Exhibit 99.1


For Immediate Release:                          Company Contact:
- ---------------------                           ---------------
June 5, 2002                                    Nancy C. Broadbent
                                                Chief Financial Officer
                                                (215) 579-7388

                                                Investor Relations:
                                                Lisa Carlton-Wilson
                                                In-Site Communications
                                                (212) 759-3929



                        COLLAGENEX PHARMACEUTICALS ADOPTS
          AMENDED AND RESTATED SHAREHOLDER PROTECTION RIGHTS AGREEMENT



Newtown,  PA, June 5, 2002 - CollaGenex  Pharmaceuticals,  Inc.  (Nasdaq:  CGPI)
today  announced that its Board of Directors had adopted an Amended and Restated
Shareholder  Protection  Rights Agreement (the "Restated  Plan").  Such Restated
Plan supercedes,  in its entirety, the Company's existing Shareholder Protection
Rights Agreement  initially adopted on September 15, 1997 (the "Original Plan"),
as amended.  Rights  attached to  outstanding  shares of common  stock under the
Original  Plan and  rights  attached  to shares of  common  stock  issued by the
Company  after the date  hereof  will be  governed  pursuant to the terms of the
Restated Plan.

     The  Restated  Plan is not adopted in response  to any  specific  effort to
acquire  control of the  Company,  but  rather to  continue  to ensure  that all
CollaGenex'  stockholders  are  treated  fairly in the  event of an  unsolicited
takeover of the Company or other tactics  intended to gain control of CollaGenex
without maximizing stockholder value.

     The Restated  Plan,  like the Original  Plan,  provides  generally that if,
without prior approval of the Board of Directors,  a third party acquires 20% or
more of CollaGenex'  common stock,  all  stockholders of the Company (other than
the  acquiring  party) will be entitled  to buy shares of the  Company's  common
stock having a market  value equal to double the  exercise  price for each right
they hold. In addition,  if,  subsequent to the time a third party acquires such
interest in the Company's common stock, the Company merges or consolidates  with
another party and is not the surviving  entity,  or the Company  transfers  more
than 50% of its assets or earning power to another party,





all  stockholders  of the Company (other than the acquiring or surviving  party)
shall have substantially  equivalent rights to purchase the equity securities of
such acquiring or surviving party.  The Board of Directors  approved an exercise
price of $65.00  per  right,  based,  in part,  upon the  recommendation  of its
financial  advisors.  Any such  issuance  under the  Restated  Plan would have a
substantial dilutive effect on the acquiring or surviving party.

     CollaGenex  Pharmaceuticals,  Inc.  is a specialty  pharmaceutical  company
currently  focused on providing  innovative  medical therapies to the dental and
dermatology markets. The Company's lead product,  Periostat(R), is the first and
only  pharmaceutical to treat periodontal disease by inhibiting the enzymes that
destroy  periodontal  support  tissues.  Periostat  is  marketed  to the  dental
community  through  a  professional   pharmaceutical  sales  force  composed  of
approximately 120 sales representatives and managers.  Currently,  the Company's
dental  sales  force  is  also  marketing  Vioxx(R),  a Merck  & Co.  drug  that
CollaGenex  co-promotes  for the treatment of acute dental pain, and Atridox(R),
Atrisorb(R)  and  Atrisorb-D(R),  Atrix  Laboratories  Inc.'s  products  for the
treatment of adult periodontitis.

     Research  has  shown  that the  enzyme  suppression  technology  underlying
Periostat may also be applicable to other diseases involving  destruction of the
body's connective tissues, including cancer metastases (Metastat(R)) and a broad
range of  inflammatory  diseases.  CollaGenex  is  developing a series of novel,
proprietary  compounds  known as IMPACS  (Inhibitors  of Multiple  Proteases and
Cytokines) to address these applications.  The Company intends to pursue further
research and development of these  technologies  primarily through  partnerships
with third parties.

     To receive additional information on the Company, please visit our Web site
at www.collagenex.com, which is not a part of this press release.
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     This press release contains  forward-looking  statements within the meaning
of Section 21E of the Securities and Exchange Act of 1934, as amended. Investors
are cautioned that  forward-looking  statements involve risks and uncertainties,
which may affect the Company's business and prospects. The Company's business of
selling, marketing and developing pharmaceutical products is subject to a number
of significant  risks,  including  risks relating to the  implementation  of the
Company's sales and marketing plans for Periostat and other products that the




Company markets,  risks inherent in research and development  activities,  risks
associated  with  conducting  business  in a highly  regulated  environment  and
uncertainty  relating to clinical trials of products under  development,  all as
discussed  in the  Company's  periodic  filings  with  the U.S.  Securities  and
Exchange Commission.



Periostat(R),  Metastat(R)  and  IMPACS(TM)  are  United  States  trademarks  of
CollaGenex Pharmaceuticals,  Inc. Periostat(R) is a European Community trademark
of CollaGenex Pharmaceuticals, Inc.

Periostat(R) and IMPACS(R) are United Kingdom trademarks of the Company's wholly
owned subsidiary,  CollaGenex International Limited. CollaGenex(R) is a European
Community and United Kingdom trademark of CollaGenex International Limited.



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