SCHEDULE 14A
                                 (Rule 14a-101)

                     INFORMATION REQUIRED IN PROXY STATEMENT

                            SCHEDULE 14A INFORMATION

           Proxy Statement Pursuant to Section 14(a) of the Securities
                      Exchange Act of 1934 (Amendment No. )

Filed by the Registrant |X|
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Check the appropriate box:
|_| Preliminary Proxy Statement     |_|  Confidential, for Use of the Commission
                                         Only (as permitted by Rule 14a-6(e)(2))
|X| Definitive Proxy Statement
|_| Definitive Additional Materials
|_| Soliciting Material Under Rule 14a-12

                        CollaGenex Pharmaceuticals, Inc.
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified in Its Charter)


- --------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if Other Than the Registrant)

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                        COLLAGENEX PHARMACEUTICALS, INC.
                               41 University Drive
                                Newtown, PA 18940



                                               April 23, 2003

To Our Stockholders:

     You are cordially invited to attend the 2003 Annual Meeting of Stockholders
of CollaGenex  Pharmaceuticals,  Inc. at 8:30 A.M., local time, on Tuesday,  May
20, 2003,  at the  Philadelphia  Airport  Marriott  Hotel,  One  Arrivals  Road,
Philadelphia, Pennsylvania.

     The Notice of Meeting and Proxy  Statement on the following  pages describe
the matters to be presented at the meeting.

     It is important  that your shares be  represented at this meeting to assure
the presence of a quorum. Whether or not you plan to attend the meeting, we hope
that you will have your stock represented by signing,  dating and returning your
proxy in the enclosed envelope, as soon as possible. Your stock will be voted in
accordance with the instructions you have given in your proxy.

     Thank you for your continued support.


                                          Sincerely,


                                          /s/ Brian M. Gallagher

                                          Brian M. Gallagher, Ph.D.
                                          Chairman, President and
                                          Chief Executive Officer






                        COLLAGENEX PHARMACEUTICALS, INC.
                               41 University Drive
                                Newtown, PA 18940


                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                             To Be Held May 20, 2003


     The Annual Meeting of Stockholders of COLLAGENEX  PHARMACEUTICALS,  INC., a
Delaware  corporation,  will be held at the Philadelphia Airport Marriott Hotel,
One Arrivals Road, Philadelphia, Pennsylvania, on Tuesday, May 20, 2003, at 8:30
A.M., local time, for the following purposes:

(1)  To  elect  seven  directors  to serve  until  the next  Annual  Meeting  of
     Stockholders  and until their  respective  successors  shall have been duly
     elected and qualified;

(2)  To amend our 1996 Stock  Option  Plan to  increase  the  maximum  aggregate
     number of shares of common stock  available  for issuance  thereunder  from
     2,500,000 to 3,000,000  shares and to reserve an additional  500,000 shares
     of our common  stock for  issuance in  connection  with such  increase  for
     awards to be granted under the 1996 Stock Option Plan;

(3)  To ratify the appointment of KPMG LLP as our  independent  auditors for the
     year ending December 31, 2003; and

(4)  To  transact  such other  business as may  properly  come before the Annual
     Meeting or any adjournment or adjournments thereof.

     Holders of our common  stock and Series D preferred  stock of record at the
close of business on April 14, 2003 are entitled to notice of and to vote at the
Annual Meeting,  or any adjournment or adjournments  thereof. A complete list of
such  stockholders  will be open to the  examination  of any  stockholder at our
principal executive offices at 41 University Drive, Newtown, Pennsylvania 18940,
during  ordinary  business  hours,  for a period of 10 days  prior to the Annual
Meeting as well as on the day of the Annual  Meeting.  The Annual Meeting may be
adjourned  from time to time without  notice other than by  announcement  at the
Annual Meeting.

     IT IS IMPORTANT THAT YOUR SHARES BE REPRESENTED REGARDLESS OF THE NUMBER OF
SHARES YOU MAY HOLD.  WHETHER  OR NOT YOU PLAN TO ATTEND THE  MEETING IN PERSON,
PLEASE  COMPLETE,  DATE AND SIGN THE ENCLOSED PROXY CARD AND MAIL IT PROMPTLY IN
THE ENCLOSED RETURN ENVELOPE.  THE PROMPT RETURN OF PROXIES WILL ENSURE A QUORUM
AND SAVE US THE  EXPENSE OF FURTHER  SOLICITATION.  EACH  PROXY  GRANTED  MAY BE
REVOKED BY THE STOCKHOLDER APPOINTING SUCH PROXY AT ANY TIME BEFORE IT IS VOTED.
IF YOU RECEIVE MORE THAN ONE PROXY CARD BECAUSE  YOUR SHARES ARE  REGISTERED  IN
DIFFERENT NAMES OR ADDRESSES, EACH SUCH PROXY CARD SHOULD BE SIGNED AND RETURNED
TO ASSURE THAT ALL OF YOUR SHARES WILL BE VOTED.


                                           By Order of the Board of Directors

                                           /s/ Nancy C. Broadbent

                                           Nancy C. Broadbent
                                           Secretary


Newtown, Pennsylvania
April 23, 2003

             Our 2002 Annual Report accompanies the Proxy Statement.





                        COLLAGENEX PHARMACEUTICALS, INC.
                               41 University Drive
                                Newtown, PA 18940


                     --------------------------------------

                                 PROXY STATEMENT

                     --------------------------------------

     This Proxy  Statement is furnished in connection  with the  solicitation by
the Board of Directors of CollaGenex Pharmaceuticals,  Inc. (also referred to in
this Proxy Statement as the "Company," "CollaGenex," "we" or "us") of proxies to
be voted at our Annual Meeting of  Stockholders  to be held on Tuesday,  May 20,
2003  at  the   Philadelphia   Airport   Marriott  Hotel,   One  Arrivals  Road,
Philadelphia,   PA  at  8:30  a.m.,  local  time,  and  at  any  adjournment  or
adjournments thereof.  Holders of record of our common stock, $.01 par value per
share, and Series D cumulative  convertible  preferred stock, $.01 par value per
share, as of the close of business on April 14, 2003, will be entitled to notice
of and to  vote  at the  Annual  Meeting  and any  adjournment  or  adjournments
thereof.  As of that date,  there  were  11,408,704  shares of our common  stock
issued and  outstanding  and entitled to vote and 200,000 shares of our Series D
preferred  stock issued and  outstanding  and  entitled to vote.  Such shares of
Series D  preferred  stock were,  as of such date,  convertible  into  2,021,572
shares of common  stock.  Except for the proposal to elect the Series D Director
(as  hereinafter  defined),  as set forth  below,  each share of common stock is
entitled  to one  vote  on any  matter  presented  at the  Annual  Meeting.  The
aggregate number of common stock votes entitled to be cast at the Annual Meeting
is 13,430,276,  including the 2,021,572 shares underlying the Series D preferred
stock to be voted on an as converted  to common stock basis.  The holders of all
classes of stock will vote as a single class for all proposals generally, except
that only the holders of Series D preferred  stock will vote as a separate class
for the proposal to elect the Series D Director.

     If proxies in the accompanying form are properly executed and returned, the
shares of common stock and Series D preferred stock represented  thereby will be
voted in the manner specified therein. If not otherwise specified, the shares of
common  stock and Series D preferred  stock  represented  by the proxies will be
voted (i) FOR, as applicable,  the election of the seven nominees named below as
directors,  (ii) FOR a proposal to amend our 1996 Stock  Option Plan to increase
the maximum  aggregate  number of shares of common stock  available for issuance
thereunder  from  2,500,000  to  3,000,000  shares and to reserve an  additional
500,000 shares of our common stock for issuance in connection with such increase
for  awards  to be  granted  under the 1996  Stock  Option  Plan,  (iii) FOR the
ratification of the appointment of KPMG LLP as our independent  auditors for the
year ending  December 31, 2003,  and (iv) in the discretion of the persons named
in the enclosed form of proxy,  on any other  proposals  which may properly come
before the Annual  Meeting  or any  adjournment  or  adjournments  thereof.  Any
stockholder  who has  submitted  a proxy may revoke it at any time  before it is
voted,  by written  notice  addressed  to and  received by the  Secretary of the
Company, by submitting a duly executed proxy bearing a later date or by electing
to vote in person at the Annual Meeting. The mere presence at the Annual Meeting
of the person appointing a proxy does not, however, revoke the appointment.

     The  presence,  in person or by proxy,  of  holders of shares of our common
stock,  including the shares of common stock  underlying  the Series D preferred
stock to be voted on an as converted to common  stock  basis,  in the  aggregate
having a majority of the votes entitled to be cast by such holders at the Annual
Meeting,  shall  constitute a quorum with respect to all matters  except for the
election of directors. The presence, in person or by proxy, of holders of shares
of each of our common  stock and our Series D preferred  stock having a majority
of the votes entitled to be cast by each respective class of stock at the Annual
Meeting  shall  constitute a quorum with respect to the election of directors to
be elected by each respective  class.  The affirmative  vote by the holders of a
plurality of the shares of common stock  represented at the Annual Meeting,  but
not including the shares of common stock underlying the Series D preferred stock
to be voted on an as  converted  to common  stock  basis,  is  required  for the
election of  directors  other than the Series D  Director,  provided a quorum of
such  stockholders is present in person or by proxy. The affirmative vote by the
holders of a majority of the shares of Series D preferred  stock  represented at
the Annual  Meeting  is  required  for the  election  of the Series D  Director,
provided  a quorum is  present.  All  actions  proposed  herein  other  than the
election of directors  may be taken upon the  affirmative  vote of  stockholders
possessing a majority of the requisite  voting power  represented  at the Annual
Meeting, provided a quorum is present in person or by proxy.





     Abstentions  are included in the shares  present at the Annual  Meeting for
purposes of determining  whether a quorum is present,  and are counted as a vote
against for  purposes of  determining  whether a proposal  is  approved.  Broker
non-votes  (when  shares  are  represented  at the  Annual  Meeting  by a  proxy
specifically conferring only limited authority to vote on certain matters and no
authority to vote on other  matters) are  included in the  determination  of the
number of shares  represented  at the Annual Meeting for purposes of determining
whether a quorum is present  but are not counted  for  purposes  of  determining
whether a proposal has been approved and thus have no effect on the outcome.

     This Proxy  Statement,  together  with the related  proxy  cards,  is being
mailed to our  stockholders  on or about April 23,  2003.  The Annual  Report to
Stockholders  of the Company for the year ended  December  31,  2002,  including
financial statements,  is being mailed together with this Proxy Statement to all
stockholders  of record as of April 14,  2003.  In  addition,  we have  provided
brokers,  dealers,  banks,  voting trustees and their nominees,  at our expense,
with  additional  copies of the Annual Report so that such record  holders could
supply such materials to beneficial owners as of April 14, 2003.

                                      -2-




                              ELECTION OF DIRECTORS

     At the Annual  Meeting,  seven  directors  are to be elected  (which number
shall  constitute  our entire Board of  Directors) to hold office until the 2004
Annual  Meeting  of  Stockholders  and until  their  successors  shall have been
elected and  qualified.  The holders of common  stock,  voting as a class,  will
elect six directors. The holders of Series D preferred stock, voting as a class,
will elect one director  (referred  to in this proxy  statement as the "Series D
Director").

     It is the  intention of the persons  named in the enclosed form of proxy to
vote the stock represented thereby, unless otherwise specified in the proxy, for
the  election as  directors of the persons  whose names and  biographies  appear
below. All such persons are, at present,  members of our Board of Directors.  In
the event any of the nominees should become  unavailable or unable to serve as a
director,  it is  intended  that  votes  will be cast for a  substitute  nominee
designated  by our Board of  Directors.  The Board of Directors has no reason to
believe that the nominees named will be unable to serve if elected.  Each of the
nominees has  consented to being named in this Proxy  Statement  and to serve if
elected.

     We are  currently in the process of  recruiting a new  President  and Chief
Executive  Officer.  Brian Gallagher,  our current President and Chief Executive
Officer,  has agreed to serve in such  capacity  pending  the  appointment  of a
successor and to assist in an orderly  transition  process.  In connection  with
such  transition,  Dr. Gallagher has agreed to resign his position as a director
of the Company if requested by the Board of  Directors.  It is expected that Dr.
Gallagher's  successor  would also serve as a director of the Company whether or
not Dr. Gallagher continues to serve as a director.

     The current  members of our Board of  Directors,  who are also nominees for
election to our Board of Directors, are as follows:

Common Stock Directors:
- ----------------------




                                                         Served as a         Position(s) with
Name                                        Age         Director Since       the Company
- ----                                        ---         --------------       -----------------

                                                                    
Brian M. Gallagher, Ph.D.............       55               1994            President, Chief Executive Officer
                                                                             and Chairman of the Board

Peter R. Barnett, D.M.D..............       51               1997            Director

Robert C. Black......................       60               1999            Director

James E. Daverman....................       53               1995            Director

Robert J. Easton.....................       58               1993            Director

W. James O'Shea......................       53               2000            Director

Series D Preferred Stock Director:
- ----------------------------------
                                                         Served as a         Position(s) with
Name                                        Age         Director Since       the Company
- ----                                        ---         --------------       ----------------
Stephen A. Kaplan....................       44               1999            Director


     The principal  occupations and business  experience,  for at least the past
five years, of each nominee are as follows:

                                      -3-


     Dr.  Gallagher  joined  CollaGenex  in April  1994 as  President  and Chief
Executive  Officer,  and has been a member of our Board of Directors since 1994.
On March  10,  2000,  Dr.  Gallagher  was  appointed  Chairman  of the  Board of
Directors.   From  1988  until  April  1994,  Dr.   Gallagher  was  employed  by
Bristol-Myers Squibb Company and its predecessor, Squibb Corporation, in various
executive positions including strategic planning, worldwide product and business
development  and marketing.  From 1991 until April 1994, Dr.  Gallagher was Vice
President  and  General  Manager of Squibb  Diagnostics  in the in vivo  imaging
pharmaceutical  division. Prior to 1991, Dr. Gallagher served for ten years with
E.I.  DuPont  de  Nemours  &  Co.  in  a  variety  of  pharmaceutical  research,
development, marketing and business management positions.

     Dr.  Barnett  has been a member of our Board of  Directors  since  February
1997. Dr. Barnett has served as President and Chief  Executive  Officer of Group
Dental  Service,  Inc., a dental  insurance  company,  since November 2002. From
September  2001  to  November  2002,  he  served  as an  independent  healthcare
consultant.  Dr. Barnett was formerly the President, Chief Executive Officer and
a member of the Board of Directors  of  HealthASPex,  Inc., a claims  technology
firm,  from  June  2000 to  September  2001.  He was also  President  and  Chief
Operating  Officer of United Dental Care,  Inc., a managed dental benefits firm,
where he served in such capacity  from January 1995 until May 2000.  From August
1994 to January 1995, Dr. Barnett was Executive  Director of Prudential DMO, and
from March 1993 to August 1994,  he served as an  independent  consultant in the
managed care field.  From January 1985 to March 1993,  Dr.  Barnett was a Senior
Vice President with Pearle Vision, Inc.

     Mr. Black has been a member of our Board of Directors since September 1999.
He was President of the Zeneca Pharmaceuticals Division of AstraZeneca,  Inc., a
pharmaceutical   company,   until  his   retirement  in  June  1999.  He  joined
AstraZeneca,  Inc. in 1965 as a  pharmaceutical  sales  representative  and held
numerous positions of increasing  responsibility in sales and marketing prior to
becoming President of the Zeneca Pharmaceuticals Division in 1991.

     Mr.  Daverman  has been a member of our Board of Directors  since  November
1995. He is a managing general partner of Marquette Partners,  a venture capital
investment  company,  which he founded in 1987.  Mr.  Daverman is  President  of
Marquette  Management  Partners,  LLC, the general partner of Marquette  Venture
Partners,  L.P.  and a general  partner of MG II, L.P.,  the general  partner of
Marquette  Venture  Partners  II, L.P.  and MVP II  Affiliates  Fund,  L.P.  Mr.
Daverman  serves as a director  and  compensation  committee  member of numerous
privately held companies.

     Mr. Easton has been a member of our Board of Directors since November 1993.
He currently serves as Chairman of Easton  Associates,  a healthcare  consulting
firm,  and has held  this  position  since May 2000.  He was  formerly  Managing
Director of IBM  Healthcare  Consulting,  Inc., a major  health care  consulting
firm,  where he served in such capacity  from 1981 to May 2000.  Mr. Easton is a
former President of the Biomedical Marketing Association. Mr. Easton is a member
of  the  Boards  of   Directors  of   eXegenics,   Inc.   (formerly   Cytoclonal
Pharmaceuticals, Inc.), Cepheid, Inc., and several privately held companies.

     Mr.  O'Shea  has been a member of our Board of  Directors  since  September
2000. He currently serves as President and Chief Operating  Officer of Sepracor,
Inc., a position he has held since  October 1999.  Formerly,  he was Senior Vice
President of AstraZeneca,  Inc., a pharmaceutical  company, from 1975 to October
1999.

     Mr.  Kaplan  has been a member of our Board of  Directors  since  September
1999.  He is a principal and portfolio  manager of Oaktree  Capital  Management,
LLC, which is the general partner of OCM Principal  Opportunities  Fund, L.P., a
venture  capital fund. He has held such  positions  since June 1995 and November
1993,  respectively.  From November 1993 to May 1995 he was Managing Director of
Trust  Company  of  The  West.   Mr.  Kaplan  serves  as  a  director  of  Regal
Entertainment  Group  and  General  Maritime  Corporation,  as well as  numerous
privately held companies.

     Pursuant to the terms of the  Certificate of  Designation,  Preferences and
Rights of Series D  Cumulative  Convertible  Preferred  Stock,  as amended,  the
holders of the Series D  preferred  stock,  acting as a single  class,  have the
right to designate and elect one member of our Board of  Directors.  The holders
of the Series D preferred  stock have exercised  such right by  designating  Mr.
Kaplan to serve as a member of our Board of Directors.

     Except as set forth above with respect to Dr. Gallagher, all directors will
hold  office  until the next  annual  meeting of  stockholders  and until  their
successors shall have been duly elected and qualified. None of our directors are
related to any other director or to any of our executive officers.

                                      -4-


     THE BOARD OF DIRECTORS  RECOMMENDS THAT STOCKHOLDERS,  AS APPLICABLE,  VOTE
FOR EACH OF THE  NOMINEES FOR THE BOARD OF  DIRECTORS.  PLEASE NOTE THAT PROXIES
CANNOT BE VOTED FOR A GREATER NUMBER OF PERSONS THAN THE NOMINEES NAMED ABOVE.

COMMITTEES AND MEETINGS OF THE BOARD

     Our Board of Directors currently consists of Brian M. Gallagher, Ph.D., who
serves  as  Chairman,  Peter R.  Barnett,  D.M.D.,  Robert  C.  Black,  James E.
Daverman,  Robert J. Easton, W. James O' Shea and Stephen A. Kaplan. Our Amended
and  Restated  By-Laws  currently  provide  that the total  number of  directors
comprising our Board of Directors  shall be such number as is fixed by our Board
of  Directors,  but in no event  less  than  one.  Pursuant  to the terms of the
Certificate  of  Designation,  Preferences  and  Rights of  Series D  Cumulative
Convertible Preferred Stock, as amended, our Board of Directors shall consist of
not less than five and not more than nine directors.  Our Board of Directors has
provided that our full Board of Directors  shall be comprised of nine directors.
Although we have nominated,  and are only seeking to elect, seven members to our
Board of Directors at this time, we are actively recruiting potential candidates
for  these  two  vacancies.  These  two  vacancies  may be filled by the vote or
written consent of a majority of our directors  elected by the holders of record
of our  common  stock,  and  shall  serve  until  the  next  annual  meeting  of
stockholders, unless earlier removed or such directors resign.

     There were seven  meetings  of the Board of  Directors  during  2002.  Each
incumbent director attended at least 75% of the aggregate of all meetings of the
Board of  Directors  held  during  the  period in which he served as a  director
during 2002 and the total number of meetings  held by the  committee on which he
served during the period, if applicable.

     There  are  currently  three  committees  of the  Board of  Directors:  the
Compensation Committee; the Nominating Committee; and the Audit Committee.

The Compensation Committee of the Board of Directors

     The  Compensation  Committee  currently  consists of W. James  O'Shea,  who
serves as  Chairman,  Robert C. Black and  Robert J.  Easton.  The  Compensation
Committee  was  established  in March 1996 and held four  meetings in 2002.  The
primary   responsibilities  of  the  Compensation  Committee  include  approving
salaries and incentive compensation for our executive officers and administering
our stock option plans.

The Nominating Committee of the Board of Directors

     The Nominating  Committee currently consists of Robert C. Black, who serves
as Chairman,  Peter R. Barnett and Stephen A. Kaplan.  The Nominating  Committee
was  established  in  March  2000 and held two  meetings  in 2002.  The  primary
responsibility   of  the  Nominating   Committee  is  reviewing  and  nominating
candidates for election to the Board of Directors. The Nominating Committee will
consider  nominees for the Board of Directors  suggested by  stockholders  whose
names are submitted in writing to the Nominating Committee in care of the office
of the Corporate Secretary of the Company.

The Audit Committee of the Board of Directors

     The Audit Committee currently consists of James E. Daverman,  who serves as
Chairman,  Robert J.  Easton  and Peter R.  Barnett.  The  Audit  Committee  was
established  in March  1996 and  currently  acts  under a  charter  adopted  and
approved on May 8, 2000.  The Audit  Committee  held four meetings in 2002.  The
primary  responsibilities  of the Audit  Committee  include:  (i) evaluating and
recommending  to the  Board  of  Directors  the  engagement  of our  independent
auditors;  (ii)  reviewing the results and scope of the audit and other services
provided by our independent  auditors;  and (iii) monitoring on a periodic basis
our internal  controls.  Such  responsibilities  are more fully set forth in the
Audit Committee  Charter adopted by us on May 8, 2000, a copy of which was filed
as an Appendix to our proxy  statement  filed with the  Securities  and Exchange
Commission on April 18, 2001.

     Each  Audit  Committee  Member  is an  independent  member  of the Board of
Directors  as  defined  in  Rule  4200(a)(14)  of the  National  Association  of
Securities Dealers' listing standards.  As an independent  director of our Board
of Directors,  each Audit Committee  Member is not an officer or employee of the
Company  or our  subsidiaries  or does not  have a  relationship  which,  in the
opinion  of our  Board  of  Directors,  would  interfere  with the  exercise  of
independent judgement in carrying out the responsibilities of a director.

                                      -5-



COMPENSATION OF DIRECTORS

     During 2002,  Brian M. Gallagher,  Ph.D. was not paid any  compensation for
his services as Chairman of the Board.  Effective July 2002,  each  non-employee
director shall receive an annual retainer of $12,000 (such retainer was prorated
for the  period  from  July 2002 to  December  2002),  a fee of $2,000  for each
regularly  scheduled meeting of the Board of Directors attended in person and an
annual  fee of  $1,000  for each  Committee  on which  they  serve.  We  provide
reimbursement  to directors for  reasonable and necessary  expenses  incurred in
connection  with  attendance  at  meetings of the Board of  Directors  and other
Company business.

     From  time-to-time,  members of the Board of  Directors  have been  granted
options to purchase  shares of our common  stock.  See  "SECURITY  OWNERSHIP  OF
CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED SHAREHOLDER MATTERS."

     On July 8,  2002,  we  granted to each  non-employee  director,  options to
purchase  10,356 shares of common stock at an exercise price per share of $6.60.
Such options vest in four equal annual  installments  commencing  one year after
the date of grant. Beginning with the 2003 Annual Meeting of Stockholders,  upon
re-election, each non-employee director shall automatically be granted an option
to purchase  12,000 shares of common stock, at an exercise price per share equal
to the then current fair market value per share.  All such options  shall become
exercisable in four equal annual installments commencing one year after the date
of grant,  provided that the optionee  then remains a director.  Pursuant to our
1996 Non-Employee  Director Stock Option Plan, each new non-employee director is
automatically granted an option to purchase 25,000 shares of common stock, at an
exercise  price per share equal to the then current fair market value per share.
All such options become exercisable in five equal annual installments commencing
one year after the date of grant,  provided  that the  optionee  then  remains a
director.  The  right to  exercise  annual  installments  of  options  under the
Non-Employee Plan will be reduced proportionately based on the optionee's actual
attendance at meetings of the Board of Directors if the optionee fails to attend
at least 75% of the  meetings  of the Board of  Directors  held in any  calendar
year.

REPORT OF THE AUDIT COMMITTEE

February 18, 2003

To the Board of Directors of CollaGenex Pharmaceuticals, Inc.:

We  have  reviewed  and  discussed  with   management   the  Company's   audited
consolidated  financial  statements  as of and for the year ended  December  31,
2002.

Management  is  responsible  for the Company's  internal  controls and financial
reporting  process.  The  Company's  independent  auditors are  responsible  for
performing  an audit  of the  Company's  consolidated  financial  statements  in
accordance with auditing  standards  generally  accepted in the United States of
America and to issue a report on those  consolidated  financial  statements.  As
appropriate,  the Audit  Committee  reviews,  evaluates and  discusses  with the
Company's management, internal accounting,  financial and auditing personnel and
the independent auditors, the following:

o    the plan for, and the  independent  auditors'  report on, each audit of the
     Company's consolidated financial statements;

o    the  Company's  financial  disclosure  documents,  including  all financial
     statements and reports filed with the Securities and Exchange Commission or
     sent to stockholders;

o    management's  selection,  application and disclosure of critical accounting
     policies;

o    changes in the  Company's  accounting  practices,  principles,  controls or
     methodologies;

o    significant  developments or changes in accounting  rules applicable to the
     Company; and

o    the adequacy of the Company's internal  controls,  accounting and financial
     personnel.

We have discussed with the Company's  independent  auditors the matters required
to be discussed by Statement on Auditing  Standards No. 61,  Communication  with
Audit Committees,  as amended,  by the Auditing  Standards Board of the American
Institute  of  Certified  Public  Accountants  ("SAS 61").  SAS 61 requires  the
Company's  independent  auditors to discuss with the Company's Audit  Committee,
among other things, the following:

o    methods to account for significant unusual transactions;

                                      -6-



o    the effect of significant  accounting policies in controversial or emerging
     areas for which there is a lack of authoritative guidance or consensus;

o    the  process  used by  management  in  formulating  particularly  sensitive
     accounting estimates and the basis for the auditor's  conclusions regarding
     the reasonableness of those estimates; and

o    disagreements   with   management   over  the   application  of  accounting
     principles,  the  basis  for  management's  accounting  estimates  and  the
     disclosures in the financial statements.

We have received,  reviewed and discussed the written disclosures and the letter
from  the  independent  auditors  required  by  Independence   Standard  No.  1,
Independence Discussions with Audit Committees,  as amended, by the Independence
Standards  Board  ("Independence  Standards  Board Standard No. 1"), and we have
discussed with the auditors the auditors'  independence.  Independence Standards
Board  Standard  No. 1 requires  auditors  annually  to  disclose in writing all
relationships  that in the  auditor's  professional  opinion  may be  reasonably
thought to bear on  independence,  confirm  their  independence  and engage in a
discussion of independence.

We have considered  whether the non-audit  services  provided by the independent
auditors,  as set forth in the section of the Company's proxy statement entitled
"Independent  Auditor's Fees and Other Matters", are compatible with maintaining
the public accountants' independence.

Based on the reviews and  discussions  referred to above,  we  recommend  to the
Board of Directors that the consolidated  financial statements referred to above
be  included  in the  Company's  Annual  Report on Form 10-K for the year  ended
December 31, 2002.

James E.  Daverman
Audit Committee Chairman

Robert J. Easton
Audit Committee Member

Peter R. Barnett
Audit Committee Member

INDEPENDENT AUDITORS' FEES AND OTHER MATTERS

     The following  table presents fees for  professional  services  rendered by
KPMG LLP for the audit of our annual consolidated  financial  statements for the
year ended December 31, 2002,  and fees for other services  rendered by KPMG LLP
for the year ended December 31, 2002:

                     Fee                          Amount
Audit Fees
(excluding audit-related services)(1) ...        $110,000
                                                 ========
Financial Information Systems Design and
Implementation(2)........................      $        0
                                                 ========
All Other Fees:

Audit-Related Fees (3)...................        $ 22,000

Other Non-Audit Services(4)..............        $ 28,600
                                                 --------
   Total                                         $ 50,600
                                                 ========

(1)  Such amount includes  professional services rendered in connection with the
     audit of our consolidated  financial  statements for the most recent fiscal
     year and the reviews of the  condensed  consolidated  financial  statements
     included  in each of our  Quarterly  Reports on Form 10-Q during the fiscal
     year ended December 31, 2002.

                                      -7-



(2)  KPMG LLP did not provide any professional  services to us or our affiliates
     for the fiscal year ended  December 31, 2002 in connection  with  financial
     information  systems  design  or  implementation,   the  operation  of  our
     information system or the management of our local area network.

(3)  Such amount  consists  principally of  professional  services  rendered for
     issuing  consents in connection with our filing of registration  statements
     and certain accounting consultation for potential transactions.

(4)  Other  non-audit  related  fees  consisted  principally  of tax  compliance
     services.


                                      -8-






                               EXECUTIVE OFFICERS

         The following table identifies our current executive officers:

                                                       Capacities in                       In Current
Name                                            Age    Which Served                        Position Since
- ----                                            ---    --------------                      ---------------

                                                                                           
Brian M. Gallagher, Ph.D.................       55     President, Chief Executive          April 1994
                                                       Officer and Chairman of the         (Director since November
                                                       Board                               1994 and Chairman since
                                                                                           March 2000)

Robert A. Ashley(1)......................       45     Senior Vice President,              January 1999
                                                       Commercial Development              (Vice President,
                                                                                           Commercial Development
                                                                                           since September 1994)

Nancy C. Broadbent(2)....................       47     Chief Financial Officer,            March 1996
                                                       Treasurer and Secretary

David P. Pfeiffer(3).....................       40     Senior Vice President,              December 2000
                                                       Sales and Marketing                 (Vice President, Marketing
                                                                                           since June 1997)


     As  previously  reported,  we have  commenced  an  executive  search  for a
successor President and Chief Executive Officer to Dr. Gallagher.  Dr. Gallagher
has agreed to remain in his current position until a successor is appointed, and
he will work  closely  with the  Company  as a  consultant  for a period of time
thereafter to ensure a smooth transition. We have established a search committee
of our board of directors and have engaged an executive  recruiting firm to help
identify a  successor  to Dr.  Gallagher.  The Company  and Dr.  Gallagher  have
executed an agreement,  pursuant to which we shall compensate Dr. Gallagher for,
among other things,  his services during the transition  period and to recognize
his historical  contributions to the Company.  We also entered into a consulting
agreement  with Dr.  Gallagher  pursuant  to which  he will  provide  consulting
services  to us for a period of 24 months  following  the  appointment  of a new
chief executive officer.

(1)  Mr.  Ashley  joined   CollaGenex  in  September  1994  as  Vice  President,
     Commercial Development. He was promoted to Senior Vice President in January
     1999.  From 1989 until  September  1994,  he was employed by  Bristol-Myers
     Squibb  Company  and  its  predecessor,   Squibb  Corporation,  in  various
     positions   including   product   development,   commercial   and  business
     development and, most recently, as Director,  Business Development where he
     was responsible for the worldwide product and market development of several
     new drugs. From 1979 to 1989, Mr. Ashley held various positions at Amersham
     International (UK) Ltd.,  including research,  development,  manufacturing,
     sales and marketing positions, as well as worldwide product development and
     product launch positions.

(2)  Ms. Broadbent joined  CollaGenex in March 1996 as Chief Financial  Officer,
     Treasurer and Secretary.  From October 1994 until March 1996, Ms. Broadbent
     served as Senior Vice President,  Chief  Financial  Officer and director of
     Human Genome Sciences,  Inc., a pharmaceuticals  company. From January 1993
     to October 1994, she served as Vice President and Chief  Financial  Officer
     of Cangene,  Inc., a biopharmaceutical  company.  From January 1992 through
     December 1992, Ms. Broadbent served as an independent financial consultant.
     From March 1990 to December  1991,  she was  employed by Baring  Brothers &
     Co.,  Inc.,  initially  as  Senior  Vice  President  and then as  Executive
     Director,  Corporate Finance.  Prior to that, Ms. Broadbent served for nine
     years in  corporate  finance  positions  with  Salomon  Brothers,  Inc. and
     PaineWebber Incorporated.

                                      -9-



(3)  Mr. Pfeiffer joined  CollaGenex in June 1997 as Vice President,  Marketing.
     He was promoted to Senior Vice  President,  Sales and Marketing in December
     2000.  From September 1995 until June 1997, Mr. Pfeiffer served as Director
     of Marketing,  Health Management Services, for SmithKline Beecham. From May
     1994 to September 1995, he served as Director,  Disease Management Services
     of   Stuart   Disease   Management   Services,   a   division   of   Zeneca
     Pharmaceuticals.  From  October 1991 to May 1994 he was employed in various
     product management positions with Zeneca  Pharmaceuticals  Group. From July
     1988 to October  1991,  he held various  marketing  and product  management
     positions with the Lederle Laboratories Division of American Cyanamid.

     None of our executive  officers are related to any other executive  officer
or to any of our directors.  Our executive  officers are elected annually by the
Board of  Directors  and serve  until  their  successors  are duly  elected  and
qualified.

SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

     Section 16(a) of the Securities Exchange Act of 1934, as amended,  requires
our directors,  officers and  stockholders who beneficially own more than 10% of
any class of our  equity  securities  registered  pursuant  to Section 12 of the
Exchange  Act to file  initial  reports of  ownership  and reports of changes in
ownership with respect to our equity securities with the Securities and Exchange
Commission.  All reporting  persons are required by the  Securities and Exchange
Commission's  regulations  to furnish us with  copies of all  reports  that such
reporting persons file with the Securities and Exchange  Commission  pursuant to
Section 16(a).

     Based  solely on our review of the copies of such forms  received by us and
upon written  representations of our reporting persons received by us, except as
described  below,  each such reporting  person has filed all of their respective
reports pursuant to Section 16(a) on a timely basis.  Robert J. Easton, a member
of our  board of  directors,  failed  to timely  file a Form 4  relating  to the
issuance of shares of our common  stock in payment of dividends on shares of our
Series D preferred  stock held by Mr. Easton.  Mr. Easton  subsequently  filed a
Form 5 with the Securities and Exchange  Commission on February 13, 2003.  James
E.  Daverman,  a member of our board of  directors,  is  President  of Marquette
Management  Partners,  LLC, the general partner of Marquette  Venture  Partners,
L.P.  and a general  partner of MG II,  L.P.,  the general  partner of Marquette
Venture  Partners II, L.P. and MVP II Affiliates Fund, L.P.  Representatives  of
Marquette  Venture  Partners II, L.P. and MVP II Affiliates Fund, L.P. failed to
timely file a Form 4 relating to the  issuance of shares of our common  stock in
payment of dividends on shares of our Series D preferred stock held by Marquette
Venture  Partners II, L.P. and MVP II Affiliates  Fund,  L.P. A Form 5 was filed
with the  Securities  and Exchange  Commission on February 13, 2003 on behalf of
Marquette Venture Partners II, L.P. and MVP II Affiliates Fund, L.P.


                                      -10-



                             EXECUTIVE COMPENSATION

Summary of Compensation in Fiscal 2002, 2001 and 2000

     The following Summary Compensation Table sets forth information  concerning
compensation  during  the  years  ended  December  31,  2002,  2001 and 2000 for
services  in all  capacities  awarded  to,  earned by or paid to each person who
served as our Chief Executive Officer at any time during 2002, each other of our
executive officers as of December 31, 2002 and certain individuals who served as
executive  officers  during a part of 2002,  whose  aggregate cash  compensation
exceeded  $100,000  at the end of 2002  (collectively  referred to as the "Named
Executives").



                           SUMMARY COMPENSATION TABLE

- ----------------------------------------------------------------------------------------------------------------------
                                                                                             Long-Term Compensation
                                                          Annual Compensation(1)                     Awards
                                                      ----------------------------------------------------------------
                                                                                                    Securities
                                                                                                    Underlying
    Name and Principal Position         Year           Salary                Bonus                    Options
                                                        ($)                   ($)                       (#)
                (a)                      (b)            (c)                   (d)                       (g)
- ----------------------------------------------------------------------------------------------------------------------

                                                                                            
Brian M. Gallagher, Ph.D.......         2002           324,450                 79,436                   75,000
     President, Chief Executive         2001           315,000                131,615                  100,000
     Officer and Chairman of the        2000           300,000                 35,615                   95,000
     Board

Robert A. Ashley................        2002           231,750                 72,827                   40,000
     Senior Vice President,             2001           225,000                 93,908                   80,000
     Commercial Development             2000           215,000                 29,708                   40,000

Nancy C. Broadbent..............        2002           216,300                 72,807                   30,000
     Chief Financial Officer,           2001           210,000                 87,881                   50,000
     Treasurer and Secretary            2000           200,000                  3,881                   25,000

David F. Pfeiffer ..............        2002           231,750                 72,759                   40,000
     Senior Vice President,  Sales      2001           225,000                 93,812                   80,000
     and Marketing                      2000           210,000                 29,012                   50,000

Douglas C. Gehrig...............        2002           206,000                 57,166                   30,000
     Vice President, Corporate          2001           200,000                 82,712                   50,000
     Accounts                           2000           190,000                 27,912                   40,000

Michael Romanowicz, D.M.D.,
     R.Ph......................         2002           175,000                 58,836                   30,000
     Vice President of                  2001           140,000                 31,412                   15,000
     Professional Affairs and           2000           125,000                 26,214                    9,000
     Managed Care

- -----------


(1)  In accordance with the rules of the Securities and Exchange Commission, the
     costs of certain  perquisites and other personal  benefits are not included
     because  they did not  exceed,  in the case of each  Named  Executive,  the
     lesser of $50,000 or 10% of the total annual salary and bonus for the Named
     Executives for the fiscal years reported in the above table.

                                      -11-



Option Grants in 2002

         The following table sets forth information concerning individual grants
of stock options made during 2002 to each of the Named Executives.




                        OPTION GRANTS IN LAST FISCAL YEAR

                                         Individual Grants
- ------------------------------------------------------------------------------------------------------------------------
                                                                                                 Potential Realizable
                                                    Percent of                                         Value at
                                     Number of         Total                                   Assumed Annual Rates of
                                     Securities       Options                                           Stock
                                     Underlying     Granted to     Exercise                     Price Appreciation for
                                      Options      Employees in     or Base                             Option
                                      Granted         Fiscal         Price       Expiration            Term (3)
              Name                      (#)          Year (1)      ($/Sh)(2)        Date         5%($)        10%($)
               (a)                      (b)             (c)           (d)           (e)           (f)          (g)
- ------------------------------------------------------------------------------------------------------------------------
                                                                                         
Brian M. Gallagher, Ph.D.....           75,000          12.17        7.97         1/24/12         375,922     952,660

Robert A. Ashley.............           40,000           6.49        7.97         1/24/12         200,492     508,085

Nancy C. Broadbent...........           30,000           4.87        7.97         1/24/12         150,369     381,064

David F. Pfeiffer............           40,000           6.49        7.97         1/24/12         200,492     508,085

Douglas C. Gehrig............           30,000           4.87        7.97         1/24/12         150,369     381,064

Michael Romanowicz,
     D.M.D. .................           30,000           4.87        7.95         1/01/12         149,991     380,108
- -----------


(1)  Based on an  aggregate  of 616,086  options  granted to  employees in 2002,
     including options granted to Named Executives.

(2)  Based on a grant date fair market  value  equal to the grant date  exercise
     price per share of the applicable  option for each of the Named  Executives
     and assumes no adjustments to the grant date exercise price.

(3)  Amounts  reported in these columns  represent  amounts that may be realized
     upon exercise of the options  immediately  prior to the expiration of their
     terms assuming the specified compound rates of appreciation (5% and 10%) on
     the market  value of the common  stock on the date of option grant over the
     term  of  the  options.   These  numbers  are  calculated  based  on  rules
     promulgated by the  Securities  and Exchange  Commission and do not reflect
     the Company's estimate of future stock price growth.  Actual gains, if any,
     on stock option  exercises  and common stock  holdings are dependent on the
     timing of such  exercise and the future  performance  of the common  stock.
     There can be no assurance  that the rates of  appreciation  assumed in this
     table can be achieved  or that the  amounts  will be received by the option
     holder.

                                      -12-




Aggregated Option Exercises in 2002 and Year End Option Values

     The  following  table sets forth  information  concerning  each exercise of
options  during 2002 by each of the Named  Executives  and the year end value of
unexercised in-the-money options.



                 AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR
                        AND FISCAL YEAR END OPTION VALUES

- -------------------------------------------------------------------------------------------------------------------------
                                                                               Number of                   Value of
                                                                         Securities Underlying           Unexercised
                                                                              Unexercised               In-the-Money
                                                                               Options at                 Options at
                                            Shares                               Fiscal                     Fiscal
                                           Acquired                            Year-End                   Year-End
                                              on             Value                (#)                        ($)(1)
                                           Exercise         Realized           Exercisable/               Exercisable/
                 Name                         (#)             ($)            Unexercisable              Unexercisable
                  (a)                         (b)             (c)                 (d)                         (e)
- --------------------------------------------------------------------------------------------------------------------------

                                                                                                      
Brian M. Gallagher, Ph.D.........             --               --           333,000/237,000             1,263,250/420,750

Robert A. Ashley.................             --               --           151,500/131,000               525,605/283,520

Nancy C. Broadbent...............            5,000           28,000          105,000/90,000               275,450/190,875

David F. Pfeiffer................             --               --           143,000/132,000               189,520/280,280

Douglas C. Gehrig................             --               --            126,999/98,001               137,887/187,638

Michael  Romanowicz, D.M.D.......             --               --             24,250/49,750                31,758/101,064
- ----------


(1)  Based on a year end fair market value of the underlying securities equal to
     $9.49 per share, less the exercise price payable for such shares.

EMPLOYMENT   CONTRACTS,   TERMINATION   OF  EMPLOYMENT   AND   CHANGE-IN-CONTROL
ARRANGEMENTS

     We have  executed  indemnification  agreements  with each of our  executive
officers  and  directors  pursuant  to which we have  agreed to  indemnify  such
parties to the full extent permitted by law, subject to certain  exceptions,  if
any such party  becomes  subject to an action  because such party is a director,
officer,  employee, agent or fiduciary of the Company. In general, our employees
are covered by confidentiality agreements.

     On September  18, 2002, we entered into change of control  agreements  with
each of Dr. Gallagher, Ms. Broadbent and Messrs. Ashley, Gehrig and Pfeiffer. In
the event the employment of Dr. Gallagher, Ms. Broadbent, Mr. Ashley, Mr. Gehrig
or Mr. Pfeiffer is terminated as a result of an Involuntary  Termination  within
24 months of a Change of  Control  (each as  defined  in such  agreements),  the
change of control  agreements  provide  for,  among other  things (i) a lump sum
payment of 1.5 times base  salary and 1.5 times the  average  bonus paid for the
three fiscal years prior to the Termination Date (as defined in the agreements),
(ii) health  coverage and benefits for a period of 24 months,  and (iii) certain
outplacement/administrative support for a period of 18 months.

     In addition,  each of Dr.  Gallagher,  Ms.  Broadbent  and Messrs.  Ashley,
Gehrig and  Pfeiffer  have agreed that during the term of his or her  employment
and for a period of two years  thereafter,  such  person  will not  directly  or
indirectly provide services to or for any business engaged in research regarding
the  development,   manufacture,  testing,  marketing  or  sale  of  collagenase
inhibiting drugs for application in periodontal disease or any other application
which, during the period of such person's employment with us, is either marketed
or in advanced clinical development by us.

                                      -13-


     As  previously  reported,  we have  commenced  an  executive  search  for a
successor President and Chief Executive Officer to Dr. Gallagher.  Dr. Gallagher
has agreed to remain in his current position until a successor is appointed, and
he will work  closely  with the  Company  as a  consultant  for a period of time
thereafter to ensure a smooth transition. We have established a search committee
of our board of directors and have engaged an executive  recruiting firm to help
identify a  successor  to Dr.  Gallagher.  The Company  and Dr.  Gallagher  have
executed  a  Transition  Agreement  and  Release,  pursuant  to  which  we shall
compensate  Dr.  Gallagher  for,  among other  things,  his services  during the
transition period and to recognize his historical  contributions to the Company.
Under the terms of such  agreement,  Dr.  Gallagher  is eligible for a one-time,
lump sum bonus of $150,000,  to be paid to Dr.  Gallagher in connection with his
separation  from the  Company.  Of such amount,  $50,000  shall be earned by Dr.
Gallagher  automatically  on the date of his  separation  from the  Company  and
$100,000 shall be paid on such date based upon his continued  performance  prior
to  separation.  The Company  has also agreed to  reimburse  Dr.  Gallagher  for
certain COBRA premiums, or to make certain comparable payments to Dr. Gallagher,
for a period of 24 months following his separation from the Company. The Company
also agreed to pay Dr. Gallagher a lump sum of $15,000 at the time of separation
for certain expenses.  The Company also agreed,  effective upon the execution of
such  agreement,  to accelerate Dr.  Gallagher's  right to exercise all unvested
stock options  previously  granted to him. In addition,  the exercise  dates for
certain of Dr. Gallagher's options were extended to the latest date on which the
options would have expired according to their respective terms.

     As a result of the  Transition  Agreement  and  Release,  we  recognized  a
non-cash  compensation charge relating to modifications of Dr. Gallagher's stock
option  agreements of  approximately  $251,000 in the first quarter of 2003. The
Company also agreed to reimburse Dr. Gallagher for certain excise taxes, if any,
imposed  on him in  connection  with  such  agreement.  We also  entered  into a
consulting  agreement  with Dr.  Gallagher  pursuant  to  which he will  provide
consulting services to us for a period of 24 months following the appointment of
a new chief executive officer. Under such agreement,  Dr. Gallagher is obligated
to provide  approximately 80 hours of consulting  services to the Company during
the first two months  following his  separation and  approximately  15 hours per
month thereafter  through the second anniversary date of his separation from the
Company. Dr. Gallagher shall provide such services as an independent  contractor
at a rate of $27,037.50 per month.

COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

     The Compensation Committee currently consists of, and during 2002 consisted
of, W.  James  O'Shea,  who  serves as  Chairman,  Robert C. Black and Robert J.
Easton.  There are no, and during  2002  there were no,  Compensation  Committee
interlocks.

     As of March 15, 2003, Mr. Easton, in his individual  capacity,  held 26,409
shares of our common stock.  Such shares of common stock include those shares of
common stock which were previously  issued by us upon conversion of our Series A
preferred  stock,  Series  B  preferred  stock  and  Series  C  preferred  stock
previously held by Mr. Easton.  As of March 15, 2003, Mr. Easton also held 2,000
shares of our Series D preferred stock which were convertible into 20,216 shares
of our common stock as of such date.

     In September  1995, we entered into a  registration  rights  agreement with
each of the then  holders  of our  Series A,  Series B and  Series C  redeemable
preferred stock pursuant to which we have granted certain registration rights to
such stockholders.  Pursuant to such registration rights agreement,  at any time
beginning  six months after June 20,  1996,  the  effective  date of our initial
public  offering,  the holders of at least a majority of the common stock issued
upon the conversion of the Series A, Series B and Series C redeemable  preferred
stock (referred to collectively as the "Registrable Securities") have the right,
subject to certain  restrictions set forth in the registration rights agreement,
to require that we register the Registrable Securities requested by such holders
at our expense (on no more than two occasions) on either a Form S-1, Form S-2 or
Form S-3 Registration Statement under the Securities Act of 1933, as amended. We
are not,  however,  required to register any Registrable  Securities unless such
shares represent at least 10% of our outstanding  shares of common stock, or, if
less than 10%, if the anticipated aggregate offering price exceeds $1,000,000.

     The holders of Registrable  Securities  also have the right to an unlimited
number  of  registrations  on Form S-3  under  the  Securities  Act of 1933,  as
amended. We are not, however,  required to effect such a registration unless the
requesting holders reasonably  anticipate having an aggregate  disposition price
of at least $500,000.

     Also pursuant to the registration rights agreement,  if, at any time during
the  seven-year  period  commencing on the effective  date of our initial public
offering,  we propose to register any of our common  stock under the  Securities
Act of 1933, as amended,  for sale to the public, the holders of the Registrable
Securities have unlimited
                                      -14-



piggyback  registration rights at our expense,  subject to certain  restrictions
set forth in the registration rights agreement.

     Also in September  1995, we granted to the then holders of Series A, Series
B and Series C redeemable  preferred  stock  certain  rights to  participate  in
certain future  offerings  undertaken by us. Such rights to participate  require
that,  with certain  exceptions  including,  but not limited to, an underwritten
public  offering,  any time we propose to issue,  sell or  exchange,  or reserve
therefor,  any  securities,  we  must  first  offer  to  sell  to  each  of  the
pre-conversion  holders of Series A, Series B and Series C redeemable  preferred
stock their respective pro rata share of such securities at a price and on terms
identical to the price and terms of the securities  proposed to be issued,  sold
or exchanged in the applicable offering.

     In  May  1999,  we  entered  into a  Stockholder  and  Registration  Rights
Agreement  with each of the holders of our Series D preferred  stock pursuant to
which,  among other things, we registered on a Registration  Statement on a Form
S-3,  all of the shares of our common  stock  underlying  the shares of Series D
preferred stock then issued and  outstanding.  The Stockholder and  Registration
Rights Agreement further obligates us to register,  on a Registration  Statement
on Form S-3, all of the shares of common stock issued as dividends on the Series
D preferred  stock to the holders  thereof  within a  reasonable  period of time
after each such dividend  payment is made. We are obligated to keep current each
such Registration  Statement on Form S-3 until such time as all of the shares of
common stock  registered  thereunder have been sold or are otherwise exempt from
registration.

     The  holders of at least a majority  of the Series D  preferred  stock also
have the right, subject to certain  restrictions,  to require us to register the
shares  of  common  stock  underlying  their  Series  D  preferred  stock  on  a
Registration  Statement  on  Form  S-1  at our  expense  (on no  more  than  two
occasions). Also, pursuant to the Stockholder and Registration Rights Agreement,
if we propose to register  any of our  securities  under the  Securities  Act of
1933, as amended,  for sale to the public, the holders of the Series D preferred
stock have certain piggyback  registration  rights with respect to the shares of
common stock underlying  their Series D preferred stock at our expense,  subject
to certain  restrictions.  In addition,  if we grant registration  rights to the
holders of any of our securities  that are more favorable than the  registration
rights granted under the Stockholder and Registration Rights Agreement, then the
holders of the Series D  preferred  stock  shall be deemed to have been  granted
such superior  registration  rights as well with respect to the shares of common
stock underlying  their Series D preferred stock.  Also pursuant to the terms of
the  Stockholder  and  Registration  Rights  Agreement,  the holders of Series D
preferred  stock have  certain  rights of first  refusal with respect to certain
stock  issuances  by us,  beginning  twelve  months  after  the date of  initial
issuance of the Series D preferred stock.


                                      -15-



PERFORMANCE GRAPH

     The following graph compares the cumulative total stockholder return on our
common stock with the cumulative  total return on the Nasdaq Composite Index and
the  Nasdaq  Pharmaceutical  Index  (capitalization  weighted)  for  the  period
beginning  on January  1, 1998 and ending on the last day of our last  completed
fiscal year.

                 COMPARISON OF CUMULATIVE TOTAL RETURN(1)(2)(3)

              Among CollaGenex, the Nasdaq Composite Index and the
                           Nasdaq Pharmaceutical Index
                            (Capitalization Weighted)












                      [THE FOLLOWING TABLE WAS REPRESENTED
                   AS A LINE GRAPH IN THE PRINTED MATERIALS]


















                     Base
                    Period     June    December   June    December   June   December    June    December   June   December
    Company/       January 1,   30,       31,      30,      31,       30,      31,       30,       31,      30,       31,
   Index Name         1998     1998      1998     1999     1999      2000     2000      2001      2001     2002      2002
- -------------      ---------  ------  --------  -------  -------   -------  -------   -------   -------   ------   ------
                                                                                   
CGPI.........       $100.00   $ 68.96  $ 76.96  $ 80.00  $200.00   $ 75.04  $ 29.52   $ 65.60    $64.80   $59.20    $75.92
NASDAQ.......       $100.00   $109.24  $144.64  $160.36  $182.32   $295.21  $302.18   $199.65   $162.93   $138.97  $115.56
NASDAQ PHAR..       $100.00   $146.95  $231.68  $250.08  $271.84   $297.09  $217.94   $129.37   $115.58   $92.22    $91.06



(1)  Graph  assumes $100  invested on January 1, 1998 in our common  stock,  the
     Nasdaq Composite Index and the Nasdaq  Pharmaceutical Index (capitalization
     weighted).

(2)  Total return assumes reinvestment of dividends.

(3)  Year ended December 31.

                                      -16-




COMPENSATION COMMITTEE REPORT ON EXECUTIVE COMPENSATION

     The Compensation Committee has furnished the following report:

     The Compensation  Committee is comprised of three  non-employee  directors.
The  Compensation  Committee  recommends,  and the Board  approves,  all matters
relating to executive compensation, including setting and administering policies
governing executive salaries, bonuses (if any) and stock option awards (if any).
The  Compensation  Committee meets twice annually to set performance  objectives
for the Chief Executive Officer and to determine the annual  compensation of the
CEO  and  our  other  senior  executives.  The  CEO is not  present  during  the
discussion of his compensation.

Executive Compensation Policy
- -----------------------------

     The  goal  of our  executive  compensation  policy  is to  ensure  that  an
appropriate  relationship exists between executive compensation and the creation
of stockholder value, while at the same time attracting and retaining  qualified
senior management. In order to continually attract and retain highly experienced
executives,   our  compensation   packages  for  senior  executives  are  highly
competitive  with  those paid to  executives  of other  emerging  pharmaceutical
companies.

Compensation Mix
- ----------------

     Our executive  compensation  packages  generally  include three components:
base salary, a discretionary annual cash bonus and stock options.

Base Salary
- -----------

     The  Compensation  Committee  seeks to  establish  base  salaries  for each
position  and  level of  responsibility  which  are  competitive  with  those of
executive officers at other emerging pharmaceutical companies.

Discretionary Cash Bonus
- ------------------------

     The Compensation  Committee  believes that  discretionary  cash bonuses are
important to motivate and reward executive officers.  However,  cash bonuses are
not  guaranteed.  Annual cash bonuses are awarded to  executives  based on their
achievements  against a stated list of objectives  developed at the beginning of
each year by senior management and the Compensation  Committee.  Such objectives
are reviewed and approved by the Board of Directors.

Stock Options
- -------------

     Stock option  grants are  designed to align the long term  interests of our
executives with those of our stockholders by rewarding executives for increasing
stockholder value. All executive officers are awarded option grants upon joining
the  Company  which  are   competitive   with  those  at   comparable   emerging
pharmaceutical  companies.  In addition,  the  Compensation  Committee may award
additional  stock option grants  annually.  When  granting  stock  options,  the
Compensation  Committee considers the recommendation of our CEO and the relative
performance and contributions of each officer compared to that of other officers
within the Company  with  similar  levels of  responsibility.  The  Compensation
Committee has in the past  granted,  and may continue to grant from time to time
in the future,  options to our executive  officers  containing target milestones
with respect to the trading  price of our common stock and  accelerated  vesting
upon the achievement of such milestones.

Compensation of the Chief Executive Officer
- -------------------------------------------

     In establishing the Chief Executive  Officer's  compensation  package,  the
Compensation  Committee seeks to maintain a level of total current  compensation
that is  competitive  with  that  paid to  chief  executive  officers  of  other
comparable emerging pharmaceutical companies. In addition, in order to align the
Chief Executive Officer's interests with the interests of our stockholders,  the
Compensation  Committee  attempts to make a substantial  portion of the value of
the Chief Executive  Officer's total compensation  dependent on the appreciation
of our stock price.

                                      -17-



     The Chief  Executive  Officer's  performance  is evaluated  annually by the
Compensation  Committee  against a stated  list of short,  medium  and long term
objectives developed by the Compensation Committee at the beginning of each year
and approved by the Board of Directors.  Based on his  achievements  relating to
these  objectives,  the  Compensation  Committee  recommended,   and  the  Board
approved,  a bonus to Dr.  Gallagher of $79,436 for 2002, which was paid in 2003
and set his base salary at $324,450 effective January 1, 2003.

Tax Considerations
- ------------------

     Section 162(m) of the Internal Revenue Code of 1986, as amended,  generally
disallows a tax deduction to public companies for certain compensation in excess
of $1  million  paid to the  company's  CEO  and  the  four  other  most  highly
compensated  executive  officers.  Certain  compensation,   including  qualified
performance-based  compensation,  will not be subject to the deduction  limit if
certain  requirements are met. The Compensation  Committee reviews the potential
effect  of  Section  162(m)  periodically  and uses its  judgment  to  authorize
compensation  payments  that may be subject  to the limit when the  Compensation
Committee  believes such payments are  appropriate  and in the best interests of
the Company and our  stockholders,  after  taking  into  consideration  changing
business conditions and the performance of our employees.

                                       Compensation Committee Members:

                                       W. James O'Shea, Chairman
                                       Robert C. Black, Member
                                       Robert J. Easton, Member


                                      -18-



         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT
                         AND RELATED SHAREHOLDER MATTERS

     There were, as of March 15, 2003,  approximately  121 holders of record and
approximately  3,023 beneficial holders of our common stock. The following table
sets forth certain  information,  as of March 15, 2003, with respect to holdings
of our common stock by (i) each person known by us to be the beneficial owner of
more than 5% of the total number of shares of the common stock outstanding as of
such date,  based on currently  available  Schedules  13D and 13G filed with the
SEC,  (ii)  each of our  directors  (which  includes  all  nominees)  and  Named
Executives, and (iii) all directors and executive officers as a group.




                                                                     Amount and Nature of                   Percent
Name and Address of Beneficial Owner(1)                             Beneficial Ownership(1)               of Class(2)
- ---------------------------------------                        -------------------------------           --------------

                                                                                                     
(i) Certain Beneficial Owners:

Oaktree Capital Management, LLC
OCM Principal Opportunities Fund, L.P.
333 South Grand Avenue, 28th Floor
Los Angeles, California 90071..........................                  2,220,823(3)                       16.8%

Perseus-Soros BioPharmaceutical Fund, L.P.
c/o Soros Fund Management LLC
888 Seventh Avenue, 29th Floor
New York, NY  10106 ...................................                  1,266,668(4)                       10.9%

Wellington Management Company, LLP
75 State Street
Boston, Massachusetts 02109............................                  1,116,927(5)                        9.8%

Marquette Venture Partners II, L.P.
and MVP II Affiliates Fund, L.P.
520 Lake Cook Road, Suite 450
Deerfield, Illinois 60015..............................                  1,028,031(6)                        8.9%

Ashford Capital Management, Inc.
P.O. Box 4172
Wilmington, Delaware 19807.............................                    869,766(7)                        7.5%

(ii)     Directors (which includes all nominees) and Named Executives:

Brian M. Gallagher, Ph.D...............................                    695,000(8)                        5.8%
Robert A. Ashley.......................................                    220,100(9)                        1.9%
Nancy C. Broadbent.....................................                   186,500(10)                        1.6%
David F. Pfeiffer......................................                   195,500(11)                        1.7%
Douglas C. Gehrig......................................                   166,820(12)                        1.4%
Michael  Romanowicz, D.M.D.............................                    33,000(13)                           *
Peter R. Barnett, D.M.D................................                    28,900(14)                           *
Robert Black...........................................                    15,000(15)                           *
James E. Daverman......................................                 1,108,031(16)                        9.6%
Robert J. Easton.......................................                    76,075(17)                           *
Stephen Kaplan.........................................                 2,233,823(18)                       16.9%
W. James O'Shea........................................                    10,000(19)                           *

(iii) All Directors and executive officers as a
         group (10 persons)............................                 4,768,929(20)                       32.8%
- -----------


*        Less than 1%

                                      -19-



(1)  Except  as set  forth  in the  footnotes  to  this  table  and  subject  to
     applicable  community  property law, the persons and entities  named in the
     table have sole voting and investment power with respect to all shares.

(2)  Applicable  percentage  of ownership for each holder is based on 11,406,204
     shares of common stock outstanding on March 15, 2003, plus any common stock
     equivalents  and  presently  exercisable  stock options or warrants held by
     each such  holder,  and options or warrants  held by each such holder which
     will become exercisable within 60 days after March 15, 2003.

(3)  Includes  1,789,090  shares of common stock issuable upon the conversion of
     177,000 shares the Series D preferred stock held thereby and 431,733 shares
     of common  stock,  including  shares of common  stock  issued in payment of
     dividends on the Series D preferred stock.

(4)  Includes  266,668 shares of common stock  underlying  warrants which are or
     may be exercisable as of March 15, 2003 or 60 days after such date.

(5)  As  disclosed  on a Schedule  13G filed with the  Securities  and  Exchange
     Commission  on  February  12,  2003,  assuming  no  changes  in  beneficial
     ownership  since such filing.  According to such Schedule  13G,  Wellington
     Management Company, in its capacity as investment adviser, may be deemed to
     beneficially own 1,116,927 shares of common stock, which shares are held of
     record by clients of Wellington  Management Company.  Wellington Management
     Company  reports  that it has  shared  power to vote or direct  the vote of
     519,100  shares and shared  power to dispose or direct the  disposition  of
     1,116,927  shares,  while its clients have the right to receive,  or direct
     the receipt of, dividends from, or proceeds from the sale of, such shares.

(6)  Includes  an  aggregate  of  1,024,215  shares  of  common  stock  owned by
     Marquette Venture Partners II, L.P. (which includes 98,269 shares of common
     stock  issuable  upon  the  conversion  of  9,722  shares  of the  Series D
     preferred stock held thereby, and 925,946 shares of common stock, including
     shares of common  stock  issued in payment of  dividends  on such  Series D
     preferred  stock) and an aggregate of 3,816 shares of common stock owned by
     MVP II Affiliates  Fund,  L.P. (which includes 2,810 shares of common stock
     issuable upon the conversion of 278 shares of the Series D preferred  stock
     held thereby, and 1,006 shares of common stock,  including shares of common
     stock issued in payment of dividends on such Series D preferred stock).

(7)  Includes  195,000 shares of common stock  registered in the name of Ashford
     Capital  Partners,  LP and 171,700 shares of common stock registered in the
     name of Anvil  Investment  Associates,  LP. Also includes  53,333 shares of
     common stock underlying  warrants held by Ashford Capital Partners,  LP and
     53,333 shares of common stock underlying  warrants held by Anvil Investment
     Associates,  LP, which are or may be exercisable as of March 15, 2003 or 60
     days after such date.  Theodore H.  Ashford is Chairman  and CEO of Ashford
     Capital  Management,  Inc., the Advisor to the general  partners of Ashford
     Capital Partners, LP and Anvil Investment Associates,  LP and, as such, has
     the power to vote or direct  the vote of and to  dispose  of or direct  the
     disposition of the shares owned by Ashford Capital  Partners,  LP and Anvil
     Investment  Associates,  LP. Mr.  Ashford  expressly  disclaims  beneficial
     ownership  of such  shares,  except  as to his  proportionate  interest  in
     Ashford Capital Partners, LP and Anvil Investment Associates, LP.

(8)  Includes 570,000 shares of common stock underlying options which are or may
     be exercisable as of March 15, 2003 or 60 days after such date.

(9)  Includes 197,500 shares of common stock underlying options which are or may
     be exercisable as of March 15, 2003 or 60 days after such date.

(10) Includes 137,500 shares of common stock underlying options which are or may
     be  exercisable  as of March 15,  2003 or 60 days  after  such  date.  Also
     includes 2,000 shares of common stock held as custodian for Ms. Broadbent's
     minor  child,  2,000  shares  of  common  stock  held  in the  name  of Ms.
     Broadbent's spouse and 1,000 shares of common stock held in the name of Ms.
     Broadbent's parent who resides with Ms. Broadbent.

(11) Includes  188,000  shares  of common  stock  underlying  options  which are
     exercisable as of March 15, 2003 or 60 days after such date.

                                      -20-



(12) Includes  161,500  shares  of common  stock  underlying  options  which are
     exercisable as of March 15, 2003 or 60 days after such date.

(13) Includes  33,000  shares  of  common  stock  underlying  options  which are
     exercisable as of March 15, 2003 or 60 days after such date.

(14) Includes  25,000  shares  of  common  stock  underlying  options  which are
     exercisable as of March 15, 2003 or 60 days after such date.

(15) Includes  15,000  shares  of  common  stock  underlying  options  which are
     exercisable as of March 15, 2003 or 60 days after such date.

(16) James E. Daverman is President of Marquette Management  Partners,  LLC, the
     general partner of Marquette Venture  Partners,  L.P. and a general partner
     of MG II, L.P., the general partner of Marquette  Venture Partners II, L.P.
     and MVP II Affiliates  Fund,  L.P.  and, as such,  has the power to vote or
     direct  the vote of and to  dispose  of or direct  the  disposition  of the
     shares owned by Marquette  Venture  Partners II, L.P. and MVP II Affiliates
     Fund, L.P. Mr. Daverman expressly  disclaims  beneficial  ownership of such
     shares,  except  as to his  proportionate  interest  in  Marquette  Venture
     Partners II, L.P. and MVP II Affiliates  Fund, L.P.  Includes 25,000 shares
     of common stock  underlying  options which are  exercisable as of March 15,
     2003 or 60 days after such date and 55,000 shares of common stock otherwise
     held by Mr. Daverman, individually.

(17) Includes  25,000  shares  of  common  stock  underlying  options  which are
     exercisable as of March 15, 2002 or 60 days after such date.  Also includes
     20,216 shares of common stock  issuable upon the conversion of 2,000 shares
     of the Series D  preferred  stock held by Mr.  Easton and 26,409  shares of
     common  stock,  including  shares of common  stock  issued  in  payment  of
     dividends on such Series D preferred  stock.  Also includes 4,450 shares of
     common stock held as trustee for the Rachel Easton Charitable Trust.

(18) Stephen  Kaplan is a principal of OCM Principal  Opportunities  Fund,  L.P.
     and, as such, has the power to vote or direct the vote of and to dispose of
     or  direct  the   disposition   of  the  shares  owned  by  OCM   Principal
     Opportunities  Fund,  L.P.  Mr.  Kaplan  expressly   disclaims   beneficial
     ownership of such shares,  except as to his  proportionate  interest in OCM
     Principal  Opportunities  Fund, L.P.  Includes 3,000 shares of common stock
     held by Mr. Kaplan in his  individual  capacity and 10,000 shares of common
     stock  underlying  options which are exercisable as of March 15, 2003 or 60
     days after such date.

(19) Includes  10,000  shares  of  common  stock  underlying  options  which are
     exercisable as of March 15, 2003 or 60 days after such date.

(20) See Notes 8 through 19.

                                      -21-




SERIES D PREFERRED STOCK

     There  were,  as of March 15,  2003,  6 holders  of record of our  Series D
preferred stock. The following table sets forth certain information, as of March
15,  2003,  with respect to the  beneficial  ownership of our Series D preferred
stock by (i) each person known by us to be the beneficial  owner of more than 5%
of the total number of shares of Series D preferred stock outstanding as of such
date,  (ii)  each of our  directors  (which  includes  all  nominees)  and Named
Executives who  beneficially  own shares of Series D preferred  stock, and (iii)
all directors and officers as a group.




                                                                 Amount and Nature of
                                                                     Beneficial                       Percent
Name and Address of Beneficial Owner(1)                              Ownership(1)                   of Class(2)
- ----------------------------------------                      -------------------------            -------------
                                                                                                
(i) Certain Beneficial Owners:

OCM Principal Opportunities Fund, L.P..................                177,000(3)                     88.5%
Richard A. Horstmann...................................                 10,000(4)                      5.0%
Marquette Venture Partners II, L.P. and
   MVP II Affiliates Fund, L.P.........................                 10,000(5)                      5.0%
(ii)     Directors (which includes all nominees) and
         Named Executives:
Robert J. Easton.......................................                  2,000(6)                      1.0%
Stephen Kaplan.........................................                177,000(7)                     88.5%
(iii)    All Directors and officers as a
         group (13 persons)............................                189,000(5)(6)(7)               94.5%
- -----------


(1)  Except  as set  forth  in the  footnotes  to  this  table  and  subject  to
     applicable  community  property law, the persons and entities  named in the
     table have sole voting and investment power with respect to all shares.

(2)  Applicable  percentage of ownership is based on 200,000  shares of Series D
     preferred stock outstanding on March 15, 2003.

(3)  Such  shares of Series D preferred  stock are  convertible  into  1,789,090
     shares of common stock.

(4)  Such shares of Series D preferred stock are convertible into 101,079 shares
     of common stock.

(5)  Of such  shares of  Series D  preferred  stock,  9,722  shares  are held by
     Marquette  Venture Partners II, L.P. and are convertible into 98,269 shares
     of common  stock.  Also,  of such shares of Series D preferred  stock,  278
     shares are held by MVP II Affiliates  Fund, L.P. and are  convertible  into
     2,810 shares of common stock.

(6)  Such shares of Series D preferred stock are convertible  into 20,216 shares
     of common stock.

(7)  Stephen  Kaplan is a principal of OCM Principal  Opportunities  Fund,  L.P.
     and, as such, has the power to vote or direct the vote of and to dispose of
     or  direct  the   disposition   of  the  shares  owned  by  OCM   Principal
     Opportunities  Fund,  L.P.  Mr.  Kaplan  expressly   disclaims   beneficial
     ownership of such shares,  except as to his  proportionate  interest in OCM
     Principal Opportunities Fund, L.P.

                                      -22-




Equity Compensation Plan Information

     The following table provides  information  about the securities  authorized
for issuance under our equity compensation plans as of December 31, 2002.





- -----------------------------------------------------------------------------------------------------------------
                                              Number of                                  Number of securities
                                          securities to be                             remaining available for
                                            issued upon       Weighted-average          future issuance under
                                            exercise of       exercise price of          equity compensation
                                            outstanding          outstanding               plans (excluding
                                         options, warrants    options, warrants        securities reflected in
                                             and rights           and rights                 column (a))
             Plan Category                      (a)                   (b)                         (c)
- ------------------------------------------------------------------------------------------------------------------
                                                                                      
(i) Equity compensation plans approved
    by security holders:

    Option Plans(1)................            2,237,695               $9.70                   730,209(2)

(ii) Equity compensation plans not
     approved by
     security holders(3)...........            1,300,335               $6.32                       --

Total...............................           3,538,030               $8.46                    730,209

- ----------



(1)  Includes information  regarding the following  stockholder-approved  equity
     compensation plans: (i) 1992 Stock Option Plan, as amended; (ii) 1996 Stock
     Option Plan;  and (iii) 1996  Non-Employee  Director  Stock Option Plan, as
     amended.

(2)  With respect to the 1996 Stock Option Plan, this table includes the 630,209
     shares  available for issuance prior to the Annual Meeting but excludes the
     additional  500,000  shares  that would be  available  for  issuance if the
     proposal  set forth  herein to  increase  the maximum  aggregate  number of
     shares of common stock  available for issuance  under the 1996 Stock Option
     Plan is approved at the Annual Meeting.

(3)  The following  describes the material  features of our equity  compensation
     plans that have not been approved by our security holders,  as set forth in
     the above table:

          On March 12,  2001,  we  consummated  a  private  equity  offering  of
     1,500,000  shares of common stock for an aggregate  purchase  price of $7.5
     million.  The investors in such financing were issued  warrants to purchase
     an aggregate of 400,000 shares of our common stock,  which are  exercisable
     for up to three years from the date of such  financing at an exercise price
     per  share of  $6.00.  We also  issued  to our  financial  advisor  in such
     financing warrants to purchase an aggregate of 150,000 shares of our common
     stock,  142,860 of which  remained  outstanding  as of December  31,  2002,
     exercisable  for up to three  years from the date of such  financing  at an
     exercise price of $5.70 per share,  as partial  consideration  for services
     rendered in connection with the financing.  All such warrants may be deemed
     automatically  exercised  in  certain  circumstances  based  upon our stock
     price.

          On February 14, 2002, we entered into an equity line arrangement under
     the terms of a Common Stock  Purchase  Agreement with  Kingsbridge  Capital
     Limited.  The equity line  provided  for the sale of up to $8.5  million in
     registered  shares of our common  stock to  Kingsbridge.  The  equity  line
     terminated  pursuant to its terms on February 13,  2003,  and prior to such
     termination,  we had drawn down and issued an  aggregate  of  approximately
     $1.3  million in  registered  shares of common stock under such equity line
     arrangement.  In connection  with the  consummation  of the equity line and
     pursuant to the terms of a warrant agreement executed

                                      -23-


     by us, we issued  Kingsbridge  a warrant to purchase  40,000  shares of our
     common stock at an exercise  price of $9.38 per share.  Such warrant became
     exercisable  as of August 14, 2002,  and will expire on August 13, 2007. We
     have  registered  the shares of our common  stock which may be issued by us
     upon any exercise of the warrant by Kingsbridge under a shelf  registration
     statement on Form S-3.

          On January 15, 1999 and February 27, 2001, we granted options to Brian
     M. Gallagher,  Ph.D., our current President and Chief Executive Officer, to
     purchase  75,000 and 100,000 shares of our common stock,  respectively,  at
     respective  per share exercise  prices of $10.063 and $5.1875.  Pursuant to
     the terms of the  Transition  Agreement  and Release we  executed  with Dr.
     Gallagher (i) the vesting period of the options granted on January 15, 1999
     has been  accelerated  such  that they are fully  vested  and shall  remain
     exercisable  until  January 14,  2009,  and (ii) the vesting  period of the
     options  granted on February 27, 2001 has been  accelerated  such that they
     are fully vested and shall remain exercisable until February 26, 2011.

          On January 15,  1999 and  February  27,  2001,  we granted  options to
     Robert A. Ashley, our Senior Vice President of Commercial  Development,  to
     purchase  35,000 and 80,000  shares of our common stock,  respectively,  at
     respective  per share exercise  prices of $10.063 and $5.1875.  The options
     granted  on  January  15,  1999  vest in  five  equal  annual  installments
     beginning on the first  anniversary  of the date of grant and expire on the
     earlier  of  January  14,  2009 or 90 days  after Mr.  Ashley  ceases to be
     employed by the  Company.  Such  January  options  will become  immediately
     exercisable  if the  closing  price of our common  stock,  as quoted on the
     Nasdaq  National  Market,  exceeds a  predetermined  per share  price for a
     certain  number of consecutive  days.  The options  granted on February 27,
     2001 vest in five  equal  installments  beginning  on the date of grant and
     thereafter on each anniversary of the date of grant.  Such February options
     expire on the  earlier of  February  26,  2011 or 90 days after Mr.  Ashley
     ceases to be employed by the Company.

          On January 15, 1999 and February 27, 2001, we granted options to Nancy
     C. Broadbent,  our Chief  Financial  Officer,  Treasurer and Secretary,  to
     purchase  25,000 and 50,000  shares of our common stock,  respectively,  at
     respective  per share exercise  prices of $10.063 and $5.1875.  The options
     granted  on  January  15,  1999  vest in  five  equal  annual  installments
     beginning on the first  anniversary  of the date of grant and expire on the
     earlier of January  14,  2009 or 90 days after Ms.  Broadbent  ceases to be
     employed by the  Company.  Such  January  options  will become  immediately
     exercisable  if the  closing  price of our common  stock,  as quoted on the
     Nasdaq  National  Market,  exceeds a  predetermined  per share  price for a
     certain  number of consecutive  days.  The options  granted on February 27,
     2001 vest in five  equal  installments  beginning  on the date of grant and
     thereafter on each anniversary of the date of grant.  Such February options
     expire on the earlier of February  26, 2011 or 90 days after Ms.  Broadbent
     ceases to be employed by the Company.

          On January 15, 1999 and February 27, 2001, we granted options to David
     F. Pfeiffer, our Senior Vice President of Sales and Marketing,  to purchase
     25,000 and 80,000 shares of our common stock,  respectively,  at respective
     per share exercise  prices of $10.063 and $5.1875.  The options  granted on
     January 15, 1999 vest in five equal  annual  installments  beginning on the
     first anniversary of the date of grant and expire on the earlier of January
     14,  2009 or 90 days  after  Mr.  Pfeiffer  ceases  to be  employed  by the
     Company.  Such January options will become  immediately  exercisable if the
     closing price of our common stock, as quoted on the Nasdaq National Market,
     exceeds a predetermined per share price for a certain number of consecutive
     days.  The  options  granted  on  February  27,  2001  vest in  five  equal
     installments  beginning  on the  date  of  grant  and  thereafter  on  each
     anniversary  of the date of  grant.  Such  February  options  expire on the
     earlier of  February  26, 2011 or 90 days after Mr.  Pfeiffer  ceases to be
     employed by the Company.

          On January 15,  1999 and  February  27,  2001,  we granted  options to
     Douglas C. Gehrig,  our Vice President of Corporate  Accounts,  to purchase
     25,000 and 50,000 shares of our common stock,  respectively,  at respective
     per share exercise  prices of $10.063 and $5.1875.  The options  granted on
     January 15, 1999 vest in five equal  annual  installments  beginning on the
     first anniversary of the date of grant and expire on the earlier of January
     14, 2009 or 90 days after Mr.  Gehrig ceases to be employed by the Company.
     Such January  options will become  immediately  exercisable  if the closing
     price of our common stock, as quoted on the Nasdaq National Market, exceeds
     a predetermined  per share price for a certain number of consecutive  days.
     The options  granted on February  27, 2001 vest in five equal  installments
     beginning on the date of grant and  thereafter on each  anniversary  of the
     date of grant.  Such February options expire on the earlier of February 26,
     2011 or 90 days after Mr. Gehrig ceases to be employed by the Company.

                                      -24-



          On October 12, 2000,  we granted  options to Michael  Romanowicz,  our
     Vice President of Professional  Affairs and Managed Care, to purchase 9,000
     shares of our common  stock at an  exercise  price of $5.00 per share.  The
     options  vest in four  equal  annual  installments  beginning  on the first
     anniversary  of the date of grant and expire on the  earlier of October 11,
     2010 or 90 days after Mr. Romanowicz ceases to be employed by the Company.

          On October 12, 2000, we granted  options to  approximately  128 of our
     employees to purchase an aggregate of 228,750 shares of our common stock at
     an exercise price of $5.00 per share. Such options generally vest in two to
     four equal annual  installments  beginning on the first  anniversary of the
     date of grant and  expire on the  earlier of  October  11,  2010 or 90 days
     after  employment  with the Company  terminates.  As of December  31, 2002,
     20,275 of such  options had been  exercised  and 53,000 of such options had
     been canceled.

          In  addition,  on May 16,  1996,  June 3, 1996 and January 15, 1999 we
     granted options to four employees to purchase an aggregate of 18,500 shares
     of common  stock with  exercise  prices  ranging  from $2.00 to $10.063 per
     share. As of December 31, 2002, 10,500 of such options had been exercised.

                                      -25-




                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

     For transactions and information  relating to certain  registration  rights
and rights to participate in certain future offerings  undertaken by us, held by
Mr. Easton,  who currently  serves,  and during 2002 served,  as a member of our
Compensation  Committee,  please  see  "EXECUTIVE  COMPENSATION  -  Compensation
Committee Interlocks and Insider Participation."

     James E.  Daverman,  a member  of our  board of  directors,  is a  managing
general partner of Marquette  Venture  Partners,  a venture  capital  investment
company  which he founded in 1987.  Additionally,  Mr.  Daverman is President of
Marquette  Management  Partners,  LLC, the general partner of Marquette  Venture
Partners,  L.P.  and a general  partner of MG II, L.P.,  the general  partner of
Marquette  Venture  Partners  II, L.P. and MVP II  Affiliates  Fund,  L.P.  Both
Marquette  Venture Partners II, L.P. and MVP II Affiliates Fund, L.P. are, as of
March 15, 2003, holders of 925,946 and 1,006 shares, respectively, of our common
stock.  Such  shares  include  those  shares  of our  common  stock  which  were
previously issued by us upon conversion of our Series A preferred stock,  Series
B preferred stock and Series C preferred  stock  previously held by each entity.
Such  entities are entitled,  therefore,  to identical  registration  rights and
rights to  participate  in future  offerings  undertaken by us as is Mr. Easton,
with respect to such shares of our common stock.

     As of March 15, 2003:  (i) Marquette  Venture  Partners II, L.P. and MVP II
Affiliates  Fund,  L.P.  held an  aggregate  of 10,000  shares  of our  Series D
preferred  stock which were  convertible  into an aggregate of 101,079 shares of
our common stock as of such date;  and (ii) OCM  Principal  Opportunities  Fund,
L.P., with which Mr. Kaplan, a member of our board of directors,  is affiliated,
held an aggregate of 177,000  shares of our Series D preferred  stock which were
convertible  into  1,789,090  shares of our  common  stock.  Such  entities  are
entitled,  therefore, to identical registration rights and rights to participate
in future  offerings  undertaken  by us as is Mr.  Easton,  with respect to such
shares of Series D preferred stock.

                         1996 STOCK OPTION PLAN PROPOSAL

     The 1996  Stock  Option  Plan was  adopted  by the Board of  Directors  and
approved by our stockholders on March 22, 1996 and March 29, 1996, respectively.
Those eligible to receive stock option grants or stock purchase rights under the
1996 Stock Option Plan include our  employees,  directors and  consultants.  The
1996 Stock Option Plan was adopted to

          o    attract and retain the best available  personnel for positions of
               substantial responsibility;

          o    provide additional incentives to employees,  members of the Board
               of Directors and consultants of the Company and our subsidiaries;
               and

          o    promote the success of our business.

     Currently there are 2,500,000  shares of common stock reserved for issuance
upon the exercise of options and/or stock purchase rights granted under the 1996
Stock Option Plan.

     The 1996 Stock Option Plan is administered by the  Compensation  Committee,
which is  comprised  solely of outside  directors.  The  Compensation  Committee
determines, among other things, the

          o    nature of the options to be granted;

          o    persons, or grantees, who are to receive options;

          o    number of shares to be subject to each option;

          o    exercise price of the options; and

          o    vesting schedule of the options.

                                      -26-



     The 1996 Stock Option Plan provides for the granting of options intended to
qualify as incentive  stock  options,  or ISOs, as defined in Section 422 of the
Internal  Revenue Code of 1986, as amended,  or the Code, to our employees.  The
1996 Stock Option Plan also  provides for the  granting of non  statutory  stock
options,  or NSOs to  employees,  non-employee  directors  and  consultants  who
perform  services for us or our  subsidiaries.  The  exercise  price of all ISOs
granted  under the 1996 Stock  Option  Plan may not be less than the fair market
value of the shares at the time the option is granted.  In addition,  no ISO may
be granted to an employee  who owns more than 10% of the total  combined  voting
power of all classes of our stock unless the exercise  price as to that employee
is at least 110% of the fair market value of the stock at the time of the grant.
To the extent that options  designated as ISOs become  exercisable for the first
time  during  any  calendar  year  (under  all  plans  of the  Company  and  its
subsidiaries)  for common stock having a fair market value greater than $100,000
(determined for each share as of the date of grant of the options  covering such
share),  the portion of such options  which exceeds such amount shall be treated
as NSOs. Options may be exercisable for a period of not more than ten years from
the date of grant;  provided,  however,  that the term of an ISO  granted  to an
employee  who owns  more  than 10% of the  total  combined  voting  power of all
classes of our stock may not  exceed  five  years.  The  exercise  price of NSOs
granted  under the 1996 Stock  Option  Plan may not be less than 85% of the fair
market value per share of the common stock on the date of grant.  No NSOs may be
granted to a person who owns more than 10% of the total combined voting power of
all classes of our stock  unless the  exercise  price to that person is at least
110% of the fair  market  value  of the  stock  at the  time of the  grant.  The
exercise  price must be paid in full at the time an option is exercised,  and at
the Compensation  Committee's discretion,  all or part of the exercise price may
be paid with previously  owned shares or other approved  methods of payment.  An
option is  exercisable  as determined by the  Compensation  Committee.  The 1996
Stock Option Plan will terminate on March 21, 2006.

     Subject to the terms as specified in any option  agreement,  the  following
time table applies with respect to exercising  outstanding  vested  options if a
grantee's employment or consulting relationship is terminated:

Reason for termination during term of
employment or consulting relationship            Latest exercise date
- -------------------------------------            ---------------------
- --------------------------------------------------------------------------------
Disability                          One year following termination by grantee
- --------------------------------------------------------------------------------
Death                               One year following death by grantee's estate
- --------------------------------------------------------------------------------
Any other reason                    90 days following termination by grantee
- --------------------------------------------------------------------------------

     Options are not assignable or otherwise  transferable except by will or the
laws of descent and distribution  and shall be exercisable  during the grantee's
lifetime only by the grantee.

     The 1996 Stock  Option  Plan also  permits the  awarding of stock  purchase
rights at not less  than 50% of the fair  market  value of the  shares as of the
date offered.  The 1996 Stock Option Plan requires the execution of a restricted
stock purchase  agreement in a form  determined by the  Compensation  Committee.
Once a stock purchase right is exercised,  the purchaser will have the rights of
a stockholder.  The purchaser will be a stockholder when the purchase is entered
on our records.

     The 1996 Stock Option Plan provides that in the event of a

o  reorganization;                            o  recapitalization;
o  stock split;                               o  stock dividend;
o  combination of or reclassification         o  or any other change in
   of shares;                                    the corporate  structure
                                                 or our shares,

the Board of Directors  shall make  adjustments  with respect to the shares that
may be  issued  under  the  1996  Stock  Option  Plan or  that  are  covered  by
outstanding options, or in the option price per share.

     The Board  shall  notify  the  grantee  at least  fifteen  days  prior to a
dissolution  or  liquidation  of  the  Company.  The  outstanding  options,  not
previously  exercised,  will terminate  immediately prior to the consummation of
such proposed  action.  In the event of a merger or consolidation of the Company
or the sale of all or substantially all of

                                      -27-



our assets (hereinafter referred to as a "merger"), the outstanding options will
be  assumed  or an  equivalent  option  will be  substituted  by such  successor
corporation  or a parent or subsidiary of such  successor  corporation.  If such
successor  corporation  does not agree to assume the  outstanding  options or to
substitute  equivalent  options,  the Board of Directors  will,  in lieu of such
assumption  or  substitution,  provide  for the  grantee  to have  the  right to
exercise all of his or her outstanding  options. If the Board of Directors makes
an option fully exercisable in lieu of assumption or substitution,  in the event
of a merger,  the Board of  Directors  shall  notify the grantee that the option
will be fully  exercisable  for a period of  fifteen  days from the date of such
notice,  and the option will terminate  upon the expiration of such period.  The
option will be considered  assumed if, following the merger,  the option confers
the right to  purchase,  for each  share of common  stock  subject to the option
immediately  prior to the merger,  the  consideration  (whether stock,  cash, or
other securities or property)  received in the merger by holders of common stock
for each share held on the  effective  date of the  transaction  (and if holders
were offered a choice of consideration,  the type of consideration chosen by the
holders of a majority of the outstanding shares). If such consideration received
in the merger was not solely  common stock of the successor  corporation  or its
parent,  the  Board  of  Directors  may,  with  the  consent  of  the  successor
corporation and the  participant,  provide for the  consideration to be received
upon the exercise of an option for each share of stock  subject to the option to
be solely common stock of the successor  corporation or its parent equal in fair
market value to the per share consideration  received by holders of common stock
in the merger or sale of assets.

     The Board may at any time amend,  alter,  suspend or  discontinue  the 1996
Stock Option Plan, but no such action will be made which would impair the rights
of any grantee under any grant previously made,  without such grantee's consent.
In addition,  to the extent  necessary  and  desirable to comply with Rule 16b-3
under the Exchange Act of 1934, as amended,  or with Section 422 of the Code (or
any other  applicable  law or  regulation,  including  the  requirements  of the
National Association of Securities Dealers or an established stock exchange), we
shall obtain  stockholder  approval of any 1996 Stock  Option Plan  amendment in
such  a  manner  and to  such a  degree  as  required.  Any  such  amendment  or
termination  of the 1996 Stock Option Plan is not  permitted  to affect  options
already  granted and such options will remain in full force and effect as if the
1996 Stock  Option  Plan had not been  amended or  terminated,  unless  mutually
agreed  otherwise  between  each  grantee  and the  Board  of  Directors,  which
agreement must be in writing and signed by the grantee and the Company.

FEDERAL INCOME TAX ASPECTS

     The following  generally  summarizes  the United States  federal income tax
consequences  that generally will arise with respect to awards granted under the
1996 Stock  Option  Plan.  This summary is based on the tax laws in effect as of
the date of this Proxy  Statement.  Changes  to these  laws could  alter the tax
consequences described below.

INCENTIVE STOCK OPTIONS

     A participant  will not have income upon the grant of an ISO. Also,  except
as described  below, a participant  will not have income upon exercise of an ISO
if the  participant  has  been  employed  by us or  any  of  our  majority-owned
corporate  subsidiaries  at all times  beginning  with the option grant date and
ending three months before the date the participant exercises the option. If the
participant has not been so employed during that time, then the participant will
be taxed as described below under "Non Statutory Stock Options." The exercise of
an ISO may subject the participant to the alternative minimum tax.

     A participant will have income upon the sale of the stock acquired under an
ISO at a profit (if sales  proceeds  exceed  the  exercise  price).  The type of
income will depend on when the  participant  sells the stock.  If a  participant
sells the stock more than two years  after the option was  granted and more than
one  year  after  the  option  was  exercised,  then all of the  profit  will be
long-term  capital gain.  If a  participant  sells the stock prior to satisfying
these waiting periods, then the participant will have engaged in a disqualifying
disposition  and a portion of the profit will be  ordinary  income and a portion
may be capital gain.  This capital gain will be long-term if the participant has
held the stock for more than one year and  otherwise  will be  short-term.  If a
participant sells the stock at a loss (sales proceeds are less than the exercise
price),  then the  loss  will be a  capital  loss.  This  capital  loss  will be
long-term if the participant held the stock for more than one year and otherwise
will be short-term.

                                      -28-



NON STATUTORY STOCK OPTIONS

     A  participant  will not have income upon the grant of a NSO. A participant
will have  compensation  income upon the exercise of a NSO equal to the value of
the stock on the day the  participant  exercised  the option  less the  exercise
price.  Upon sale of the stock,  the participant  will have capital gain or loss
equal to the difference between the sales proceeds and the value of the stock on
the day the option was exercised. This capital gain or loss will be long-term if
the  participant has held the stock for more than one year and otherwise will be
short-term.

Restricted Stock

     A  participant  will not have  income  upon the grant of  restricted  stock
unless an election under Section 83(b) of the Code is made within 30 days of the
date of grant. If a timely 83(b) election is made, then a participant  will have
compensation  income  equal to the value of the stock less the  purchase  price.
When the stock is sold, the participant  will have capital gain or loss equal to
the difference between the sales proceeds and the value of the stock on the date
of grant.  If the  participant  does not make an 83(b)  election,  then when the
stock vests the participant will have compensation  income equal to the value of
the stock on the vesting date less the purchase  price.  When the stock is sold,
the participant  will have capital gain or loss equal to the sales proceeds less
the value of the stock on the vesting  date.  Any  capital  gain or loss will be
long-term if the participant held the stock for more than one year and otherwise
will be short-term.

TAX CONSEQUENCES TO US

     There will be not tax consequences to us except that we will be entitled to
a deduction when a participant has compensation  income. Any such deduction will
be subject to the limitations of Section 162(m) of the Code.

                                      -29-




PREVIOUSLY GRANTED OPTIONS UNDER THE 1996 STOCK OPTION PLAN

     Through March 31, 2003, we had granted  options to purchase an aggregate of
2,589,116(1)  shares of common  stock  under the 1996  Stock  Option  Plan at an
average  exercise  price of $10.64 per share.  As of March 31,  2003,  1,217,976
options to purchase shares were vested and 20,775 options to purchase shares had
been exercised  under the 1996 Stock Option Plan. The following table sets forth
the  options  granted  under  the  1996  Stock  Option  Plan  to (i)  the  Named
Executives;  (ii) all current executive  officers as a group;  (iii) all current
Directors  who are not  executive  officers  as a group;  (iv) each  nominee for
election as a Director;  (v) each associate of any of such Directors,  executive
officers or  nominees;  (vi) each person who has received or is to receive 5% of
such options or rights; and (vii) all employees,  including all current officers
who are not executive officers, as a group:



                                                      Options Granted
                                                          through           Weighted Average
                      Name                           March 31, 2003(2)       Exercise Price        Expiration Date
- ---------------------------------------------        ------------------     -----------------      ----------------

                                                                                                
Brian M. Gallagher, Ph.D., President, Chief
   Executive Officer and Chairman of the
   Board.....................................             295,000                $10.96            2/2007 - 1/2012

Robert A. Ashley, Senior Vice President,
   Commercial Development....................             154,000                $10.82            2/2007 - 1/2013

Nancy C. Broadbent, Chief Financial Officer,
   Treasurer and Secretary...................             129,000                $10.03            2/2007 - 1/2013

David F. Pfeiffer, Senior Vice President,
   Sales and Marketing.......................             194,000                $11.48            7/2007 - 1/2013

Douglas C. Gehrig, Vice President, Corporate
   Accounts..................................             169,000                $11.34            7/2007 - 1/2013

Michael Romanowicz, D.M.D., R.Ph., Vice
   President of Professional Affairs and
   Managed Care .............................              84,000                $10.58           11/2009 - 1/2013

Peter R. Barnett, D.M.D......................              10,356                 $6.60                 7/2012

Robert C. Black..............................              10,356                 $6.60                 7/2012

James E. Daverman............................              10,356                 $6.60                 7/2012

Robert J. Easton.............................              10,356                 $6.60                 7/2012

W. James O'Shea..............................              10,356                 $6.60                 7/2012

Stephen A. Kaplan............................              10,356                 $6.60                 7/2012

All current executive officers as a group
   (4 persons)(3)............................             772,000                $10.91            2/2007 - 1/2013

All current Directors who are not executive
   officers as a group (6 persons)...........              62,136                 $6.60                 7/2012

All employees, including all current
   officers who are not executive officers,
   as a group (148 persons)(3)(4)............           1,754,980                $10.67           11/2006 - 3/2013


         As of March 31, 2003, the market value of the common stock underlying
the 1996 Stock Option Plan was $8.55 per share.

- -----------


(1)  Of the  2,589,116  options  granted as of March 31,  2003,  292,625 of such
     options have been canceled and may be reissued by us.

(2)  Options are granted  under the 1996 Stock  Option Plan  pursuant to various
     vesting  schedules.  In general,  such  options  vest over two to five year
     periods.
                                      -30-



(3)  All  152  of  our  current   employees  and  consultants  are  eligible  to
     participate in the 1996 Stock Option Plan.

(4)  Includes 3 consultants who were granted options to purchase an aggregate of
     60,000 shares of common stock at an exercise price of $12.19 per share with
     an expiration date of February 2009.

     Each of the following  individuals prior to the proposed increase in shares
of common stock  available  under the 1996 Stock  Option  Plan,  holds more than
five-percent  (5%) of the total  options  issuable  under the 1996 Stock  Option
Plan: Brian M. Gallagher, Ph.D. 11.8%; Robert A. Ashley 6.2%; Nancy C. Broadbent
5.2%;  David F.  Pfeiffer  7.8%;  and Douglas C. Gehrig 6.8%.  Subsequent to the
adoption of the proposed  amendment  to the 1996 Stock  Option Plan,  as further
discussed  below,  each  of  the  following  individuals  will  hold  more  than
five-percent  of the total  options  issuable  under the 1996 Stock Option Plan:
Brian M. Gallagher,  Ph.D. 9.8%;  Robert A. Ashley 5.1%; David F. Pfeiffer 6.5%;
and Douglas C. Gehrig 5.6%.

PROPOSED AMENDMENT

     Stockholders are being asked to consider and vote upon a proposed amendment
to the 1996 Stock Option Plan to increase the maximum aggregate number of shares
of common stock  available  for  issuance  under the 1996 Stock Option Plan from
2,500,000 to 3,000,000 shares and to reserve an additional 500,000 shares of our
common  stock for  issuance in  connection  with such  increase for awards to be
granted under the 1996 Stock Option Plan.

     The Board of Directors  believes that the  Amendment  provides an important
inducement  to recruit  and retain the best  available  personnel.  The Board of
Directors believes that providing employees with an opportunity to invest in the
Company rewards them appropriately for their efforts on behalf of the Company.

   THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR THE APPROVAL OF THE AMENDMENT.

               RATIFICATION OF APPOINTMENT OF INDEPENDENT AUDITORS

     Our Board of Directors intends,  subject to stockholder approval, to retain
KPMG LLP as our independent auditors for the year ending December 31, 2003. KPMG
LLP also served as our independent auditors for 2002.

     THE  BOARD  OF  DIRECTORS  RECOMMENDS  A VOTE FOR THE  RATIFICATION  OF THE
APPOINTMENT OF KPMG LLP AS OUR INDEPENDENT AUDITORS FOR THE YEAR ENDING DECEMBER
31, 2003.

     Representatives  of KPMG LLP are expected to attend the Annual  Meeting and
have an opportunity to make a statement and/or respond to appropriate  questions
from stockholders.

                             STOCKHOLDERS' PROPOSALS

     Stockholders who intend to have a proposal  considered for inclusion in our
proxy  materials for  presentation  at our 2004 Annual  Meeting of  Stockholders
pursuant  to Rule  14a-8  under the  Securities  and  Exchange  Act of 1934,  as
amended,  must submit the proposal to us at our offices at 41 University  Drive,
Newtown,  Pennsylvania  18940,  attention  Nancy C.  Broadbent,  not later  than
December 20, 2003.

     Stockholders  who  intend to  present a proposal  at such  meeting  without
inclusion of such proposal in our proxy  materials  pursuant to Rule 14a-8 under
the  Securities  Exchange  Act of 1934,  as  amended,  are  required  to provide
advanced notice of such proposal to us at the  aforementioned  address not later
than February 25, 2004.

         If we do not receive notice of a stockholder proposal within this
timeframe, our management will use their discretionary authority to vote the
shares they represent, as our Board of Directors may recommend. We reserve the
right to reject, rule out of order, or take other appropriate action with
respect to any proposal that does not comply with these other applicable
requirements.

                                      -31-


                    HOUSEHOLDING OF ANNUAL MEETING MATERIALS

     Some banks,  brokers and other nominee record holders may be  participating
in the practice of  "householding"  proxy  statements and annual  reports.  This
means that only one copy of our Proxy  Statement or Annual  Report may have been
sent to multiple  stockholders  in your  household.  We will promptly  deliver a
separate  copy of either  document  to you if you  write to us at 41  University
Drive, Newtown, Pennsylvania 18940, or call us at (215) 579-7388. If you want to
receive  separate copies of the Annual Report and Proxy Statement in the future,
or if you are receiving  multiple copies and would like to receive only one copy
for your  household,  you should  contact your bank,  broker,  or other  nominee
record holder, or you may contact us at the above address and phone number.

                                  OTHER MATTERS

     The Board of  Directors  is not aware of any  matter  to be  presented  for
action at the Annual  Meeting other than the matters  referred to above and does
not intend to bring any other matters  before the Annual  Meeting.  However,  if
other matters  should  properly come before the Annual  Meeting,  it is intended
that holders of the proxies will vote thereon in their discretion.

                                     GENERAL

     The  accompanying  proxy is  solicited  by and on  behalf  of our  Board of
Directors,  whose notice of meeting is attached to this Proxy Statement, and the
entire cost of such solicitation will be borne by us.

     In addition to the use of the mails,  proxies may be  solicited by personal
interview,  telephone and telegram by directors, officers and other employees of
the Company who will not be specially  compensated for these  services.  We will
also request that brokers,  nominees,  custodians and other fiduciaries  forward
soliciting  materials to the beneficial  owners of shares held of record by such
brokers,  nominees,  custodians  and other  fiduciaries.  We will reimburse such
persons for their reasonable expenses in connection therewith.

     Certain  information  contained  in this Proxy  Statement  relating  to the
occupations  and security  holdings of our  directors and officers is based upon
information received from the individual directors and officers.

     WE WILL FURNISH,  WITHOUT CHARGE, A COPY OF OUR REPORT ON FORM 10-K FOR THE
YEAR ENDED DECEMBER 31, 2002,  INCLUDING  CONSOLIDATED  FINANCIAL STATEMENTS AND
SCHEDULE  THERETO BUT NOT INCLUDING  EXHIBITS,  TO EACH OF OUR  STOCKHOLDERS  OF
RECORD ON APRIL 14, 2003, AND TO EACH  BENEFICIAL  STOCKHOLDER ON THAT DATE UPON
WRITTEN  REQUEST  MADE  TO  MS.  NANCY  C.  BROADBENT,   SECRETARY,   COLLAGENEX
PHARMACEUTICALS,  INC., 41 UNIVERSITY  DRIVE,  NEWTOWN,  PENNSYLVANIA  18940.  A
REASONABLE FEE WILL BE CHARGED FOR COPIES OF REQUESTED EXHIBITS.

     PLEASE DATE, SIGN AND RETURN THE PROXY CARD AT YOUR EARLIEST CONVENIENCE IN
THE  ENCLOSED  RETURN  ENVELOPE.  A PROMPT  RETURN  OF YOUR  PROXY  CARD WILL BE
APPRECIATED AS IT WILL SAVE THE EXPENSE OF FURTHER MAILINGS.


                                             By Order of the Board of Directors

                                             /s/ Nancy C. Broadbent

                                             Nancy C. Broadbent
                                             Secretary
Newtown, Pennsylvania
April 23, 2003

                                      -32-








                                 PREFERRED STOCK
                        COLLAGENEX PHARMACEUTICALS, INC.

               PROXY SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS
            OF THE CORPORATION FOR THE ANNUAL MEETING OF STOCKHOLDERS

     The undersigned hereby  constitutes and appoints Brian M. Gallagher,  Ph.D.
and Nancy C.  Broadbent,  and each of them, his or her true and lawful agent and
proxy with full  power of  substitution  in each,  to  represent  and to vote on
behalf of the undersigned all of the shares of CollaGenex Pharmaceuticals,  Inc.
(the "Company")  which the undersigned is entitled to vote at the Annual Meeting
of Stockholders of the Company to be held at the  Philadelphia  Airport Marriott
Hotel, One Arrivals Road,  Philadelphia,  Pennsylvania at 8:30 A.M., local time,
on Tuesday, May 20, 2003, and at any adjournment or adjournments  thereof,  upon
the following  proposals more fully described in the Notice of Annual Meeting of
Stockholders  and Proxy  Statement  for the Meeting  (receipt of which is hereby
acknowledged).

     This  proxy when  properly  executed  will be voted in the manner  directed
herein by the undersigned stockholder.  If no direction is made, this proxy will
be voted FOR proposals 1, 2 and 3.

                  (continued and to be signed on reverse side)






                        ANNUAL MEETING OF STOCKHOLDERS OF

                        COLLAGENEX PHARMACEUTICALS, INC.

                                 PREFERRED STOCK

                                  MAY 20, 2003

           Please date, sign and mail your proxy card in the envelope
                         provided as soon as possible.






PLEASE SIGN, DATE AND RETURN PROMPTLY IN THE ENCLOSED ENVELOPE. PLEASE MARK YOUR
VOTE IN BLUE OR BLACK INK AS SHOWN HERE. [X]



                                                                                                          
1. ELECTION OF DIRECTOR
                                                              Nominee:
         [_]      FOR                                         Stephen A. Kaplan

         [_]      WITHHOLD AUTHORITY

2. APPROVAL OF PROPOSAL TO AMEND THE COMPANY'S 1996 STOCK                                  FOR           AGAINST      ABSTAIN
   OPTION PLAN TO INCREASE THE MAXIMUM AGGREGATE NUMBER                                    [  ]          [  ]         [  ]
   OF SHARES OF COMMON STOCK AVAILABLE FOR ISSUANCE
   THEREUNDER FROM 2,500,000 SHARES TO 3,000,000 SHARES AND
   TO RESERVE AN ADDITIONAL 500,000 SHARES OF COMMON STOCK
   OF THE COMPANY FOR ISSUANCE IN CONNECTION WITH SUCH INCREASE
   FOR AWARDS TO BE GRANTED UNDER THE 1996 STOCK OPTION PLAN.

3. APPROVAL OF PROPOSAL TO RATIFY THE APPOINTMENT OF                                       FOR           AGAINST      ABSTAIN
   KPMG LLP AS THE INDEPENDENT AUDITORS OF THE COMPANY                                     [  ]          [  ]         [  ]
   FOR THE YEAR ENDING DECEMBER 31, 2003.

4. In his or her discretion, the proxy is authorized to vote upon other matters as may     FOR           AGAINST      ABSTAIN
   properly come before the Meeting.                                                       [  ]          [  ]         [  ]


                                                      Please check the box if you are
                                                      planning to attend the Meeting in person. [  ]

To  change  the  address  on your  account,  please  check  the box at right and
indicate your new address in the address  space above.  Please note that changes
to the registered name(s) on the account may not be submitted via this method. [  ]

Signature of Preferred Stockholder                 Date:            Signature of Preferred Stockholder                  Date:
                                  ---------------        ----------                                   -----------------      ------
                                                                                                      IF HELD JOINTLY


Note:Please  sign  exactly  as your  name or names  appear on this  Proxy.  When
     shares are held jointly, each holder should sign. When signing as executor,
     administrator,  attorney,  trustee or  guardian,  please give full title as
     such. If the signer is a  corporation,  please sign full  corporate name by
     duly  authorized  officer,  giving  full  title as  such.  If  signer  is a
     partnership, please sign in partnership name by authorized person.







                                  COMMON STOCK
                        COLLAGENEX PHARMACEUTICALS, INC.

               PROXY SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS
            OF THE CORPORATION FOR THE ANNUAL MEETING OF STOCKHOLDERS

     The undersigned hereby  constitutes and appoints Brian M. Gallagher,  Ph.D.
and Nancy C.  Broadbent,  and each of them, his or her true and lawful agent and
proxy with full  power of  substitution  in each,  to  represent  and to vote on
behalf of the undersigned all of the shares of CollaGenex Pharmaceuticals,  Inc.
(the "Company")  which the undersigned is entitled to vote at the Annual Meeting
of Stockholders of the Company to be held at the  Philadelphia  Airport Marriott
Hotel, One Arrivals Road,  Philadelphia,  Pennsylvania at 8:30 A.M., local time,
on Tuesday, May 20, 2003, and at any adjournment or adjournments  thereof,  upon
the following  proposals more fully described in the Notice of Annual Meeting of
Stockholders  and Proxy  Statement  for the Meeting  (receipt of which is hereby
acknowledged).

     This  proxy when  properly  executed  will be voted in the manner  directed
herein by the undersigned stockholder.  If no direction is made, this proxy will
be voted FOR proposals 1, 2 and 3.

                  (continued and to be signed on reverse side)







                        ANNUAL MEETING OF STOCKHOLDERS OF

                        COLLAGENEX PHARMACEUTICALS, INC.

                                  COMMON STOCK

                                  MAY 20, 2003

           Please date, sign and mail your proxy card in the envelope
                         provided as soon as possible.

                Please detach and mail in the envelope provided.







PLEASE SIGN, DATE AND RETURN PROMPTLY IN THE ENCLOSED ENVELOPE. PLEASE MARK YOUR
VOTE IN BLUE OR BLACK INK AS SHOWN HERE. |X|



                                                                                                    
1.       ELECTION OF DIRECTORS                                                    Nominees:
         [_]      For All Nominees                                        [_]     Brian M. Gallagher, Ph.D.  [_]  James E. Daverman
         [_]      Withhold Authority for All Nominees                     [_]     Peter R. Barnett, D.M.D.   [_]  Robert J. Easton
         [_]      For All Except (See instructions below)                 [_]     Robert C. Black            [_]   W. James O'Shea


Instruction:  To withhold  authority to vote for any individual  nominee(s) mark
"FOR  ALL  EXCEPT"  and  fill in the  circle  next to each  nominee  you wish to
withhold, as shown here: [X]

2.       APPROVAL OF PROPOSAL TO AMEND THE COMPANY'S 1996 STOCK                               FOR           AGAINST         ABSTAIN
         OPTION PLAN TO INCREASE THE MAXIMUM AGGREGATE NUMBER                                 [  ]          [  ]            [  ]
         OF SHARES OF COMMON STOCK AVAILABLE FOR ISSUANCE
         THEREUNDER FROM 2,500,000 SHARES TO 3,000,000 SHARES AND
         TO RESERVE AN ADDITIONAL 500,000 SHARES OF COMMON STOCK
         OF THE COMPANY FOR ISSUANCE IN CONNECTION WITH SUCH INCREASE
         FOR AWARDS TO BE GRANTED UNDER THE 1996 STOCK OPTION PLAN.

3.       APPROVAL OF PROPOSAL TO RATIFY THE APPOINTMENT OF                                    FOR           AGAINST         ABSTAIN
         KPMG LLP AS THE INDEPENDENT AUDITORS OF THE COMPANY                                  [  ]          [  ]            [  ]
         FOR THE YEAR ENDING DECEMBER 31, 2003.

4.       In his or her discretion, the proxy is authorized to vote upon other matters as may  FOR           AGAINST         ABSTAIN
         properly come before the Meeting.                                                    [  ]          [  ]            [  ]

                                                      Please check the box if you are
                                                      planning to attend the Meeting in person.  [  ]

To  change  the  address  on your  account,  please  check  the box at right and
indicate your new address in the address  space above.  Please note that changes
to the  registered  name(s) on the account may not be submitted via this method.
[  ]

PLEASE MARK, SIGN, DATE AND RETURN THIS PROXY CARD PROMPTLY,  USING THE ENCLOSED
ENVELOPE.


Signature of Common Stockholder                      Date:            Signature of Common Stockholder                 Date:
                               --------------------       ------------                               -----------------     --------
                                                                                                     IF HELD JOINTLY


Note:  Please  sign  exactly as your name or names  appear on this  Proxy.  When
shares are held  jointly,  each holder  should  sign.  When signing as executor,
administrator, attorney, trustee or guardian, please give full title as such. If
the signer is a corporation,  please sign full corporate name by duly authorized
officer,  giving full title as such. If signer is a partnership,  please sign in
partnership name by authorized person.


                                                                      APPENDIX A

                        COLLAGENEX PHARMACEUTICALS, INC.

                                 1996 STOCK PLAN



          1.  Purposes  of the Plan.  The  purposes  of this  Stock  Plan are to
     attract  and  retain  the  best   available   personnel  for  positions  of
     substantial  responsibility,  to provide additional incentive to Employees,
     non-Employee  members of the Board and  Consultants  of the Company and its
     Subsidiaries and to promote the success of the Company's business.  Options
     granted  under the Plan may be incentive  stock  options (as defined  under
     Section 422 of the Code) or non-statutory  stock options,  as determined by
     the  Administrator  at the time of grant of an option  and  subject  to the
     applicable  provisions  of Section  422 of the Code,  as  amended,  and the
     regulations  promulgated  thereunder.  Stock  purchase  rights  may also be
     granted under the Plan.

          2. Certain  Definitions.  As used herein,  the  following  definitions
     shall apply:

          (a) "Administrator" means the Board or any of its Committees appointed
     pursuant to Section 4 of the Plan.

          (b) "Board" means the Board of Directors of the Company.

          (c) "Code" means the Internal Revenue Code of 1986, as amended.

          (d)  "Committee"  means  the  Committee  appointed  by  the  Board  of
     Directors in accordance with paragraph (a) of Section 4 of the Plan.

          (e) "Common Stock" means the Common Stock of the Company.

          (f)  "Company"  means  CollaGenex  Pharmaceuticals,  Inc.,  a Delaware
     corporation.

          (g)  "Consultant"  means any  person,  including  an  advisor,  who is
     engaged by the Company or any Parent or subsidiary  to render  services and
     is compensated  for such services,  and any director of the Company whether
     compensated for such services or not.

          (h)  "Continuous  Status  as an  Employee"  means the  absence  of any
     interruption  or termination of the employment  relationship by the Company
     or any Subsidiary. Continuous Status as an Employee shall not be considered
     interrupted in the case of: (i) sick leave; (ii) military leave;  (iii) any
     other leave of absence  approved by the Board,  provided that such leave is
     for a period of not more than ninety (90) days,  unless  reemployment  upon
     the  expiration  of such leave is  guaranteed  by contract  or statute,  or
     unless provided  otherwise  pursuant to Company policy adopted from time to
     time;  or (iv)  transfers  between  locations of the Company or between the
     Company, its Subsidiaries or its successor.




          (i)  "Employee"  means any person,  including  officers and directors,
     employed by the Company or any Parent or  Subsidiary  of the  Company.  The
     payment of a  director's  fee by the  Company  shall not be  sufficient  to
     constitute "employment" by the Company.

          (j)  "Exchange  Act" means the  Securities  Exchange  Act of 1934,  as
     amended.

          (k) "Fair Market  Value"  means,  as of any date,  the value of Common
     Stock determined as follows:

          (i) If the Common Stock is listed on any established stock exchange or
     a national market system including  without  limitation the National Market
     System of the National  Association of Securities  Dealers,  Inc. Automated
     Quotation  ("Nasdaq")  System,  its Fair Market  Value shall be the closing
     sales price for such stock (or the closing bid, if no sales were  reported)
     as quoted on such system or exchange for the last market  trading day prior
     to the time of determination as reported in the Wall Street Journal or such
     other source as the Administrator deems reliable or;

          (ii) If the Common  Stock is quoted on Nasdaq (but not on the National
     Market  System  thereof) or  regularly  quoted by a  recognized  securities
     dealer but selling prices are not reported,  its Fair Market Value shall be
     the mean between the high and low asked prices for the Common Stock or;

          (iii) In the absence of an  established  market for the Common  Stock,
     the Fair Market  Value  thereof  shall be  determined  in good faith by the
     Administrator.

          (l) "Incentive Stock Option" means an Option intended to qualify as an
     incentive stock option within the meaning of Section 422 of the Code.

          (m)  "Nonstatutory  Stock  Option"  means an Option  not  intended  to
     qualify as an Incentive Stock Option.

          (n) "Option" means a stock option granted pursuant to the Plan.

          (o) "Optioned Stock" means the Common Stock subject to an Option.

          (p) "Optionee" means an Employee or Consultant who receives an Option.

          (q) "Parent"  means a "parent  corporation",  whether now or hereafter
     existing, as defined in Section 424(e) of the Code.

          (r) "Plan" means this 1996 Stock Plan.

          (s) "Restricted  Stock" means shares of Common Stock acquired pursuant
     to a grant of stock purchase rights under Section 11 below.

                                      -2-



          (t)  "Share"  means  a share  of the  Common  Stock,  as  adjusted  in
     accordance with Section 13 of the Plan.

          (u)  "Subsidiary"  means a  "subsidiary  corporation",  whether now or
     hereafter existing, as defined in Section 424(f) of the Code.

          3. Stock Subject to the Plan.  Subject to the provisions of Section 13
     of the Plan, the maximum  aggregate  number of shares which may be optioned
     and sold under the Plan is 2,500,000 shares of Common Stock, such number of
     shares  determined on a post-reverse  stock split  recapitalization  basis,
     such  recapitalization  to be completed upon  consummation of the Company's
     proposed  initial  public  offering  of Common  Stock.  The  shares  may be
     authorized, but unissued, or reacquired Common Stock.

          If an option  should  expire or become  unexercisable  for any  reason
     without having been exercised in full,  the  unpurchased  Shares which were
     subject thereto shall,  unless the Plan shall have been terminated,  become
     available for future grant under the Plan.

     4. Administration of the Plan.

          (a) Procedure.

          (i)  Administration  With  Respect to  Directors  and  officers.  With
     respect to grants of Options or stock purchase  rights to Employees who are
     also officers or directors of the Company,  the Plan shall be  administered
     by (A) the Board if the Board may  administer  the Plan in compliance  with
     Rule 16b-3  promulgated  under the  Exchange Act or any  successor  thereto
     ("Rule  16b-3") with respect to a plan intended to qualify  thereunder as a
     discretionary  plan,  or  (B)  a  Committee  designated  by  the  Board  to
     administer the Plan,  which Committee shall be constituted in such a manner
     as to permit  the Plan to comply  with Rule  16b-3  with  respect to a plan
     intended to qualify  thereunder as a  discretionary  plan.  Once appointed,
     such Committee  shall  continue to serve in its  designated  capacity until
     otherwise  directed by the Board.  From time to time the Board may increase
     the size of the Committee and appoint  additional  members thereof,  remove
     members  (with or without  cause) and appoint  new members in  substitution
     therefor,  fill vacancies,  however  caused,  and remove all members of the
     Committee and  thereafter  directly  administer the Plan, all to the extent
     permitted  by  Rule  16b-3  with  respect  to a plan  intended  to  qualify
     thereunder as a discretionary plan.

          (ii) Multiple  Administrative  Bodies. If permitted by Rule 16b-3, the
     Plan may be  administered  by different  bodies with respect to  directors,
     non-director officers and Employees who are neither directors nor officers.

          (iii)  Administration With Respect to Consultants and Other Employees.
     With respect to grants of Options or stock purchase rights to Employees who
     are neither  directors nor officers of the Company or to  Consultants,  the
     Plan shall be  administered  by (A) the Board,  if the Board may administer
     the Plan in compliance  with Rule 16b-3,  or (B) a Committee  designated by
     the Board,  which  Committee  shall be  constituted  in such a manner as to
     satisfy the legal

                                      -3-



     requirements  relating to the  administration  of  incentive  stock  option
     plans, if any, of Delaware corporate law and applicable securities laws and
     of the Code (the "Applicable Laws").  Once appointed,  such Committee shall
     continue to serve in its designated  capacity until  otherwise  directed by
     the  Board.  From  time to time  the  Board  may  increase  the size of the
     Committee and appoint additional  members thereof,  remove members (with or
     without  cause) and  appoint  new members in  substitution  therefor,  fill
     vacancies,  however  caused,  and remove all members of the  Committee  and
     thereafter directly administer the Plan, all to the extent permitted by the
     Applicable Laws.

          (b) Powers of the Administrator. Subject to the provisions of the Plan
     and in the case of a Committee,  the specific duties delegated by the Board
     to such  Committee,  the  Administrator  shall have the  authority,  in its
     discretion:

          (i) to  determine  the Fair  Market  Value  of the  Common  Stock,  in
     accordance with Section 2(k) of the Plan;

          (ii) to select the officers, Consultants and Employees to whom Options
     and stock purchase rights may from time to time be granted hereunder;

          (iii) to  determine  whether  and to what  extent  Options  and  stock
     purchase rights or any combination thereof, are granted hereunder;

          (iv) to  determine  the number of shares of Common Stock to be covered
     by each such award granted hereunder;

          (v) to approve forms of agreement for use under the Plan;

          (vi) to determine the terms and conditions,  not inconsistent with the
     terms of the  Plan,  of any award  granted  hereunder  (including,  but not
     limited to, the share price and any  restriction or limitation or waiver of
     forfeiture  restrictions  regarding  any Option or other  award  and/or the
     shares of Common Stock relating thereto, based in each case on such factors
     as the Administrator shall determine, in its sole discretion);

          (vii) to determine whether and under what  circumstances an Option may
     be settled in cash under subsection 9(f) instead of Common Stock;

          (viii)  to   determine   whether,   to  what  extent  and  under  what
     circumstances  Common  Stock and other  amounts  payable with respect to an
     award  under this Plan shall be  deferred  either  automatically  or at the
     election of the  participant  (including  providing for and determining the
     amount,  if any, of any deemed  earnings on any deferred  amount during any
     deferral period);

          (ix) to reduce the  exercise  price of any Option to the then  current
     Fair Market Value if the Fair Market  Value of the Common Stock  covered by
     such Option shall have declined since the date the Option was granted; and

                                      -4-


          (x) to  determine  the  terms  and  restrictions  applicable  to stock
     purchase rights and the Restricted Stock purchased by exercising such stock
     purchase rights.

          (c) Effect of Committee's Decision. All decisions,  determinations and
     interpretations  of the  Administrator  shall be final and  binding  on all
     Optionees and any other holders of any Options.

          5. Eligibility.

          (a)  Nonstatutory  Stock  Options  may be  granted  to  Employees  and
     Consultants.  Incentive Stock Options may be granted only to Employees.  An
     Employee  or  Consultant  who has been  granted  an  Option  may,  if he is
     otherwise eligible, be granted an additional Option or Options.

          (b) Each Option shall be designated in the written option agreement as
     either an Incentive Stock Option or a Nonstatutory  Stock Option.  However,
     notwithstanding  such  designations,  to the extent that the aggregate Fair
     Market  Value of the Shares with  respect to which  Options  designated  as
     Incentive  Stock Options are exercisable for the first time by any optionee
     during any  calendar  year (under all plans of the Company or any Parent or
     Subsidiary)  exceeds  $100,000,  such  excess  Options  shall be treated as
     Nonstatutory Stock Options.

          (c) For purposes of Section  5(b),  Incentive  Stock  Options shall be
     taken into  account in the order in which they were  granted,  and the Fair
     Market  Value of the Shares shall be  determined  as of the time the Option
     with respect to such Shares is granted.

          (d) The Plan shall not confer upon any Optionee any right with respect
     to continuation of employment or consulting  relationship with the Company,
     nor shall it interfere in any way with his right or the Company's  right to
     terminate his employment or consulting  relationship  at any time,  with or
     without cause.

          6. Term of Plan.  The Plan shall become  effective upon the earlier to
     occur of its  adoption  by the Board of  Directors  or its  approval by the
     shareholders  of the  Company as  described  in Section 19 of the Plan.  It
     shall  continue  in  effect  for a term of ten  (10)  years  unless  sooner
     terminated under Section 15 of the Plan.

          7. Term of Option. The term of each Option shall be the term stated in
     the Option Agreement;  provided,  however, that in the case of an Incentive
     Stock  Option,  the term shall be no more than ten (10) years from the date
     of grant  thereof or such  shorter  term as may be  provided  in the Option
     Agreement. However, in the case of an Option granted to an Optionee who, at
     the time the  Option is  granted,  owns  stock  representing  more than ten
     percent (10%) of the voting power of all classes of stock of the Company or
     any Parent or  Subsidiary,  the term of the Option  shall be five (5) years
     from the date of grant  thereof or such  shorter term as may be provided in
     the Option Agreement.

                                      -5-



          8. Option Exercise Price and Consideration.

          (a) The per share exercise price for the Shares to be issued  pursuant
     to exercise of an Option shall be such price as is determined by the Board,
     but shall be subject to the following:

          (i) In the case of an Incentive Stock Option

               (A) granted to an Employee  who, at the time of the grant of such
          Incentive Stock Option,  owns stock representing more than ten percent
          (10%) of the voting  power of all  classes of stock of the  Company or
          any Parent or  Subsidiary,  the per Share  exercise  price shall be no
          less  than  110% of the Fair  Market  Value  per  Share on the date of
          grant.

               (B) granted to any Employee,  the per Share  exercise price shall
          be no less than 100% of the Fair Market Value per Share on the date of
          grant.

          (ii) In the case of a Nonstatutory Stock Option

               (A)  granted  to a person  who,  at the time of the grant of such
          Option,  owns stock  representing  more than ten percent  (10%) of the
          voting  power of all  classes of stock of the Company or any Parent or
          Subsidiary, the per Share exercise price shall be no less than 110% of
          the Fair Market Value per Share on the date of the grant.

               (B) granted to any person,  the per Share exercise price shall be
          no less  than 85% of the Fair  Market  Value  per Share on the date of
          grant.

          (b) The  consideration  to be paid for the  Shares to be  issued  upon
     exercise of an Option, including the method of payment, shall be determined
     by the Administrator (and, in the case of an Incentive Stock Option,  shall
     be determined  at the time of grant) and may consist  entirely of (1) cash,
     (2) check,  (3) promissory  note, (4) other Shares which (x) in the case of
     Shares  acquired  upon  exercise of an Option either have been owned by the
     Optionee  for more  than six  months on the date of  surrender  or were not
     acquired,  directly or  indirectly,  from the Company,  and (y) have a Fair
     Market Value on the date of surrender equal to the aggregate exercise price
     of the Shares as to which said Option shall be exercised, (5) authorization
     from the Company to retain from the total  number of Shares as to which the
     Option is exercised that number of Shares having a Fair Market Value on the
     date of exercise equal to the exercise price for the total number of Shares
     as to which the option is  exercised,  (6) delivery of a properly  executed
     exercise  notice  together  with  irrevocable  instructions  to a broker to
     promptly  deliver  to the  Company  the  amount  of sale  or loan  proceeds
     required  to pay the  exercise  price,  (7) by  delivering  an  irrevocable
     subscription  agreement  for the Shares  which  irrevocably  obligates  the
     option  holder to take and pay for the Shares not more than  twelve  months
     after  the  date  of  delivery  of  the  subscription  agreement,  (8)  any
     combination  of  the  foregoing  methods  of  payment,  or (9)  such  other
     consideration  and  method of  payment  for the  issuance  of Shares to the
     extent permitted under  Applicable Laws. In making its  determination as to
     the type of

                                      -6-



     consideration to accept, the Administrator  shall consider if acceptance of
     such consideration may be reasonably expected to benefit the Company.

          9. Exercise of Option.

          (a)  Procedure  for  Exercise;  Rights as a  Shareholder.  Any  Option
     granted  hereunder  shall be  exercisable  at such  times  and  under  such
     conditions  as  determined  by  the  Administrator,  including  performance
     criteria with respect to the Company  and/or the Optionee,  and as shall be
     permissible under the terms of the Plan.

     An Option may not be exercised for a fraction of a Share.

          An Option shall be deemed to be exercised  when written notice of such
     exercise has been given to the Company in accordance  with the terms of the
     Option by the person  entitled to exercise  the Option and full payment for
     the Shares with respect to which the Option is exercised  has been received
     by the  Company.  Full  payment may, as  authorized  by the  Administrator,
     consist of any  consideration and method of payment allowable under Section
     8(b) of the Plan. Until the issuance (as evidenced by the appropriate entry
     on the books of the Company or of a duly  authorized  transfer agent of the
     Company) of the stock certificate  evidencing such Shares, no right to vote
     or receive  dividends or any other rights as a shareholder shall exist with
     respect to the Optioned Stock,  notwithstanding the exercise of the Option.
     The  Company  shall  issue (or cause to be issued)  such stock  certificate
     promptly  upon  exercise of the Option.  No  adjustment  will be made for a
     dividend  or other right for which the record date is prior to the date the
     stock certificate is issued, except as provided in Section 11 of the Plan.

          Exercise of an Option in any manner  shall result in a decrease in the
     number of Shares which  thereafter  may be available,  both for purposes of
     the Plan and for sale under the Option, by the number of Shares as to which
     the Option is exercised.

          (b)  Termination  of  Employment.  In the event of  termination  of an
     Optionee's consulting relationship or Continuous Status as an Employee with
     the Company (as the case may be), such Optionee may, but only within ninety
     (90) days (or such other period of time as is determined by the Board, with
     such  determination  in the case of an Incentive Stock Option being made at
     the time of grant of the Option and not  exceeding  ninety (90) days) after
     the date of such  termination  (but in no event  later than the  expiration
     date of the term of such  Option  as set  forth in the  Option  Agreement),
     exercise his Option to the extent that Optionee was entitled to exercise it
     at the  date of such  termination.  To the  extent  that  Optionee  was not
     entitled  to  exercise  the Option at the date of such  termination,  or if
     Optionee does not exercise such Option to the extent so entitled within the
     time specified herein, the Option shall terminate.

          (c) Disability of Optionee.  Notwithstanding the provisions of Section
     9(b)  above,  in the  event  of  termination  of an  Optionee's  consulting
     relationship  or Continuous  Status as an Employee as a result of his total
     and  permanent  disability  (as  defined in Section  22(e)(3) of the Code),
     Optionee  may,  but only  within  twelve  (12) months from the date of such
     termination  (but in no event later than the expiration date of the term of
     such Option as set forth in the Option  Agreement),  exercise the Option to
     the extent otherwise entitled to exercise it at the date of such

                                      -7-


     termination.  To the extent that  Optionee was not entitled to exercise the
     Option at the date of  termination,  or if Optionee  does not exercise such
     Option to the extent so  entitled  within the time  specified  herein,  the
     Option shall terminate.

          (d) Death of Optionee.  In the event of the death of an Optionee,  the
     Option may be exercised,  at any time within  twelve (12) months  following
     the date of death (but in no event  later than the  expiration  date of the
     term  of  such  Option  as set  forth  in  the  Option  Agreement),  by the
     Optionee's  estate or by a person who  acquired  the right to exercise  the
     Option by bequest or  inheritance,  but only to the extent the Optionee was
     entitled  to exercise  the Option at the date of death.  To the extent that
     Optionee   was  not  entitled  to  exercise  the  Option  at  the  date  of
     termination,  or if Optionee does not exercise such Option to the extent so
     entitled within the time specified herein, the Option shall terminate.

          (e) Rule 16b-3. Options granted to persons subject to Section 16(b) of
     the  Exchange  Act must  comply  with Rule  16b-3 and  shall  contain  such
     additional  conditions  or  restrictions  as may be required  thereunder to
     qualify for the maximum  exemption from Section 16 of the Exchange Act with
     respect to Plan transactions.

          (f) Buyout Provisions.  The Administrator may at any time offer to buy
     out for a payment in cash or Shares, an Option previously granted, based on
     such  terms  and  conditions  as  the  Administrator  shall  establish  and
     communicate to the Optionee at the time that such offer is made.

          10.  Non-Transferability  of  Options.  The  Option  may not be  sold,
     pledged, assigned, hypothecated,  transferred, or disposed of in any manner
     other  than by will or by the laws of descent  or  distribution  and may be
     exercised,  during the lifetime of the Optionee,  only by the Optionee. The
     terms of the Option  shall be binding upon the  executors,  administrators,
     heirs, successors and assigns of the Optionee.

          11. Stock Purchase Rights.

          (a) Rights to Purchase.  Stock  purchase  rights may be issued  either
     alone,  in addition  to, or in tandem with other awards  granted  under the
     Plan and/or cash awards made outside of the Plan.  After the  Administrator
     determines  that it will offer stock  purchase  rights  under the Plan,  it
     shall  advise  the  offeree  in  writing  of  the  terms,   conditions  and
     restrictions related to the offer, including the number of Shares that such
     person  shall be entitled to  purchase,  the price to be paid (which  price
     shall not be less than 50% of the Fair Market Value of the Shares as of the
     date of the offer),  and the time within which such person must accept such
     offer,  which shall in no event exceed  thirty (30) days from the date upon
     which the Administrator  made the determination to grant the stock purchase
     right.  The offer shall be  accepted by  execution  of a  Restricted  Stock
     purchase agreement in the form determined by the Administrator.

          (b) Repurchase Option. Unless the Administrator  determines otherwise,
     the  Restricted  Stock  purchase   agreement  shall  grant  the  Company  a
     repurchase option exercisable

                                      -8-



     upon the voluntary or involuntary termination of the purchaser's employment
     with the  Company  for any  reason  (including  death or  Disability).  The
     purchase  price for Shares  repurchased  pursuant to the  Restricted  Stock
     purchase  agreement  shall be the original  price paid by the purchaser and
     may be paid by  cancellation  of any  indebtedness  of the purchaser to the
     Company.  The  repurchase  option shall lapse at such rate as the Committee
     may determine.

          (c) Other  Provisions.  The Restricted Stock purchase  agreement shall
     contain such other terms,  provisions and conditions not inconsistent  with
     the Plan as may be determined by the  Administrator in its sole discretion.
     In addition,  the provisions of Restricted  Stock purchase  agreements need
     not be the same with respect to each purchaser.

          (d)  Rights  as a  Shareholder.  Once  the  stock  purchase  right  is
     exercised,  the  purchaser  shall have the rights  equivalent to those of a
     shareholder, and shall be a shareholder when his or her purchase is entered
     upon the records of the duly authorized  transfer agent of the Company.  No
     adjustment  will be made for a dividend or other right for which the record
     date is prior to the date the stock purchase right is exercised,  except as
     provided in Section 13 of the Plan.

          12. Stock Withholding to Satisfy  Withholding Tax Obligations.  At the
     discretion  of  the  Administrator,   Optionees  may  satisfy   withholding
     obligations  as provided  in this  paragraph.  When an Optionee  incurs tax
     liability in connection with an Option or stock purchase  right,  which tax
     liability is subject to tax withholding  under applicable tax laws, and the
     Optionee is obligated to pay the Company an amount  required to be withheld
     under  applicable  tax laws, the Optionee may satisfy the  withholding  tax
     obligation  by electing to have the Company  withhold from the Shares to be
     issued  upon  exercise  of  the  Option,  or the  Shares  to be  issued  in
     connection  with the stock  purchase  right,  if any, that number of Shares
     having a Fair Market Value equal to the amount required to be withheld. The
     Fair Market Value of the Shares to be withheld  shall be  determined on the
     date that the amount of tax to be  withheld is to be  determined  (the "Tax
     Date").

          All elections by an Optionee to have Shares  withheld for this purpose
     shall be made in  writing in a form  acceptable  to the  Administrator  and
     shall be subject to the following restrictions:

          (a) the election must be made on or prior to the applicable Tax Date;

          (b) once made,  the election shall be irrevocable as to the particular
     Shares of the Option or Right as to which the election is made;

          (c) all elections  shall be subject to the consent or  disapproval  of
     the Administrator;

          (d) if the Optionee is subject to Rule 16b-3, the election must comply
     with the  applicable  provisions of Rule 16b-3 and shall be subject to such
     additional conditions

                                      -9-


     or  restrictions  as may be required  thereunder to qualify for the maximum
     exemption  from  Section  16 of the  Exchange  Act  with  respect  to  Plan
     transactions.

          In the  event  the  election  to have  Shares  withheld  is made by an
     Optionee and the Tax Date is deferred  under Section 83 of the Code because
     no election is filed under  Section 83(b) of the Code,  the Optionee  shall
     receive the full number of Shares with respect to which the Option or stock
     purchase  right is exercised  but such  Optionee  shall be  unconditionally
     obligated to tender back to the Company the proper  number of Shares on the
     Tax Date.

          13.  Adjustments Upon Changes in Capitalization or Merger.  Subject to
     any  required  action by the  shareholders  of the  Company,  the number of
     shares of Common Stock covered by each outstanding  Option,  and the number
     of shares of Common Stock which have been authorized for issuance under the
     Plan but as to which no  Options  have yet been  granted or which have been
     returned to the Plan upon  cancellation or expiration of an Option, as well
     as the price per share of Common  Stock  covered  by each such  outstanding
     Option,  shall be proportionately  adjusted for any increase or decrease in
     the number of issued shares of Common Stock  resulting  from a stock split,
     reverse stock split, stock dividend, combination or reclassification of the
     Common  Stock,  or any other  increase  or decrease in the number of issued
     shares of Common Stock effected  without  receipt of  consideration  by the
     Company;  provided,  however, that conversion of any convertible securities
     of the Company shall not be deemed to have been "effected  without  receipt
     of  consideration."  Such  adjustment  shall  be made by the  Board,  whose
     determination  in that  respect  shall be final,  binding  and  conclusive.
     Except as expressly  provided herein,  no issuance by the Company of shares
     of stock of any class,  or securities  convertible  into shares of stock of
     any class,  shall affect, and no adjustment by reason thereof shall be made
     with respect to, the number or price of shares of Common  Stock  subject to
     an Option.

          In the  event  of  the  proposed  dissolution  or  liquidation  of the
     Company,  the Board shall  notify the  Optionee at least  fifteen (15) days
     prior to such  proposed  action.  To the extent it has not been  previously
     exercised,  the Option will terminate immediately prior to the consummation
     of such proposed  action.  In the event of a merger or consolidation of the
     Company  with  or  into  another   corporation   or  the  sale  of  all  or
     substantially all of the Company's assets  (hereinafter,  a "merger"),  the
     Option shall be assumed or an  equivalent  option shall be  substituted  by
     such  successor  corporation  or a parent or subsidiary  of such  successor
     corporation. In the event that such successor corporation does not agree to
     assume the Option or to substitute an equivalent  option,  the Board shall,
     in lieu of such  assumption  or  substitution,  provide for the Optionee to
     have the right to  exercise  the  Option as to all of the  Optioned  Stock,
     including Shares as to which the Option would not otherwise be exercisable.
     If the Board makes an Option fully  exercisable  in lieu of  assumption  or
     substitution in the event of a merger,  the Board shall notify the Optionee
     that the Option  shall be fully  exercisable  for a period of fifteen  (15)
     days from the date of such notice,  and the Option will  terminate upon the
     expiration of such period.  For the purposes of this paragraph,  the Option
     shall be considered  assumed if, following the merger,  the Option or right
     confers  the right to  purchase,  for each  Share of stock  subject  to the
     Option immediately prior to the merger,  the consideration  (whether stock,
     cash, or other

                                      -10-



     securities  or property)  received in the merger by holders of Common Stock
     for  each  Share  held on the  effective  date of the  transaction  (and if
     holders were offered a choice of  consideration,  the type of consideration
     chosen by the holders of a majority of the outstanding  Shares);  provided,
     however,  that if such consideration  received in the merger was not solely
     common stock of the  successor  corporation  or its Parent,  the Board may,
     with the consent of the successor corporation and the participant,  provide
     for the  consideration to be received upon the exercise of the Option,  for
     each Share of stock subject to the Option, to be solely common stock of the
     successor  corporation  or its Parent equal in Fair Market Value to the per
     share  consideration  received by holders of Common  Stock in the merger or
     sale of assets.

          14. Time of Granting  Options.  The date of grant of an Option  shall,
     for all  purposes,  be the  date  on  which  the  Administrator  makes  the
     determination  granting such Option, or such other date as is determined by
     the Board.  Notice of the determination  shall be given to each Employee or
     Consultant to whom an Option is so granted  within a reasonable  time after
     the date of such grant.

          15. Amendment and Termination of the Plan.

          (a) Amendment and Termination. The Board may at any time amend, alter,
     suspend or discontinue the Plan, but no amendment,  alteration,  suspension
     or  discontinuation  shall be made  which  would  impair  the rights of any
     Optionee under any grant theretofore made,  without his or her consent.  In
     addition,  to the extent  necessary and desirable to comply with Rule 16b-3
     under  the  Exchange  Act or with  Section  422 of the Code  (or any  other
     applicable law or regulation,  including the requirements of the NASD or an
     established stock exchange),  the Company shall obtain shareholder approval
     of any Plan amendment in such a manner and to such a degree as required.

          (b)  Effect  of  Amendment  or  Termination.  Any  such  amendment  or
     termination of the Plan shall not affect Options  already  granted and such
     Options  shall remain in full force and effect as if this Plan had not been
     amended  or  terminated,  unless  mutually  agreed  otherwise  between  the
     Optionee and the Board,  which  agreement  must be in writing and signed by
     the Optionee and the Company.

          16.  Conditions  Upon  Issuance of Shares.  Shares shall not be issued
     pursuant to the  exercise of an Option  unless the  exercise of such Option
     and the issuance and delivery of such Shares pursuant  thereto shall comply
     with all relevant  provisions of law, including,  without  limitation,  the
     Securities  Act of 1933,  as  amended,  the  Exchange  Act,  the  rules and
     regulations  promulgated  thereunder,  and the  requirements  of any  stock
     exchange  upon which the  Shares  may then be listed,  and shall be further
     subject to the  approval of counsel for the  Company  with  respect to such
     compliance.

          As a condition to the  exercise of an Option,  the Company may require
     the person  exercising  such Option to represent and warrant at the time of
     any such exercise that the Shares are being  purchased  only for investment
     and without any present intention to sell or distribute

                                      -11-


     such  Shares  if,  in the  opinion  of  counsel  for  the  Company,  such a
     representation is required by any of the aforementioned relevant provisions
     of law.

          17. Reservation of Shares. The Company,  during the term of this Plan,
     will at all times reserve and keep available such number of Shares as shall
     be sufficient to satisfy the requirements of the Plan.

          The inability of the Company to obtain  authority  from any regulatory
     body  having  jurisdiction,  which  authority  is deemed  by the  Company's
     counsel  to be  necessary  to the  lawful  issuance  and sale of any Shares
     hereunder,  shall  relieve the Company of any  liability  in respect of the
     failure to issue or sell such Shares as to which such  requisite  authority
     shall not have been obtained.

          18.  Agreements.  Options and stock purchase rights shall be evidenced
     by written  agreements in such form as the Board shall approve from time to
     time.

          19. Shareholder Approval.  Continuance of the Plan shall be subject to
     approval  by the  shareholders  of the  Company  within  twelve (12) months
     before or after the date the Plan is  adopted.  Such  shareholder  approval
     shall be obtained in the degree and manner required under  applicable state
     and federal law.

          20.  Information  to  Optionees.  The  Company  shall  provide to each
     Optionee, during the period for which such Optionee has one or more Options
     outstanding,  copies of all annual reports and other  information which are
     provided to all  shareholders  of the  Company.  The  Company  shall not be
     required to provide such  information  if the issuance of Options under the
     Plan is  limited  to key  employees  whose  duties in  connection  with the
     Company assure their access to equivalent information.


                                      -12-