Exhibit 10.4

                        FIRST LOAN MODIFICATION AGREEMENT


      This  First  Loan   Modification   Agreement   (this  "Loan   Modification
Agreement") is entered into as of March 22, 2002, by and between  SILICON VALLEY
BANK, a California-chartered  bank, with its principal place of business at 3003
Tasman Drive,  Santa Clara,  California 95054 and with a loan production  office
located at One Newton Executive Park, Suite 200, 2221 Washington Street, Newton,
Massachusetts  02462,  doing  business  under  the name  "Silicon  Valley  East"
("Bank") and COLLAGENEX  PHARMACEUTICALS,  INC., a Delaware corporation with its
chief executive  office located at 41 University  Drive,  Newtown,  Pennsylvania
18940 ("Borrower").

1.  DESCRIPTION  OF  EXISTING   INDEBTEDNESS   AND   OBLIGATIONS.   Among  other
indebtedness and obligations which may be owing by Borrower to Bank, Borrower is
indebted to Bank  pursuant  to a loan  arrangement  dated as of March 19,  2001,
evidenced by, among other documents, a certain Loan and Security Agreement dated
as of March  19,  2001,  between  Borrower  and  Bank  (the  "Loan  Agreement").
Capitalized  terms used but not  otherwise  defined  herein  shall have the same
meaning as in the Loan Agreement.

Hereinafter, all indebtedness and obligations owing by Borrower to Bank shall be
referred to as the "Obligations".

2.  DESCRIPTION  OF COLLATERAL.  Repayment of the  Obligations is secured by the
Collateral  as described in the Loan  Agreement  and the  Intellectual  Property
Collateral,  as described in the Intellectual  Property Security Agreement dated
as of March 19, 2001, between the Borrower and the Bank (together with any other
collateral security granted to Bank, the "Security Documents").

Hereinafter,   the  Security  Documents,   together  with  all  other  documents
evidencing,  securing or otherwise  executed in connection  with the Obligations
shall be referred to as the "Existing Loan Documents".

3. DESCRIPTION OF CHANGE IN TERMS.

      Modifications to Loan Agreement. From and after the execution of this Loan
Modification Agreement, the Loan Agreement shall be amended as follows:

            1.    By deleting the text  "$3,000,000"  appearing in Section 1 (A)
                  (i)  of the  Schedule,  and  inserting  "$4,000,000"  in  lieu
                  thereof."

            2.    By adding the following text at the end of the "Interest Rate"
                  subsection appearing in Section 2 of the Schedule:

                  "In the event  Borrower  achieves two (2)  consecutive  fiscal
                  quarters  of  profitability,   as  determined  by  Silicon  in
                  accordance with generally accepted accounting principles,  the
                  applicable interest rate shall be reduced from a rate equal to
                  the "Prime  Rate" in effect from time to time,  plus 1.50% per
                  annum, to a rate equal to the "Prime Rate" in effect from time
                  to time, plus 1.00% per annum."

            3.    By deleting the following  text  appearing in Section 3 of the
                  Schedule:

                  "Collateral  Handling  Fee:  $800.00  per  month,  payable  in
                  arrears."

                  and replacing it with the following text:

                  "Collateral Handling Fee: $800.00 per month ($500.00 per month
                  when  there are no  borrowings  or other  amounts  outstanding
                  under the Loan and Security Agreement), payable in arrears."

            4.    By deleting  the  following  text  appearing  in Section 4 of
                  the Schedule:






                  "One year from the date of this Agreement."

                  and replacing it with the following text:

                  "March 15, 2004."

            5.    By  deleting  the  following  text  appearing  in the  Minimum
                  Tangible Net Worth covenant in Section 5 of the Schedule:

                  "(b)  $4,000,000,   plus  75%  of  the  Borrower's  cumulative
                  quarterly profitability, thereafter;"

                  and replacing it with the following text:

                  "(b)  $5,000,000,   plus  75%  of  the  Borrower's  cumulative
                  quarterly profitability, thereafter;"

            6.    By deleting the  following  text  appearing in Section 5(c) of
                  the Schedule:

                  "Borrower  must maintain a minimum of $2,000,000 in cash,  net
                  of borrowings  under this  Agreement,  at all times during the
                  term of this Agreement."

                  and replacing it with the following text:

                  "Borrower  must  maintain a minimum of  $2,000,000  in cash at
                  Silicon, net of borrowings under this Agreement,  at all times
                  during the term of this Agreement."

            7.    By deleting the  following  text  appearing in Section 9(1) of
                  the Schedule:

                  "In order for Silicon to properly monitor its loan arrangement
                  with  Borrower,  Borrower  shall  at all  times  maintain  its
                  primary banking relationship with Silicon."

                  and replacing it with the following text:

                  "In order for Silicon to properly monitor its loan arrangement
                  with  Borrower,  Borrower  and  MMP,  Inc.,  a  subsidiary  of
                  Borrower and a Guarantor of the Obligations of the Borrower to
                  Silicon,  shall at all times  maintain  their primary  banking
                  relationships   and  all  other  material  cash  balances  and
                  investments with Silicon. For the purposes of this subsection,
                  the term "material" shall be determined by Silicon in its sole
                  discretion  and,  in all  events,  accounts  with a balance in
                  excess  of  $50,000.00  shall  be  deemed  to  be  "material".
                  Notwithstanding   the  foregoing,   MMP,  Inc.,  may  maintain
                  balances with third party  institutions in an aggregate amount
                  not to exceed $1,500,000  provided that MMP, Inc. causes to be
                  delivered to Silicon account  control  agreements in such form
                  and substance as Silicon may require."

            8.    By deleting text "$600 per person" appearing in Section 5.4 of
                  the Loan Agreement and replacing it with the following text:

                  "$700 per person,"

            9.    By adding the following  text at the end of Section 5.5(x) of
                  the Loan Agreement:





                  "except for,  prior to the  occurrence of an Event of Default,
                  preferred  stock  cash  dividends  in an amount  not to exceed
                  $400,000 in calendar  year 2002,  $1,600,000  in calendar year
                  2003,  and  $400,000  in the first  quarter of  calendar  year
                  2004."

4.  RATIFICATION OF INTELLECTUAL  PROPERTY SECURITY  AGREEMENT.  Borrower hereby
ratifies,  confirms and reaffirms, all and singular, the terms and conditions of
a certain  Intellectual  Property Security  Agreement dated as of March 19, 2001
between Borrower and Bank, and acknowledges, confirms and agrees that, except as
previously  disclosed in writing to Bank, said  Intellectual  Property  Security
Agreement contains an accurate and complete listing of all Intellectual Property
Collateral (as defined in said  Intellectual  Property  Security  Agreement) and
shall remain in full force and effect.

5. ADDITIONAL  COVENANTS.  Borrower shall not,  without  providing the Bank with
thirty (30) days prior  written  notice:  (i) relocate its  principal  executive
office or add any new offices or business  locations or keep any  Collateral  in
any additional  locations,  or (ii) change its jurisdiction of organization,  or
(iii) change its  organizational  structure or type, (iv) change its legal name,
or (v) change any organizational number (if any) assigned by its jurisdiction of
organization.  In addition,  the Borrower hereby certifies that no Collateral is
in the possession of any third party bailee other than Cord  Logistics  (such as
at a warehouse).  In the event that Borrower,  after the date hereof, intends to
store or otherwise deliver the Collateral to such a bailee,  then Borrower shall
first  receive,  the  prior  written  consent  of  Bank  and  such  bailee  must
acknowledge  in  writing  that the  bailee is holding  such  Collateral  for the
benefit of Bank.

6. WAIVER. Bank hereby waives Borrower's failure to comply with the Tangible Net
Worth  covenant  requirement  set forth in the  Schedule  to the Loan  Agreement
tested as of January 31, 2002 (the "Existing Default"). This waiver applies only
to the specific Existing Default,  is a one-time waiver, and shall not be deemed
to  constitute  a continuing  waiver of this or any other  provision of the Loan
Agreement or a waiver of this Tangible Net Worth covenant for any other period.

7.  AUTHORIZATION  TO FILE.  Borrower  hereby  authorizes Bank to file financing
statements without notice to Borrower,  with all appropriate  jurisdictions,  as
Bank deems  appropriate,  in order to further perfect or protect Bank's interest
in the Collateral.

8. CONSISTENT  CHANGES.  The Existing Loan Documents are hereby amended wherever
necessary to reflect the changes described above.

9.  RATIFICATION OF LOAN  DOCUMENTS.  Borrower hereby  ratifies,  confirms,  and
reaffirms  all terms and  conditions  of the  Existing  Loan  Documents  and all
security  or  other  collateral  granted  to the  Bank,  and  confirms  that the
indebtedness secured thereby includes, without limitation, the Obligations.

10. NO DEFENSES OF BORROWER.  The Borrower hereby  acknowledges  and agrees that
the Borrower has no offsets, defenses, claims, or counterclaims against the Bank
or  the  Bank's  officers,  directors,  employees,  attorneys,  representatives,
predecessors,  affiliates,  subsidiaries,  parents, successors, and assigns with
respect to the Obligations,  and/or the Existing Loan Documents, and that if the
Borrower  now  has,  or  ever  did  have,  any  offsets,  defenses,  claims,  or
counterclaims  against the Bank or the Bank's  officers,  directors,  employees,
attorneys,  representatives,  predecessors,  affiliates,  subsidiaries, parents,
successors, and assigns, whether known or unknown, at law or in equity, from the
beginning  of the world  through  this date and through the time of execution of
this Loan  Modification  Agreement,  with respect to the Obligations  and/or the
Existing  Loan  Documents,  all of them are  hereby  expressly  WAIVED,  and the
Borrower hereby RELEASES the Bank and the Bank's officers, directors, employees,
attorneys,  representatives,  predecessors,  successors,  and  assigns  from any
liability therefor.

11. FEES.  Upon or prior to the execution of this Loan  Modification  Agreement,
Borrower  shall pay to Bank a fee in the amount of  $20,000.00  and, on one year
from the date of this Loan Modification Agreement, Borrower shall pay to Bank an
additional fee in the amount of $15,000.00, which fees shall be retained by Bank
and not applied in reduction of the Obligations. In addition, the Borrower shall
reimburse Bank for all legal fees and expenses  incurred in connection with this
amendment to the Existing Loan Documents.







12. CONTINUING  VALIDITY.  Borrower understands and agrees that in modifying the
existing   Obligations,   Bank  is  relying  upon  Borrower's   representations,
warranties, and agreements, as set forth in the Existing Loan Documents.  Except
as expressly modified pursuant to this Loan Modification Agreement, the terms of
the  Existing  Loan  Documents  remain  unchanged  and in full force and effect.
Bank's  agreement  to modify  the  existing  Obligations  pursuant  to this Loan
Modification  Agreement  in no way  shall  obligate  Bank  to  make  any  future
modifications to the Obligations.  Nothing in this Loan  Modification  Agreement
shall constitute a satisfaction of the Obligations.  It is the intention of Bank
and Borrower to retain as liable parties all makers of Existing Loan  Documents,
unless the party is  expressly  released  by Bank in  writing.  No maker will be
released by virtue of this Loan Modification Agreement.

13.  JURISDICTION/VENUE.  Borrower accepts for itself and in connection with its
properties,  unconditionally,  the  non-exclusive  jurisdiction  of any state or
federal court of competent  jurisdiction in the Commonwealth of Massachusetts in
any action, suit, or proceeding of any kind against it which arises out of or by
reason of this Loan Modification Agreement;  provided,  however, that if for any
reason  Bank  cannot  avail  itself  of  the  courts  of  the   Commonwealth  of
Massachusetts,   then  venue  shall  lie  in  Santa  Clara  County,  California.
NOTWITHSTANDING THE FOREGOING, THE BANK SHALL HAVE THE RIGHT TO BRING ANY ACTION
OR  PROCEEDING  AGAINST THE  BORROWER OR ITS PROPERTY IN THE COURTS OF ANY OTHER
JURISDICTION  WHICH THE BANK DEEMS  NECESSARY OR APPROPRIATE IN ORDER TO REALIZE
ON THE COLLATERAL OR TO OTHERWISE ENFORCE THE BANK'S RIGHTS AGAINST THE BORROWER
OR ITS PROPERTY.


            [The remainder of this page is intentionally left blank]






      This Loan Modification  Agreement is executed as a sealed instrument under
the laws of the  Commonwealth  of  Massachusetts  as of the date  first  written
above.

BORROWER:                                 BANK:

COLLAGENEX PHARMACEUTICALS, INC.          SILICON VALLEY BANK,  doing business
                                          as SILICON VALLEY EAST

By: /s/ Nancy C. Broadbent                By: /s/ John V. Atanasoff
   -----------------------------             ----------------------------------

Name: Nancy C. Broadbent                  Name: John V. Atanasoff
     ---------------------------               --------------------------------

Title: Chief Financial Officer            Title: Regional Market Manager
      --------------------------                -------------------------------



ACKNOWLEDGED AND AGREED:

MMP, INC.

By: /s/ Frank Ruffo
   -----------------------------

Name: Frank Ruffo
     ---------------------------

Title: Secretary and Treasurer
      --------------------------





                             PERFECTION CERTIFICATE
                                       OF
                        COLLAGENEX PHARMACEUTICALS, INC.


      The undersigned, Nancy C. Broadbent of COLLAGENEX PHARMACEUTICALS, INC., a
Delaware  corporation  (the  "Company"),  hereby certifies with reference to the
Loan and Security  Agreement dated as of March 19, 2001, as amended of even date
between the Company and SILICON VALLEY BANK (the "Bank") (terms defined  therein
being used herein as therein  defined),  to the Bank as follows (for purposes of
this Perfection Certificate,  those questions for which no response is completed
shall be deemed to read "NONE"):

      1.    Names.

     (a) The exact legal name of the Company as it appears in its certificate of
incorporation, as amended to date, is as follows:

                        CollaGenex Pharmaceuticals, Inc.


     (b) The  following is a list of all other names  (including  trade names or
similar  appellations)  used by the  Company,  or any of its  divisions or other
business  units,  or any other  business  or  organization  to which the Company
became the  successor  by merger,  consolidation,  acquisition,  change in form,
nature or jurisdiction  of organization or otherwise,  now or at any time during
the past five years together with the dates such names were used:

                        CollaGenex, Inc (4/10/96)


     (c) The  following is a list of all  subsidiaries  of the Company  (whether
wholly owned, or where the Company has a controlling or majority interest):

                        MMP Technologies, Inc
                        CollaGenex International, LTD


     (d) The following is the type of organization of the Company:

                        C Corporation


     (e) The jurisdiction of organization of the Company is as follows:

                        North America, Europe and Asia


     (f)  The   following  is  the   Company's   state   issued   organizational
identification number, if any:

                        Delaware 2284752






            (g) The Company's federal taxpayer identification number is:

                        52-1758016


            (h) The Company currently maintains its bank and investment accounts
at:

                (1)  Bank  Accounts - SVB,  First  Union,  DBAB

                (2)  Investment Accounts - SVB, Evergreen Investments (First
                     Union)

                (3)  Payroll Accounts - SVB

                (4)  Other  depository/operating accounts - SVB


            (i) The Company  currently has the following  commercial tort claims
against other parties:

                        None


            (j) Attached hereto as SCHEDULE A is the information  required above
for any other business or organization to which the Company became the successor
by merger, consolidation, acquisition, change in form, nature or jurisdiction of
organization or otherwise, now or at any time during the past five (5) years:

                        None


      2.    Current Locations.

            (a) The  following is the mailing  address of the  Company:

      Mailing Address                   City                    State
      ---------------                   ----                    -----

      41 University Dr                  Newtown                 Pennsylvania


            (b) If different from its mailing  address,  the Company's  place of
business,  or if more than one,  its CHIEF  EXECUTIVE  OFFICE is  located at the
following address:

      Mailing Address                   City                    State
      ---------------                   ----                    -----

      N/A


            (c) If different from the addresses set forth in  subparagraphs  (a)
and (b)  above,  the  following  are all other  locations  in which the  Company
maintains any books or records  relating to any of the Collateral  consisting of
accounts, instruments, chattel paper, general intangibles or mobile goods:

      Mailing Address                   City                    State
      ---------------                   ----                    -----

      N/A





            (d) If different from the addresses set forth in subparagraphs  (a),
(b) or (c) above, the following are all places of business of the Company and/or
locations maintained by the Company where any Collateral consisting of equipment
and/or inventory are located:

                        Mailing
                        Address                 City            State
                        -------                 ----            -----

Cord Logistics          15 Ingram Blvd          LaVergne        Tennessee


            (e) The  following  are the names and  addresses  of all  persons or
entities  other  than  the  Company  (such  as  lessees,  bailees,   consignees,
warehousemen,  or purchasers  of chattel  paper),  which have  possession or are
intended to have possession of any of the Collateral  consisting of instruments,
chattel paper,  inventory or equipment and the nature of such party's possession
(such as lessee, bailee, consignee, warehouseman, purchaser of chattel paper, or
other):

              Mailing                                       Nature of
Name          Address          City          State          Possession
- ----          -------          ----          -----          ----------


      3.   Prior  Locations. (a) Set forth below is the information  required by
subparagraphs (a), (b), (c) and (d) of paragraph 2 with respect to each location
or place of business previously maintained by the Company at any time during the
past five (5) years in a state in which the Company has previously  maintained a
location or place of business:

      Mailing Address                   City                    State
      ---------------                   ----                    -----


            (a) Set forth below is the information  required by subparagraph (e)
of paragraph 2 with respect to each other location at which,  or other person or
entity with which,  any of the  Collateral  consisting of  instruments,  chattel
paper,  inventory or equipment has been  previously  held at any time during the
past twelve months:

              Mailing                                       Nature of
Name          Address          City          State          Possession
- ----          -------          ----          -----          ----------





      4.   Attached hereto as SCHEDULE B is the  information  required by U.C.C.
ss.9-502(b)  or  former  U.C.C.  ss.9-402(5)  of each  state in which any of the
Collateral  consisting  of  fixtures  are or are to be located  and the name and
address of each real estate recording office where a mortgage on the real estate
on which such fixtures are or are to be located would be recorded.


      5.   NO UNUSUAL TRANSACTIONS.   Except for  those purchases, acquisitions,
and other transactions as set forth in SCHEDULE A or SCHEDULE C attached hereto,
all of the Collateral has been  originated by the Company in the ordinary course
of the  Company's  business or consists of goods which have been acquired by the
Company in the ordinary course from a person in the business of selling goods of
that kind.


      The undersigned hereby acknowledges and agrees that the Bank is relying on
the  representations  and  warranties  made  herein  in  connection  with a loan
transaction or  transactions  to be entered into between the undersigned and the
Bank.

      IN WITNESS  WHEREOF,  I have  hereunto set my hand this 22nd day of March,
2002, and this document shall constitute a document under seal under the laws of
the Commonwealth of Massachusetts.

                                       COLLAGENEX PHARMACEUTICALS, INC.


                                       By: /s/ Nancy C. Broadbent
                                         --------------------------------------
                                                   (duly authorized)

                                       Name: Nancy C. Broadbent
                                            -----------------------------------





                             PERFECTION CERTIFICATE
                                       OF
                                    MMP, INC.


      The undersigned, Nancy C. Broadbent, of MMP Technologies, INC., a Delaware
corporation  (the  "Company"),  hereby  certifies with reference to the Loan and
Security  Agreement  dated as of March 19, 2001, as amended of even date between
Collagenex  Pharmaceuticals,  Inc. and SILICON  VALLEY BANK (the "Bank")  (terms
defined  therein being used herein as therein  defined),  to the Bank as follows
(for  purposes of this  Perfection  Certificate,  those  questions  for which no
response is completed shall be deemed to read "NONE"):

      1.    Names.

            (a)  The  exact  legal  name of the  Company  as it  appears  in its
certificate of incorporation, as amended to date, is as follows:

                        MMP Technologies, Inc


     (b) The  following is a list of all other names  (including  trade names or
similar  appellations)  used by the  Company,  or any of its  divisions or other
business  units,  or any other  business  or  organization  to which the Company
became the  successor  by merger,  consolidation,  acquisition,  change in form,
nature or jurisdiction  of organization or otherwise,  now or at any time during
the past five years together with the dates such names were used:

                         None


            (c) The  following  is a list  of all  subsidiaries  of the  Company
(whether  wholly  owned,  or where the  Company  has a  controlling  or majority
interest):

                        None


            (d) The following is the type of organization of the Company:

                        C Corporation


            (e) The jurisdiction of organization of the Company is as follows:

                        United States of America


            (f) The  following  is the  Company's  state  issued  organizational
identification number, if any:

                        Delaware 3059678


            (g) The Company's federal taxpayer identification number is:

                        51-0391038


            (h) The Company currently maintains its bank and investment accounts
at:





                (1)  Bank Accounts -  Wilmington Trust

                (2)  Investment Accounts - Wilmington Trust

                (3)  Payroll Accounts- Wilmington Trust

                (4)  Other depository/operating accounts - Wilmington Trust


            (i) The Company  currently has the following  commercial tort claims
against other parties:

                        None


            (j) Attached hereto as SCHEDULE A is the information  required above
for any other business or organization to which the Company became the successor
by merger, consolidation, acquisition, change in form, nature or jurisdiction of
organization  or  otherwise,  now or at any time during the past five (5) years:

                        None


      2. Current Locations.

            (a) The following is the mailing address of the Company:

      Mailing Address                   City                    State
      ---------------                   ----                    -----

      103 Springer Building             Wilmington              Delaware


            (b) If different from its mailing  address,  the Company's  place of
business,  or if more than one,  its CHIEF  EXECUTIVE  OFFICE is  located at the
following address:

      Mailing Address                   City                    State
      ---------------                   ----                    -----

      N/A


            (c) If different from the addresses set forth in  subparagraphs  (a)
and (b)  above,  the  following  are all other  locations  in which the  Company
maintains any books or records  relating to any of the Collateral  consisting of
accounts, instruments, chattel paper, general intangibles or mobile goods:

      Mailing Address                   City                    State
      ---------------                   ----                    -----

      N/A


            (d) If different from the addresses set forth in subparagraphs  (a),
(b) or (c) above, the following are all places of business of the Company and/or
locations maintained by the Company where any Collateral consisting of equipment
and/or inventory are located:





      Mailing Address                   City                    State
      ---------------                   ----                    -----

      N/A


            (e) The  following  are the names and  addresses  of all  persons or
entities  other  than  the  Company  (such  as  lessees,  bailees,   consignees,
warehousemen,  or purchasers  of chattel  paper),  which have  possession or are
intended to have possession of any of the Collateral  consisting of instruments,
chattel paper,  inventory or equipment and the nature of such party's possession
(such as lessee, bailee, consignee, warehouseman, purchaser of chattel paper, or
other):

              Mailing                                       Nature of
Name          Address          City          State          Possession
- ----          -------          ----          -----          ----------

N/A


      3. Prior  Locations.  (a) Set forth below is the  information  required by
subparagraphs (a), (b), (c) and (d) of paragraph 2 with respect to each location
or place of business previously maintained by the Company at any time during the
past five (5) years in a state in which the Company has previously  maintained a
location or place of business:

      Mailing Address                   City                    State
      ---------------                   ----                    -----

      N/A


            (b) Set forth below is the information  required by subparagraph (e)
of paragraph 2 with respect to each other location at which,  or other person or
entity with which,  any of the  Collateral  consisting of  instruments,  chattel
paper,  inventory or equipment has been  previously  held at any time during the
past twelve months:

              Mailing                                       Nature of
Name          Address          City          State          Possession
- ----          -------          ----          -----          ----------

N/A


      4.  Attached  hereto as SCHEDULE B is the  information  required by U.C.C.
ss.9-502(b)  or  former  U.C.C.  ss.9-402(5)  of each  state in which any of the
Collateral  consisting  of  fixtures  are or are to be located  and the name and
address of each real estate recording office where a mortgage on the real estate
on which such fixtures are or are to be located would be recorded.


      5. No Unusual Transactions. Except for those purchases,  acquisitions, and
other transactions as set forth in SCHEDULE A or SCHEDULE C attached hereto, all
of the Collateral has been  originated by the Company in the ordinary  course of
the  Company's  business or  consists  of goods which have been  acquired by the
Company in the ordinary course from a person in the business of selling goods of
that kind.





      The undersigned hereby acknowledges and agrees that the Bank is relying on
the  representations  and  warranties  made  herein  in  connection  with a loan
transaction or  transactions  to be entered into between the undersigned and the
Bank.


      IN WITNESS  WHEREOF,  I have  hereunto set my hand this 22nd day of March,
2002, and this document shall constitute a document under seal under the laws of
the Commonwealth of Massachusetts.

                                       MMP TECHNOLOGIES, INC.


                                       By: /s/ Nancy C., Broadbent
                                          -------------------------------------
                                                  (duly authorized)

                                       Name: Nancy C. Broadbent
                                            -----------------------------------