HALE AND DORR LLP
               (a Massachusetts Limited Liability Partnership and
                       includes Professional Corporations)
                               Counsellors at Law
                              650 College Road East
                           Princeton, New Jersey 08540


                                             May 31, 2002


Senesco Technologies, Inc.
303 George Street, Suite 420
New Brunswick, New Jersey 08901

      Re:   Registration Statement on Form S-3
            ----------------------------------

Ladies and Gentlemen:

     This  opinion  is  furnished  to you  in  connection  with  a  Registration
Statement  on Form  S-3 (the  "Registration  Statement"),  to be filed  with the
Securities and Exchange Commission (the "Commission") on May 31, 2002, under the
Securities Act of 1933, as amended (the "Securities  Act"), for the registration
of an aggregate of 12,304,795 shares of common stock,  $0.01 par value per share
(the  "Shares"),  of Senesco  Technologies,  Inc., a Delaware  corporation  (the
"Company"),  which  will be sold by certain  stockholders  of the  Company  (the
"Selling Stockholders").

     We are acting as counsel for the Company in connection with the sale by the
Selling  Stockholders  of the  Shares.  We have  examined  signed  copies of the
Registration  Statement to be filed with the  Commission.  We have also examined
and relied upon the minutes of  meetings  of the  stockholders  and the Board of
Directors of the Company as provided to us by the Company, stock record books of
the Company as provided to us by the Company,  the Certificate of  Incorporation
and By-Laws of the  Company,  each as  restated  and/or  amended to date,  those
certain  securities  purchase  agreements,  registration  rights agreements and,
where  applicable,  warrant  agreements  filed as exhibits  to the  Registration
Statement (collectively,  the "Agreements"), by and between the Company and each
respective  Selling  Stockholder  and such  other  documents  as we have  deemed
necessary for purposes of rendering the opinions hereinafter set forth.

     In  our  examination  of the  foregoing  documents,  we  have  assumed  the
genuineness of all signatures, the authenticity of all documents submitted to us
as originals, the conformity to original documents of all documents submitted to
us as copies, the authenticity of the originals of such latter documents and the
legal competence of all signatories to such documents.

     We assume that the appropriate action will be taken, prior to the offer and
sale of the  Shares,  to  register  and  qualify  the  Shares for sale under all
applicable state securities or "blue sky" laws.



Senesco Technologies, Inc.
May 31, 2002
Page 2



     We express no  opinion  herein as to the laws of any state or  jurisdiction
other than the  corporate  laws of the State of Delaware,  the state laws of the
State of New Jersey and the federal laws of the United States of America.

     Based upon and subject to the  foregoing,  we are of the  opinion  that the
Shares have been duly  authorized  for issuance and, when such Shares are issued
in accordance  with the terms and  conditions of the  Company's  Certificate  of
Incorporation and the Agreements,  as applicable,  will be validly issued, fully
paid and nonassessable.

     It is understood  that this opinion is to be used only in  connection  with
the offer and sale of the Shares while the Registration Statement is in effect.

     Please note that we are opining only as to the matters  expressly set forth
herein, and no opinion should be inferred as to any other matters.  This opinion
is based upon  currently  existing  statutes,  rules,  regulations  and judicial
decisions,  and we disclaim any obligation to advise you of any change in any of
these sources of law or  subsequent  legal or factual  developments  which might
affect any matters or opinions set forth herein.

     We hereby  consent to the filing of this opinion with the  Commission as an
exhibit to the  Registration  Statement in accordance  with the  requirements of
Item  601(b)(5) of Regulation S-B under the Securities Act and to the use of our
name therein and in the related Prospectus under the caption "Legal Matters." In
giving  such  consent,  we do not hereby  admit that we are in the  category  of
persons whose consent is required  under Section 7 of the  Securities Act or the
rules and regulations of the Commission.


                                       Very truly yours,

                                       /s/ Hale and Dorr LLP

                                       HALE AND DORR LLP