UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              Washington, DC 20549

                                  SCHEDULE 14A
                                 (Rule 14a-101)

                     INFORMATION REQUIRED IN PROXY STATEMENT

                            SCHEDULE 14A INFORMATION

           Proxy Statement Pursuant to Section 14(a) of the Securities
                      Exchange Act of 1934 (Amendment No. )

   Filed by the Registrant      |X|
   Filed by a Party other than the Registrant   |_|

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   |_|  Preliminary Proxy Statement
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        (as permitted by Rule 14a-6(e)(2))
   |X|  Definitive Proxy Statement
   |_|  Definitive Additional Materials
   |_|  Soliciting Material Pursuant to ss.240.14a-12

                        CollaGenex Pharmaceuticals, Inc.
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified in Its Charter)


- --------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if Other Than the Registrant)

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                        COLLAGENEX PHARMACEUTICALS, INC.
                               41 University Drive
                                Newtown, PA 18940



                                          April 23, 2004

To Our Stockholders:

      You  are  cordially  invited  to  attend  the  2004  Annual  Meeting  of
Stockholders of CollaGenex Pharmaceuticals,  Inc. at 8:30 A.M., local time, on
Tuesday,  May 25,  2004, at the  Philadelphia  Marriott  Downtown Hotel,  1201
Market Street, Philadelphia, Pennsylvania 19107.

      The Notice of Meeting and Proxy  Statement on the following pages describe
the matters to be presented at the meeting.

      It is important  that your shares be represented at this meeting to assure
the presence of a quorum. Whether or not you plan to attend the meeting, we hope
that you will have your stock represented by signing,  dating and returning your
proxy in the enclosed envelope, as soon as possible. Your stock will be voted in
accordance with the instructions you have given in your proxy.

      Thank you for your continued support.


                                          Sincerely,

                                          /s/ Colin W. Stewart

                                          Colin W. Stewart
                                          President and Chief Executive
                                          Officer





                        COLLAGENEX PHARMACEUTICALS, INC.
                               41 University Drive
                                Newtown, PA 18940


                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                             To Be Held May 25, 2004


      The Annual Meeting of Stockholders of COLLAGENEX PHARMACEUTICALS,  INC., a
Delaware corporation,  will be held at the Philadelphia Marriott Downtown Hotel,
1201 Market Street, Philadelphia,  Pennsylvania 19107, on Tuesday, May 25, 2004,
at 8:30 A.M., local time, for the following purposes:

(1) To  elect  eight  directors  to  serve  until  the next  Annual  Meeting  of
    Stockholders  and until  their  respective  successors  shall have been duly
    elected and qualified;

(2) To ratify the  appointment of KPMG LLP as our  independent  auditors for the
    year ending December 31, 2004; and

(3) To  transact  such other  business  as may  properly  come before the Annual
    Meeting or any adjournment or adjournments thereof.

      Holders of our common stock and Series D preferred  stock of record at the
close of business on April 14, 2004 are entitled to notice of and to vote at the
Annual Meeting,  or any adjournment or adjournments  thereof. A complete list of
such  stockholders  will be open to the  examination  of any  stockholder at our
principal executive offices at 41 University Drive, Newtown, Pennsylvania 18940,
during  ordinary  business  hours,  for a period of 10 days  prior to the Annual
Meeting as well as on the day of the Annual  Meeting.  The Annual Meeting may be
adjourned  from time to time without  notice other than by  announcement  at the
Annual Meeting.

      IT IS IMPORTANT THAT YOUR SHARES BE  REPRESENTED  REGARDLESS OF THE NUMBER
OF SHARES YOU MAY HOLD. WHETHER OR NOT YOU PLAN TO ATTEND THE MEETING IN PERSON,
PLEASE  COMPLETE,  DATE AND SIGN THE ENCLOSED PROXY CARD AND MAIL IT PROMPTLY IN
THE ENCLOSED RETURN ENVELOPE.  THE PROMPT RETURN OF PROXIES WILL ENSURE A QUORUM
AND SAVE US THE  EXPENSE OF FURTHER  SOLICITATION.  EACH  PROXY  GRANTED  MAY BE
REVOKED BY THE STOCKHOLDER APPOINTING SUCH PROXY AT ANY TIME BEFORE IT IS VOTED.
IF YOU RECEIVE MORE THAN ONE PROXY CARD BECAUSE  YOUR SHARES ARE  REGISTERED  IN
DIFFERENT NAMES OR ADDRESSES, EACH SUCH PROXY CARD SHOULD BE SIGNED AND RETURNED
TO ASSURE THAT ALL OF YOUR SHARES WILL BE VOTED.


                                          By Order of the Board of Directors

                                          /s/ Nancy C. Broadbent

                                          Nancy C. Broadbent
                                          Secretary


Newtown, Pennsylvania
April 23, 2004


             Our 2003 Annual Report accompanies the Proxy Statement.






                        COLLAGENEX PHARMACEUTICALS, INC.
                               41 University Drive
                                Newtown, PA 18940


          ------------------------------------------------------------
                                 PROXY STATEMENT
          ------------------------------------------------------------

      This Proxy Statement is furnished in connection  with the  solicitation by
the Board of Directors of CollaGenex Pharmaceuticals,  Inc. (also referred to in
this Proxy Statement as the "Company," "CollaGenex," "we" or "us") of proxies to
be voted at our Annual Meeting of  Stockholders  to be held on Tuesday,  May 25,
2004  at  the  Philadelphia   Marriott   Downtown  Hotel,  1201  Market  Street,
Philadelphia,   Pennsylvania  19107  at  8:30  a.m.,  local  time,  and  at  any
adjournment or adjournments thereof. Holders of record of our common stock, $.01
par value per share, and Series D cumulative  convertible  preferred stock, $.01
par value per share,  as of the close of  business  on April 14,  2004,  will be
entitled to notice of and to vote at the Annual  Meeting and any  adjournment or
adjournments  thereof.  As of that  date,  there were  14,131,377  shares of our
common stock issued and  outstanding  and entitled to vote and 200,000 shares of
our Series D preferred  stock issued and  outstanding and entitled to vote. Such
shares of Series D  preferred  stock  were,  as of such date,  convertible  into
2,021,572 shares of common stock.  Except for the proposal to elect the Series D
Director (as  hereinafter  defined),  as set forth  below,  each share of common
stock is entitled to one vote on any matter presented at the Annual Meeting. The
aggregate number of common stock votes entitled to be cast at the Annual Meeting
is 16,152,949,  including the 2,021,572 shares underlying the Series D preferred
stock to be voted on an as converted  to common stock basis.  The holders of all
classes of stock will vote as a single class for all proposals generally, except
that only the holders of Series D preferred  stock will vote as a separate class
for the proposal to elect the Series D Director.

      If proxies in the  accompanying  form are properly  executed and returned,
the shares of common stock and Series D preferred stock represented thereby will
be voted in the manner specified therein. If not otherwise specified, the shares
of common stock and Series D preferred stock  represented by the proxies will be
voted (i) FOR, as applicable,  the election of the eight nominees named below as
directors,  (ii)  FOR the  ratification  of the  appointment  of KPMG LLP as our
independent  auditors for the year ending  December  31, 2004,  and (iii) in the
discretion  of the persons  named in the  enclosed  form of proxy,  on any other
proposals  which may properly come before the Annual Meeting or any  adjournment
or adjournments thereof. Any stockholder who has submitted a proxy may revoke it
at any time before it is voted,  by written notice  addressed to and received by
the  Secretary of the Company,  by  submitting a duly  executed  proxy bearing a
later  date or by  electing  to vote in person at the Annual  Meeting.  The mere
presence  at the  Annual  Meeting  of the  person  appointing  a proxy does not,
however, revoke the appointment.

      The  presence,  in person or by proxy,  of holders of shares of our common
stock,  including the shares of common stock  underlying  the Series D preferred
stock to be voted on an as converted to common  stock  basis,  in the  aggregate
having a majority of the votes entitled to be cast by such holders at the Annual
Meeting,  shall  constitute a quorum with respect to all matters  except for the
election of directors. The presence, in person or by proxy, of holders of shares
of each of our common  stock and our Series D preferred  stock having a majority
of the votes entitled to be cast by each respective class of stock at the Annual
Meeting  shall  constitute a quorum with respect to the election of directors to
be elected by each respective  class.  The affirmative  vote by the holders of a
plurality of the shares of common stock  represented at the Annual Meeting,  but
not including the shares of common stock underlying the Series D preferred stock
to be voted on an as  converted  to common  stock  basis,  is  required  for the
election of  directors  other than the Series D  Director,  provided a quorum of
such  stockholders is present in person or by proxy. The affirmative vote by the
holders of a majority of the shares of Series D preferred  stock  represented at
the Annual  Meeting  is  required  for the  election  of the Series D  Director,
provided  a quorum is  present.  All  actions  proposed  herein  other  than the
election of directors  may be taken upon the  affirmative  vote of  stockholders
possessing a majority of the requisite  voting power  represented  at the Annual
Meeting, provided a quorum is present in person or by proxy.






      Abstentions  are included in the shares  present at the Annual Meeting for
purposes of determining  whether a quorum is present,  and are counted as a vote
against for  purposes of  determining  whether a proposal  is  approved.  Broker
non-votes  (when  shares  are  represented  at the  Annual  Meeting  by a  proxy
specifically conferring only limited authority to vote on certain matters and no
authority to vote on other  matters) are  included in the  determination  of the
number of shares  represented  at the Annual Meeting for purposes of determining
whether a quorum is present  but are not counted  for  purposes  of  determining
whether a proposal has been approved and thus have no effect on the outcome.

      This Proxy  Statement,  together  with the related  proxy cards,  is being
mailed to our  stockholders  on or about April 23,  2004.  The Annual  Report to
Stockholders  of the Company for the year ended  December  31,  2003,  including
consolidated  financial  statements,  is being mailed  together  with this Proxy
Statement to all  stockholders  of record as of April 14, 2004. In addition,  we
have provided brokers,  dealers,  banks, voting trustees and their nominees,  at
our expense,  with  additional  copies of the Annual  Report so that such record
holders could supply such materials to beneficial owners as of April 14, 2004.



                                      -2-



                              ELECTION OF DIRECTORS

      At the Annual  Meeting,  eight  directors are to be elected  (which number
shall  constitute  our entire Board of  Directors) to hold office until the 2005
Annual  Meeting  of  Stockholders  and until  their  successors  shall have been
elected and  qualified.  The holders of common  stock,  voting as a class,  will
elect seven  directors.  The holders of Series D  preferred  stock,  voting as a
class,  will elect one  director  (referred  to in this proxy  statement  as the
"Series D Director").

      It is the  intention of the persons named in the enclosed form of proxy to
vote the stock represented thereby, unless otherwise specified in the proxy, for
the  election as  directors of the persons  whose names and  biographies  appear
below. All such persons are, at present,  members of our Board of Directors.  In
the event any of the nominees should become  unavailable or unable to serve as a
director,  it is  intended  that  votes  will be cast for a  substitute  nominee
designated  by our Board of  Directors.  The Board of Directors has no reason to
believe that the nominees named will be unable to serve if elected.  Each of the
nominees has  consented to being named in this Proxy  Statement  and to serve if
elected.

      The current  members of our Board of Directors,  who are also nominees for
election to our Board of Directors, are as follows:

Common Stock Directors:
- -----------------------

                                    Served as a     Position(s) with
Name                         Age   Director Since     the Company
- ----                         ---   --------------   ----------------
Colin W. Stewart..........   52        2003         President and Chief
                                                      Executive Officer
Brian M. Gallagher, Ph.D..   56        1994         Director
Peter R. Barnett, D.M.D...   52        1997         Director
Robert C. Black...........   61        1999         Director
James E. Daverman.........   54        1995         Chairman of the Board and
                                                      Director
Robert J. Easton..........   59        1993         Director
W. James O'Shea...........   54        2000         Director


Series D Preferred Stock Director:
- ----------------------------------

                                    Served as a     Position(s) with
Name                         Age   Director Since     the Company
- ----                         ---   --------------   ----------------

Stephen A. Kaplan.........   45        1999         Director

      The principal  occupations and business experience,  for at least the past
five years, of each nominee are as follows:



                                      -3-



      Mr.  Stewart  joined  CollaGenex  in December  2003 as President and Chief
Executive  Officer,  and has  been a member  of our  Board  of  Directors  since
December 2003.  From October 1998 until November 2003, Mr. Stewart served as the
President  and  Chief  Executive   Officer  of  Muro   Pharmaceutical,   Inc.  a
pharmaceutical  company.  From 1988 to 1998,  Mr.  Stewart was  employed by ASTA
Medica Ltd. in a number of sales,  marketing and general management positions of
increasing   responsibility.   Prior  to  1988,  Mr.  Stewart  was  employed  by
Sterling-Winthrop,  Ltd., a United Kingdom pharmaceutical  company, for 13 years
in sales and general management.

      Dr.  Gallagher was our President  and Chief  Executive  Officer from April
1994 until December 2003, has been a member of our Board of Directors since 1994
and was  Chairman of the Board of  Directors  from March 2000  through  December
2003.  From 1988 until April 1994, Dr.  Gallagher was employed by  Bristol-Myers
Squibb Company and its predecessor,  Squibb  Corporation,  in various  executive
positions  including   strategic   planning,   worldwide  product  and  business
development  and marketing.  From 1991 until April 1994, Dr.  Gallagher was Vice
President  and  General  Manager of Squibb  Diagnostics  in the in vivo  imaging
pharmaceutical  division. Prior to 1991, Dr. Gallagher served for ten years with
E.I.  DuPont  de  Nemours  &  Co.  in  a  variety  of  pharmaceutical  research,
development, marketing and business management positions.

      Dr.  Barnett has been a member of our Board of  Directors  since  February
1997. Dr.  Barnett has served as an  independent  consultant in the managed care
field since November  2003.  Prior to that,  from November 2002 through  October
2003,  Dr.  Barnett  served as President  and Chief  Executive  Officer of Group
Dental  Service,  Inc.,  a dental  insurance  company.  From  September  2001 to
November 2002, he served as an independent  healthcare  consultant.  Dr. Barnett
was formerly the President, Chief Executive Officer and a member of the Board of
Directors of  HealthASPex,  Inc., a claims  technology  firm,  from June 2000 to
September  2001.  He was also  President and Chief  Operating  Officer of United
Dental  Care,  Inc., a managed  dental  benefits  firm,  where he served in such
capacity from January 1995 until May 2000. From August 1994 to January 1995, Dr.
Barnett was Executive  Director of Prudential DMO, and from March 1993 to August
1994, he served as an  independent  consultant  in the managed care field.  From
January 1985 to March 1993,  Dr. Barnett was a Senior Vice President with Pearle
Vision, Inc.

      Mr.  Black  has been a member of our Board of  Directors  since  September
1999. He was President of the Zeneca  Pharmaceuticals  Division of  AstraZeneca,
Inc., a  pharmaceutical  company,  until his  retirement in June 1999. He joined
AstraZeneca,  Inc. in 1965 as a  pharmaceutical  sales  representative  and held
numerous positions of increasing  responsibility in sales and marketing prior to
becoming President of the Zeneca Pharmaceuticals Division in 1991.

      Mr.  Daverman has been a member of our Board of Directors  since  November
1995 and became the  Chairman of the Board of  Directors  in January  2004.  Mr.
Daverman is managing  general partner of Redfish  Partners,  L.P., an investment
and consulting company. Mr. Daverman also is a Senior Advisor to Robert W. Baird
and Co. Incorporated,  an investment banking  organization,  and Chairman of the
Advisory Boards of Baird Venture  Partners and Baird Capital  Partners,  Baird's
private  equity  businesses.  Until October 2003 when he retired,  Mr.  Daverman
served as managing  general  partner of Marquette  Venture  Partners,  a venture
capital  investment  company that he co-founded in 1986. Mr.  Daverman is also a
member of the board of directors of Welch Allyn Holdings, Inc., a global medical
products company that is family owned. He chairs the Compensation and Management
Development  Committee of the board of directors  of Welch Allyn.  Mr.  Daverman
serves on the board of directors of several other privately-held companies.

      Mr.  Easton  has been a member of our Board of  Directors  since  November
1993.  He currently  serves as the Chairman of Easton  Associates,  a healthcare
consulting  firm,  and has held this  position  since May 2000.  He was formerly
Managing  Director  of IBM  Healthcare  Consulting,  Inc.,  a major  health care
consulting  firm,  where he served in such capacity  from 1981 to May 2000.  Mr.
Easton is a former President of the Biomedical Marketing Association. Mr. Easton
is  a  member  of  the  Board  of  Directors   of  Cepheid,   Inc.  and  several
privately-held companies.

      Mr.  O'Shea has been a member of our Board of  Directors  since  September
2000. He currently serves as President and Chief Operating  Officer of Sepracor,
Inc., a position he has held since  October 1999.  Formerly,  he was Senior Vice
President of AstraZeneca,  Inc., a pharmaceutical  company, from 1975 to October
1999.

      Mr.  Kaplan has been a member of our Board of  Directors  since  September
1999.  He is a principal and portfolio  manager of Oaktree  Capital  Management,
LLC, which is the general partner of OCM Principal  Opportunities  Fund, L.P., a
venture  capital fund. He has held such  positions  since June 1995 and November
1993,



                                      -4-



respectively.  From November 1993 to May 1995 he was Managing  Director of Trust
Company of The West.  Mr.  Kaplan  serves as a director  of Regal  Entertainment
Group and  General  Maritime  Corporation,  as well as  numerous  privately-held
companies.

      Pursuant to the terms of the Certificate of  Designation,  Preferences and
Rights of Series D  Cumulative  Convertible  Preferred  Stock,  as amended,  the
holders of the Series D  preferred  stock,  acting as a single  class,  have the
right to designate and elect one member of our Board of  Directors.  The holders
of the Series D preferred  stock have exercised  such right by  designating  Mr.
Kaplan to serve as a member of our Board of Directors.

      All  directors   will  hold  office  until  the  next  annual  meeting  of
stockholders  and until  their  successors  shall  have been  duly  elected  and
qualified.  None of our directors are related to any other director or to any of
our executive officers.

      THE BOARD OF DIRECTORS RECOMMENDS THAT STOCKHOLDERS,  AS APPLICABLE,  VOTE
FOR EACH OF THE  NOMINEES FOR THE BOARD OF  DIRECTORS.  PLEASE NOTE THAT PROXIES
CANNOT BE VOTED FOR A GREATER NUMBER OF PERSONS THAN THE NOMINEES NAMED ABOVE.



                                      -5-



                              CORPORATE GOVERNANCE

General
- -------

      We believe that good  corporate  governance is important to ensure that we
are managed for the long-term benefit of our stockholders. During the past year,
we have continued to review our corporate  governance policies and practices and
to  compare  them  to  those  suggested  by  various  authorities  in  corporate
governance and the practices of other public  companies.  We have also continued
to review the provisions of the Sarbanes-Oxley Act of 2002, the new and proposed
rules of the Securities and Exchange Commission and the new listing standards of
the NASDAQ National Market.

      Based on this review,  in January  2004,  our Board of  Directors  adopted
Corporate  Governance  Guidelines,  a Code of  Business  Conduct  and Ethics and
charters for each of our  Nominating  and  Corporate  Governance  Committee  and
Compensation  Committee.  In February  2004,  we also  amended and  restated the
charter for our Audit Committee. This section describes key corporate governance
guidelines  and  practices  that we have  adopted.  You can access  our  current
committee charters, Corporate Governance Guidelines and Code of Business Conduct
and  Ethics in the  "Corporate  Governance"  section of our  website  located at
www.collagenex.com  or  by  writing  to:  Nancy  C.  Broadbent,  c/o  CollaGenex
Pharmaceuticals, Inc., 41 University Drive, Newtown, Pennsylvania 18940.

Corporate Governance Guidelines
- -------------------------------

      The Board has adopted corporate governance  guidelines to assist the Board
in the  exercise  of its  duties  and  responsibilities  and to  serve  the best
interests of the Company and its stockholders. These guidelines, which provide a
framework for the conduct of the Board's business, include that:

     o    the  principal  responsibility  of the  directors  is to  oversee  the
          management of the Company;

     o    a majority of the members of the Board shall be independent directors;

     o    the  non-management/independent  directors meet regularly in executive
          session;

     o    directors  have full and free access to  management  and, as necessary
          and appropriate, independent advisors;

     o    new directors  participate in an orientation program and all directors
          are expected to  participate  in continuing  director  education on an
          ongoing basis; and

     o    at least  annually,  the  Board  and its  committees  will  conduct  a
          self-evaluation to determine whether they are functioning effectively.

Determination of Independence
- -----------------------------

      Under NASDAQ rules that become  applicable to us on the date of the Annual
Meeting,  a director will only qualify as an  "independent  director" if, in the
opinion of our Board of  Directors,  that  person  does not have a  relationship
which would interfere with the exercise of independent  judgment in carrying out
the  responsibilities of a director.  Our Board of Directors has determined that
none of  Messrs.  Barnett,  Black,  Daverman,  O'Shea,  Kaplan or  Easton  has a
relationship which would interfere with the exercise of independent  judgment in
carrying out the responsibilities of a director and that each of these directors
is an  "independent  director" as defined under Rule  4200(a)(15)  of the NASDAQ
Stock Market, Inc. Marketplace Rules.

Director Candidates
- -------------------

      The process followed by the Nominating and Corporate  Governance Committee
to identify and evaluate director  candidates includes requests to Board members
and  others  for  recommendations,  meetings  from  time  to  time  to  evaluate
biographical   information  and  background   material   relating  to  potential
candidates and interviews of selected candidates by members of the Committee and
the Board.



                                      -6-



      In considering whether to recommend any particular candidate for inclusion
in the Board's  slate of  recommended  director  nominees,  the  Nominating  and
Corporate  Governance  Committee  will  apply  the  criteria  set  forth  in our
Nominating and Corporate  Governance  Committee Charter.  These criteria include
the  candidate's  integrity,  business  acumen,  knowledge  of our  business and
industry, experience, diligence, conflicts of interest and the ability to act in
the  interests  of all  stockholders.  The  Committee  does not assign  specific
weights to particular criteria and no particular criterion is a prerequisite for
each prospective  nominee. We believe that the backgrounds and qualifications of
our  directors,  considered  as a  group,  should  provide  a  composite  mix of
experience,  knowledge  and  abilities  that will allow the Board to fulfill its
responsibilities.

      Stockholders  may recommend  individuals  to the  Nominating and Corporate
Governance  Committee  for  consideration  as potential  director  candidates by
submitting their names, together with appropriate  biographical  information and
background  materials and a statement as to whether the  stockholder or group of
stockholders  making the  recommendation  has beneficially owned more than 5% of
our common stock for at least a year as of the date such recommendation is made,
to  Nominating  and Corporate  Governance  Committee,  c/o Corporate  Secretary,
CollaGenex  Pharmaceuticals,  Inc., 41 University Drive,  Newtown,  Pennsylvania
18940.  Assuming that appropriate  biographical and background material has been
provided on a timely basis, the Committee will evaluate  stockholder-recommended
candidates  by  following   substantially   the  same   process,   and  applying
substantially  the same  criteria,  as it follows for  candidates  submitted  by
others.

Communications from Stockholders
- --------------------------------

      The Board will give appropriate  attention to written  communications that
are  submitted  by  stockholders,  and will respond if and as  appropriate.  The
Chairman of the Nominating and Corporate Governance Committee, subject to advice
and assistance from our Chief Executive  Officer and, if requested,  our outside
legal  counsel,  is primarily  responsible  for monitoring  communications  from
stockholders  and for  providing  copies or summaries to the other  directors as
considered appropriate.

      Under  procedures  approved  by a majority of the  independent  directors,
communications  are  forwarded  to all  directors  if they  relate to  important
substantive matters and include suggestions or comments that the Chairman of the
Board  considers  to be  important  for  the  directors  to  know.  In  general,
communications relating to corporate governance and long-term corporate strategy
are more  likely  to be  forwarded  than  communications  relating  to  ordinary
business affairs, personal grievances and matters as to which we tend to receive
repetitive or duplicative communications.

      Stockholders  who wish to send  communications  on any  topic to the Board
should  address  such  communications  to  Board  of  Directors,  c/o  Corporate
Secretary,  CollaGenex  Pharmaceuticals,  Inc.,  41 University  Drive,  Newtown,
Pennsylvania 18940.

Code of Business Conduct and Ethics
- -----------------------------------

      We have adopted a written Code of Business Conduct and Ethics that applies
to our  directors,  officers and  employees,  including our principal  executive
officer,   principal   financial  officer,   principal   accounting  officer  or
controller,  or persons performing similar functions. We have posted the Code of
Business   Conduct   and   Ethics  on  our   website,   which  is   located   at
www.collagenex.com.  In  addition,  we intend to  disclose  on our  website  any
amendments  to, or waivers  from,  any provision of the Code that applies to our
principal executive officer,  principal financial officer,  principal accounting
officer or controller, or persons performing similar functions.

Board of Directors and Attendance by Members of the Board of Directors at
- -------------------------------------------------------------------------
Meetings
- --------

      Our Board of Directors  currently  consists of Colin W. Stewart,  Brian M.
Gallagher,  Ph.D., Peter R. Barnett, D.M.D., Robert C. Black, James E. Daverman,
who  serves as  Chairman,  Robert J.  Easton,  W.  James O' Shea and  Stephen A.
Kaplan. Our Amended and Restated By-Laws currently provide that the total number
of directors  comprising our Board of Directors shall be such number as is fixed
by our Board of Directors,  but in no event less than one. Pursuant to the terms
of the Certificate of Designation, Preferences and Rights of Series D Cumulative
Convertible Preferred Stock, as amended, our Board of Directors shall consist of
not less than five and not more than nine directors.  Our Board of Directors has
provided that our full Board of Directors  shall be comprised of nine directors.
Although we have nominated,  and are only seeking to elect, eight members to our
Board of Directors at this time, we are actively recruiting potential candidates
for the one vacancy.  This vacancy may be filled by the vote


                                      -7-



or written  consent of a majority  of our  directors  elected by the  holders of
record of our common  stock,  and shall serve  until the next annual  meeting of
stockholders, unless earlier removed or such director resigns.

      There were five meetings of the Board of Directors during 2003. Except for
Mr.  Stewart,  who became a member of our Board of Directors  in December  2003,
each  director  attended at least 75% of the  aggregate  of all  meetings of the
Board of  Directors  held during the period in which he served as a director and
the total number of meetings held by the committee on which he served during the
period, if applicable.

      Our Corporate Governance Guidelines provide that directors are expected to
attend the annual meeting of  stockholders.  Except for Mr. Stewart who became a
member of our Board of Directors in December  2003,  all directors  attended the
2003 Annual Meeting of Stockholders.

Committees of the Board
- -----------------------

      The Board of Directors has established three standing  committees - Audit,
Compensation  and Nominating  and Corporate  Governance - each of which operates
under a charter that has been approved by our Board of Directors. Current copies
of each committee's  charter are posted on the Corporate  Governance  section of
our website  located at  www.collagenex.com.  In  addition,  a copy of the Audit
Committee Charter, as in effect on the date of this proxy statement, is attached
hereto as Appendix A.
          ----------

      The Board of Directors has  determined  that all of the members of each of
the Board's three standing  committees are  independent as defined under the new
rules of the NASDAQ Stock Market that become applicable to us on the date of the
2004  Annual  Meeting,  including,  in the  case  of all  members  of the  Audit
Committee,  the independence  requirements  contemplated by Rule 10A-3 under the
Securities  Exchange Act of 1934.  In addition,  all of the members of the Audit
Committee  are  independent  as defined by the rules of the NASDAQ  Stock Market
that apply to us until the date of the 2004 Annual Meeting.

      Audit Committee of the Board of Directors
      -----------------------------------------

      The Audit Committee currently consists of James E. Daverman, who served as
the Chairman  during  2003,  Robert J. Easton and Peter R.  Barnett,  who serves
currently as Chairman.  During 2003, Messrs.  Daverman,  Easton and Barnett were
the only members of the Audit Committee.  The Audit Committee was established in
March 1996 and  currently  acts under a charter that was adopted and approved on
May 8, 2000 and that was  amended  and  restated  in  February  2004.  The Audit
Committee  held five  meetings in 2003. It is  anticipated  that each of Messrs.
Daverman,  Easton  and  Barnett,  if elected  to the Board of  Directors  by our
stockholders,  will  continue  to  serve  on  the  Audit  Committee.  Our  Audit
Committee's  responsibilities include:

     o    appointing,   approving  the   compensation   of,  and  assessing  the
          independence of our independent auditor;

     o    overseeing the work of our independent auditor,  including through the
          receipt  and   consideration   of  certain  reports  from  independent
          auditors;

     o    reviewing and discussing with management and the independent  auditors
          our annual and quarterly consolidated financial statements and related
          disclosures;

     o    monitoring our internal control over financial  reporting,  disclosure
          controls and procedures and code of business conduct and ethics;

     o    discussing our risk management policies;

     o    establishing   procedures   for   the   receipt   and   retention   of
          accounting-related complaints and concerns;

     o    meeting  independently  with our internal auditing staff,  independent
          auditors and management; and



                                      -8-



     o    preparing the audit  committee  report required by SEC rules (which is
          included on pages 10 and 11 of this proxy statement).

      Pursuant to the Audit Committee Charter,  the Audit Committee has reviewed
and discussed the audited  consolidated  financial statements for the year ended
December 31, 2003 with our management and  independent  auditors.  Additionally,
the Audit  Committee has  discussed  with the  independent  auditors the matters
required by Statement of Auditing Standards ("SAS") 61, has received the written
disclosures  and the  letter  from  the  independent  auditors  required  by the
Independence  Standards  Board  Standard  No.  1  and  has  discussed  with  the
independent auditors the independent  auditors'  independence.  Based in part on
the foregoing,  the Audit  Committee  recommended to the Board of Directors that
the consolidated  financial statements as of and for the year ended December 31,
2003 audited by KPMG LLP be included in our Annual Report on Form 10-K.

      The Board of Directors  has  determined  that James  Daverman is an "audit
committee financial expert" as defined in Item 401(h) of Regulation S-K.

      Compensation Committee of the Board of Directors
      ------------------------------------------------

      The  Compensation  Committee  currently  consists of W. James O'Shea,  who
serves as  Chairman,  Robert C. Black and  Robert J.  Easton.  The  Compensation
Committee  was  established  in March  1996 and  currently  acts under a charter
adopted and approved in January  2004.  The  Compensation  Committee  held eight
meetings in 2003. The primary  responsibilities  of the  Compensation  Committee
include approving salaries and incentive compensation for our executive officers
and  administering  our  stock  option  plans.  In  addition,  our  Compensation
Committee has the following principal duties:

     o    annually  reviewing  and  approving  corporate  goals  and  objectives
          relevant to the Chief Executive Officer's compensation;

     o    determining the Chief Executive Officer's compensation;

     o    reviewing and approving,  or making  recommendations to the Board with
          respect to, the compensation of our other executive officers;

     o    overseeing and administering our cash and equity incentive plans; and

     o    reviewing  and making  recommendations  to the Board  with  respect to
          director compensation.

          Nominating  and  Corporate   Governance  Committee  of  the  Board  of
          ----------------------------------------------------------------------
          Directors
          ---------

      In January  2004,  our Board of  Directors  reconstituted  our  Nominating
Committee to expand its  responsibilities  and formed a Nominating and Corporate
Governance Committee, which currently consists of Robert C. Black, who serves as
Chairman,  Peter R. Barnett and Stephen A. Kaplan.  The Nominating and Corporate
Governance  Committee  currently  acts under a charter  adopted and  approved in
January  2004.  The   Nominating   Committee  held  one  meeting  in  2003.  The
responsibilities of the Nominating and Corporate Governance Committee include:

     o    identifying and recommending nominees for election as directors and to
          each of the Board's committees;

     o    reviewing  and making  recommendations  to the Board  with  respect to
          management succession planning;

     o    reviewing  and  assessing  the  adequacy of our  corporate  governance
          guidelines  and  recommending  any  proposed  changes  to our Board of
          Directors; and

     o    overseeing an annual evaluation of the Board.



                                      -9-



Compensation of Directors
- -------------------------

      During 2003,  Brian M. Gallagher,  Ph.D. was not paid any compensation for
his services as Chairman of the Board. Each non-employee director is entitled to
receive  an annual  retainer  of  $12,000,  a fee of $2,000  for each  regularly
scheduled meeting of the Board of Directors attended in person and an annual fee
of $1,000 for each Committee on which he or she serves. We provide reimbursement
to directors for reasonable and necessary  expenses  incurred in connection with
attendance at meetings of the Board of Directors and other Company business.

      From  time-to-time,  members of the Board of  Directors  have been granted
options to purchase  shares of our common  stock.  See  "SECURITY  OWNERSHIP  OF
CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED SHAREHOLDER MATTERS."

      On May 20,  2003,  we granted to each  non-employee  director,  options to
purchase 12,000 shares of common stock at an exercise price per share of $10.80.
Such options vest in four equal annual  installments  commencing  one year after
the date of grant. In addition,  on May 20, 2003, Mr. O'Shea was granted options
to  purchase  2,500  shares of common  stock at an  exercise  price per share of
$10.80. Such options vest in four equal annual installments  commencing one year
after the date of grant. Beginning with the 2003 Annual Meeting of Stockholders,
upon re-election,  each non-employee  director shall automatically be granted an
option to purchase 12,000 shares of common stock, at an exercise price per share
equal to the then current fair market  value per share.  All such options  shall
become exercisable in four equal annual  installments  commencing one year after
the date of grant, provided that the optionee then remains a director.  Pursuant
to our 1996  Non-Employee  Director  Stock  Option Plan,  each new  non-employee
director is automatically  granted an option to purchase 25,000 shares of common
stock,  at an  exercise  price per share equal to the then  current  fair market
value per share.  All such  options  become  exercisable  in five  equal  annual
installments  commencing  one year  after the date of grant,  provided  that the
optionee then remains a director.  The right to exercise annual  installments of
options under the Non-Employee Plan will be reduced proportionately based on the
optionee's  actual  attendance  at  meetings  of the Board of  Directors  if the
optionee  fails to attend at least 75% of the meetings of the Board of Directors
held in any calendar year.

Report of the Audit Committee of the Board of Directors
- -------------------------------------------------------

      The Audit Committee has furnished the following report:

To the Board of Directors of CollaGenex Pharmaceuticals, Inc.:

      The Audit  Committee  has  reviewed  our  audited  consolidated  financial
statements for the fiscal year ended  December 31, 2003 and has discussed  these
consolidated  financial  statements  with  our  management  and our  independent
auditors.  Management is responsible  for the  preparation  of our  consolidated
financial  statements  and for  maintaining  an  adequate  system of  disclosure
controls and procedures and internal  control over financial  reporting for that
purpose.  Our independent auditors are responsible for conducting an independent
audit  of our  annual  consolidated  financial  statements  in  accordance  with
generally accepted accounting  principles and issuing a report on the results of
their audit.  The Audit  Committee is  responsible  for  providing  independent,
objective oversight of these processes.

      The Audit  Committee  has also received  from,  and  discussed  with,  our
independent  auditors various  communications that our independent  auditors are
required to provide to the Audit Committee, including the matters required to be
discussed  by  Statement  on Auditing  Standards  61  (Communication  with Audit
Committees).  SAS 61 requires our independent auditors to discuss with our Audit
Committee, among other things, the following:

     o    methods used to account for significant unusual transactions;

     o    the effect of  significant  accounting  policies in  controversial  or
          emerging areas for which there is a lack of authoritative  guidance or
          consensus;

     o    the process used by management in formulating  particularly  sensitive
          accounting  estimates  and the  basis  for the  auditors'  conclusions
          regarding the reasonableness of those estimates; and



                                      -10-



     o    disagreements  with  management  over the  application  of  accounting
          principles,  the basis for management's  accounting  estimates and the
          disclosures in the consolidated financial statements.

      Our  independent  auditors  also  provided  the Audit  Committee  with the
written  disclosures  and the letter  required by  Independence  Standards Board
Standard No. 1 (Independence  Discussions with Audit  Committees).  Independence
Standards Board Standard No. 1 requires auditors annually to disclose in writing
all relationships that, in the auditor's professional opinion, may reasonably be
thought to bear on independence, confirm their perceived independence and engage
in a discussion of independence. In addition, the Audit Committee discussed with
the independent auditors their independence from CollaGenex. The Audit Committee
also  considered  whether the independent  auditors'  provision of certain other
non-audit  related  services to us is compatible with maintaining such auditors'
independence.

      Based on its discussions with management and the independent auditors, and
its review of the representations and information provided by management and the
independent auditors,  the Audit Committee recommended to our Board of Directors
that the audited  consolidated  financial  statements  be included in our Annual
Report on Form 10-K for the year ended December 31, 2003.

James E. Daverman
Audit Committee Chairman

Robert J. Easton
Audit Committee Member

Peter R. Barnett
Audit Committee Member


Independent Auditors' Fees and Other Matters
- --------------------------------------------

      The following  table  summarizes the fees incurred by us for  professional
services rendered by KPMG LLP, our independent auditor, for each of the last two
fiscal years:

Fee Category                     2003                    2002
- ------------                   ---------              ---------

Audit Fees.............        $ 191,500              $ 132,000
Audit-Related Fees.....        $      --              $      --
Tax Fees...............        $  43,870              $  28,600
All Other Fees.........        $      --              $      --
                               ---------              ---------
    Total Fees.........        $ 235,370              $ 160,600
                               =========              =========

      Audit Fees
      ----------

      Audit  fees  consist of fees for the audit of our  consolidated  financial
statements, the review of the interim consolidated financial statements included
in our quarterly reports on Form 10-Q and other  professional  services provided
in connection with regulatory filings or engagements.

      Audit-Related Fees
      ------------------

      There were no fees to report in this category for 2003 and 2002.

      Tax Fees
      --------

      Tax fees consist of fees for tax  compliance,  tax advice and tax planning
services.



                                      -11-



      All Other Fees
      --------------

      There were no fees to report in this category for 2003 and 2002.

      Audit Committee Pre-Approval Policy and Procedures
      --------------------------------------------------

      The Audit  Committee has adopted  policies and procedures  relating to the
approval of all audit and  non-audit  services  that are to be  performed by our
independent auditor.  This policy generally provides that we will not engage our
independent  auditor to render audit or non-audit services unless the service is
specifically approved in advance by the Audit Committee.

      All engagements entered into with KPMG LLP subsequent to May 6, 2003, were
approved in accordance with the procedures described above.



                                      -12-



                               EXECUTIVE OFFICERS

      The following table identifies our current executive officers:

                                       Capacities in           In Current
Name                            Age    Which Served            Position Since
- ----                            ---    -------------           --------------

Colin W. Stewart............     52    President, Chief         December 2003
                                        Executive Officer
                                        and Director

Klaus Theobald(1)...........     45    Senior Vice              January 2004
                                        President and
                                        Chief Medical
                                        Officer

Nancy C. Broadbent(2).......     47    Chief Financial          March 1996
                                        Officer, Treasurer
                                        and Secretary

David F. Pfeiffer(3)........     40    Senior Vice              December 2000
                                        President, Sales        (Vice President,
                                        and Marketing           Marketing since
                                                                June 1997)


(1)  Dr. Theobald joined CollaGenex in January 2004 as Senior Vice President and
     Chief Medical Officer. From February 2003 to January 2004, Dr. Theobald was
     pursuing personal interests. Prior to joining CollaGenex, from June 2002 to
     February 2003, Dr. Theobald was the President and Chief  Executive  Officer
     of  Allergenics,  Inc. a  biotechnology  company  focused  on oral  protein
     delivery.  Prior to that,  from July 1986 to May 2002,  Dr.  Theobald  held
     various senior positions at Aventis Behring and its predecessor  companies,
     and most  recently  served as Chief Medical  Offficer of Aventis  Behring's
     Genesis Therapeutics subsidiary.

(2)  Ms. Broadbent joined  CollaGenex in March 1996 as Chief Financial  Officer,
     Treasurer and Secretary.  From October 1994 until March 1996, Ms. Broadbent
     served as Senior Vice President,  Chief  Financial  Officer and director of
     Human Genome Sciences, Inc., a pharmaceutical company. From January 1993 to
     October 1994, she served as Vice President and Chief  Financial  Officer of
     Cangene,  Inc.,  a  biopharmaceutical  company.  From  January 1992 through
     December 1992, Ms. Broadbent served as an independent financial consultant.
     From March 1990 to December  1991,  she was  employed by Baring  Brothers &
     Co.,  Inc.,  initially  as  Senior  Vice  President  and then as  Executive
     Director,  Corporate Finance.  Prior to that, Ms. Broadbent served for nine
     years in  corporate  finance  positions  with  Salomon  Brothers,  Inc. and
     PaineWebber Incorporated.

(3)  Mr. Pfeiffer joined  CollaGenex in June 1997 as Vice President,  Marketing.
     He was promoted to Senior Vice  President,  Sales and Marketing in December
     2000.  From September 1995 until June 1997, Mr. Pfeiffer served as Director
     of Marketing,  Health Management Services, for SmithKline Beecham. From May
     1994 to September 1995, he served as Director,  Disease Management Services
     of   Stuart   Disease   Management   Services,   a   division   of   Zeneca
     Pharmaceuticals.  From  October 1991 to May 1994 he was employed in various
     product management positions with Zeneca  Pharmaceuticals  Group. From July
     1988 to October  1991,  he held various  marketing  and product  management
     positions with the Lederle Laboratories Division of American Cyanamid.

      None of our executive  officers are related to any other executive officer
or to any of our directors.  Our executive  officers are elected annually by the
Board of  Directors  and serve  until  their  successors  are duly  elected  and
qualified.

Section 16(a) Beneficial Ownership Reporting Compliance
- -------------------------------------------------------

      Section 16(a) of the Securities Exchange Act of 1934, as amended, requires
our directors,  officers and  stockholders who beneficially own more than 10% of
any class of our  equity  securities  registered  pursuant  to Section 12 of the
Exchange  Act to file  initial  reports of  ownership  and reports of changes in
ownership with respect to our equity securities with the Securities and Exchange
Commission.  All reporting  persons are required by the



                                      -13-



Securities  and Exchange  Commission's  regulations to furnish us with copies of
all reports that such  reporting  persons file with the  Securities and Exchange
Commission pursuant to Section 16(a).

      Based solely on our review of the copies of such forms  received by us and
upon written  representations of our reporting persons received by us, except as
described  below,  each such reporting  person has filed all of their respective
reports pursuant to Section 16(a) on a timely basis. Each of Nancy C. Broadbent,
Robert A.  Ashley  and  David F.  Pfeiffer  failed to timely  file a Form 4 with
respect to the grant of stock  options on January 24, 2003.  Ms.  Broadbent  and
Messrs.  Pfeiffer  and  Ashley  filed  such  information  on a Form  4 with  the
Securities and Exchange Commission on April 28, 2003, June 13, 2003 and June 16,
2003,  respectively.  Each of  James W.  O'Shea,  James  E.  Daverman,  Peter R.
Barnett,  Robert J.  Easton,  Robert C. Black and  Stephen A.  Kaplan  failed to
timely file a Form 4 with respect to the grant of stock options on May 20, 2003.
Mr. O'Shea filed such  information  on a Form 4 with the Securities and Exchange
Commission on June 16, 2003. Messrs. Daverman and Barnett filed such information
on a Form 4 with the  Securities  and  Exchange  Commission  on June  30,  2003.
Messrs.  Easton,  Black and Kaplan filed such  information  on a Form 4 with the
Securities and Exchange Commission on July 7, 2003.



                                      -14-



                             EXECUTIVE COMPENSATION

Summary of Compensation in Fiscal Years 2003, 2002 and 2001
- -----------------------------------------------------------

      The following Summary Compensation Table sets forth information concerning
compensation  during  the  years  ended  December  31,  2003,  2002 and 2001 for
services  in all  capacities  awarded  to,  earned by or paid to each person who
served as our Chief Executive Officer at any time during 2003, each other of our
executive officers as of December 31, 2003 and certain individuals who served as
executive  officers  during a part of 2003,  whose  aggregate cash  compensation
exceeded  $100,000  at the end of 2003  (collectively  referred to as the "Named
Executives").



                           SUMMARY COMPENSATION TABLE

- --------------------------------------------------------------------------------
                                                        Long-Term
                                      Annual Com-      Compensation
                                      pensation (1)      Awards
                                   -----------------   ------------
                                                        Securities     All Other
                                                         Underlying    Compensa-
    Name and Principal      Year   Salary   Bonus         Options        tion
         Position                    ($)      ($)           (#)           ($)
            (a)             (b)      (c)      (d)           (g)           (i)
- --------------------------------------------------------------------------------

                                                      
Colin W. Stewart........    2003     22,538(2)   50,000(2) 300,000        --
   President, Chief
   Executive Officer
   and Director

Brian M. Gallagher,
 Ph.D.(3).............      2003    304,786     155,787         --   251,000(4)
   President, Chief         2002    324,450      79,436     75,000        --
   Executive Officer        2001    315,000     131,615    100,000        --
   and Chairman of
   the Board

Robert A. Ashley (5)..      2003    238,702      91,804     24,000        --
   Senior Vice              2002    231,750      72,827     40,000        --
   President,               2001    225,000      93,908     80,000        --
   Commercial
   Development

Nancy C. Broadbent....      2003    222,789      86,112     24,000        --
   Chief Financial          2002    216,300      72,807     30,000        --
   Officer, Treasurer       2001    210,000      87,881     50,000        --
   and Secretary

David F. Pfeiffer ....      2003    238,702      91,840     24,000        --
   Senior Vice              2002    231,750      72,759     40,000        --
   President, Sales         2001    225,000      93,812     80,000        --
   and Marketing


- -----------

(1)   In accordance  with the rules of the Securities  and Exchange  Commission,
      the costs of  certain  perquisites  and other  personal  benefits  are not
      included because they did not exceed, in the case of each Named Executive,
      the lesser of $50,000 or 10% of the total annual  salary and bonus for the
      Named Executives for the fiscal years reported in the above table.

(2)   On December 8, 2003, Mr. Stewart joined  CollaGenex as President and Chief
      Executive Officer and a member of our Board of Directors. During 2003, Mr.
      Stewart  was paid  $22,538 in base  salary  compensation.  Pursuant to Mr.
      Stewart's employment agreement,  Mr. Stewart is entitled to an annual base
      salary of  $350,000.  Mr.  Stewart  was also  awarded an  initial  $50,000
      one-time, sign-on bonus in December 2003.

(3)   As previously reported,  during 2003 we commenced a search for a successor
      President and Chief  Executive  Officer to Dr.  Gallagher.  On December 8,
      2003, Colin W. Stewart joined  CollaGenex and Dr. Gallagher  resigned from
      his position as  President,  Chief  Executive  Officer and Chairman of the
      Board. Dr. Gallagher continues to serve as one of our directors.



                                      -15-



(4)   In March 2003, Dr. Gallagher was awarded non-cash  compensation,  relating
      to certain modifications of Dr. Gallagher's stock option agreements.  This
      non-cash compensation was valued at $251,000 based on the variance between
      the  applicable  option  exercise  price and the then  current fair market
      value of the Company's common stock at the time of modification.

(5)   On February 27, 2004, Mr. Ashley resigned from his position as Senior Vice
      President, Commercial Development.



                                      -16-



Option Grants in 2003
- ---------------------

      The following table sets forth information concerning individual grants of
stock options made during 2003 to each of the Named Executives.



                               OPTION GRANTS IN LAST FISCAL YEAR
- ------------------------------------------------------------------------------------------------
                         Individual Grants
- ------------------------------------------------------------------------------------------------
                                     Percent
                                     of Total                               Potential
                                     Options                                Realizable
                      Number of      Granted to                               Value
                      Securities     Employees     Exercise             at Assumed Annual
                      Underlying      in             or      Expir-        Rates of Stock
                       Options       Fiscal         Base     ation       Price Appreciation
      Name            Granted        Year(1)       Price      Date        For Option Term (3)
                        (#)                      ($/Sh)(2)            5%($)            10%($)
       (a)              (b)           (c)           (d)       (e)       (f)               (g)
- ------------------------------------------------------------------------------------------------
                                                                   

Colin W. Stewart....  300,000        36.37        10.25    12/7/2013 1,933,850       4,900,758

Brian M. Gallagher,
  Ph.D..............       --          --           --         --        --                 --

Robert A. Ashley....   24,000         2.90        10.16    1/23/2013   153,350         388,618

Nancy C. Broadbent..   24,000         2.90        10.16    1/23/2013   153,350         388,618

David F. Pfeiffer...   24,000         2.90        10.16    1/23/2013   153,350         388,618


- -----------

(1)  Based on an  aggregate  of 824,850  options  granted to  employees in 2003,
     including options granted to the Named Executives.

(2)  Based on a grant date fair market  value  equal to the grant date  exercise
     price per share of the applicable  option for each of the Named  Executives
     and assumes no adjustments to the grant date exercise price.

(3)  Amounts  reported in these columns  represent  amounts that may be realized
     upon exercise of the options  immediately  prior to the expiration of their
     terms assuming the specified compound rates of appreciation (5% and 10%) on
     the market  value of the common  stock on the date of option grant over the
     term  of  the  options.   These  numbers  are  calculated  based  on  rules
     promulgated by the  Securities  and Exchange  Commission and do not reflect
     the Company's estimate of future stock price growth.  Actual gains, if any,
     on stock option  exercises  and common stock  holdings are dependent on the
     timing of such  exercise and the future  performance  of the common  stock.
     There can be no assurance  that the rates of  appreciation  assumed in this
     table can be achieved  or that the  amounts  will be received by the option
     holder.



                                      -17-



Aggregated Option Exercises in 2003 and Year End Option Values
- --------------------------------------------------------------

      The following  table sets forth  information  concerning  each exercise of
options  during 2003 by each of the Named  Executives  and the year end value of
unexercised in-the-money options.



                 AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR
                      AND FISCAL YEAR-END OPTION VALUES
- -----------------------------------------------------------------------------------------------
                                                                Number of
                                                               Securities         Value of
                                                               Underlying        Unexercised
                                                               Unexercised      In-the-Money
                                                             Options at Fiscal  Options at Fiscal
                                      Shares       Value         Year-End        Year-End
                                   Acquired on     Value          (#)              ($)(1)
                                    Exercise      Realized    Exercisable/      Eexercisable
       Name                           (#)          ($)        Unexercisable     Unexercisable
       (a)                            (b)          (c)            (d)              (e)
- ------------------------------------------------------------------------------------------------
                                                                   
Colin W. Stewart .............          --            --          0/300,000          0/264,000

Brian M. Gallagher,  Ph.D ....     100,000     1,311,480          470,000/0        1,383,775/0

Robert A. Ashley .............          --            --    197,500/109,000    894,341/315,709

Nancy C. Broadbent ...........      21,000       172,838     116,500/81,500    391,598/218,565

David F. Pfeiffer ............      45,000       394,842    143,000/111,000    198,668/313,575


- ----------

(1)  Based on a year end fair market value of the underlying securities equal to
     $11.13 per share, less the exercise price payable for such shares.

Employment Contracts, Termination of Employment and Change-in-Control
- ---------------------------------------------------------------------
Arrangements
- ------------

      We have  executed  indemnification  agreements  with each of our executive
officers  and  directors  pursuant  to which we have  agreed to  indemnify  such
parties to the full extent permitted by law, subject to certain  exceptions,  if
any such party  becomes  subject to an action  because such party is a director,
officer,  employee, agent or fiduciary of the Company. In general, our employees
are covered by confidentiality agreements.

      On September 18, 2002, we entered into change of control  agreements  with
each of Ms. Broadbent and Mr. Pfeiffer and with Mr. Stewart on December 8, 2003.
In the event the employment of Mr.  Stewart,  Ms.  Broadbent or Mr.  Pfeiffer is
terminated  as a result  of an  Involuntary  Termination  within  24 months of a
Change of Control  (each as defined in such  agreements),  the change of control
agreements  provide for,  among other things (i) a lump sum payment of 1.5 times
base  salary and 1.5 times the  average  bonus paid for the three  fiscal  years
prior to the  Termination  Date (as  defined  in the  agreements),  (ii)  health
coverage  and  benefits   for  a  period  of  24  months,   and  (iii)   certain
outplacement/administrative support for a period of 18 months.

      In  addition,  each of Ms.  Broadbent  and Mr.  Pfeiffer  have agreed that
during  the  term  of  his or her  employment  and  for a  period  of two  years
thereafter,  they person will not directly or indirectly  provide services to or
for any business  engaged in research  regarding the  development,  manufacture,
testing,  marketing or sale of collagenase  inhibiting  drugs for application in
periodontal  disease or any other application which,  during the period of their
employment  with us, is either marketed or in advanced  clinical  development by
us.  Pursuant to the terms of the  Transition  Agreement  and Release we entered
into with Dr.  Gallagher on March 18, 2003, Dr.  Gallagher has agreed that until
September 18, 2004 he will not engage in any business or enterprise  (whether as
owner, partner, officer,  director,  employee,  consultant,  investor, lender or
otherwise,  except as the holder of not more than 1% of the



                                      -18-



outstanding  stock of a  publicly-held  company)  that  develops,  manufactures,
markets,  licenses,  sells or provides any product or service that competes with
any product or service  developed,  manufactured,  marketed,  licensed,  sold or
provided, or planned to be developed, manufactured,  marketed, licensed, sold or
provided, by us while Dr. Gallagher was our employee.

      During 2003,  we commenced an executive  search for a successor  President
and Chief  Executive  Officer to Dr.  Gallagher and on December 8, 2003 we hired
Colin W.  Stewart as the  successor to Dr.  Gallagher.  We executed a Transition
Agreement and Release with Dr.  Gallagher,  pursuant to which we compensated Dr.
Gallagher for, among other things, his services during the transition period and
in recognition of his historical contributions to CollaGenex. Under the terms of
such  agreement,  Dr.  Gallagher was eligible for a one-time,  lump sum bonus of
$150,000, which was paid to Dr. Gallagher in connection with his separation from
CollaGenex. Of such amount, $50,000 was earned by Dr. Gallagher automatically on
the date of his  separation  from the Company and $100,000 was paid on such date
based upon his performance prior to separation.  We also agreed to reimburse Dr.
Gallagher for certain COBRA premiums,  or to make certain comparable payments to
Dr.  Gallagher,  for a  period  of  24  months  following  his  separation  from
CollaGenex.  We also paid Dr.  Gallagher  a lump sum of  $15,000  at the time of
separation for certain  expenses.  In addition,  effective upon the execution of
such agreement,  we accelerated Dr.  Gallagher's  right to exercise all unvested
stock options  previously  granted to him and the exercise  dates for certain of
Dr.  Gallagher's  options were  extended to the latest date on which the options
would have expired according to their respective terms.

      As a result of the  Transition  Agreement  and  Release,  we  recognized a
non-cash  compensation charge relating to modifications of Dr. Gallagher's stock
option  agreements  of  approximately  $251,000 in the first quarter of 2003. We
also agreed to reimburse Dr. Gallagher for certain excise taxes, if any, imposed
on him in  connection  with such  agreement.  We also  entered into a consulting
agreement  with Dr.  Gallagher  pursuant  to which  he will  provide  consulting
services  to us for a period  of 24  months  following  the  appointment  of Mr.
Stewart. Under such agreement,  Dr. Gallagher provided approximately 80 hours of
consulting  services to  CollaGenex  during the first two months  following  his
separation and has agreed to provide approximately 15 hours per month thereafter
through the second  anniversary  date of his  separation  from  CollaGenex.  Dr.
Gallagher shall provide such services as an independent  contractor at a rate of
$27,037.50 per month.

      We entered into an Incentive  Bonus  Agreement  with an effective  date of
August 27, 2003, with David F. Pfeiffer,  our Senior Vice  President,  Sales and
Marketing,   pursuant  to  which  Mr.   Pfeiffer  shall   receive,   in  certain
circumstances,  an incentive bonus equal to his annual base salary.  Pursuant to
the terms of such  agreement,  the incentive  bonus shall be payable only if (i)
Mr. Pfeiffer remains actively  employed with us through August 27, 2004, or (ii)
we terminate Mr. Pfeiffer's employment without cause prior to August 27, 2004.

      On December 8, 2003,  we entered  into a Stock Option  Agreement  with Mr.
Stewart,  pursuant to which we granted  inducement stock options to Mr. Stewart,
effective the date of commencement of his employment. These options were granted
without    stockholder    approval   pursuant   to   NASDAQ   Marketplace   Rule
4350(i)(1)(A)(iv)   under  the  following  terms:  300,000  non-qualified  stock
options,  exercise  price  equal to the fair  market  value on the  grant  date,
ten-year  duration  and vesting at the rate of 20% for each year of service with
the Company. In certain circumstances, if the closing price of our common stock,
as quoted on the NASDAQ  National  Market,  exceeds a  pre-determined  per share
price for a certain number of  consecutive  days, a portion of such options will
vest immediately.

Compensation Committee Interlocks and Insider Participation
- -----------------------------------------------------------

      The  Compensation  Committee  currently  consists  of, and  during  2003
consisted  of, W. James  O'Shea,  who serves as Chairman,  Robert C. Black and
Robert J.  Easton.  There are no, and during 2003 there were no,  Compensation
Committee interlocks.

      As of April 1, 2004, Mr. Easton, in his individual  capacity,  held 26,409
shares of our common stock.  Such shares of common stock include those shares of
common stock which were previously  issued by us upon conversion of our Series A
preferred  stock,  Series  B  preferred  stock  and  Series  C  preferred  stock
previously  held by Mr. Easton.  As of April 1, 2004, Mr. Easton also held 2,000
shares of our Series D preferred stock which were convertible into 20,216 shares
of our common stock as of such date.

      During  2003,  we engaged an outside  firm to perform  certain  consulting
services  for  approximately  $55,000.  One of the primary  stakeholders  in the
outside firm is Mr. Easton, a current member of our Board of Directors.



                                      -19-



      In September  1995, we entered into a registration  rights  agreement with
each of the then  holders  of our  Series A,  Series B and  Series C  redeemable
preferred stock pursuant to which we have granted certain registration rights to
such stockholders.  Pursuant to such registration rights agreement,  at any time
beginning  six months after June 20,  1996,  the  effective  date of our initial
public  offering,  the holders of at least a majority of the common stock issued
upon the conversion of the Series A, Series B and Series C redeemable  preferred
stock (referred to collectively as the "Registrable Securities") have the right,
subject to certain  restrictions set forth in the registration rights agreement,
to require that we register the Registrable Securities requested by such holders
at our expense (on no more than two occasions) on either a Form S-1, Form S-2 or
Form S-3 Registration Statement under the Securities Act of 1933, as amended. We
are not,  however,  required to register any Registrable  Securities unless such
shares represent at least 10% of our outstanding  shares of common stock, or, if
less than 10%, if the anticipated aggregate offering price exceeds $1,000,000.

      The holders of Registrable  Securities also have the right to an unlimited
number  of  registrations  on Form S-3  under  the  Securities  Act of 1933,  as
amended. We are not, however,  required to effect such a registration unless the
requesting holders reasonably  anticipate having an aggregate  disposition price
of at least $500,000.

      Also in September 1995, we granted to the then holders of Series A, Series
B and Series C redeemable  preferred  stock  certain  rights to  participate  in
certain future  offerings  undertaken by us. Such rights to participate  require
that,  with certain  exceptions  including,  but not limited to, an underwritten
public  offering,  any time we propose to issue,  sell or  exchange,  or reserve
therefor,  any  securities,  we  must  first  offer  to  sell  to  each  of  the
pre-conversion  holders of Series A, Series B and Series C redeemable  preferred
stock their respective pro rata share of such securities at a price and on terms
identical to the price and terms of the securities  proposed to be issued,  sold
or exchanged in the applicable offering.

      In May  1999,  we  entered  into a  Stockholder  and  Registration  Rights
Agreement  with each of the holders of our Series D preferred  stock pursuant to
which,  among other things,  we registered on a Registration  Statements on Form
S-3 all of the  shares of our  common  stock  underlying  the shares of Series D
preferred stock and all of the shares of common stock issued as dividends on the
Series D  preferred  stock to the  holders  thereof.  We are  obligated  to keep
current each such  Registration  Statement on Form S-3 until such time as all of
the shares of common stock registered thereunder have been sold or are otherwise
exempt from registration.

      The holders of at least a majority  of the Series D  preferred  stock also
have the right, subject to certain  restrictions,  to require us to register the
shares  of  common  stock  underlying  their  Series  D  preferred  stock  on  a
Registration  Statement  on  Form  S-1  at our  expense  (on no  more  than  two
occasions). Also, pursuant to the Stockholder and Registration Rights Agreement,
if we propose to register  any of our  securities  under the  Securities  Act of
1933, as amended,  for sale to the public, the holders of the Series D preferred
stock have certain piggyback  registration  rights with respect to the shares of
common stock underlying  their Series D preferred stock at our expense,  subject
to certain  restrictions.  In addition,  if we grant registration  rights to the
holders of any of our securities  that are more favorable than the  registration
rights granted under the Stockholder and Registration Rights Agreement, then the
holders of the Series D  preferred  stock  shall be deemed to have been  granted
such superior  registration  rights as well with respect to the shares of common
stock underlying  their Series D preferred stock.  Also pursuant to the terms of
the  Stockholder  and  Registration  Rights  Agreement,  the holders of Series D
preferred  stock have  certain  rights of first  refusal with respect to certain
stock  issuances  by us,  beginning  twelve  months  after  the date of  initial
issuance of the Series D preferred stock.



                                      -20-



Performance Graph
- -----------------

      The following graph compares the cumulative  total  stockholder  return on
our common stock with the cumulative  total return on the Nasdaq Composite Index
and the Nasdaq  Pharmaceutical  Index  (capitalization  weighted) for the period
beginning  on January  1, 1999 and ending on the last day of our last  completed
fiscal year.

                COMPARISON OF CUMULATIVE TOTAL RETURN(1)(2)(3)

             Among CollaGenex, the Nasdaq Composite Index and the
                           Nasdaq Pharmaceutical Index
                            (Capitalization Weighted)












                        [GRAPHIC REPRESENTATION OF TABLE]
















                 Base
                Period
                January   June   December   June    December   June   December   June   December  June   December
 Company/           1,     30,      31,      30,       31,      30,      31,      30,      31,     30,      31,
Index Name        1999    1999     1999     2000      2000     2001     2001     2002     2002    2003     2003
                -------  -------  -------  -------  -------  -------  -------  -------  -------  -------  -------
                                                                         
CGPI .........  $100.00  $103.95  $259.88   $97.51   $38.36   $85.24   $84.20   $76.92   $98.65  $137.84  $115.70
NASDAQ .......  $100.00  $122.53  $185.34  $181.14  $111.83   $98.36   $88.71   $67.00   $61.33   $74.39   $91.70
NASDAQ PHAR...  $100.00  $111.93  $188.55  $257.04  $235.19  $216.36  $200.44  $127.15  $129.53  $175.86  $189.85


- -----------

(1)  Graph  assumes $100  invested on January 1, 1999 in our common  stock,  the
     Nasdaq Composite Index and the Nasdaq  Pharmaceutical Index (capitalization
     weighted).

(2)  Total return assumes reinvestment of dividends.

(3)  Year ended December 31.



                                      -21-



Compensation Committee Report on Executive Compensation
- -------------------------------------------------------

      The Compensation Committee has furnished the following report:

      The Compensation  Committee is comprised of three  non-employee  directors
and currently  acts under a charter  adopted and approved in January  2004.  The
Compensation Committee recommends,  and the Board approves, all matters relating
to  executive   compensation,   including  setting  and  administering  policies
governing executive salaries, bonuses (if any) and stock option awards (if any).
The Compensation Committee shall meet as often as it deems necessary in order to
perform its  responsibilities.  The Compensation  Committee meets at least twice
annually to set performance  objectives for the Chief  Executive  Officer and to
determine the annual  compensation of the Chief Executive  Officer and our other
senior  executives.  The Chief  Executive  Officer  is not  present  during  the
discussion of his compensation.

Executive Compensation Policy
- -----------------------------

      The  goal  of our  executive  compensation  policy  is to  ensure  that an
appropriate  relationship exists between executive compensation and the creation
of stockholder value, while at the same time attracting and retaining  qualified
senior management. In order to continually attract and retain highly experienced
executives,   our  compensation   packages  for  senior  executives  are  highly
competitive  with  those paid to  executives  of other  emerging  pharmaceutical
companies.

Compensation Mix
- ----------------

      Our executive  compensation  packages  generally include three components:
base salary, a discretionary annual cash bonus and stock options.

Base Salary
- -----------

      The  Compensation  Committee  seeks to  establish  base  salaries for each
position  and  level  of  responsibility  that  are  competitive  with  those of
executive officers at other emerging pharmaceutical companies.

Discretionary Cash Bonus
- ------------------------

      The Compensation  Committee  believes that  discretionary cash bonuses are
important to motivate and reward executive officers.  However,  cash bonuses are
not  guaranteed.  Annual cash bonuses are awarded to  executives  based on their
achievements  against a stated list of objectives  developed at the beginning of
each year by senior management and the Compensation  Committee.  Such objectives
are reviewed and approved by the Board of Directors.

Stock Options
- -------------

      Stock option grants are designed to align the  long-term  interests of our
executives with those of our stockholders by rewarding executives for increasing
stockholder value. All executive officers are awarded option grants upon joining
the  Company   that  are   competitive   with  those  at   comparable   emerging
pharmaceutical  companies.  In addition,  the  Compensation  Committee may award
additional  stock option grants  annually.  When  granting  stock  options,  the
Compensation  Committee  considers  the  recommendation  of our Chief  Executive
Officer and the relative  performance and contributions of each officer compared
to  that  of  other   officers   within  the  Company  with  similar  levels  of
responsibility.  The  Compensation  Committee has in the past  granted,  and may
continue  to grant from time to time in the  future,  options  to our  executive
officers  containing  target milestones with respect to the trading price of our
common stock and accelerated vesting upon the achievement of such milestones.

Compensation of the Chief Executive Officer
- -------------------------------------------

      In establishing the Chief Executive Officer's  compensation  package,  the
Compensation  Committee seeks to maintain a level of total current  compensation
that is  competitive  with  that  paid to  chief  executive  officers  of  other
comparable emerging pharmaceutical companies. In addition, in order to align the
Chief Executive Officer's interests with the interests of our stockholders,  the
Compensation  Committee  attempts to make a substantial  portion of the value of
the Chief Executive  Officer's total compensation  dependent on the appreciation
of our stock price.



                                      -22-



      The Chief  Executive  Officer's  performance is evaluated  annually by the
Compensation  Committee  against a stated  list of short,  medium  and long term
objectives developed by the Compensation Committee at the beginning of each year
and approved by the Board of Directors.  As previously discussed,  Dr. Gallagher
resigned from his position as President and Chief Executive Officer effective as
of  December 8, 2003.  In  connection  with Dr.  Gallagher's  services  during a
transition period during 2003 and in recognition of his historical contributions
to CollaGenex,  Dr. Gallagher was paid a lump sum bonus of $150,000. On December
8, 2003,  Colin W.  Stewart was  appointed  our  President  and Chief  Executive
Officer.  Mr. Stewart's base salary will initially be $350,000.  Mr. Stewart was
also awarded an initial  $50,000  one-time,  sign-on bonus in December  2003. In
establishing  Mr.  Stewart's  compensation,  we  examined  Mr.  Stewart's  prior
experience  and  breadth  of  knowledge,  as well as the  size,  complexity  and
historical performance of our business, our position as compared to our peers in
the industry and the specific challenges we face.

Tax Considerations
- ------------------

      Section 162(m) of the Internal Revenue Code of 1986, as amended, generally
disallows a tax deduction to public companies for certain compensation in excess
of $1.0  million  paid to the  company's  CEO and the  four  other  most  highly
compensated  executive  officers.  Certain  compensation,   including  qualified
performance-based  compensation,  will not be subject to the deduction  limit if
certain  requirements are met. The Compensation  Committee reviews the potential
effect  of  Section  162(m)  periodically  and uses its  judgment  to  authorize
compensation  payments  that may be subject  to the limit when the  Compensation
Committee  believes such payments are  appropriate  and in the best interests of
the Company and our  stockholders,  after  taking  into  consideration  changing
business conditions and the performance of our employees.

                                          Compensation Committee Members:

                                          W. James O'Shea, Chairman
                                          Robert C. Black, Member
                                          Robert J. Easton, Member



                                      -23-



         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT
                         AND RELATED SHAREHOLDER MATTERS

      There were, as of April 1, 2004,  approximately  112 holders of record and
approximately  3,972 beneficial holders of our common stock. The following table
sets forth certain information, as of April 1, 2004, with respect to holdings of
our common  stock by (i) each person known by us to be the  beneficial  owner of
more than 5% of the total number of shares of the common stock outstanding as of
such date,  based on currently  available  Schedules  13D and 13G filed with the
SEC,  (ii)  each of our  directors  (which  includes  all  nominees)  and  Named
Executives, and (iii) all directors and executive officers as a group.

                                                                        Percent
                                            Amount and Nature of           of
Name and Address of Beneficial Owner(1)   Beneficial Ownership(1)       Class(2)
- ---------------------------------------   -----------------------       --------

(i)   Certain Beneficial Owners:

Oaktree Capital Management, LLC
OCM Principal Opportunities Fund, L.P.
333 South Grand Avenue, 28th Floor
Los Angeles, California 90071............     1,852,005(3)                13.1%

Zesiger Capital Group LLC
320 Park Avenue, 30th Floor
New York, New York 10022.................       982,200(4)                 7.0%

Wellington Management Company, LLP
75 State Street
Boston, Massachusetts 02109..............       768,509(5)                 5.4%

(ii)  Directors (which includes all
      nominees) and Named Executives:

Colin W. Stewart.........................               --                    *
Brian M. Gallagher, Ph.D.................       595,000(6)                 4.1%
Robert A. Ashley.........................       254,500(7)                 1.8%
Nancy C. Broadbent.......................       200,875(8)                 1.4%
David F. Pfeiffer........................       197,500(9)                 1.4%
Peter R. Barnett, D.M.D..................       34,489(10)                    *
Robert Black.............................       25,589(11)                    *
James E. Daverman........................       85,859(12)                    *
Robert J. Easton.........................       81,934(13)                    *
Stephen A. Kaplan........................    1,880,594(14)                13.3%
W. James O'Shea..........................       21,214(15)                    *

(iii) All Directors and executive
      officers as a
      group (12 persons).................    3,377,554(16)                22.1%

- -----------

*     Less than 1%



                                      -24-



(1)  Except  as set  forth  in the  footnotes  to  this  table  and  subject  to
     applicable  community  property law, the persons and entities  named in the
     table have sole voting and investment power with respect to all shares.

(2)  Applicable  percentage  of ownership for each holder is based on 14,131,377
     shares of common stock  outstanding on April 1, 2004, plus any common stock
     equivalents  and  presently  exercisable  stock options or warrants held by
     each such  holder,  and options or warrants  held by each such holder which
     will become exercisable within 60 days after April 1, 2004.

(3)  Includes  1,789,090  shares of common stock issuable upon the conversion of
     177,000 shares the Series D preferred  stock held thereby and 62,933 shares
     of common  stock,  including  shares of common  stock  issued in payment of
     dividends on the Series D preferred stock.

(4)  As  disclosed  on a Schedule  13G filed with the  Securities  and  Exchange
     Commission  on  February  13,  2004,  assuming  no  changes  in  beneficial
     ownership  since such  filing.  According  to such  Schedule  13G,  Zesiger
     Capital Group LLC, in its capacity as investment adviser,  may be deemed to
     beneficially  own 982,200 shares of common stock,  which shares are held of
     record by clients of Zesiger  Capital Group LLC.  Zesiger Capital Group LLC
     reports  that it has  shared  power to vote or direct  the vote of  746,500
     shares and shared  power to  dispose or direct the  disposition  of 982,200
     shares.

(5)  As  disclosed  on a Schedule  13G filed with the  Securities  and  Exchange
     Commission  on  February  12,  2004,  assuming  no  changes  in  beneficial
     ownership  since such filing.  According to such Schedule  13G,  Wellington
     Management  Company,  LLP, in its capacity as  investment  adviser,  may be
     deemed to beneficially own 768,509 shares of common stock, which shares are
     held of record by clients of Wellington Management Company, LLP. Wellington
     Management Company,  LLP reports that it has shared power to vote or direct
     the vote of  725,809  shares  and  shared  power to  dispose  or direct the
     disposition of 768,509 shares, while its clients have the right to receive,
     or direct the receipt of,  dividends  from,  or proceeds  from the sale of,
     such shares.

(6)  Includes 395,000 shares of common stock underlying options which are or may
     be exercisable as of April 1, 2004 or 60 days after such date.

(7)  Includes 244,500 shares of common stock underlying options which are or may
     be exercisable as of April 1, 2004 or 60 days after such date.

(8)  Includes 150,000 shares of common stock underlying options which are or may
     be  exercisable  as of April  1,  2004 or 60 days  after  such  date.  Also
     includes  2,000 shares of common stock held in the name of Ms.  Broadbent's
     spouse and 1,000 shares of common stock held in the name of Ms. Broadbent's
     parent, who resides with Ms. Broadbent.

(9)  Includes  190,000  shares  of common  stock  underlying  options  which are
     exercisable as of April 1, 2004 or 60 days after such date.

(10) Includes  30,589  shares  of  common  stock  underlying  options  which are
     exercisable as of April 1, 2004 or 60 days after such date.

(11) Includes  25,589  shares  of  common  stock  underlying  options  which are
     exercisable as of April 1, 2004 or 60 days after such date.

(12) Includes  30,589  shares  of  common  stock  underlying  options  which are
     exercisable as of April 1, 2004 or 60 days after such date.

(13) Includes  30,859  shares  of  common  stock  underlying  options  which are
     exercisable  as of April 1, 2004 or 60 days after such date.  Also includes
     20,216 shares of common stock  issuable upon the conversion of 2,000 shares
     of the Series D  preferred  stock held by Mr.  Easton and 26,409  shares of
     common  stock,  including



                                      -25-



     shares of common  stock  issued in payment of  dividends  on such  Series D
     preferred stock. Also includes 4,450 shares of common stock held as trustee
     for the Rachel Easton Charitable Trust.

(14) Stephen  Kaplan is a principal of OCM Principal  Opportunities  Fund,  L.P.
     and, as such, has the power to vote or direct the vote of and to dispose of
     or  direct  the   disposition   of  the  shares  owned  by  OCM   Principal
     Opportunities  Fund,  L.P.  Mr.  Kaplan  expressly   disclaims   beneficial
     ownership of such shares,  except as to his  proportionate  interest in OCM
     Principal  Opportunities  Fund, L.P.  Includes 3,000 shares of common stock
     held by Mr. Kaplan in his  individual  capacity and 25,589 shares of common
     stock  underlying  options which are  exercisable as of April 1, 2004 or 60
     days after such date.

(15) Includes  21,214  shares  of  common  stock  underlying  options  which are
     exercisable as of April 1, 2004 or 60 days after such date.

(16) See Notes 6 through 15.



                                      -26-



Series D Preferred Stock
- ------------------------

      There  were,  as of April 1, 2004,  six  holders of record of our Series D
preferred stock. The following table sets forth certain information, as of April
1, 2004,  with  respect to the  beneficial  ownership  of our Series D preferred
stock by (i) each person known by us to be the beneficial  owner of more than 5%
of the total number of shares of Series D preferred stock outstanding as of such
date,  (ii)  each of our  directors  (which  includes  all  nominees)  and Named
Executives who  beneficially  own shares of Series D preferred  stock, and (iii)
all directors and executive officers as a group.

                                                                        Percent
                                            Amount and Nature of           of
Name and Address of Beneficial Owner(1)   Beneficial Ownership(1)       Class(2)
- ---------------------------------------   -----------------------       --------
(i)   Certain Beneficial Owners:

OCM Principal Opportunities Fund, L.P....        177,000(3)               88.5%
Richard A. Horstmann.....................         10,000(4)                5.0%
Marquette Venture Partners II, L.P. and
  MVP II Affiliates Fund, L.P............         10,000(5)                5.0%

(ii)  Directors (which includes all
      nominees) and Named Executives:

Robert J. Easton.........................          2,000(6)                1.0%
Stephen A. Kaplan........................        177,000(7)               88.5%

(iii) All Directors and executive
      officers as a
      group (12 persons).................        179,000(6)(7)            89.5%

- -----------

(1)  Except  as set  forth  in the  footnotes  to  this  table  and  subject  to
     applicable  community  property law, the persons and entities  named in the
     table have sole voting and investment power with respect to all shares.

(2)  Applicable  percentage of ownership is based on 200,000  shares of Series D
     preferred stock outstanding on April 1, 2004.

(3)  Such  shares of Series D preferred  stock are  convertible  into  1,789,090
     shares of common stock.

(4)  Such shares of Series D preferred stock are convertible into 101,079 shares
     of common stock.

(5)  Of such  shares of  Series D  preferred  stock,  9,722  shares  are held by
     Marquette  Venture Partners II, L.P. and are convertible into 98,269 shares
     of common  stock.  Also,  of such shares of Series D preferred  stock,  278
     shares are held by MVP II Affiliates  Fund, L.P. and are  convertible  into
     2,810 shares of common stock.

(6)  Such shares of Series D preferred stock are convertible  into 20,216 shares
     of common stock.

(7)  Stephen A. Kaplan is a principal of OCM Principal  Opportunities Fund, L.P.
     and, as such, has the power to vote or direct the vote of and to dispose of
     or  direct  the   disposition   of  the  shares  owned  by  OCM   Principal
     Opportunities  Fund,  L.P.  Mr.  Kaplan  expressly   disclaims   beneficial
     ownership of such shares,  except as to his  proportionate  interest in OCM
     Principal Opportunities Fund, L.P.



                                      -27-



                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

      For  transactions  and information  relating to (i) an outside  consulting
firm  that  performed  services  for us and for  which  Mr.  Easton is a primary
stakeholder,  and (ii) certain  registration rights and rights to participate in
certain future  offerings  undertaken by us, held by Mr.  Easton,  who currently
serves,  and during  2003  served,  as a member of our  Compensation  Committee,
please see  "EXECUTIVE  COMPENSATION  -  Compensation  Committee  Interlocks and
Insider Participation."

      Until October 2003, James E. Daverman, Chairman of our Board of Directors,
served as a managing general partner of Marquette  Venture  Partners,  a venture
capital investment company which he founded in 1987. Additionally,  Mr. Daverman
served as President of Marquette Management  Partners,  LLC, the general partner
of Marquette  Venture  Partners,  L.P. and a general partner of MG II, L.P., the
general  partner of Marquette  Venture  Partners II, L.P. and MVP II  Affiliates
Fund, L.P.

      As of April 1, 2004:  (i) Marquette  Venture  Partners II, L.P. and MVP II
Affiliates  Fund,  L.P.  held an  aggregate  of 10,000  shares  of our  Series D
preferred  stock which were  convertible  into an aggregate of 101,079 shares of
our common stock as of such date;  and (ii) OCM  Principal  Opportunities  Fund,
L.P., with which Mr. Kaplan, a member of our Board of Directors,  is affiliated,
held an aggregate of 177,000  shares of our Series D preferred  stock which were
convertible  into  1,789,090  shares of our  common  stock.  Such  entities  are
entitled,  therefore, to identical registration rights and rights to participate
in future  offerings  undertaken  by us as is Mr.  Easton,  with respect to such
shares of Series D preferred stock.

               RATIFICATION OF APPOINTMENT OF INDEPENDENT AUDITORS

      Our Board of Directors intends, subject to stockholder approval, to retain
KPMG LLP as our independent auditors for the year ending December 31, 2004. KPMG
LLP also served as our independent auditors for 2003.

      The  Board of  Directors  recommends  a vote FOR the  ratification  of the
appointment of KPMG LLP as our independent auditors for the year ending December
31, 2004.

      Representatives  of KPMG LLP are expected to attend the Annual Meeting and
have an opportunity to make a statement and/or respond to appropriate  questions
from stockholders.

                             STOCKHOLDERS' PROPOSALS

      Stockholders who intend to have a proposal considered for inclusion in our
proxy  materials for  presentation  at our 2005 Annual  Meeting of  Stockholders
pursuant  to Rule  14a-8  under the  Securities  and  Exchange  Act of 1934,  as
amended,  must submit the proposal to us at our offices at 41 University  Drive,
Newtown,  Pennsylvania  18940,  attention  Nancy C.  Broadbent,  not later  than
December 23, 2004.

      Stockholders  who  intend to present a proposal  at such  meeting  without
inclusion of such proposal in our proxy  materials  pursuant to Rule 14a-8 under
the  Securities  Exchange  Act of 1934,  as  amended,  are  required  to provide
advanced notice of such proposal to us at the  aforementioned  address not later
than March 7, 2005.

      If  we do  not  receive  notice  of a  stockholder  proposal  within  this
timeframe,  our management  will use their  discretionary  authority to vote the
shares they represent,  as our Board of Directors may recommend.  We reserve the
right to  reject,  rule out of order,  or take  other  appropriate  action  with
respect  to any  proposal  that does not  comply  with  these  other  applicable
requirements.

                    HOUSEHOLDING OF ANNUAL MEETING MATERIALS

      Some banks,  brokers and other nominee record holders may be participating
in the practice of  "householding"  proxy  statements and annual  reports.  This
means that only one copy of our Proxy  Statement or Annual  Report may have been
sent to multiple  stockholders  in your  household.  We will promptly  deliver a
separate  copy of either  document  to you if you  write to us at 41  University
Drive, Newtown, Pennsylvania 18940, or call us



                                      -28-



at (215) 579-7388.  If you want to receive  separate copies of the Annual Report
and Proxy Statement in the future,  or if you are receiving  multiple copies and
would like to receive only one copy for your household,  you should contact your
bank, broker, or other nominee record holder, or you may contact us at the above
address and phone number.

                                  OTHER MATTERS

      The Board of  Directors  is not aware of any  matter to be  presented  for
action at the Annual  Meeting other than the matters  referred to above and does
not intend to bring any other matters  before the Annual  Meeting.  However,  if
other matters  should  properly come before the Annual  Meeting,  it is intended
that holders of the proxies will vote thereon in their discretion.

                                     GENERAL

      The  accompanying  proxy is  solicited  by and on  behalf  of our Board of
Directors,  whose notice of meeting is attached to this Proxy Statement, and the
entire cost of such solicitation will be borne by us.

      In addition to the use of the mails,  proxies may be solicited by personal
interview,  telephone and telegram by directors, officers and other employees of
the Company who will not be specially  compensated for these  services.  We will
also request that brokers,  nominees,  custodians and other fiduciaries  forward
soliciting  materials to the beneficial  owners of shares held of record by such
brokers,  nominees,  custodians  and other  fiduciaries.  We will reimburse such
persons for their reasonable expenses in connection therewith.

      Certain  information  contained  in this Proxy  Statement  relating to the
occupations  and security  holdings of our  directors and officers is based upon
information received from the individual directors and officers.

      WE WILL FURNISH, WITHOUT CHARGE, A COPY OF OUR REPORT ON FORM 10-K FOR THE
YEAR ENDED DECEMBER 31, 2003,  INCLUDING  CONSOLIDATED  FINANCIAL STATEMENTS AND
SCHEDULE  THERETO BUT NOT INCLUDING  EXHIBITS,  TO EACH OF OUR  STOCKHOLDERS  OF
RECORD ON APRIL 14, 2004, AND TO EACH  BENEFICIAL  STOCKHOLDER ON THAT DATE UPON
WRITTEN  REQUEST  MADE  TO  MS.  NANCY  C.  BROADBENT,   SECRETARY,   COLLAGENEX
PHARMACEUTICALS,  INC., 41 UNIVERSITY  DRIVE,  NEWTOWN,  PENNSYLVANIA  18940.  A
REASONABLE FEE WILL BE CHARGED FOR COPIES OF REQUESTED EXHIBITS.

      PLEASE DATE,  SIGN AND RETURN THE PROXY CARD AT YOUR EARLIEST  CONVENIENCE
IN THE  ENCLOSED  RETURN  ENVELOPE.  A PROMPT  RETURN OF YOUR PROXY CARD WILL BE
APPRECIATED AS IT WILL SAVE THE EXPENSE OF FURTHER MAILINGS.


                                       By Order of the Board of Directors

                                       /s/ Nancy C. Broadbent

                                       Nancy C. Broadbent
                                       Secretary
Newtown, Pennsylvania
April 23, 2004



                                      -29-



                                   APPENDIX A

                        COLLAGENEX PHARMACEUTICALS, INC.

                  AMENDED AND RESTATED AUDIT COMMITTEE CHARTER

A.    PURPOSE

      The purpose of the Audit  Committee  is to assist the Board of  Directors'
      oversight of the Company's  accounting and financial  reporting  processes
      and the audits of the Company's financial statements.

B.    STRUCTURE AND MEMBERSHIP

      1.    NUMBER.  The Audit Committee shall consist of at least three members
            of the Board of Directors.

      2.    INDEPENDENCE.  Except as otherwise permitted by the applicable
            NASDAQ rules, each member of the Audit Committee shall be
            independent as defined by NASDAQ rules, meet the criteria for
            independence set forth in Rule 10A-3(b)(1) under the Exchange Act
            (subject to the exemptions provided in Rule 10A-3(c)), and not
            have participated in the preparation of the financial statements
            of the Company or any current subsidiary of the Company at any
            time during the past three years.

      3.    FINANCIAL LITERACY.  Each member of the Audit Committee must be
            able to read and understand fundamental financial statements,
            including the Company's balance sheet, income statement, and cash
            flow statement, at the time of his or her appointment to the
            Audit Committee.  In addition, at least one member must have past
            employment experience in finance or accounting, requisite
            professional certification in accounting, or any other comparable
            experience or background which results in the individual's
            financial sophistication, including being or having been a chief
            executive officer, chief financial officer or other senior
            officer with financial oversight responsibilities.  Unless
            otherwise determined by the Board of Directors (in which case
            disclosure of such determination shall be made in the Company's
            annual report filed with the SEC), at least one member of the
            Audit Committee shall be an "audit committee financial expert"
            (as defined by applicable SEC rules).

      4.    CHAIR.  Unless  the Board of  Directors  elects a Chair of the Audit
            Committee, the Audit Committee shall elect a Chair by majority vote.

      5.    COMPENSATION.  The compensation of Audit Committee  members shall be
            as  determined  by the  Board of  Directors.  No member of the Audit
            Committee  may  receive,  directly or  indirectly,  any  consulting,
            advisory  or other  compensatory  fee from the Company or any of its
            subsidiaries,  other  than  fees  paid in his or her  capacity  as a
            member of the Board of Directors or a committee of the Board.

      6.    SELECTION  AND  REMOVAL.  Members  of the Audit  Committee  shall be
            appointed by the Board of Directors,  upon the recommendation of the
            Nominations Committee.  The Board of Directors may remove members of
            the Audit Committee from such committee, with or without cause.

C.    AUTHORITY AND RESPONSIBILITIES

      General
      -------

      The Audit Committee shall discharge its responsibilities, and shall assess
      the information  provided by the Company's  management and the independent
      auditor,   in  accordance  with  its  business  judgment.   Management  is
      responsible  for  the  preparation,  presentation,  and  integrity  of the
      Company's  financial   statements  and  for  the  appropriateness  of  the
      accounting principles and reporting policies that are used by the Company.
      The  independent  auditors are  responsible  for  auditing  the  Company's
      financial  statements  and for reviewing the Company's  unaudited  interim
      financial statements. The authority and responsibilities set forth in this
      Charter  do not  reflect  or create  any duty or  obligation  of the Audit
      Committee  to plan or conduct any audit,  to determine or certify that the
      Company's financial statements are complete,  accurate,  fairly presented,
      or  in  accordance  with  generally  accepted  accounting   principles  or
      applicable law, or to guarantee the independent auditor's report.






      Oversight of Independent Auditors
      ---------------------------------

      1.    SELECTION.   The  Audit  Committee  shall  be  solely  and  directly
            responsible   for  appointing,   evaluating,   retaining  and,  when
            necessary,  terminating the engagement of the  independent  auditor.
            The  Audit  Committee  may,  in  its  discretion,  seek  stockholder
            ratification of the independent auditor it appoints.

      2.    INDEPENDENCE.   The Audit Committee shall take, or recommend that
            the full Board of Directors take, appropriate action to oversee
            the independence of the independent auditor.  In connection with
            this responsibility, the Audit Committee shall obtain and review
            a formal written statement from the independent auditor
            describing all relationships between the auditor and the Company,
            including the disclosures required by Independence Standards
            Board Standard No. 1.  The Audit Committee shall actively engage
            in dialogue with the auditor concerning any disclosed
            relationships or services that might impact the objectivity and
            independence of the auditor.

      3.    COMPENSATION.  The  Audit  Committee  shall  have  sole  and  direct
            responsibility  for  setting  the  compensation  of the  independent
            auditor. The Audit Committee is empowered, without further action by
            the Board of Directors, to cause the Company to pay the compensation
            of the independent auditor established by the Audit Committee.

      4.    PREAPPROVAL OF SERVICES.  The Audit Committee  shall  preapprove all
            audit  services to be provided to the Company,  whether  provided by
            the  principal  auditor  or  other  firms,  and all  other  services
            (review,  attest and non-audit) to be provided to the Company by the
            independent auditor;  provided,  however,  that de minimis non-audit
            services may instead be approved in accordance  with  applicable SEC
            rules.

      5.    OVERSIGHT.  The independent auditor shall report directly to the
            Audit Committee, and the Audit Committee shall have sole and
            direct responsibility for overseeing the work of the independent
            auditor, including resolution of disagreements between Company
            management and the independent auditor regarding financial
            reporting.  In connection with its oversight role, the Audit
            Committee shall, from time to time as appropriate, receive and
            consider the reports required to be made by the independent
            auditor regarding:

               o    critical accounting policies and practices;

               o    alternative  treatments within generally accepted accounting
                    principles  for policies and  practices  related to material
                    items  that have been  discussed  with  Company  management,
                    including  ramifications  of  the  use of  such  alternative
                    disclosures and treatments,  and the treatment  preferred by
                    the independent auditor; and

               o    other   material   written    communications   between   the
                    independent auditor and Company management.

            In connection with its oversight  role, the Audit  Committee  should
            also  review  with the  independent  auditors,  from time to time as
            appropriate:

            (i)   significant  risks  and  uncertainties  with  respect  to  the
                  quality, accuracy or fairness of presentation of the Company's
                  financial statements;

            (ii)  recently  disclosed  problems  with  respect  to the  quality,
                  accuracy  or  fairness  of   presentation   of  the  financial
                  statements of companies  similarly situated to the Company and
                  recommended  actions  which  might  be  taken  to  prevent  or
                  mitigate the risk of problems at the Company arising from such
                  matters;

            (iii) any accounting  adjustments that were noted or proposed by the
                  auditor but were "passed" (as immaterial or otherwise);

            (iv)  any communications between the audit team and the audit firm's
                  national  office  respecting  auditing  or  accounting  issues
                  presented by the engagement;

            (v)   any  "management"  or "internal  control"  letter  issued,  or
                  proposed to be issued, by the audit firm to the Company;

            (vi)  accounting for unusual transactions;






            (vii) adjustments  arising from audits that could have a significant
                  impact on the Company's financial reporting process; and

            (viii)any  recent  SEC  comments  on  the   Company's  SEC  reports,
                  including in particular  any  unresolved or  future-compliance
                  comments.

      Audited Financial Statements
      ----------------------------

      6.    REVIEW AND DISCUSSION.  The Audit Committee shall review and discuss
            with the Company's  management and independent auditor the Company's
            audited  financial  statements,  including  the matters  about which
            Statement on Auditing  Standards No. 61  (Codification of Statements
            on Auditing Standards, AU ss.380) requires discussion.

      7.    RECOMMENDATION TO BOARD REGARDING  FINANCIAL  STATEMENTS.  The Audit
            Committee  shall consider  whether it will recommend to the Board of
            Directors  that  the  Company's  audited  financial   statements  be
            included in the Company's Annual Report on Form 10-K.

      8.    AUDIT COMMITTEE REPORT.  The Audit Committee shall prepare an annual
            committee   report  for  inclusion  where  necessary  in  the  proxy
            statement of the Company  relating to its annual meeting of security
            holders.

      Review of Other Financial Disclosures
      -------------------------------------

      9.    INDEPENDENT AUDITOR REVIEW OF INTERIM FINANCIAL STATEMENTS.  The
            Audit Committee shall direct the independent auditor to use its
            best efforts to perform all reviews of interim financial
            information prior to disclosure by the Company of such
            information and to discuss promptly with the Audit Committee and
            the Chief Financial Officer any matters identified in connection
            with the auditor's review of interim financial information which
            are required to be discussed by applicable auditing standards.
            The Audit Committee shall direct management to advise the Audit
            Committee in the event that the Company proposes to disclose
            interim financial information prior to completion of the
            independent auditor's review of interim financial information.

      Controls and Procedures
      -----------------------

      10.   OVERSIGHT.  The Audit Committee shall coordinate the Board of
            Directors' oversight of the Company's internal control over
            financial reporting, disclosure controls and procedures and code
            of conduct.  The Audit Committee shall receive and review the
            reports of the CEO and CFO required by Rule 13a-14 of the
            Exchange Act.  The Audit Committee shall periodically review the
            complaint procedures to confirm that they are effectively
            operating.

      11.   PROCEDURES  FOR  COMPLAINTS.  The Audit  Committee  shall  establish
            procedures   for  (i)  the  receipt,   retention  and  treatment  of
            complaints  received by the Company regarding  accounting,  internal
            accounting controls or auditing matters;  and (ii) the confidential,
            anonymous  submission  by  employees  of  the  Company  of  concerns
            regarding questionable accounting or auditing matters.

      12.   RELATED-PARTY  TRANSACTIONS.  The Audit  Committee  shall review all
            "related party transactions" (defined as transactions required to be
            disclosed  pursuant  to Item 404 of  Regulation  S-K) on an  ongoing
            basis,  and all such  transactions  must be  approved  by the  Audit
            Committee.

      13.   ADDITIONAL  POWERS. The Audit Committee shall have such other duties
            as may be delegated from time to time by the Board of Directors.

D.    PROCEDURES AND ADMINISTRATION

      1.    MEETINGS.  The  Audit  Committee  shall  meet as  often  as it deems
            necessary  in order  to  perform  its  responsibilities.  The  Audit
            Committee  may also act by  unanimous  written  consent in lieu of a
            meeting.  The Audit  Committee  shall  periodically  meet separately
            with: (i) the independent auditor; (ii) Company management and (iii)
            the Company's internal auditors. The Audit Committee shall keep such
            records of its meetings as it shall deem appropriate.

      2.    SUBCOMMITTEES.  The Audit Committee may form and delegate  authority
            to one or more subcommittees (including a subcommittee consisting of
            a single member),  as it deems  appropriate  from time to time under
            the  circumstances.






            Any decision  of a subcommittee to preapprove audit, review,  attest
            or  non-audit  services   shall  be  presented  to  the  full  Audit
            Committee at its next scheduled meeting.

      3.    REPORTS TO BOARD.  The Audit Committee shall report regularly to the
            Board of Directors.

      4.    CHARTER.  At least  annually,  the Audit  Committee shall review and
            reassess  the adequacy of this  Charter and  recommend  any proposed
            changes to the Board of Directors for approval.

      5.    INDEPENDENT ADVISORS.  The Audit Committee is authorized, without
            further action by the Board of Directors, to engage such
            independent legal, accounting and other advisors as it deems
            necessary or appropriate to carry out its responsibilities.  Such
            independent advisors may be the regular advisors to the Company.
            The Audit Committee is empowered, without further action by the
            Board of Directors, to cause the Company to pay the compensation
            of such advisors as established by the Audit Committee.

      6.    INVESTIGATIONS.  The Audit  Committee  shall have the  authority  to
            conduct or  authorize  investigations  into any  matters  within the
            scope  of  its   responsibilities  as  it  shall  deem  appropriate,
            including the authority to request any officer,  employee or advisor
            of the  Company  to meet with the Audit  Committee  or any  advisors
            engaged by the Audit Committee.

      7.    FUNDING. The Audit Committee is empowered, without further action by
            the Board of  Directors,  to cause the  Company to pay the  ordinary
            administrative expenses of the Audit Committee that are necessary or
            appropriate in carrying out its duties.








                                           PREFERRED STOCK
                                  COLLAGENEX PHARMACEUTICALS, INC.

                         PROXY SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS
                      OF THE CORPORATION FOR THE ANNUAL MEETING OF STOCKHOLDERS

     The undersigned  hereby  constitutes and appoints Colin W. Stewart and Nancy C. Broadbent,  and
each of them, his or her true and lawful agent and proxy with full power of substitution in each, to
represent and to vote on behalf of the undersigned all of the shares of CollaGenex  Pharmaceuticals,
Inc. (the "Company") which the undersigned is entitled to vote at the Annual Meeting of Stockholders
of the  Company  to be held  at the  Philadelphia  Marriott  Downtown  Hotel,  1201  Market  Street,
Philadelphia,  Pennsylvania  19107 at 8:30 A.M.,  local time, on Tuesday,  May 25, 2004,  and at any
adjournment or adjournments thereof, upon the following proposals more fully described in the Notice
of Annual Meeting of Stockholders  and Proxy  Statement for the Meeting  (receipt of which is hereby
acknowledged).

     This  proxy  when  properly  executed  will be  voted  in the  manner  directed  herein  by the
undersigned stockholder. If no direction is made, this proxy will be voted FOR proposals 1 and 2.

                            (continued and to be signed on reverse side)






                                  ANNUAL MEETING OF STOCKHOLDERS OF

                                  COLLAGENEX PHARMACEUTICALS, INC.

                                           PREFERRED STOCK

                                            May 25, 2004

      PLEASE DATE, SIGN AND MAIL YOUR PROXY CARD IN THE ENVELOPE PROVIDED AS SOON AS POSSIBLE.






PLEASE SIGN,  DATE AND RETURN  PROMPTLY IN THE ENCLOSED  ENVELOPE.  PLEASE MARK YOUR VOTE IN BLUE OR
BLACK INK AS SHOWN HERE. |X|


1.   ELECTION OF DIRECTOR
                                                      Nominee:
     |_|  FOR                                         Stephen A. Kaplan

     |_|  WITHHOLD AUTHORITY

                                                                               
2.   APPROVAL OF PROPOSAL TO RATIFY THE APPOINTMENT OF          FOR       AGAINST       ABSTAIN
     KPMG LLP AS THE INDEPENDENT AUDITORS OF THE COMPANY        |_|       |_|           |_|
     FOR THE YEAR ENDING DECEMBER 31, 2004.

3.   In his or her discretion, the proxy is authorized          FOR       AGAINST       ABSTAIN
     to vote upon other matters as may properly come            |_|       |_|           |_|
     before the Meeting.


                              Please check the box if you are
                              planning to attend the Meeting in person.   |_|

TO CHANGE THE ADDRESS ON YOUR  ACCOUNT,  PLEASE CHECK THE BOX AT RIGHT AND INDICATE YOUR NEW ADDRESS
IN THE ADDRESS SPACE ABOVE.  PLEASE NOTE THAT CHANGES TO THE  REGISTERED  NAME(S) ON THE ACCOUNT MAY
NOT BE SUBMITTED VIA THIS METHOD. |_|


Signature of Preferred Stockholder                          Date:
                                  ------------------------       -------------
Signature of Preferred Stockholder                          Date:
                                  ------------------------       -------------
                                        IF HELD JOINTLY

Note:     Please  sign  exactly as your name or names  appear on this  Proxy.  When  shares are held
          jointly,  each holder  should sign.  When signing as  executor,  administrator,  attorney,
          trustee  or  guardian,  please  give full title as such.  If the signer is a  corporation,
          please sign full corporate name by duly authorized officer,  giving full title as such. If
          signer is a partnership, please sign in partnership name by authorized person.






                                            COMMON STOCK
                                  COLLAGENEX PHARMACEUTICALS, INC.

                         PROXY SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS
                      OF THE CORPORATION FOR THE ANNUAL MEETING OF STOCKHOLDERS

     The undersigned  hereby  constitutes and appoints Colin W. Stewart and Nancy C. Broadbent,  and
each of them, his or her true and lawful agent and proxy with full power of substitution in each, to
represent and to vote on behalf of the undersigned all of the shares of CollaGenex  Pharmaceuticals,
Inc. (the "Company") which the undersigned is entitled to vote at the Annual Meeting of Stockholders
of the  Company  to be held  at the  Philadelphia  Marriott  Downtown  Hotel,  1201  Market  Street,
Philadelphia,  Pennsylvania  19107 at 8:30 A.M.,  local time, on Tuesday,  May 25, 2004,  and at any
adjournment or adjournments thereof, upon the following proposals more fully described in the Notice
of Annual Meeting of Stockholders  and Proxy  Statement for the Meeting  (receipt of which is hereby
acknowledged).

     This  proxy  when  properly  executed  will be  voted  in the  manner  directed  herein  by the
undersigned stockholder. If no direction is made, this proxy will be voted FOR proposals 1 and 2.

                            (continued and to be signed on reverse side)






                                  ANNUAL MEETING OF STOCKHOLDERS OF

                                  COLLAGENEX PHARMACEUTICALS, INC.

                                            COMMON STOCK

                                            May 25, 2004

      Please date, sign and mail your proxy card in the envelope provided as soon as possible.

                          Please detach and mail in the envelope provided.






PLEASE SIGN,  DATE AND RETURN  PROMPTLY IN THE ENCLOSED  ENVELOPE.  PLEASE MARK YOUR VOTE IN BLUE OR
BLACK INK AS SHOWN HERE. |X|


1.   ELECTION OF DIRECTORS                              Nominees:
     |_|  For All Nominees                         |_|  Colin W. Stewart          |_|  James E. Daverman
     |_|  Withhold Authority for All Nominees      |_|  Peter R. Barnett, D.M.D   |_|  Robert J. Easton
     |_|  For All Except (See instructions below)  |_|  Robert C. Black           |_|  W. James O'Shea
                                                   |_|  Brian M. Gallagher, Ph.D.

INSTRUCTION:  To withhold authority to vote for any individual  nominee(s) mark "FOR ALL EXCEPT" and
fill in the circle next to each nominee you wish to withhold, as shown here: |X|

2.   APPROVAL OF PROPOSAL TO RATIFY THE APPOINTMENT OF         FOR       AGAINST       ABSTAIN
     KPMG LLP AS THE INDEPENDENT AUDITORS OF THE COMPANY       |_|       |_|           |_|
     FOR THE YEAR ENDING DECEMBER 31, 2004.

3.  In his or her discretion, the proxy is authorized to       FOR       AGAINST       ABSTAIN
    vote upon other matters as may properly come before        |_|       |_|           |_|
    the Meeting.


                              Please check the box if you are
                              planning to attend the Meeting in person.   |_|

TO CHANGE THE ADDRESS ON YOUR  ACCOUNT,  PLEASE CHECK THE BOX AT RIGHT AND INDICATE YOUR NEW ADDRESS
IN THE ADDRESS SPACE ABOVE.  PLEASE NOTE THAT CHANGES TO THE  REGISTERED  NAME(S) ON THE ACCOUNT MAY
NOT BE SUBMITTED VIA THIS METHOD. |_|


Signature of Preferred Stockholder                          Date:
                                  ------------------------       -------------
Signature of Preferred Stockholder                          Date:
                                  ------------------------       -------------
                                        IF HELD JOINTLY

Note:     Please  sign  exactly as your name or names  appear on this  Proxy.  When  shares are held
          jointly,  each holder  should sign.  When signing as  executor,  administrator,  attorney,
          trustee  or  guardian,  please  give full title as such.  If the signer is a  corporation,
          please sign full corporate name by duly authorized officer,  giving full title as such. If
          signer is a partnership, please sign in partnership name by authorized person.