SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                         -------------------------------

                                    FORM 8-K

                                 CURRENT REPORT

                     PURSUANT TO SECTION 13 OR 15(d) OF THE

                         SECURITIES EXCHANGE ACT OF 1934


        Date of report (Date of earliest event reported) October 3, 2003
                                                         ---------------


                        CollaGenex Pharmaceuticals, Inc.
                        --------------------------------
               (Exact Name of Registrant as Specified in Charter)


        Delaware                    0-28308                     52-1758016
- --------------------------------------------------------------------------------
      (State or Other       (Commission File Number)        (IRS Employer
       Jurisdiction                                      Identification No.)
     of Incorporation)


41 University Drive, Newtown, Pennsylvania                             18940
- --------------------------------------------------------------------------------
(Address of Principal Executive Offices)                             (Zip Code)


                                 (215) 579-7388
                        ---------------------------------
                         (Registrant's telephone number,
                              including area code)


         ---------------------------------------------------------------
          (Former Name or Former Address, if Changed Since Last Report)





ITEM 5.  OTHER EVENTS.

      On  February  6,  2003,  CollaGenex  Pharmaceuticals,   Inc.,  a  Delaware
corporation (the "Company") filed a registration statement (File No. 333-103008)
(the  "Registration  Statement")  on Form S-3 with the  Securities  and Exchange
Commission (the "Commission") relating to the public offering,  pursuant to Rule
415 under the  Securities  Act of 1933,  as amended,  of up to an  aggregate  of
2,000,000 shares of common stock, par value $0.01 per share (the "Common Stock")
of the Company.  On August 12, 2003, the Company filed an Amendment No. 1 to the
Registration  Statement.  The  Commission  declared the  Registration  Statement
effective on August 25, 2003.

      On October 3, 2003,  the Company  entered into  agreements for the sale of
2,000,000 shares of Common Stock registered under the Registration  Statement to
certain  institutional  investors,  at a purchase price of $10.0 per share,  for
aggregate  gross proceeds of $20.0 million,  which generated net proceeds to the
Company of approximately $18.8 million after the payment of placement agent fees
and related expenses.

      The placement agents also assisted Marquette Venture Partners II, L.P. and
OCM Principal  Opportunities  Fund,  L.P. in selling  341,302 shares and 320,000
shares of previously acquired Common Stock, respectively,  on the same financial
terms as the sale of Common Stock by the Company.  Each of these funds continues
to have a representative on the Company's Board of Directors.

      A copy of the press  releases  relating to the issuance of Common Stock by
the  Company  and the sale of  shares  by the  selling  stockholders  are  filed
herewith as Exhibit 99.1 and Exhibit 99.2,  respectively,  and are  incorporated
herein by reference. The foregoing  descriptions of the issuance of Common Stock
by the Company and the sale of shares by the selling  stockholders are qualified
in their entirety by reference to such Exhibits.






ITEM 7.  FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS.

         (c)  Exhibits.

         Exhibit No.    Description
         -----------    -----------

            99.1        Press Release dated October 3, 2003
            99.2        Press Release dated October 7, 2003






                                   SIGNATURES


      Pursuant to the  requirements of the Securities  Exchange Act of 1934, the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned, hereunto duly authorized.


                                    COLLAGENEX PHARMACEUTICALS, INC.


                                    By:  /s/ Nancy C. Broadbent
                                         -----------------------------
                                         Nancy C. Broadbent
                                         Chief Financial Officer
                                         (Principal Financial Officer)


Date:  October 8, 2003