EXHIBIT 10.14

                                 LEASE AGREEMENT


         1. Parties.  This lease,  dated for reference  purposes only,  Tuesday,
August 13, 1996, is made by and between Bay Business Centers,  Inc., Lessor, and
Jenner Technologies hereinafter called Lessee.

         2. Premises. Lessee hereby leases from Lessor the premises described as
2010 Crow Canyon Place, Suite #100, San Ramon, CA 94583, Office #330 & #332.

         3. Term. A six month term shall commence on September 1, 1996 and shall
continue until February 1, 1997. Lessee shall give a 60-day notice in writing of
its intent to renew or cancel  Lease  Agreement,  prior to  termination  date of
February 1, 1997. If a 60-day notice is not rendered, Lessor will consider Lease
Agreement to be renewed for an additional term, at the then going rate. Holdover
- - in the event Lessee  holds over beyond the end of the Lease term,  the monthly
recurring  charges shall be assessed at 150% their monthly rate and the holdover
period shall be for no less than one month.

         4.  Possession.  If Lessor for any  reason  whatsoever  cannot  deliver
possession  of the leased  premises  to Lessee at the  commencement  of the term
hereof, this shall not be void or voidable, nor shall Lessor be liable to Lessee
for any loss or damage resulting therefrom, nor shall the expiration date of the
above term be in any way extended,  but in that event,  all rent shall be abated
during the period  between the  commencement  of the term,  as  provided  for in
Paragraph 3 hereinabove,  and the time Lessor delivers possession.  In the event
that  Lessor  shall  permit  Lessee to occupy the leased  premises  prior to the
commencement  date of the term,  such  occupancy  shall be subject to all of the
provisions of this Lease Agreement.  Such early possession shall not advance the
termination date hereinabove provided.

         5. Rent. Lessee agrees to pay Lessor the sum of $1050.00 per month plus
$110.00 per phone set for phone equipment  rental per month due on the first day
of each month.  Any  installment  of rent or any other  recurring  sums due from
Lessee not  received  by Lessor  within  five (5) days after such  amount is due
shall be  assessed a late  charge  equal to ten  percent  (10%) of such  overdue
amount plus $50.00.  Clerical  Services  and Other  Services  incurred  shall be
invoiced  semimonthly  on the 15th and last day of each month.  Payment for said
services  are due and payable  within  thirty (30) days of billing  date. A late
charge equal to two percent  (2%) plus $10.00 will be assessed on said  services
if payment is not  received  within  thirty  (30) days of  billing  date.  If an
installment  for rent or invoice for  services is overdue  more than thirty (30)
days,  Lessor has the right to  discontinue  all services upon the  thirty-first
(31st) day of delinquency.  Billing inquiries and/or change of address should be
directed  towards:  Bay Business  Centers,  Inc., Attn:  Accounting  Dept., 4900
Hopyard Road, Suite #100, Pleasanton,  California 94588. In the event this Lease
Agreement  term  starts on a day other than the first of the month,  the monthly
recurring charges shall be prorated for the current month and collected with the
first full month plus last month.

         The monthly rental rate stated herein is predicated on providing office
space and services, as provided in Paragraphs 13 and 14, for 1 person(s).





Additional Reception Service    $100.00/each additional person - w/o voice mail
(receiving calls & caller's)    $125.00/each additional person - with voice mail

         Lessee  hereby  agrees to notify  Lessor in writing no less than thirty
(30) days prior to addition  of staff  members  for which  Lessor  will  provide
services.

         6. Prepaid Rent & Opening Charges. Concurrently with Lessee's execution
of this Lease Agreement, Lessee shall pay the Lessor the sum of:



RECURRING CHARGES (1ST & LAST)
- -------------------------------------------------------------------------------------------------------
                                                                                              
Office Rent (1st & last) (recurring charge).............................................       $2100.00
Additional Users (1st & last) (recurring charge)........................................          $0.00
Furniture:
(1st & last) (recurring charge).........................................................        $200.00
Mail Forwarding Service (1st & last) (recurring charge).................................          $0.00
Storage Rental (1st & last) (recurring charge)..........................................          $0.00
Additional Voice Mail Box Rental ($25/each/month) (1st & last) (recurring charge).......          $0.00
Voice Mail Paging (1st & last) (recurring charge).......................................          $0.00
Phone Line Service - Dial Tone (1st & last) (recurring charge)..........................        $120.00
Phone Equipment Rental (1st & last) (recurring charge)..................................        $220.00
Speed Dial (1st & last)(recurring charge)...............................................          $0.00
Conference Calling (1st & last) (recurring charge)......................................          $0.00
Call Forwarding (1st & last) (recurring charge).........................................          $0.00
Delayed Call Forwarding (1st & last) (recurring charge).................................          $0.00
Pacific Bell Directory Listing ($2/mo.) (1st & last) (recurring charge).................          $4.00
Copy Pkg. (1st) (recurring charge)......................................................          $0.00
Conference Pkg. (1st) (recurring charge)................................................          $0.00
Administrative Pkg. (1st) (recurring charge)............................................          $0.00
Secretarial Pkg. (1st) (recurring charge)...............................................          $0.00


ONE-TIME/INSTALLATION CHARGES                                                            
- -----------------------------------------------------------------------------------------
Administrative Start-up Fee (one-time charge)...........................................        $125.00
Additional Users Administrative Start-up Fee (one-time charge)..........................
Cleaning Fee ($200/Ofc.-less than 1 yr.) (one-time charge)..............................        $200.00
Furniture Move Fee (one-time charge)....................................................          $0.00
Furniture Set-Up Fee (one-time charge)..................................................          $0.00
Lobby Directory Listing (one-time charge)...............................................         $40.00
Key Deposit ($65/set X 2 Key Set(s)) (refundable).......................................        $130.00
Single Key Deposit ($33/key X (refundable)..............................................
Storage Installation (one-time charge)..................................................          $0.00
Voice Mail Installation (one-time charge)...............................................          $0.00
Voice Mail Paging Installation (one-time charge)........................................          $0.00
Phone Line Installation (one-time charge)...............................................        $241.00
Fax/Modem Install (one-time charge).....................................................        $185.00
Phone Equipment Installation (one-time charge)..........................................        $370.00                             
Calling Feature Installation (one-time charge)..........................................          $0.00
                                                                                              ---------
                                                                                        
         TOTAL..........................................................................       $3935.00
                                                                                              ---------


*Phone  Line  Service  represents  monthly  fee for dial tone.  Phone Line Usage
(outgoing calls) is a variable charge and will be billed semimonthly, due within
10 days of statement date.


                                       -2-



         7.  Use.  The  premises  are to be used for  sales  and  administrative
purposes only.

         8.   Conditions.   Lessee  shall  not  disturb,   annoy,   endanger  or
inconvenience  other tenants in the building or suite,  nor use the premises for
any immoral, unlawful, or sleeping purposes, nor violate any law or ordinance or
commit waste, nuisance or damage upon or about the property.

         9.  Repairs,  Maintenance  and  Alterations.  Lessee shall at all times
during the term  hereof,  at its sole cost and  expense,  keep the  premises and
every part thereof in good condition and repair,  except damage thereto by fire,
earthquake,  act of God or the elements.  Lessee hereby waives the right to make
repairs at Lessor's  expense  under any law,  statute or ordinance  with respect
thereto now or hereafter in effect.  Unless otherwise expressly provided herein,
Lessor shall not be required to make any  improvements or repairs of any kind or
character on or to the leased premises during the term of this Lease  Agreement.
Lessee shall return,  upon  expiration  of this  Agreement the premises in their
original  configuration,  design, and condition to Lessor.  Lessee shall, at its
own cost and  expense,  repair or  replace  any  damage or injury to the  leased
premises, or any part thereof,  caused by Lessee or Lessee's agents,  employees,
invitees,  licensees,  or visitors;  provided,  however, if Lessee fails to make
such  repairs or  replacements  promptly,  Lessor may, at its option,  make such
repairs or  replacements,  and Lessee shall reimburse the cost thereof to Lessor
on demand,  together with interest at the maximum  annual rate  permitted by law
from the date of such work.

         If Lessee  vacates the  premises and leaves the premises in a condition
requiring  painting,  carpet  cleaning,  or other  maintenance  to  restore  the
premises  to  leasable  condition,  a minimum  fee of $200.00 per office will be
assessed and confirmed in the  termination  meeting (if  conducted) or within 30
days of date of vacancy.

         Lessee  agrees  to keep a floor  mat  under  any  and all  chairs  with
rollers/wheels at all times to protect the carpeting.

         10. Abandonment. If Lessee abandons or vacates the premises, Lessor may
at its option terminate this Lease  Agreement,  re-enter the premises and remove
all property.

         11. Essence of Time. Time is of the essence of this Lease Agreement and
all provisions hereof.

         12.  Insurance.  Lessee shall  indemnify  and hold  harmless  Lessor as
respects to any bodily injury or property damage arising out of their operations
and business conducted on premises. Lessee shall maintain liability insurance in
amounts  no less than  $300,000  combined  single  limit for  bodily  injury and
property damage.  Lessee shall provide Lessor with a certificate of insurance as
evidence  of the above  conditions  and Lessor  shall be named as an  additional
insured.


                                       -3-




         13.  Services.  Included in the monthly rental specified in Paragraph 5
herein,  Lessee shall be entitled to the following  clerical and  administrative
services:

Full-time  Receptionist  Service          Mail  Processing  Service 
(8:30 a.m.-5:00 p.m., Monday-Friday       Incoming Mail Sorted
excluding holidays)                       Outgoing - daily mail 10 pcs.

Telephone Answering                       Voice Mail 24 hrs./day,
8:30 a.m.-5:00 p.m.                       7 days/week
Monday-Friday, by Receptionist,           Complimentary 100 Voice Mail Msgs./Box
(excluding holidays)                      Additional messages @ $.35/ea.

                                          Access to Office, Building, & Copier
                                          24 hrs./day, 7 days/week

Hourly Office Rental/                     Access to:
Conference Room Facilities                Secretarial Services
By Reservation                            8:30 a.m. - 5:00 p.m.
4 Hours/month included                    Monday-Friday,
(non-cumulative)                          (excluding holidays)
                                          (Billed as Utilized, see Exhibit B)

         Lessee hereby agrees all telephone  equipment and line services will be
coordinated by Lessor with Lessor's  telephone  vendor.  Lessee shall not modify
nor change outlets, telephone sets, or jacks.

         14. Services & Non-Service Items.  Services and non-service items shall
be invoiced  semi-monthly  on the 15th and last day of each  month.  Payment for
said  services are due and payable  within  thirty (30) days of billing  date. A
finance  charge of 2% per month will be assessed for all services and  recurring
charges unpaid beyond 30 days of the invoice date.

         At the end of a term,  all charges and credits  will be applied.  It is
understood  freight  bills  and  vendor  charges  may take up to 60 days to pass
through Lessee,  therefore a 90-day period may be required to reimburse  credits
or conclude final account balance.

         If collection  time is required due to delinquent  account status a fee
of $45/hour will be assessed for  administrative  time at a minimum of $9.00 per
collection contact.

SERVICES
- --------
Secretarial Service                     Minimum billable unit 1/10 of an hour.
See Exhibit B for Rates

Word Processing (keyboarding)           Minimum billable unit 3/10 of an hour. 
See Exhibit B for Rates                 Minimum per page 3/10 of an hour(input).
                                        Editing - Minimum 2/10 of an hour.


                                       -4-




         Standard  Turnaround - 1-3 pages (24 hrs.) 4 or more pages - turnaround
determined by Bay Business Centers, Inc.

         Lessee  agrees that during the term of this  Agreement  and for six (6)
months after its  termination  will not offer  employment  to or hire any of the
employees  of Lessor.  If Lessee  does not keep that  agreement,  Lessee will be
liable to Lessor for  damages  in the sum of  twenty-five  percent  (25%) of the
annual  compensation  of each employee  involved,  it being  mutually  agreed by
Lessee and Lessor that this provision for  liquidated  damages is reasonable and
that the actual  damage  which would be  sustained  by Lessor as the result of a
failure to keep the agreement  would be, from nature of the case,  impracticable
or extremely difficult to fix.

         Further,  Lessee  shall not provide,  utilize,  or sell any services or
non-service items,  which are provided by Bay Business Centers,  Inc., as listed
on Exhibit B to other tenants or clients of Bay Business  Centers,  Inc., or for
any other person or company.

         Lessee shall not contract  with an  independent  contractor,  temporary
personnel agency, or individual for the purpose of providing  secretarial,  word
processing, or any services Bay Business Centers, Inc. provides.

         If Lessee  wishes to employ an  administrative  assistant  or  clerical
staff member,  it is with the  understanding an additional office must be leased
from Bay Business Centers,  Inc. and prior written approval is obtained from Bay
Business Centers, Inc. for its use.

         15. Notices. In every instance where it shall be necessary or desirable
for the Lessee to serve any notice or demand  upon the  Lessor,  such  notice or
demand shall be sent by United States  "Registered" or "Certified" mail, postage
prepaid, addressed to:

                              Ms. Marilyn L. Newton
                           Bay Business Centers, Inc.
                        2010 Crow Canyon Road, Suite 100
                               San Ramon, CA 94583

or at such other address of Lessor, as may appear on the records of Lessee.  Any
notice or demand to be given by the Lessor to the Lessee  shall be  effective if
mailed to (Lessee's administrative office):

                                 Mr. Tony Maida
                               Jenner Technologies
                                828 Eastbrook Ct.
                               Danville, CA 94506

Notice  mailed as  aforesaid  shall be deemed to have been served at the time of
postal meter cancellation date.


                                       -5-



         16.  Occupancy/Use of Premises.  Lessee shall not assign this Lease nor
permit the occupancy or use of any part thereof  without the written  permission
of Lessor.

         Lessee will not install or maintain a coffee maker or copier machine in
Lessee's office. Lessee further acknowledges smoking is not permitted within the
suite and must be restricted to outside of the suite.

         17.  Attorneys  Fees.  In an event of any legal  action  or  proceeding
brought by either  party  against  the other  under this  Lease  Agreement,  the
prevailing  party  shall be  entitled  to  recover  all its costs and  expenses,
including  without  limitation  the fees and  costs of  appeal,  if any,  of its
attorneys of such action or proceeding in such amount as is reasonable.

LESSEE:                                               LESSOR:
Jenner Technologies                                   Bay Business Centers, Inc.

By: /s/ ANTHONY E. MAIDA                              By: /s/ MARILYN L. NEWTON
   -----------------------------                         -----------------------
        Anthony E. Maida, III                         Title:  President
        Chief Executive Officer                       Name:  Marilyn L. Newton
        Jenner Technologies
        828 Eastbrook Court
        Danville, CA  94506



                                       -6-



                                    Exhibit A

                               [Plan of Premises]






                                    Exhibit B

   Minimum time usage is assessed as an "Administrative Assist"* at $2.00/each

                            Priority Service Charges
- --------------------------------------------------------------------------------
1-4 Hours=Priority 1+50%    4-8 Hours=Priority 2+25%    Overtime Required= +100%



                             Project Classification
====================================================================================================================================
 CLASS                        DESCRIPTION                       CLASS                       DESCRIPTION
====================================================================================================================================
                                                                 
1         Typed or clearly written source document; no edits      2     Typed or written requiring minor edits/single level
          required.                                                     outline format/minor tabbing.
- ------------------------------------------------------------------------------------------------------------------------------------
3         Difficult to read; major edits required.                4     Technical.
====================================================================================================================================




   CODE                             SERVICE DESCRIPTION                                    RATE                  UNITS
- ------------------------------------------------------------------------------------------------------------------------------------
                                                                                                       
AAA         Administrative Assistance - Bookkeeping or Mgt. Assistance..........           30.0                 Per Hour
ADT         Administrative Assists* (minimum clerical fee)......................            2.0                 Each
AIR         Airborne Shipping...................................................            0.0                 Cost + 20%
ASV         Answering Service...................................................          100.0                 Monthly
BIN         Binding.............................................................            3.5                 Each
SCP         Color Prints (Laser)................................................            2.5                 Each
COP         Copying.............................................................             .1                 Each
CRF         Conference Room/Flex Ofc. Rental (COD Clients)......................           25.0                 Per Hour
CRC         Conference/Flex Ofc. Rental (On-Account Clients)....................           20.0                 Per Hour
CSP         Coffee by the Pot (for meetings)....................................           10.0                 Each
DIR         Directory Listing (or directory change).............................           40.0                 Each    
DSS         Disk Storage (200.000 characters/disk)..............................          20.06                 Months
DUP         Duplicate Statement.................................................            5.0                 Each
EMS         Extra Messages (after monthly allowance)............................             .3                 Each
FAX         Facsimile Service...................................................            1.0                 Each Pg.
FMA         Furniture Initial Set-up............................................           50.0                 Per Office
FMV         Furniture Move......................................................            0.0                 Variable
FNT         Furniture Rental....................................................            0.0                 Per Month
FXW         Facsimile Service - Word Processing Work TO a Client................             .2                 Each Pg.            
GRP         Graphics............................................................           55.0                 Per Hour
IFM         If/Relay Message/Paging (Special Msg. Handling).....................            2.0                 Each
LAM         Lamination (Business Card Size or 8 1/2 x 11).......................    1.5 or 4.00                 Each
LMC         Long Handwritten Message............................................            2.0                 Each
LPO         List/Label Printout.................................................            2.5                 Page
MLG         Mailings:  Parcel/Express/Certified Mail Prep.......................            4.0                 Each
MSS         Mailing Address Svc.................................................           35.0                 Monthly
OLS         Overnight/Express Letter Service....................................           12.5                 Each
PCC         Phone Call (Outgoing Calls made by BBC Staff)............75/local; 1.25/toll; 2.50/LD               Each
PHH         Parcel Handling - Parcel Delivery to Office.........................            2.0                 Each
POS         Postage.............................................................            0.0                 Cost + 20%
PRS         Presentations - Multiple Font Documents.............................           45.0                 Per Hour
SPO         Printouts (per page or envelope).................................75/black; 2.50/color               Per/Pg.
REN         Rent (monthly recurring per contract)...............................            0.0                 Variable
SSS         Resume & Consultation Services......................................       By Quote                 Per Service
SCN         Scanning............................................................           10.0                 Per Image
SHP         Ship via BBC (client uses their Acct. #)............................            1.0                 Each Piece
SCR         Secretarial Service - Regular, 24-hour Turnaround...................           22.0                 Per Hour
SC2         Secretarial Service - 4-8/hour Turnaround...........................           27.5                 Per Hour
SC1         Secretarial Service - 1-4/hour Turnaround...........................           33.0                 Per Hour
SCV         Secretarial Service - Requiring Overtime............................           44.0                 Per Hour
SPS         Spreadsheets........................................................           40.0                 Per Hour
TER         Telephone Equip. Rental.............................................           55.0                 Per Set/Mo.
UPS         UPS Shipment (Parcels)..............................................            0.0                 Cost + 20%
VMS         Voice Mail Box......................................................           25.0                 Each
WIT         Witness Signatures..................................................            6.0                 Each
WCR         Word Processing Client - Regular, 24-hour Turnaround................           30.0                 Per Hour
WC2         Word Processing Client - 4-8/hour Turnaround........................           37.5                 Per Hour
WC1         Word Processing Client - 1-4/hour Turnaround........................           45.0                 Per Hour
WCV         Word Processing Client - Requiring Overtime.........................           60.0                 Per Hour
WPR         Word Processing Tenant - Regular, 24-hour Turnaround................           27.0                 Per Hour
WP2         Word Processing Tenant - 4-8/hour Turnaround........................           33.7                 Per Hour
WP1         Word Processing Tenant - 1-4/hour Turnaround........................           40.5                 Per Hour
WPV         Word Processing Tenant - Requiring Overtime.........................           54.0                 Per Hour
YSS         Supplies (see Supplies Price List)..................................            0.0                 Variable


PRICES SUBJECT TO CHANGE AT THE DISCRETION OF BAY BUSINESS CENTERS, INC.


                                       -1-