan provides for the granting of options  intended
to qualify as incentive stock options, or ISOs, as defined in Section 422 of the
Internal  Revenue Code of 1986, as amended,  or the Code, to our employees.  The
1996 Stock Option Plan also  provides for the  granting of  non-qualified  stock
options,  or NQSOs,  to employees,  non-employee  directors and  consultants who
perform  services for us or our  subsidiaries.  The  exercise  price of all ISOs
granted  under the 1996 Stock  Option  Plan may not be less than the fair market
value of the shares at the time the option is granted.  In addition,  no ISO may
be granted to an employee  who owns more than 10% of the total  combined  voting
power of all classes of our stock unless the exercise  price as to that employee
is at least 110% of the fair market value of the stock at the time of the grant.
To the extent that options  designated as ISOs become  exercisable for the first
time  during any  calendar  year for common  stock  having a fair  market  value
greater than $100,000  (determined for each share as of the date of grant of the
options  covering  such share),  the portion of such options  which exceeds such
amount shall be treated as NQSOs. Options may be exercisable for a period of not
more than ten years from the date of grant; provided,  however, that the term of
an ISO  granted  to an  employee  who owns more  than 10% of the total  combined
voting power of all classes of our stock may not exceed five years. The exercise
price of NQSOs granted under the 1996 Stock Option Plan may not be less than 85%
of the fair market value per share of the common stock on the date of grant.  No
NQSO may be  granted  to a person  who owns more than 10% of the total  combined
voting  power of all  classes  of our stock  unless the  exercise  price to that
person is at least 110% of the fair market value of the stock at the time of the
grant.  The  exercise  price  must be paid in  full  at the  time an  option  is
exercised,  and at the Compensation  Committee's discretion,  all or part of the
exercise  price  may be paid with  previously  owned  shares  or other  approved
methods of payment.  An option is exercisable as determined by the  Compensation
Committee. The 1996 Stock Option Plan will terminate on March 28, 2006.

       Subject to the terms as specified in any option agreement,  the following
time table applies with respect to exercising  outstanding  vested  options if a
grantee's employment or consulting relationship is terminated:


       Reason for termination during term of
       employment or consulting relationship                         Latest exercise date
       -------------------------------------                         --------------------
                                                          
Disability                                                   One year following termination by grantee

Death                                                        One year following death by grantee's estate

Any other reason                                             90 days following termination by grantee



       Options are not  assignable or otherwise  transferable  except by will or
the laws of  descent  and  distribution  and  shall be  exercisable  during  the
grantee's lifetime only by the grantee.

       The 1996 Stock Option Plan also  permits the  awarding of stock  purchase
rights at not less  than 50% of the fair  market  value of the  shares as of the
date offered.  The 1996 Stock Option Plan requires the execution of a restricted
stock purchase  agreement in a form  determined by the  Compensation  Committee.
Once a stock purchase right is exercised,  the purchaser will have the rights of
a stockholder.  The purchaser will be a stockholder when the purchase is entered
on our records.

       The 1996 Stock Option Plan provides that in the event of a

o      reorganization;                            o      recapitalization;

o      stock split;                               o      stock dividend;

o      combination of or  reclassification        o      or any other change in
       of shares;                                        the corporate structure
                                                         or our shares,
the Board of Directors  shall make  adjustments  with respect to the shares that
may be  issued  under  the  1996  Stock  Option  Plan or  that  are  covered  by
outstanding options, or in the option price per share.

       The Board  shall  notify  the  grantee at least  fifteen  days prior to a
dissolution  or  liquidation  of  the  Company.  The  outstanding  options,  not
previously  exercised,  will terminate  immediately prior to the consummation of
such proposed  action.  In the event of a merger or consolidation of the Company
or the sale of all or substantially all of our assets  (hereinafter  referred to
as a "merger"),  the outstanding options will be assumed or an equivalent option
will be substituted  by such successor  corporation or a parent or subsidiary of
such  successor  corporation.  If such


                                       -24-


successor  corporation  does not agree to assume the  outstanding  options or to
substitute  equivalent  options,  the Board of Directors  will,  in lieu of such
assumption  or  substitution,  provide  for the  grantee  to have  the  right to
exercise all of his or her outstanding  options. If the Board of Directors makes
an option fully exercisable in lieu of assumption or substitution,  in the event
of a merger,  the Board of  Directors  shall  notify the grantee that the option
will be fully  exercisable  for a period of  fifteen  days from the date of such
notice,  and the option will terminate  upon the expiration of such period.  The
option will be considered  assumed if, following the merger,  the option confers
the right to  purchase,  for each  share of common  stock  subject to the option
immediately  prior to the merger,  the  consideration  (whether stock,  cash, or
other securities or property)  received in the merger by holders of common stock
for each share held on the  effective  date of the  transaction  (and if holders
were offered a choice of consideration,  the type of consideration chosen by the
holders of a majority of the outstanding shares). If such consideration received
in the merger was not solely  common stock of the successor  corporation  or its
parent,  the  Board  of  Directors  may,  with  the  consent  of  the  successor
corporation and the  participant,  provide for the  consideration to be received
upon the exercise of an option for each share of stock  subject to the option to
be solely common stock of the successor  corporation or its parent equal in fair
market value to the per share consideration  received by holders of common stock
in the merger or sale of assets.

       The Board may at any time amend,  alter,  suspend or discontinue the 1996
Stock Option Plan, but no such action will be made which would impair the rights
of any grantee under any grant previously made,  without such grantee's consent.
In addition,  to the extent  necessary  and  desirable to comply with Rule 16b-3
under the Exchange Act of 1934, as amended,  or with Section 422 of the Code (or
any other  applicable  law or  regulation,  including  the  requirements  of the
National Association of Securities Dealers or an established stock exchange), we
shall obtain  stockholder  approval of any 1996 Stock  Option Plan  amendment in
such  a  manner  and to  such a  degree  as  required.  Any  such  amendment  or
termination  of the 1996 Stock Option Plan is not  permitted  to affect  options
already  granted and such options will remain in full force and effect as if the
1996 Stock  Option  Plan had not been  amended or  terminated,  unless  mutually
agreed  otherwise  between  each  grantee  and the  Board  of  Directors,  which
agreement must be in writing and signed by the grantee and the Company.

FEDERAL INCOME TAX ASPECTS

       The following  generally  summarizes the United States federal income tax
consequences  that generally will arise with respect to awards granted under the
1996 Stock  Option  Plan.  This summary is based on the tax laws in effect as of
the date of this Proxy  Statement.  Changes  to these  laws could  alter the tax
consequences described below.

INCENTIVE STOCK OPTIONS

       A participant will not have income upon the grant of an ISO. Also, except
as described  below, a participant  will not have income upon exercise of an ISO
if the  participant  has  been  employed  by us or  any  of  our  majority-owned
corporate  subsidiaries  at all times  beginning  with the option grant date and
ending three months before the date the participant exercises the option. If the
participant has not been so employed during that time, then the participant will
be taxed as described below under "Non-Qualified Stock Options." The exercise of
an ISO may subject the participant to the alternative minimum tax.

       A participant  will have income upon the sale of the stock acquired under
an ISO at a profit (if sales proceeds  exceed the exercise  price).  The type of
income will depend on when the  participant  sells the stock.  If a  participant
sells the stock more than two years  after the option was  granted and more than
one  year  after  the  option  was  exercised,  then all of the  profit  will be
long-term  capital gain.  If a  participant  sells the stock prior to satisfying
these waiting periods, then the participant will have engaged in a disqualifying
disposition  and a portion of the profit will be  ordinary  income and a portion
may be capital gain.  This capital gain will be long-term if the participant has
held the stock for more than one year and  otherwise  will be  short-term.  If a
participant sells the stock at a loss (sales proceeds are less than the exercise
price),  then the  loss  will be a  capital  loss.  This  capital  loss  will be
long-term if the participant held the stock for more than one year and otherwise
will be short-term.

                                       -25-


NON-QUALIFIED STOCK OPTIONS

       A  participant  will  not  have  income  upon  the  grant  of a  NQSO.  A
participant will have  compensation  income upon the exercise of a NQSO equal to
the value of the stock on the day the participant  exercised the option less the
exercise price.  Upon sale of the stock,  the participant will have capital gain
or loss equal to the difference  between the sales proceeds and the value of the
stock on the day the option was  exercised.  This  capital  gain or loss will be
long-term  if the  participant  has held the  stock  for more  than one year and
otherwise will be short-term.

RESTRICTED STOCK

       A  participant  will not have income upon the grant of  restricted  stock
unless an election under Section 83(b) of the Code is made within 30 days of the
date of grant. If a timely 83(b) election is made, then a participant  will have
compensation  income  equal to the value of the stock less the  purchase  price.
When the stock is sold, the participant  will have capital gain or loss equal to
the difference between the sales proceeds and the value of the stock on the date
of grant.  If the  participant  does not make an 83(b)  election,  then when the
stock vests the participant will have compensation  income equal to the value of
the stock on the vesting date less the purchase  price.  When the stock is sold,
the participant  will have capital gain or loss equal to the sales proceeds less
the value of the stock on the vesting  date.  Any  capital  gain or loss will be
long-term if the participant held the stock for move than one year and otherwise
will be short-term.

TAX CONSEQUENCES TO US

       There will be not tax  consequences to us except that we will be entitled
to a deduction when a participant has  compensation  income.  Any such deduction
will be subject to the limitations of Section 162(m) of the Code.


                                       -26-


PREVIOUSLY GRANTED OPTIONS UNDER THE 1996 STOCK OPTION PLAN

       Through March 31, 2002,  we had granted  options to purchase an aggregate
of  2,064,630(1)  shares of common  stock under the 1996 Stock Option Plan at an
average  exercise  price of $10.93  per  share.  As of March 31,  2002,  855,866
options to purchase shares were vested and 12,775 options to purchase shares had
been exercised  under the 1996 Stock Option Plan. The following table sets forth
the  options  granted  under  the  1996  Stock  Option  Plan  to (i)  the  Named
Executives;  (ii) all current executive  officers as a group; (iii) each nominee
for election as a Director;  (iv) all current  Directors  who are not  executive
officers as a group;  (v) each  associate  of any of such  Directors,  executive
officers or  nominees;  (vi) each person who has received or is to receive 5% of
such options or rights; and (vii) all employees,  including all current officers
who are not executive officers, as a group:



                                                   OPTIONS GRANTED
                                                       THROUGH         WEIGHTED AVERAGE
                      NAME                         MARCH 31, 2002(2)    EXERCISE PRICE      EXPIRATION DATE
- ----------------------------------------------     -----------------  ------------------   -----------------
                                                                                   

Brian M. Gallagher, Ph.D.....................             295,000            $10.96         2/2007 - 1/2012
Robert A. Ashley.............................             130,000            $10.94         2/2007 - 1/2012
Nancy C. Broadbent...........................             105,000            $10.21         2/2007 - 1/2012
Douglas C. Gehrig............................             150,000            $11.49         7/2007 - 1/2012
David F. Pfeiffer............................             170,000            $11.67         7/2007 - 1/2012
All current executive officers as a group
   (7 persons)(3)............................             975,000            $10.88         2/2007 - 1/2012
All current Directors who are not executive
   officers as a group (6 persons)...........               --                  --                --
All employees, including all current
   officers who are not executive officers,
   as a group (150 persons)(3)(4)............            1,089,630           $10.98         11/2006-3/2012


       As of March 31, 2002, the market value of the common stock underlying the
1996 Stock Option Plan was $11.00 per share.

- -----------

(1)    Of the 2,064,630  options  granted as of March 31, 2002,  232,000 of such
       options have been canceled and may be reissued by us.

(2)    Options are granted  under the 1996 Stock Option Plan pursuant to various
       vesting schedules. In general, such options vest over two (2) to five (5)
       year periods.

(3)    All 157 of our employees and  consultants  are eligible to participate in
       the 1996 Stock Option Plan.

(4)    Includes 3 consultants  who were granted options to purchase an aggregate
       of 60,000 shares of common stock at an exercise price of $12.19 per share
       with an expiration date of February 2009.

       Each of the  following  individuals  prior to the  proposed  increase  in
shares of common stock  available  under the 1996 Stock Option Plan,  holds more
than five-percent (5%) of the total options issuable under the 1996 Stock Option
Plan: Brian M. Gallagher, Ph.D. 14.8%; Robert A. Ashley 6.5%; Nancy C. Broadbent
5.3%;  Douglas C.  Gehrig 7.5% and David F.  Pfeiffer  8.5%.  Subsequent  to the
adoption of the proposed  amendment  to the 1996 Stock  Option Plan,  as further
discussed  below,  each  of  the  following  individuals  will  hold  more  than
five-percent  of the total  options  issuable  under the 1996 Stock Option Plan:
Brian M. Gallagher,  Ph.D. 11.8%;  Robert A. Ashley 5.2%; Douglas C. Gehrig 6.0%
and David F. Pfeiffer 6.8%.



                                       -27-


PROPOSED AMENDMENT

       Stockholders  are  being  asked  to  consider  and vote  upon a  proposed
amendment to the 1996 Stock Option Plan to increase the maximum number of shares
of common stock  available  for  issuance  under the 1996 Stock Option Plan from
2,000,000 to 2,500,000 shares and to reserve an additional 500,000 shares of our
common stock for issuance in connection with awards granted under the 1996 Stock
Option Plan.

       The Board of Directors  believes that the Amendment provides an important
inducement  to recruit  and retain the best  available  personnel.  The Board of
Directors believes that providing employees with an opportunity to invest in the
Company rewards them appropriately for their efforts on behalf of the Company.

       THE  BOARD  OF  DIRECTORS  RECOMMENDS  A VOTE  FOR  THE  APPROVAL  OF THE
AMENDMENT.

               RATIFICATION OF APPOINTMENT OF INDEPENDENT AUDITORS

       Our Board of  Directors  intends,  subject to  stockholder  approval,  to
retain KPMG LLP as our  independent  auditors  for the year ending  December 31,
2002. KPMG LLP also served as our independent auditors for 2001.

       THE BOARD OF  DIRECTORS  RECOMMENDS  A VOTE FOR THE  RATIFICATION  OF THE
APPOINTMENT OF KPMG LLP AS OUR INDEPENDENT AUDITORS FOR THE YEAR ENDING DECEMBER
31, 2002.

       Representatives of KPMG LLP are expected to attend the Annual Meeting and
have an opportunity to make a statement and/or respond to appropriate  questions
from stockholders.

                             STOCKHOLDERS' PROPOSALS

       Stockholders  who intend to have a proposal  considered  for inclusion in
our proxy materials for  presentation at our 2003 Annual Meeting of Stockholders
pursuant  to Rule  14a-8  under the  Securities  and  Exchange  Act of 1934,  as
amended,  must submit the proposal to us at our offices at 41 University  Drive,
Newtown,  Pennsylvania  18940,  attention  Nancy C.  Broadbent,  not later  than
December 12, 2002.

       Stockholders  who intend to present a proposal  at such  meeting  without
inclusion of such proposal in our proxy  materials  pursuant to Rule 14a-8 under
the  Securities  Exchange  Act of 1934,  as  amended,  are  required  to provide
advanced notice of such proposal to us at the  aforementioned  address not later
than February 25, 2003.

       If we do  not  receive  notice  of a  stockholder  proposal  within  this
timeframe,  our management  will use their  discretionary  authority to vote the
shares they represent,  as our Board of Directors may recommend.  We reserve the
right to  reject,  rule out of order,  or take  other  appropriate  action  with
respect  to any  proposal  that does not  comply  with  these  other  applicable
requirements.

                    HOUSEHOLDING OF ANNUAL MEETING MATERIALS

       Some banks, brokers and other nominee record holders may be participating
in the practice of  "householding"  proxy  statements and annual  reports.  This
means that only one copy of our Proxy  Statement or Annual  Report may have been
sent to multiple  stockholders  in your  household.  We will promptly  deliver a
separate copy of either document to you if you call or write us at 41 University
Drive, Newtown, Pennsylvania 18940, or call us at (215) 579-7388. If you want to
receive  separate copies of the Annual Report and Proxy Statement in the future,
or if you are receiving  multiple copies and would like to receive only one copy
for your  household,  you should  contact your bank,  broker,  or other  nominee
record holder, or you may contact us at the above address and phone number.



                                       -28-


                                  OTHER MATTERS

       The Board of  Directors  is not aware of any matter to be  presented  for
action at the Annual  Meeting other than the matters  referred to above and does
not intend to bring any other matters  before the Annual  Meeting.  However,  if
other matters should come before the Annual Meeting, it is intended that holders
of the proxies will vote thereon in their discretion.

                                     GENERAL

       The  accompanying  proxy is  solicited  by and on  behalf of our Board of
Directors,  whose notice of meeting is attached to this Proxy Statement, and the
entire cost of such solicitation will be borne by us.

       In addition to the use of the mails, proxies may be solicited by personal
interview,  telephone and telegram by directors, officers and other employees of
the Company who will not be specially  compensated for these  services.  We will
also request that brokers,  nominees,  custodians and other fiduciaries  forward
soliciting  materials to the beneficial  owners of shares held of record by such
brokers,  nominees,  custodians  and other  fiduciaries.  We will reimburse such
persons for their reasonable expenses in connection therewith.

       Certain  information  contained in this Proxy  Statement  relating to the
occupations  and security  holdings of our  directors and officers is based upon
information received from the individual directors and officers.

       WE WILL FURNISH,  WITHOUT  CHARGE,  A COPY OF OUR REPORT ON FORM 10-K FOR
THE YEAR ENDED DECEMBER 31, 2001,  INCLUDING  CONSOLIDATED  FINANCIAL STATEMENTS
AND SCHEDULE THERETO BUT NOT INCLUDING EXHIBITS,  TO EACH OF OUR STOCKHOLDERS OF
RECORD ON APRIL 4, 2002,  AND TO EACH  BENEFICIAL  STOCKHOLDER ON THAT DATE UPON
WRITTEN  REQUEST  MADE  TO  MS.  NANCY  C.  BROADBENT,   SECRETARY,   COLLAGENEX
PHARMACEUTICALS,  INC., 41 UNIVERSITY  DRIVE,  NEWTOWN,  PENNSYLVANIA  18940.  A
REASONABLE FEE WILL BE CHARGED FOR COPIES OF REQUESTED EXHIBITS.

       PLEASE DATE, SIGN AND RETURN THE PROXY CARD AT YOUR EARLIEST  CONVENIENCE
IN THE  ENCLOSED  RETURN  ENVELOPE.  A PROMPT  RETURN OF YOUR PROXY CARD WILL BE
APPRECIATED AS IT WILL SAVE THE EXPENSE OF FURTHER MAILINGS.


                                     By Order of the Board of Directors

                                     /s/ Nancy C. Broadbent

                                     Nancy C. Broadbent,
                                       Secretary
Newtown, Pennsylvania
April 15, 2002


                                       -29-


                                  COMMON STOCK
                        COLLAGENEX PHARMACEUTICALS, INC.

               PROXY SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS
            OF THE CORPORATION FOR THE ANNUAL MEETING OF STOCKHOLDERS

       The undersigned hereby constitutes and appoints Brian M. Gallagher, Ph.D.
and Nancy C.  Broadbent,  and each of them, his or her true and lawful agent and
proxy with full  power of  substitution  in each,  to  represent  and to vote on
behalf of the undersigned all of the shares of CollaGenex Pharmaceuticals,  Inc.
(the "Company")  which the undersigned is entitled to vote at the Annual Meeting
of Stockholders of the Company to be held at the  Philadelphia  Airport Marriott
Hotel, One Arrivals Road,  Philadelphia,  Pennsylvania at 8:30 A.M., local time,
on Thursday,  May 9, 2002, and at any adjournment or adjournments  thereof, upon
the following  proposals more fully described in the Notice of Annual Meeting of
Stockholders  and Proxy  Statement  for the Meeting  (receipt of which is hereby
acknowledged).

       THIS PROXY WHEN PROPERLY  EXECUTED  WILL BE VOTED IN THE MANNER  DIRECTED
HEREIN BY THE UNDERSIGNED STOCKHOLDER.  IF NO DIRECTION IS MADE, THIS PROXY WILL
BE VOTED FOR PROPOSALS 1, 2 AND 3.

                  (CONTINUED AND TO BE SIGNED ON REVERSE SIDE)





                        PLEASE DATE, SIGN AND MAIL YOUR
                      PROXY CARD BACK AS SOON AS POSSIBLE!

                         ANNUAL MEETING OF STOCKHOLDERS
                        COLLAGENEX PHARMACEUTICALS, INC.

                                  COMMON STOCK

                                  MAY 9, 2002

                 Please detach and mail in the envelope provided


A [X] Please mark your votes as in this example.



                                                                              
1.     ELECTION OF            FOR            WITHHELD        Nominees:
       DIRECTORS.            [    ]           [    ]         Brian M. Gallagher, Ph.D.       James E. Daverman
                                                             Peter R. Barnett, D.M.D         Robert J. Easton
       VOTE FOR all the nominees listed at right;            Robert C. Black                 W. James O'Shea
       except vote withheld from the following
       nominee(s) (if any).

       -------------------------------------------------

2.     APPROVAL  OF  PROPOSAL  TO AMEND THE  COMPANY'S  1996  STOCK OPTION  PLAN                 FOR        AGAINST       ABSTAIN
       TO  INCREASE  THE  MAXIMUM  AGGREGATE  NUMBER  OF  SHARES OF COMMON STOCK               [    ]       [    ]        [    ]
       AVAILABLE  FOR  ISSUANCE  THEREUNDER  FROM  2,000,000 SHARES TO 2,500,000
       SHARES  AND TO RESERVE AN  ADDITIONAL  500,000  SHARES OF COMMON STOCK OF
       THE COMPANY  FOR  ISSUANCE  IN  CONNECTION  WITH AWARDS GRANTED UNDER THE
       1996 STOCK OPTION PLAN.

3.     APPROVAL  OF  PROPOSAL  TO  RATIFY  THE  APPOINTMENT  OF KPMG  LLP AS THE                 FOR        AGAINST      ABSTAIN
       INDEPENDENT  AUDITORS OF THE COMPANY  FOR THE YEAR  ENDING  DECEMBER  31,               [    ]       [    ]       [    ]
       2002.

4.     In his or her  discretion,  the proxy is  authorized  to vote upon  other
       matters as may properly come before the Meeting.

                                       I will                I will not
                                       [    ]                   [    ]

                                             attend the Meeting.

PLEASE MARK, SIGN, DATE AND RETURN THIS PROXY CARD PROMPTLY, USING THE ENCLOSED
ENVELOPE.

Signature of Common Stockholder                       Signature of Common Stockholder                         Dated:
                               ----------------------                                ------------------------       -----------
                                                                                        IF HELD JOINTLY


NOTE:  THIS PROXY MUST BE SIGNED EXACTLY AS THE NAME APPEARS HEREON. WHEN SHARES
       ARE  HELD  BY  JOINT  TENANTS,  BOTH  SHOULD  SIGN.  IF THE  SIGNER  IS A
       CORPORATION,  PLEASE SIGN FULL CORPORATE NAME BY DULY AUTHORIZED OFFICER,
       GIVING FULL TITLE AS SUCH. IF THE SIGNER IS A PARTNERSHIP, PLEASE SIGN IN
       PARTNERSHIP NAME BY AUTHORIZED PERSON.



                                 PREFERRED STOCK
                        COLLAGENEX PHARMACEUTICALS, INC.

               PROXY SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS
            OF THE CORPORATION FOR THE ANNUAL MEETING OF STOCKHOLDERS

       The undersigned hereby constitutes and appoints Brian M. Gallagher, Ph.D.
and Nancy C.  Broadbent,  and each of them, his or her true and lawful agent and
proxy with full  power of  substitution  in each,  to  represent  and to vote on
behalf of the undersigned all of the shares of CollaGenex Pharmaceuticals,  Inc.
(the "Company")  which the undersigned is entitled to vote at the Annual Meeting
of Stockholders of the Company to be held at the  Philadelphia  Airport Marriott
Hotel, One Arrivals Road,  Philadelphia,  Pennsylvania at 8:30 A.M., local time,
on Thursday,  May 9, 2002, and at any adjournment or adjournments  thereof, upon
the following  proposals more fully described in the Notice of Annual Meeting of
Stockholders  and Proxy  Statement  for the Meeting  (receipt of which is hereby
acknowledged).

         THIS PROXY WHEN PROPERLY EXECUTED WILL BE VOTED IN THE MANNER DIRECTED
HEREIN BY THE UNDERSIGNED STOCKHOLDER. IF NO DIRECTION IS MADE, THIS PROXY WILL
BE VOTED FOR PROPOSALS 1, 2 AND 3.

                  (CONTINUED AND TO BE SIGNED ON REVERSE SIDE)




                        PLEASE DATE, SIGN AND MAIL YOUR
                      PROXY CARD BACK AS SOON AS POSSIBLE

                         ANNUAL MEETING OF STOCKHOLDERS
                        COLLAGENEX PHARMACEUTICALS, INC.

                                PREFERRED STOCK

                                  MAY 9, 2002


                 Please detach and mail in the envelope provided


A  [   ] PLEASE MARK YOUR VOTES AS IN THIS EXAMPLE.



                                           
                                  FOR               WITHHELD
                                 [    ]              [    ]
1.     ELECTION

       OF

       STEPHEN A. KAPLAN AS DIRECTOR

2.     APPROVAL  OF PROPOSAL TO AMEND THE  COMPANY'S  1996 STOCK  OPTION PLAN TO        FOR           AGAINST         ABSTAIN
       INCREASE THE MAXIMUM AGGREGATE NUMBER OF SHARES OF COMMON STOCK AVAILABLE       [    ]         [    ]           [    ]
       FOR ISSUANCE  THEREUNDER FROM 2,000,000 SHARES TO 2,500,000 SHARES AND TO
       RESERVE AN ADDITIONAL  500,000  SHARES OF COMMON STOCK OF THE COMPANY FOR
       ISSUANCE IN  CONNECTION  WITH AWARDS  GRANTED UNDER THE 1996 STOCK OPTION
       PLAN.

3.     APPROVAL  OF  PROPOSAL  TO  RATIFY  THE  APPOINTMENT  OF KPMG  LLP AS THE        FOR           AGAINST         ABSTAIN
       INDEPENDENT  AUDITORS OF THE COMPANY  FOR THE YEAR  ENDING  DECEMBER  31,       [    ]          [    ]          [    ]
       2002.

4.     In his or her  discretion,  the proxy is  authorized  to vote upon  other
       matters as may properly come before the Meeting.

                                     I will                I will not
                                     [    ]                  [    ]
                                          attend the Meeting.

PLEASE MARK, SIGN, DATE AND RETURN THIS PROXY CARD PROMPTLY, USING THE ENCLOSED
ENVELOPE.

Signature of Preferred Stockholder                        Signature of Preferred Stockholder                       Dated:
                                  ------------------------                                  -----------------------      ----------
                                                                                                IF HELD JOINTLY


NOTE:  THIS PROXY MUST BE SIGNED EXACTLY AS THE NAME APPEARS HEREON. WHEN SHARES
       ARE  HELD  BY  JOINT  TENANTS,  BOTH  SHOULD  SIGN.  IF THE  SIGNER  IS A
       CORPORATION,  PLEASE SIGN FULL CORPORATE NAME BY DULY AUTHORIZED OFFICER,
       GIVING FULL TITLE AS SUCH. IF THE SIGNER IS A PARTNERSHIP, PLEASE SIGN IN
       PARTNERSHIP NAME BY AUTHORIZED PERSON.


                                                                     APPENDIX A

                        COLLAGENEX PHARMACEUTICALS, INC.

                                 1996 STOCK PLAN



        1.    PURPOSES OF THE PLAN.  The  purposes  of  this  Stock  Plan are to
attract and retain the best  available  personnel for  positions of  substantial
responsibility,  to provide  additional  incentive  to  Employees,  non-Employee
members of the Board and Consultants of the Company and its  Subsidiaries and to
promote the success of the Company's  business.  Options  granted under the Plan
may be incentive  stock  options (as defined  under  Section 422 of the Code) or
non-statutory  stock options,  as determined by the Administrator at the time of
grant of an option and subject to the  applicable  provisions  of Section 422 of
the Code, as amended, and the regulations promulgated thereunder. Stock purchase
rights may also be granted under the Plan.

       2.     CERTAIN  DEFINITIONS.  As used herein,  the following  definitions
shall apply:

              (a)   "Administrator"  means  the  Board  or any of its Committees
appointed pursuant to Section 4 of the Plan.

              (b)   "Board" means the Board of Directors of the Company.

              (c)   "Code"  means the Internal Revenue Code of 1986, as amended.

              (d)   "Committee"  means the Committee  appointed  by the Board of
Directors  in  accordance  with  paragraph  (a) of Section 4 of the Plan.

              (e)   "Common  stock"  means  the  Common  Stock  of  the Company.

              (f)   "Company" means CollaGenex Pharmaceuticals, Inc., a Delaware
corporation.

              (g)   "Consultant"  means any person, including an advisor, who is
engaged by the Company or any Parent or  subsidiary  to render  services  and is
compensated  for  such  services,  and  any  director  of  the  Company  whether
compensated for such services or not.

              (h)   "Continuous  Status as an Employee" means the absence of any
interruption or termination of the employment relationship by the Company or any
Subsidiary. Continuous Status as an Employee shall not be considered interrupted
in the case of: (i) sick leave;  (ii) military  leave;  (iii) any other leave of
absence  approved by the Board,  provided that such leave is for a period of not
more than ninety (90) days,  unless  reemployment  upon the  expiration  of such
leave is  guaranteed  by  contract  or  statute,  or unless  provided  otherwise
pursuant to Company policy adopted from time to time; or (iv) transfers  between
locations  of the  Company or  between  the  Company,  its  Subsidiaries  or its
successor.



              (i)   "Employee"  means   any   person,  including   officers  and
directors,  employed by the Company or any Parent or  Subsidiary of the Company.
The  payment of a  director's  fee by the  Company  shall not be  sufficient  to
constitute "employment" by the Company.

              (j)   "Exchange Act" means the Securities Exchange Act of 1934, as
amended.

              (k)   "Fair  Market  Value"  means,  as of any  date, the value of
Common Stock determined as follows:

              (i)   If the  Common  Stock  is  listed  on any  established stock
exchange or a national market system including  without  limitation the National
Market System of the National Association of Securities Dealers,  Inc. Automated
Quotation  ("Nasdaq")  System,  its Fair Market Value shall be the closing sales
price for such stock (or the closing  bid, if no sales were  reported) as quoted
on such system or exchange for the last market  trading day prior to the time of
determination as reported in the Wall Street Journal or such other source as the
Administrator deems reliable or;

              (ii)  If the  Common  Stock is quoted  on  Nasdaq  (but not on the
National Market System thereof) or regularly  quoted by a recognized  securities
dealer but selling  prices are not reported,  its Fair Market Value shall be the
mean between the high and low asked prices for the Common Stock or;

              (iii) In the  absence  of an  established  market  for the  Common
Stock,  the Fair Market Value  thereof  shall be determined in good faith by the
Administrator.

              (l)   "Incentive Stock Option" means an Option intended to qualify
as an  incentive  stock  option  within the  meaning of Section 422 of the Code.

              (m)   "Nonstatutory Stock  Option" means an Option not intended to
qualify as an Incentive Stock Option.

              (n)   "Option" means a stock option granted  pursuant to the Plan.

              (o)   "Optioned  Stock"  means  the  Common  Stock  subject  to an
Option.

              (p)   "Optionee"  means an Employee or  Consultant who receives an
Option.

              (q)   "Parent"  means  a  "parent  corporation",  whether  now or
hereafter existing, as defined in Section 424(e) of the Code.

              (r)   "Plan" means this 1996 Stock Plan.

              (s)   "Restricted  Stock"  means  shares of Common  Stock acquired
pursuant to a grant of stock purchase rights under Section 11 below.


                                       -2-


              (t)   "Share"  means a share of the Common Stock,  as  adjusted in
accordance with Section 13 of the Plan.

              (u)   "Subsidiary" means a  "subsidiary corporation", whether  now
or hereafter existing, as defined in Section 424(f) of the Code.

       3.     STOCK SUBJECT TO THE PLAN. Subject to the provisions of Section 13
of the Plan,  the maximum  aggregate  number of shares which may be optioned and
sold under the Plan is 2,000,000  shares of Common Stock,  such number of shares
determined  on  a  post-reverse   stock  split   recapitalization   basis,  such
recapitalization  to be completed upon  consummation  of the Company's  proposed
initial  public  offering of Common  Stock.  The shares may be  authorized,  but
unissued, or reacquired Common Stock.

              If an option should expire or become  unexercisable for any reason
without having been exercised in full, the unpurchased Shares which were subject
thereto shall, unless the Plan shall have been terminated,  become available for
future grant under the Plan.

       4.     ADMINISTRATION OF THE PLAN.

              (a)   Procedure.

              (i)   ADMINISTRATION WITH RESPECT TO DIRECTORS AND OFFICERS.  With
respect to grants of Options or stock purchase  rights to Employees who are also
officers or directors of the Company,  the Plan shall be administered by (A) the
Board if the  Board  may  administer  the Plan in  compliance  with  Rule  16b-3
promulgated  under the Exchange Act or any successor thereto ("Rule 16b-3") with
respect to a plan intended to qualify thereunder as a discretionary plan, or (B)
a Committee  designated by the Board to  administer  the Plan,  which  Committee
shall be  constituted in such a manner as to permit the Plan to comply with Rule
16b-3 with respect to a plan intended to qualify  thereunder as a  discretionary
plan. Once  appointed,  such Committee shall continue to serve in its designated
capacity until otherwise  directed by the Board. From time to time the Board may
increase  the size of the  Committee  and appoint  additional  members  thereof,
remove members (with or without  cause) and appoint new members in  substitution
therefor,  fill  vacancies,  however  caused,  and  remove  all  members  of the
Committee  and  thereafter  directly  administer  the  Plan,  all to the  extent
permitted by Rule 16b-3 with respect to a plan intended to qualify thereunder as
a discretionary plan.

              (ii)  MULTIPLE ADMINISTRATIVE  BODIES. If permitted by Rule 16b-3,
the Plan may be  administered  by different  bodies with  respect to  directors,
non-director  officers and Employees who are neither directors nor officers.

              (iii) ADMINISTRATION  WITH   RESPECT  TO  CONSULTANTS   AND  OTHER
EMPLOYEES.  With  respect  to  grants of  Options  or stock  purchase  rights to
Employees  who  are  neither  directors  nor  officers  of  the  Company  or  to
Consultants,  the Plan shall be  administered by (A) the Board, if the Board may
administer the Plan in compliance with Rule 16b-3, or (B) a Committee designated
by the  Board,  which  Committee  shall be  constituted  in such a manner  as to
satisfy the legal


                                       -3-


requirements  relating to the administration of incentive stock option plans, if
any, of Delaware  corporate law and applicable  securities  laws and of the Code
(the "Applicable Laws"). Once appointed,  such Committee shall continue to serve
in its designated  capacity until otherwise  directed by the Board. From time to
time the Board may increase  the size of the  Committee  and appoint  additional
members thereof,  remove members (with or without cause) and appoint new members
in substitution therefor, fill vacancies, however caused, and remove all members
of the Committee and thereafter  directly administer the Plan, all to the extent
permitted by the Applicable Laws.

              (b)   POWERS OF THE ADMINISTRATOR.  Subject  to the  provisions of
the Plan and in the case of a Committee,  the specific  duties  delegated by the
Board to such  Committee,  the  Administrator  shall have the authority,  in its
discretion:

              (i)   to  determine the Fair Market Value of the Common  Stock, in
accordance with Section 2(k) of the Plan;

              (ii)  to select the  officers, Consultants  and  Employees to whom
Options and stock purchase rights may from time to time be granted hereunder;

              (iii) to  determine  whether and to what extent  Options and stock
purchase rights or any combination thereof, are granted hereunder;

              (iv)  to determine  the  number of  shares  of Common  Stock to be
covered by each such award granted hereunder;

              (v)   to approve forms of agreement for use under the Plan;

              (vi)  to determine the terms and conditions, not inconsistent with
the  terms of the Plan,  of any  award  granted  hereunder  (including,  but not
limited  to, the share  price and any  restriction  or  limitation  or waiver of
forfeiture restrictions regarding any Option or other award and/or the shares of
Common  Stock  relating  thereto,  based  in each  case on such  factors  as the
Administrator shall determine, in its sole discretion);

              (vii) to determine whether and under what  circumstances an Option
may be settled in cash under subsection 9(f) instead of Common Stock;

              (viii)  to  determine  whether,  to what  extent  and  under  what
circumstances  Common Stock and other  amounts  payable with respect to an award
under this Plan shall be deferred either automatically or at the election of the
participant  (including providing for and determining the amount, if any, of any
deemed earnings on any deferred amount during any deferral period);

              (ix)  to reduce  the  exercise  price  of any  Option  to the then
current Fair Market  Value if the Fair Market Value of the Common Stock  covered
by such Option shall have declined since the date the Option was granted; and


                                       -4-


              (x)   to determine the terms and  restrictions applicable to stock
purchase  rights and the  Restricted  Stock  purchased by exercising  such stock
purchase rights.

              (c)   EFFECT   OF    COMMITTEE'S    DECISION.    All    decisions,
determinations  and  interpretations  of the  Administrator  shall be final  and
binding on all Optionees and any other holders of any Options.

       5.     ELIGIBILITY.

       (a)    Nonstatutory  Stock  Options  may  be  granted  to  Employees  and
Consultants.  Incentive  Stock  Options  may be granted  only to  Employees.  An
Employee or  Consultant  who has been  granted an Option may, if he is otherwise
eligible, be granted an additional Option or Options.

       (b)    Each Option shall be designated in the written option agreement as
either an  Incentive  Stock  Option or a  Nonstatutory  Stock  Option.  However,
notwithstanding such designations,  to the extent that the aggregate Fair Market
Value of the Shares with respect to which Options  designated as Incentive Stock
Options are  exercisable  for the first time by any optionee during any calendar
year  (under  all plans of the  Company  or any  Parent or  Subsidiary)  exceeds
$100,000, such excess Options shall be treated as Nonstatutory Stock Options.

       (c)    For purposes of  Section 5(b), Incentive Stock  Options  shall  be
taken into account in the order in which they were granted,  and the Fair Market
Value of the Shares shall be  determined  as of the time the Option with respect
to such Shares is granted.

       (d)    The Plan shall not confer upon any Optionee any right with respect
to continuation of employment or consulting  relationship with the Company,  nor
shall it interfere in any way with his right or the Company's right to terminate
his employment or consulting relationship at any time, with or without cause.

       6.     TERM OF PLAN. The Plan shall become  effective upon the earlier to
occur  of its  adoption  by the  Board  of  Directors  or  its  approval  by the
shareholders  of the Company as  described  in Section 19 of the Plan.  It shall
continue in effect for a term of ten (10) years unless sooner  terminated  under
Section 15 of the Plan.


                                       -5-


       7.     TERM OF OPTION.  The term of each Option  shall be the term stated
in the Option  Agreement;  provided,  however,  that in the case of an Incentive
Stock  Option,  the term  shall be no more than ten (10)  years from the date of
grant  thereof or such shorter term as may be provided in the Option  Agreement.
However,  in the case of an Option  granted to an Optionee  who, at the time the
Option is granted,  owns stock  representing  more than ten percent (10%) of the
voting power of all classes of stock of the Company or any Parent or Subsidiary,
the term of the Option shall be five (5) years from the date of grant thereof or
such shorter term as may be provided in the Option Agreement.

       8.     OPTION EXERCISE PRICE AND CONSIDERATION.

              (a)   The per share  exercise  price for the  Shares  to be issued
pursuant to exercise of an Option  shall be such price as is  determined  by the
Board, but shall be subject to the following:

              (i)   In the case of an Incentive Stock Option

                    (A)  granted to an Employee who, at the time of the grant of
such Incentive Stock Option, owns stock representing more than ten percent (10%)
of the  voting  power of all  classes  of stock of the  Company or any Parent or
Subsidiary,  the per Share exercise price shall be no less than 110% of the Fair
Market Value per Share on the date of grant.

                    (B)  granted to any Employee, the per Share  exercise price
shall be no less  than  100% of the Fair  Market  Value per Share on the date of
grant.

              (ii)  In the case of a Nonstatutory Stock Option

                    (A)  granted  to a person  who,  at the time of the grant of
such Option,  owns stock  representing more than ten percent (10%) of the voting
power of all  classes of stock of the Company or any Parent or  Subsidiary,  the
per Share exercise price shall be no less than 110% of the Fair Market Value per
Share on the date of the grant.

                    (B) granted  to any  person,  the per Share  exercise  price
shall be no less  than 85% of the Fair  Market  Value  per  Share on the date of
grant.

              (b)   The  consideration  to  be paid  for the Shares to be issued
upon exercise of an Option, including the method of payment, shall be determined
by the  Administrator  (and, in the case of an Incentive Stock Option,  shall be
determined  at the time of grant)  and may  consist  entirely  of (1) cash,  (2)
check,  (3)  promissory  note,  (4) other Shares which (x) in the case of Shares
acquired  upon  exercise of an Option either have been owned by the Optionee for
more than six months on the date of surrender or were not acquired,  directly or
indirectly,  from the  Company,  and (y) have a Fair Market Value on the date of
surrender  equal to the aggregate  exercise price of the Shares as to which said
Option shall be exercised, (5) authorization from the Company to retain from the
total number of Shares as to which the Option is exercised that number of Shares
having a Fair Market Value on the date of exercise  equal to the exercise  price


                                       -6-


for the total number of Shares as to which the option is exercised, (6) delivery
of a properly executed exercise notice together with irrevocable instructions to
a broker to promptly  deliver to the Company the amount of sale or loan proceeds
required  to  pay  the  exercise   price,   (7)  by  delivering  an  irrevocable
subscription  agreement  for the Shares which  irrevocably  obligates the option
holder to take and pay for the Shares not more than twelve months after the date
of delivery of the subscription agreement,  (8) any combination of the foregoing
methods of payment,  or (9) such other  consideration  and method of payment for
the issuance of Shares to the extent  permitted under Applicable Laws. In making
its  determination as to the type of consideration to accept,  the Administrator
shall consider if acceptance of such consideration may be reasonably expected to
benefit the Company.

       9.     EXERCISE OF OPTION.

              (a)   PROCEDURE FOR EXERCISE; RIGHTS AS A SHAREHOLDER.  Any Option
       granted  hereunder  shall be  exercisable  at such  times and under  such
       conditions  as  determined by the  Administrator,  including  performance
       criteria with respect to the Company and/or the Optionee, and as shall be
       permissible under the terms of the Plan.

              An Option may not be exercised for a fraction of a Share.

              An Option shall be deemed to be exercised  when written  notice of
such exercise has been given to the Company in accordance  with the terms of the
Option by the person  entitled to exercise  the Option and full  payment for the
Shares with  respect to which the Option is exercised  has been  received by the
Company.  Full payment may, as authorized by the  Administrator,  consist of any
consideration  and method of payment  allowable  under Section 8(b) of the Plan.
Until the issuance (as  evidenced by the  appropriate  entry on the books of the
Company or of a duly  authorized  transfer  agent of the  Company)  of the stock
certificate evidencing such Shares, no right to vote or receive dividends or any
other rights as a  shareholder  shall exist with respect to the Optioned  Stock,
notwithstanding the exercise of the Option. The Company shall issue (or cause to
be issued)  such stock  certificate  promptly  upon  exercise of the Option.  No
adjustment  will be made for a dividend or other right for which the record date
is prior to the date the stock  certificate  is issued,  except as  provided  in
Section 11 of the Plan.

              Exercise of an Option in any manner  shall result in a decrease in
the number of Shares which thereafter may be available, both for purposes of the
Plan and for sale  under  the  Option,  by the  number of Shares as to which the
Option is exercised.

              (b)  TERMINATION OF EMPLOYMENT.  In the event of termination of an
Optionee's consulting  relationship or Continuous Status as an Employee with the
Company (as the case may be),  such  Optionee  may, but only within  ninety (90)
days (or such other  period of time as is  determined  by the  Board,  with such
determination in the case of an Incentive Stock Option being made at the time of
grant of the Option and not  exceeding  ninety (90) days) after the date of such
termination  (but in no event later than the expiration date of the term of such
Option as set forth in the Option Agreement),  exercise his Option to the extent
that Optionee was entitled to exercise


                                       -7-


it at the date of such termination. To the extent that Optionee was not entitled
to exercise the Option at the date of such termination,  or if Optionee does not
exercise such Option to the extent so entitled within the time specified herein,
the Option shall terminate.

              (c)  DISABILITY  OF OPTIONEE.  Notwithstanding  the  provisions of
Section 9(b) above,  in the event of  termination  of an  Optionee's  consulting
relationship  or  Continuous  Status as an Employee as a result of his total and
permanent disability (as defined in Section 22(e)(3) of the Code), Optionee may,
but only within twelve (12) months from the date of such  termination (but in no
event later than the expiration  date of the term of such Option as set forth in
the Option  Agreement),  exercise the Option to the extent otherwise entitled to
exercise it at the date of such termination. To the extent that Optionee was not
entitled to exercise the Option at the date of termination,  or if Optionee does
not  exercise  such Option to the extent so entitled  within the time  specified
herein, the Option shall terminate.

              (d)   DEATH OF OPTIONEE. In the event of the death of an Optionee,
the Option may be exercised, at any time within twelve (12) months following the
date of death  (but in no event  later than the  expiration  date of the term of
such Option as set forth in the Option  Agreement),  by the Optionee's estate or
by a person  who  acquired  the  right to  exercise  the  Option by  bequest  or
inheritance,  but only to the extent the  Optionee  was entitled to exercise the
Option at the date of death.  To the extent that  Optionee  was not  entitled to
exercise the Option at the date of termination, or if Optionee does not exercise
such  Option to the extent so entitled  within the time  specified  herein,  the
Option shall terminate.

              (e)   RULE 16B-3.  Options granted to  persons  subject to Section
16(b) of the  Exchange  Act must comply with Rule 16b-3 and shall  contain  such
additional  conditions or restrictions as may be required  thereunder to qualify
for the maximum  exemption  from  Section 16 of the Exchange Act with respect to
Plan transactions.

              (f)   BUYOUT PROVISIONS.  The  Administrator may at any time offer
to buy out for a payment in cash or Shares, an Option previously granted,  based
on  such  terms  and  conditions  as  the  Administrator   shall  establish  and
communicate to the Optionee at the time that such offer is made.

       10.    NON-TRANSFERABILITY  OF  OPTIONS.  The  Option  may  not  be sold,
pledged, assigned, hypothecated, transferred, or disposed of in any manner other
than by will or by the laws of descent  or  distribution  and may be  exercised,
during the  lifetime of the  Optionee,  only by the  Optionee.  The terms of the
Option shall be binding upon the executors,  administrators,  heirs,  successors
and assigns of the Optionee.


                                       -8-


       11.    STOCK PURCHASE RIGHTS.

              (a)   RIGHTS TO PURCHASE.  Stock  purchase rights  may  be  issued
either alone,  in addition to, or in tandem with other awards  granted under the
Plan  and/or  cash  awards  made  outside of the Plan.  After the  Administrator
determines  that it will offer stock  purchase  rights under the Plan,  it shall
advise the offeree in writing of the terms,  conditions and restrictions related
to the offer,  including the number of Shares that such person shall be entitled
to purchase, the price to be paid (which price shall not be less than 50% of the
Fair  Market  Value of the  Shares  as of the date of the  offer),  and the time
within which such person must accept such offer,  which shall in no event exceed
thirty  (30)  days  from  the  date  upon  which  the  Administrator   made  the
determination  to grant the stock purchase right. The offer shall be accepted by
execution of a Restricted Stock purchase agreement in the form determined by the
Administrator.

              (b)   REPURCHASE  OPTION.   Unless  the  Administrator  determines
otherwise,  the Restricted  Stock purchase  agreement  shall grant the Company a
repurchase option  exercisable upon the voluntary or involuntary  termination of
the purchaser's  employment with the Company for any reason  (including death or
Disability).   The  purchase  price  for  Shares  repurchased  pursuant  to  the
Restricted  Stock  purchase  agreement  shall be the original  price paid by the
purchaser and may be paid by cancellation  of any  indebtedness of the purchaser
to the Company.  The repurchase option shall lapse at such rate as the Committee
may determine.

              (c)   OTHER PROVISIONS.  The Restricted Stock  purchase  agreement
shall contain such other terms,  provisions and conditions not inconsistent with
the Plan as may be determined by the  Administrator in its sole  discretion.  In
addition, the provisions of Restricted Stock purchase agreements need not be the
same with respect to each purchaser.

              (d)   RIGHTS AS A  SHAREHOLDER.  Once the stock  purchase right is
exercised,  the  purchaser  shall  have  the  rights  equivalent  to  those of a
shareholder, and shall be a shareholder when his or her purchase is entered upon
the records of the duly authorized  transfer agent of the Company. No adjustment
will be made for a dividend or other right for which the record date is prior to
the date the stock purchase right is exercised, except as provided in Section 13
of the Plan.

       12.    STOCK  WITHHOLDING  TO   SATISFY   WITHHOLDING  TAX   OBLIGATIONS.
At the  discretion  of the  Administrator,  Optionees  may  satisfy  withholding
obligations as provided in this paragraph. When an Optionee incurs tax liability
in connection  with an Option or stock  purchase  right,  which tax liability is
subject to tax  withholding  under  applicable  tax laws,  and the  Optionee  is
obligated to pay the Company an amount required to be withheld under  applicable
tax laws, the Optionee may satisfy the withholding tax obligation by electing to
have the Company withhold


                                       -9-


from the Shares to be issued upon  exercise  of the Option,  or the Shares to be
issued in  connection  with the stock  purchase  right,  if any,  that number of
Shares  having a Fair Market Value equal to the amount  required to be withheld.
The Fair Market Value of the Shares to be withheld  shall be  determined  on the
date that the amount of tax to be withheld is to be determined (the "Tax Date").

              All  elections  by an Optionee to have  Shares  withheld  for this
purpose shall be made in writing in a form acceptable to the  Administrator  and
shall be subject to the following restrictions:

              (a)   the election must be made on or prior to the applicable  Tax
Date;

              (b)   once  made,  the  election  shall  be  irrevocable as to the
particular Shares of the Option or Right as to which the election is made;

              (c)   all elections shall be subject to the consent or disapproval
of the Administrator;

              (d)   if the Optionee is subject to Rule 16b-3, the  election must
comply with the applicable provisions of Rule 16b-3 and shall be subject to such
additional  conditions or restrictions as may be required  thereunder to qualify
for the maximum  exemption  from  Section 16 of the Exchange Act with respect to
Plan transactions.

              In the event the  election to have  Shares  withheld is made by an
Optionee  and the Tax Date is deferred  under  Section 83 of the Code because no
election is filed under  Section 83(b) of the Code,  the Optionee  shall receive
the full  number of Shares  with  respect to which the Option or stock  purchase
right is  exercised  but such  Optionee  shall be  unconditionally  obligated to
tender back to the Company the proper number of Shares on the Tax Date.

       13.    ADJUSTMENTS  UPON CHANGES IN CAPITALIZATION OR MERGER.  Subject to
any required action by the shareholders of the Company,  the number of shares of
Common Stock  covered by each  outstanding  Option,  and the number of shares of
Common Stock which have been  authorized  for issuance  under the Plan but as to
which no Options have yet been  granted or which have been  returned to the Plan
upon  cancellation or expiration of an Option, as well as the price per share of
Common Stock covered by each such outstanding  Option,  shall be proportionately
adjusted for any  increase or decrease in the number of issued  shares of Common
Stock  resulting  from a stock  split,  reverse  stock  split,  stock  dividend,
combination or  reclassification  of the Common Stock,  or any other increase or
decrease in the number of issued shares of Common Stock effected without receipt
of  consideration  by the Company;  provided,  however,  that  conversion of any
convertible securities of the Company shall not be deemed to have been "effected
without receipt of  consideration."  Such adjustment shall be made by the Board,
whose  determination  in that respect  shall be final,  binding and  conclusive.
Except as  expressly  provided  herein,  no issuance by the Company of shares of
stock of any class, or securities convertible into shares of stock of


                                       -10-


any class,  shall affect, and no adjustment by reason thereof shall be made with
respect to, the number or price of shares of Common Stock subject to an Option.

              In the event of the proposed  dissolution  or  liquidation  of the
Company, the Board shall notify the Optionee at least fifteen (15) days prior to
such proposed action.  To the extent it has not been previously  exercised,  the
Option will terminate  immediately  prior to the  consummation  of such proposed
action.  In the event of a merger or  consolidation  of the Company with or into
another  corporation  or the sale of all or  substantially  all of the Company's
assets (hereinafter,  a "merger"),  the Option shall be assumed or an equivalent
option  shall be  substituted  by such  successor  corporation  or a  parent  or
subsidiary  of such  successor  corporation.  In the event  that such  successor
corporation  does not agree to assume the Option or to  substitute an equivalent
option, the Board shall, in lieu of such assumption or substitution, provide for
the  Optionee to have the right to exercise the Option as to all of the Optioned
Stock,  including  Shares  as  to  which  the  Option  would  not  otherwise  be
exercisable.  If the  Board  makes  an  Option  fully  exercisable  in  lieu  of
assumption or substitution in the event of a merger,  the Board shall notify the
Optionee that the Option shall be fully exercisable for a period of fifteen (15)
days  from the date of such  notice,  and the  Option  will  terminate  upon the
expiration of such period. For the purposes of this paragraph,  the Option shall
be considered  assumed if, following the merger, the Option or right confers the
right to  purchase,  for each Share of stock  subject to the Option  immediately
prior to the merger, the consideration (whether stock, cash, or other securities
or  property)  received in the merger by holders of Common  Stock for each Share
held on the  effective  date of the  transaction  (and if holders were offered a
choice of  consideration,  the type of consideration  chosen by the holders of a
majority  of  the  outstanding  Shares);   provided,   however,   that  if  such
consideration  received  in the  merger  was  not  solely  common  stock  of the
successor  corporation  or its  Parent,  the Board may,  with the consent of the
successor  corporation and the participant,  provide for the consideration to be
received upon the exercise of the Option, for each Share of stock subject to the
Option,  to be solely  common stock of the successor  corporation  or its Parent
equal in Fair Market Value to the per share consideration received by holders of
Common Stock in the merger or sale of assets.

       14.    TIME OF GRANTING OPTIONS.  The  date  of grant of an Option shall,
for all purposes, be the date on which the Administrator makes the determination
granting such Option,  or such other date as is determined by the Board.  Notice
of the  determination  shall be given to each  Employee or Consultant to whom an
Option is so granted within a reasonable time after the date of such grant.

       15.    AMENDMENT AND TERMINATION OF THE PLAN.

              (a)   AMENDMENT AND TERMINATION.  The Board may at any time amend,
alter, suspend or discontinue the Plan, but no amendment, alteration, suspension
or  discontinuation  shall be made which would impair the rights of any Optionee
under any grant theretofore made,  without his or her consent.  In addition,  to
the extent  necessary and desirable to comply with Rule 16b-3 under the Exchange
Act or with Section 422 of the Code (or any other  applicable law or regulation,
including the requirements of the NASD or an established  stock  exchange),  the


                                       -11-

Company shall obtain shareholder approval of any Plan amendment in such a manner
and to such a degree as required.

              (b)   EFFECT OF  AMENDMENT OR TERMINATION.  Any such  amendment or
termination  of the Plan  shall not  affect  Options  already  granted  and such
Options  shall  remain  in full  force  and  effect as if this Plan had not been
amended or terminated, unless mutually agreed otherwise between the Optionee and
the Board, which agreement must be in writing and signed by the Optionee and the
Company.

       16.    CONDITIONS  UPON ISSUANCE OF SHARES.  Shares shall not be issued
pursuant to the exercise of an Option unless the exercise of such Option and the
issuance  and  delivery of such Shares  pursuant  thereto  shall comply with all
relevant provisions of law, including, without limitation, the Securities Act of
1933,  as amended,  the  Exchange  Act,  the rules and  regulations  promulgated
thereunder, and the requirements of any stock exchange upon which the Shares may
then be listed,  and shall be further subject to the approval of counsel for the
Company with respect to such compliance.

              As a  condition  to the  exercise  of an Option,  the  Company may
require the person  exercising  such Option to represent and warrant at the time
of any such exercise that the Shares are being purchased only for investment and
without  any  present  intention  to sell or  distribute  such Shares if, in the
opinion of counsel for the Company,  such a representation is required by any of
the aforementioned relevant provisions of law.

       17.    RESERVATION OF SHARES.  The Company, during the term of this Plan,
will at all times reserve and keep  available  such number of Shares as shall be
sufficient to satisfy the requirements of the Plan.

              The  inability  of  the  Company  to  obtain  authority  from  any
regulatory body having jurisdiction,  which authority is deemed by the Company's
counsel to be necessary to the lawful issuance and sale of any Shares hereunder,
shall relieve the Company of any liability in respect of the failure to issue or
sell  such  Shares  as to which  such  requisite  authority  shall not have been
obtained.

       18.    AGREEMENTS.  Options and stock purchase rights  shall be evidenced
by written agreements in such form as the Board shall approve from time to time.

       19.    SHAREHOLDER APPROVAL.  Continuance of the Plan shall be subject to
approval by the  shareholders of the Company within twelve (12) months before or
after the date the Plan is adopted.  Such shareholder approval shall be obtained
in the degree and manner required under applicable state and federal law.



                                       -12-


       20.    INFORMATION  TO  OPTIONEES.  The  Company  shall  provide to  each
Optionee,  during the period for which  such  Optionee  has one or more  Options
outstanding,  copies  of all  annual  reports  and other  information  which are
provided to all  shareholders of the Company.  The Company shall not be required
to provide such information if the issuance of Options under the Plan is limited
to key employees whose duties in connection with the Company assure their access
to equivalent information.



                                       -13-