For Immediate Release:
- ---------------------
                                        Company Contact:
                                        ----------------
December 8, 2003                        Nancy C Broadbent
                                        Chief Financial Officer
                                        (215) 579-7388

                                        Investor Relations:
                                        -------------------
                                        Lisa M. Wilson
                                        In-Site Communications
                                        (212) 759-3929


            CollaGenex Pharmaceuticals Appoints New CEO and President
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     NEWTOWN, PA, DECEMBER 8, 2003 - CollaGenex  Pharmaceuticals,  Inc. (Nasdaq:
CGPI) today announced that it has appointed Colin W. Stewart to succeed Brian M.
Gallagher,  PhD,  as  the  Company's  president  and  chief  executive  officer,
effective immediately. Mr. Stewart will also be a member of the CollaGenex board
of  directors.  Dr.  Gallagher  will remain on the board as a director  and will
provide certain consulting services to the company for a period of 24 months.

      "We are pleased to welcome  Colin  Stewart to  CollaGenex as the Company's
president and chief executive officer and to its board of directors," said James
E.  Daverman,  a CollaGenex  board member since 1995.  "Colin  brings a depth of
pharmaceutical  business  experience  to  CollaGenex  at an exciting time in the
Company's  history.  He has built a solid track record of achieving strong sales
growth and profitability  through  pharmaceutical  brand  development,  creating
integrated  product  portfolios and  successfully  building and leveraging sales
forces.  He is also  experienced in bringing  products  through both the FDA and
European regulatory approval processes, and he has launched and managed numerous
pharmaceutical  products  in a  broad  range  of  therapeutic  areas,  including
dermatology  and  oncology   products  as  well  as  in-licensed   products  and
pharmaceuticals that were subject to generic competition.  We are confident that
his skills and experience  make Colin the right person to lead CollaGenex to the
next stage of its corporate development."

      Daverman  continued,  "On  behalf  of the  board,  I want to  thank  Brian
Gallagher for his service to CollaGenex over the past nine years.  Brian was the
first  employee of  CollaGenex  and led the  development  and launch of the most





successful systemic  pharmaceutical ever in the dental arena. During his tenure,
CollaGenex  became the leading  specialty  pharmaceutical  company in the dental
industry and is poised for growth in the much larger dermatology  market. We are
grateful  for his  contributions  and pleased  that he has agreed to continue to
assist us by serving as a director and consultant to the Company."

      Mr.  Stewart  said,  "I am  delighted to be joining  CollaGenex  at such a
critical and exciting time. I share the board's  vision that  CollaGenex has the
people,  products  and  technology  to  become  a  major  diversified  specialty
pharmaceutical  company,  and I am  pleased  to have the  opportunity  to play a
significant role in shaping the Company's future."

      Mr.  Stewart,  a 28-year  veteran  of the  pharmaceutical  industry,  most
recently was president and chief executive officer of Muro Pharmaceutical, Inc.,
a subsidiary of Viatris GmbH. He previously served 10 years with the ASTA Medica
Group where he managed  several  pharmaceutical  business units in  increasingly
senior management  positions.  He began his career as a sales representative for
Winthrop  Laboratories  Ltd in the  U.K.  and  subsequently  held  a  number  of
positions of increasing  responsibility  with  Winthrop in sales,  marketing and
operational management.

      Mr. Stewart, a U.K. citizen, received a Diploma in Management Studies from
Teesside  Polytechnic and a Master of Science degree in management  studies from
Durham University Business School.

      CollaGenex  Pharmaceuticals,  Inc. is a specialty  pharmaceutical  company
currently  focused on providing  innovative  medical therapies to the dental and
dermatology markets.  Currently,  the Company's  115-person  professional dental
pharmaceutical  sales  force  markets  Periostat(R),  which is  indicated  as an
adjunct to scaling and root planing for the  treatment  of adult  periodontitis.
Periostat(R) is the first and only  pharmaceutical to treat periodontal  disease
by  inhibiting  the enzymes that destroy  periodontal  support  tissues,  and by
enhancing bone protein synthesis.

      The sales force also promotes Vioxx(R), a Merck & Co. drug that CollaGenex
co-promotes  for the  treatment of acute dental pain;  Pandel,  a  prescription,
topical corticosteroid licensed from Altana, Inc.; Sirius Laboratories' AVAR(TM)





product line for the topical  control of acne  vulgaris,  rosacea and seborrheic
dermatitis;  and Atridox(R),  Atrisorb(R)  FreeFlow(TM) and Atrisorb-D FreeFlow,
Atrix Laboratories Inc.'s products for the treatment of adult periodontitis.

      Research has shown that certain  unique  properties  of the  tetracyclines
discovered  during the  development of  Periostat(R)  may be applicable to other
diseases  involving  inflammation  and/or  destruction of the body's  connective
tissues,  including acne,  rosacea,  meibomianitis and cancer metastasis,  among
others.  CollaGenex  is  further  evaluating  Periostat(R),  as  well as the new
IMPACS(R)  compounds,  to assess  whether  they are safe and  effective in these
applications.   In  addition,   CollaGenex  has  licensed  the   Restoraderm(TM)
technology,  a unique,  proprietary  dermal drug  delivery  system,  in order to
develop a range of topical  dermatological  products with enhanced pharmacologic
and cosmetic properties.

      To receive  additional  information  on the Company,  please visit our Web
site at www.collagenex.com, which does not form part of this press release.

      This press release contains forward-looking  statements within the meaning
of Section 21E of the Securities and Exchange Act of 1934, as amended. Investors
are cautioned that  forward-looking  statements involve risks and uncertainties,
which may affect the Company's business and prospects. The Company's business of
selling, marketing and developing pharmaceutical products is subject to a number
of significant  risks,  including  risks relating to the  implementation  of the
Company's sales and marketing plans for Periostat(R) and other products that the
Company markets,  the outcome and consequences of the patent litigation  against
Mutual and the outcome of  litigation  initiated  by Mutual,  risks that the FDA
will approve generic products, such as Mutual's products, that will compete with
and  limit  the  market  for  Periostat(R),   risks  inherent  in  research  and
development  activities,  risks associated with conducting  business in a highly
regulated  environment and  uncertainty  relating to clinical trials of products
under  development,  all as discussed in the Company's periodic filings with the
U.S. Securities and Exchange Commission.

Periostat(R),   IMPACS(R)  and  Metastat(R)  are  registered   trademarks,   and
Restoraderm(TM) is a trademark, of CollaGenex Pharmaceuticals, Inc.





All other trade  names,  trademarks  or service  marks are the property of their
respective owners and are not the property of CollaGenex  Pharmaceuticals,  Inc.
or any of our subsidiaries.

Pandel(R) is a trademark of Taisho Pharmaceuticals.

VIOXX(R) is a trademark of Merck & Co., Inc.

AVAR(TM) is a trademark of Sirius Laboratories, Inc.

Atridox(R) and  Atrisorb(R)  are registered  trademarks,  and  FreeFlow(TM) is a
trademark, of Atrix Laboratories, Inc.


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