EXHIBIT 10.12



                                       December 26, 1996



Thomas P.H. Twaddell, M.D., F.A.C.G.
600 Duncan Street
San Francisco, CA  94131

Dear Dr. Twaddell:

         On behalf of Jenner  Technologies  (the  "Company"),  I am  pleased  to
invite you to join the Company as its Vice  President  of Clinical  Research and
Product Development.  In this position, you will be expected to devote your fill
business time, attention and energies to the performance of your duties with the
Company.  The effective date of your employment will be on or before January 15,
1997.

         The terms of this offer of employment are as follows:

         1.       Compensation.  The Company  will pay you a salary of $7,083.33
                  twice  a month  in  accordance  with  the  Company's  standard
                  payroll policies ($170,000 annual).  Your salary will begin as
                  of the  effective  date of  employment.  The  first  and  last
                  payment by the Company to you will be adjusted,  if necessary,
                  to reflect a commencement  or termination  date other than the
                  first or last working day of a pay period.

         2.       Benefits.  You  will  be  entitled  during  the  term  of your
                  employment  to the  Company's  standard  vacation and benefits
                  covering  employees,  as such may be in  effect  from  time to
                  time,  in  addition,  when you  travel  for  Company  business
                  matters, the Company will reimburse you for all business class
                  flights, first class if business class not available.

         3.       Stock  Option.  Subject  to action by the  Company's  Board of
                  Directors and  compliance  with  applicable  state and federal
                  securities  laws,  the Company  will grant to you an option to
                  purchase 150,000 shares of the Company's Common Stock pursuant
                  to the Company's  1993 Employee  Stock Plan, or other Employee
                  Stock Plan adopted by the Company (the  "Plan").  The exercise
                  price of the option  will be $1.73 per share.  The option will
                  vest over four  years  with 1/4 of the  shares  subject to the
                  option  vesting  one  year  from  the  effective  date of your
                  employment  and 1/48 of the shares  vesting at the end of each
                  full month thereafter until all







                  shares are vested,  subject to all  provisions of the Plan and
                  your continued employment with the Company.

         4.       At-Will Employment. Your employment with the Company is for no
                  specified period and constitutes  "at-will"  employment.  As a
                  result, you are free to terminate your employment at any time,
                  for any reason or for no  reason.  Similarly,  the  Company is
                  free to terminate your  employment at any time, for any reason
                  or  for no  reason.  In  the  event  of  termination  of  your
                  employment,   you  will  not  be  entitled  to  any  payments,
                  benefits,  damages,  awards or compensation  other than as set
                  forth herein and as may  otherwise be available in  accordance
                  with the Company's  established employee plans and policies at
                  the time of termination.

         5.       Severance.  In the event your  employment  with the Company is
                  terminated without Cause by the Company,  you will be entitled
                  to  continuation  of your base  salary for a period of six (6)
                  months.  For  purposes of this  severance  provision,  "Cause"
                  means gross negligence, gross misconduct,  habitual neglect of
                  duties,  dishonesty,  criminal acts, violation of any state or
                  federal   securities  laws,  and  disobeyment  of  the  lawful
                  policies or instruction of the Board of Directors.

         6.       Proprietary Information Agreement. As a condition of accepting
                  this offer of  employment,  you will be required to  complete,
                  sign  and  return   the   Employee   Proprietary   Information
                  Agreement,  attached  hereto,  along with a copy of this offer
                  letter.

         7.       Immigration  Laws. For purposes of federal  immigration  laws,
                  you will be  required  to provide to the  Company  documentary
                  evidence of your identity and  eligibility  for  employment in
                  the United States.  Such documentation must be provided within
                  3 business days of the effective date of your  employment,  or
                  your   employment   relationship   with  the  Company  may  be
                  terminated.

         8.       General.   This  offer   letter,   the  Employee   Proprietary
                  Information Agreement and the agreement(s)  representing stock
                  options granted to you under the Plan, when signed by you, set
                  forth in the terms of your  employment  with the  Company  and
                  supersede any and all prior  representations  and  agreements,
                  whether written or oral. This agreement can only be amended in
                  a writing  signed by you and an  officer of the  Company.  Any
                  waiver of a right  under this  agreement  must be in  writing.
                  This agreement will be governed by California law.







         We look forward to you joining the Company.  If the foregoing terms are
agreeable,  please indicate your acceptance by signing the enclosed copy of this
letter in the space  provided  below and  returning  it to me,  along  with your
completed and signed Employee Proprietary Information Agreement. This offer will
terminate if not accepted on or before January 15, 1997.

                                                Sincerely,

                                                JENNER TECHNOLOGIES


                                                /s/ ANTHONY E. MAIDA
                                                ------------------------------
                                                Anthony E. Maida, III, MA, MBA
                                                Chief Executive Officer


ACCEPTED:


/s/ Thomas Twaddell
- --------------------------------------
Thomas P.H. Twaddell, M.D., F.A.C.G.