Exhibit 32.1

                CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350,

                             AS ADOPTED PURSUANT TO

                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002


     In   connection   with  the  Annual  Report  on  Form  10-K  of  CollaGenex
Pharmaceuticals,  Inc. (the "Company") for the period ended December 31, 2003 as
filed with the  Securities  and  Exchange  Commission  on the date  hereof  (the
"Report"),  the undersigned,  Colin W. Stewart,  Chief Executive  Officer of the
Company,  and Nancy C. Broadbent,  Chief Financial Officer of the Company,  each
hereby certifies, pursuant to 18 U.S.C. Section 1350, that:

     (1) The Report fully  complies  with the  requirements  of Section 13(a) or
15(d) of the Securities Exchange Act of 1934; and

     (2)  The  information  contained  in the  Report  fairly  presents,  in all
material  respects,  the  financial  condition  and results of operations of the
Company.

     A signed  original of this  written  statement  required by Section 906 has
been  provided  to  CollaGenex  Pharmaceuticals,  Inc.  and will be  retained by
CollaGenex  Pharmaceuticals,  Inc. and furnished to the  Securities and Exchange
Commission or its staff upon request.



                                                     /s/ Colin W. Stewart
                                                     -------------------------
Dated:   March 15, 2004                              Colin W. Stewart
                                                     Chief Executive Officer


                                                     /s/ Nancy C. Broadbent
                                                     -------------------------
Dated:   March 15, 2004                              Nancy C. Broadbent
                                                     Chief Financial Officer