HALE AND DORR LLP
                 (a Massachusetts Limited Liability Partnership)
                                COUNSELORS AT LAW
                              650 College Road East
                           Princeton, New Jersey 08540


                                                    March 17, 2004


Senesco Technologies, Inc.
303 George Street, Suite 420
New Brunswick, New Jersey 08901

     Re:   Registration Statement on Form S-3
           ----------------------------------

Ladies and Gentlemen:

     This  opinion  is  furnished  to you  in  connection  with  a  Registration
Statement  on Form  S-3 (the  "Registration  Statement")  to be  filed  with the
Securities and Exchange  Commission (the "Commission")  under the Securities Act
of 1933, as amended (the "Securities Act"), for the registration of an aggregate
of 2,651,663  shares of Common Stock,  $0.01 par value per share (the "Shares"),
of Senesco  Technologies,  Inc., a Delaware corporation (the "Company").  All of
the Shares are being registered on behalf of certain stockholders of the Company
(the "Selling Stockholders").

     We  are  acting  as  counsel  for  the  Company  in  connection   with  the
registration  for resale of the Shares.  We have  examined  signed copies of the
Registration  Statement to be filed with the  Commission.  We have also examined
and  relied  upon  minutes  of  meetings  of the  stockholders  and the Board of
Directors of the Company as provided to us by the Company, stock record books of
the  Company  as  provided  to us by  the  Company,  the  Amended  and  Restated
Certificate of  Incorporation  and Amended and Restated  By-Laws of the Company,
and such other  documents as we have deemed  necessary for purposes of rendering
the opinions hereinafter set forth.

     In  our  examination  of the  foregoing  documents,  we  have  assumed  the
genuineness of all signatures, the authenticity of all documents submitted to us
as originals, the conformity to original documents of all documents submitted to
us as copies, the authenticity of the originals of such latter documents and the
legal competence of all signatories to such documents.

     We assume that the appropriate action will be taken, prior to the offer and
sale of the  Shares,  to  register  and  qualify  the  Shares for sale under all
applicable state securities or "blue sky" laws.

     We express no  opinion  herein as to the laws of any state or  jurisdiction
other than the laws of the State of New Jersey,  the General  Corporation Law of
the State of Delaware and the federal laws of the United States of America.

     Based upon and subject to the  foregoing,  and  assuming the receipt of the
appropriate  consideration for the Shares, we are of the opinion that the Shares
have been duly authorized and are validly issued, fully paid and nonassessable.

     It is understood  that this opinion is to be used only in  connection  with
the offer and sale of the Shares while the Registration Statement is in effect.



     Please note that we are opining only as to the matters  expressly set forth
herein, and no opinion should be inferred as to any other matters.  This opinion
is based upon  currently  existing  statutes,  rules,  regulations  and judicial
decisions,  and we disclaim any obligation to advise you of any change in any of
these sources of law or  subsequent  legal or factual  developments  which might
affect any matters or opinions set forth herein.

     We hereby  consent to the filing of this opinion with the  Commission as an
exhibit to the  Registration  Statement in accordance  with the  requirements of
Item  601(b)(5) of Regulation S-K under the Securities Act and to the use of our
name therein and in the related prospectus under the caption "Legal Matters." In
giving  such  consent,  we do not hereby  admit that we are in the  category  of
persons whose consent is required  under Section 7 of the  Securities Act or the
rules and regulations of the Commission.

                                                 Very truly yours,

                                                 /s/ Hale and Dorr LLP

                                                 HALE AND DORR LLP