SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                         -------------------------------

                                    FORM 8-K

                                 CURRENT REPORT

                     PURSUANT TO SECTION 13 OR 15(d) OF THE

                         SECURITIES EXCHANGE ACT OF 1934


        Date of report (Date of earliest event reported) December 8, 2003
                                                         ----------------


                        CollaGenex Pharmaceuticals, Inc.
               --------------------------------------------------
               (Exact Name of Registrant as Specified in Charter)


        Delaware                    0-28308                     52-1758016
- --------------------------------------------------------------------------------
      (State or Other       (Commission File Number)        (IRS Employer
       Jurisdiction                                      Identification No.)
     of Incorporation)


41 University Drive, Newtown, Pennsylvania                             18940
- --------------------------------------------------------------------------------
(Address of Principal Executive Offices)                            (Zip Code)


                                 (215) 579-7388
                        ---------------------------------
                         (Registrant's telephone number,
                              including area code)



          -------------------------------------------------------------
          (Former Name or Former Address, if Changed Since Last Report)





ITEM 5.  OTHER EVENTS.

      On  December  8,  2003,  CollaGenex  Pharmaceuticals,   Inc.,  a  Delaware
corporation  (the  "Company"),  issued a press  release  announcing  that it has
appointed  Colin W.  Stewart  to  succeed  Brian  M.  Gallagher,  Ph.D.,  as the
Company's president and chief executive officer, effective December 8, 2003. Mr.
Stewart will also be a member of the  CollaGenex  board of  directors.  James E.
Daverman,  a member of the  CollaGenex  board of directors  since 1995, has been
appointed  chairman of the board.  Dr.  Gallagher  will remain on the board as a
director  and will  provide  certain  consulting  services  to the Company for a
period of 24 months.

      In connection  with the  appointment  of Colin W. Stewart as president and
chief  executive  officer,  the  Company  will  enter  into a Change of  Control
Agreement with Mr. Stewart. In the event Mr. Stewart's  employment is terminated
as a result  of an  Involuntary  Termination  within  24  months  of a Change of
Control  (each as defined in the  Change of  Control  Agreement),  the Change of
Control Agreement provides for, among other things (i) a lump sum payment of 1.5
times base  salary  and 1.5 times the  average  bonus paid for the three  fiscal
years  prior to the  Termination  Date (as  defined  in the  Change  of  Control
Agreement),  (ii) health  coverage and  benefits for a period of 24 months,  and
(iii) certain outplacement/administrative support for a period of 18 months.

      The foregoing  statements are qualified in their entirety by the Company's
press release, a complete copy of which is filed herewith as Exhibit 99.1 and is
incorporated herein by reference.





ITEM 7. FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS.

        (c)   Exhibits.

        Exhibit No.     Description
        -----------     -----------

          99.1          Press Release dated December 8, 2003





                                   SIGNATURES


      Pursuant to the  requirements of the Securities  Exchange Act of 1934, the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned, hereunto duly authorized.

                                    COLLAGENEX PHARMACEUTICALS, INC.



                                     By: /s/ Nancy C. Broadbent
                                         -----------------------------
                                         Nancy C. Broadbent
                                         Chief Financial Officer
                                         (Principal Financial Officer)


Date:  December 8, 2003