Exhibit 23.1

                          Independent Auditors' Consent


The Board of Directors
CollaGenex Pharmaceuticals, Inc.:

We consent to the incorporation by reference in the registration statements (No.
333-31229,  No.  333-73230 and No.  333-112564) on Form S-8 and the registration
statements (No.  333-88697,  No. 333-35634,  No. 333-53766,  No. 333-58568,  No.
333-67044, No. 333-72166, No. 333-87556, No. 333-102773,  No. 333-103008 and No.
333-107918) on Form S-3 of CollaGenex Pharmaceuticals,  Inc. of our report dated
February 20, 2004, with respect to the consolidated balance sheets of CollaGenex
Pharmaceuticals, Inc. and subsidiaries as of December 31, 2003 and 2002, and the
related  consolidated  statements of operations,  stockholders'  equity and cash
flows for each of the years in the  three-year  period ended  December 31, 2003,
and the  related  financial  statement  schedule,  for each of the  years in the
three-year  period ended December 31, 2003, which report appears in the December
31, 2003 Annual Report on Form 10-K of CollaGenex Pharmaceuticals, Inc.

                                  /s/ KPMG LLP

Princeton, New Jersey
March 15, 2004