As filed with the Securities and Exchange Commission on February 5, 2007

                                            Securities Act File No. 333-133900


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                      SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C. 20549

                               -----------------

                                   FORM N-14
                            REGISTRATION STATEMENT
                                     UNDER
                          THE SECURITIES ACT OF 1933

                               -----------------

                          Pre-Effective Amendment No.
                        Post-Effective Amendment No. 1

                               -----------------

                    BLACKROCK LARGE CAP SERIES FUNDS, INC.
              (Exact name of Registrant as Specified in Charter)

                               -----------------
                                (609) 282-2800
                       (Area Code and Telephone Number)

                               -----------------

                            800 Scudders Mill Road
                         Plainsboro, New Jersey 08536

                   (Address of Principal Executive Offices:
                    Number, Street, City, State, Zip Code)

                               -----------------

                              Robert C. Doll, Jr.
                    BlackRock Large Cap Series Funds, Inc.
             800 Scudders Mill Road, Plainsboro, New Jersey 08536
       Mailing Address: P.O. Box 9011, Princeton, New Jersey 08543-9011

                    (Name and Address of Agent for Service)

                                  copies to:



                                                   
  Frank P. Bruno, Esq.         Sarah E. Cogan, Esq.            Richard T. Prins, Esq.
   Sidley Austin LLP      Simpson Thacher & Bartlett LLP  Skadden, Arps, Meagher & Flom LLP
   787 Seventh Avenue          425 Lexington Avenue                4 Times Square
New York, New York 10019     New York, New York 10017      New York, New York 10036-6522



     No filing fee is required because of reliance on Section 24(f) of the
                       Investment Company Act of 1940.






      This Post-Effective Amendment No. 1 to the Registrant's Registration
Statement on Form N-14 (File No. 333-133900) (the "N-14 Registration
Statement") consists of the following:

      (1)   Facing Sheet of this Registration Statement

      (2)   Part C of this Registration Statement (including signature page).

      Parts A and B to the N-14 Registration Statement are unchanged from the
Proxy Statement and Prospectus filed on June 15, 2006 contained in
Pre-Effective Amendment No. 1 to the Fund's N-14 Registration Statement.

      This Post-Effective Amendment No. 1 to the N-14 Registration Statement
is being filed solely to file a tax opinion of Sidley Austin LLP, counsel for
the Registrant, as Exhibit 12 to the N-14 Registration Statement. The tax
opinion relates to the reorganization of BlackRock Large Cap Growth Equity
Portfolio, a portfolio of BlackRock FundsSM, into BlackRock Large Cap Growth
Fund (formerly known as Merrill Lynch Large Cap Growth Fund), a series of
BlackRock Large Cap Series Funds, Inc. (formerly known as Merrill Lynch Large
Cap Series Funds, Inc.).






                                    PART C
                               OTHER INFORMATION

Item 15.  Indemnification

      Reference is made to Article V of the Registrant's Articles of
Incorporation, Article VI of the Registrant's By-Laws, Section 2-418 of the
Maryland General Corporation Law and Section 9 of the Distribution Agreement.

      Insofar as the conditional advancing of indemnification moneys for
actions based on the Investment Company Act of 1940, as amended (the "1940
Act") may be concerned, Article VI of the Registrant's By-Laws provides that
such payments will be made only on the following conditions: (i) advances may
be made only on receipt of a written affirmation of such person's good faith
belief that the standard of conduct necessary for indemnification has been met
and a written undertaking to repay any such advance if it is ultimately
determined that the standard of conduct has not been met; and (ii) (a) such
promise must be secured by a security for the undertaking in form and amount
acceptable to the Registrant, (b) the Registrant is insured against losses
arising by receipt by the advance, or (c) a majority of a quorum of the
Registrant's disinterested non-party Directors, or an independent legal
counsel in a written opinion, shall determine, based upon a review of readily
available facts, that at the time the advance is proposed to be made, there is
reason to believe that the person seeking indemnification will ultimately be
found to be entitled to indemnification.

      In Section 9 of each Distribution Agreement relating to the securities
being offered hereby, the Registrant agrees to indemnify FAM Distributors,
Inc. or BlackRock Distributors, Inc., as applicable, and each person, if any,
who controls FAM Distributors, Inc. or BlackRock Distributors, Inc. within the
meaning of the Securities Act of 1933, as amended (the "1933 Act"), against
certain types of civil liabilities arising in connection with the Registration
Statement or Prospectus and Statement of Additional Information.

      Insofar as indemnification for liabilities arising under the 1933 Act
may be permitted to Directors, officers and controlling persons of the
Registrant and the principal underwriter pursuant to the foregoing provisions
or otherwise, the Registrant has been advised that in the opinion of the
Securities and Exchange Commission such indemnification is against public
policy as expressed in the 1933 Act and is, therefore, unenforceable. In the
event that a claim for indemnification against such liabilities (other than
the payment by the Registrant of expenses incurred or paid by a Director,
officer, or controlling person of the Registrant and the principal underwriter
in connection with the successful defense of any action, suit or proceeding)
is asserted by such Director, officer or controlling person or the principal
underwriter in connection with the shares being registered, the Registrant
will, unless in the opinion of its counsel the matter has been settled by
controlling precedent, submit to a court of appropriate jurisdiction the
question whether such indemnification by it is against public policy as
expressed in the 1933 Act and will be governed by the final adjudication of
such issue.








Item 16.  Exhibits.
Exhibit
Number       Description

- ---------    -----------

          
     1(a) -- Articles of Incorporation of the Registrant, filed October 20, 1999.(a)
      (b) -- Articles Supplementary Classifying Shares of Authorized Capital Stock and Creating an Additional Class of Common Stock
             dated December 9, 2002.(b)
      (c) -- Articles of Amendment to Articles of Incorporation of the Registrant, dated March 21, 2003, redesignating certain
             classes of common stock.(c)
      (d) -- Form of Articles Supplementary.(j)
      (e) -- Form of Articles of Amendment Reclassifying Shares of Authorized Capital Stock.(k)
      (f) -- Form of Articles of Amendment changing the name of the Corporation to BlackRock Large Cap Series Funds, Inc.(k)
     2    -- Amended and Restated By-Laws of the Registrant, dated April 14, 2003.(c)
     3    -- Not applicable.
     4    -- Form of Agreement and Plan of Reorganization by and between the Registrant, on behalf of Merrill Lynch Large Cap Growth
             Fund, Master Large Cap Growth Trust, on behalf of Master Large Cap Growth Portfolio, and BlackRock Funds, on behalf of
             BlackRock Large Cap Growth Equity Portfolio (the "BlackRock Fund"), a series of BlackRock Funds.(j)
     5    -- Portions of the Articles of Incorporation and By-Laws of the Registrant defining the rights of holders of shares
             of Common Stock of the Registrant.(e)
     6    -- None.
     7(a) -- Form of Unified Distribution Agreement between the Registrant and FAM Distributors, Inc.(h)
      (b) -- Form of Unified Distribution Agreement between the Registrant and BlackRock Distributors, Inc.(f)
     8    -- None.
     9    -- Form of Custodian Agreement between Registrant and Brown Brothers Harriman & Co.(g)

    10(a) -- Form of Investor A Distribution Plan.(h)
      (b) -- Form of Investor B Distribution Plan.(h)
      (c) -- Form of Investor C Distribution Plan.(h)
      (d) -- Form of Class R Distribution Plan of the Registrant.(h)
      (e) -- Form of Service Shares Distribution Plan.(k)
      (f) -- Form of Select Pricing System Plan pursuant to Rule 18f-3.(f)
    11    -- Opinion of Sidley Austin LLP, counsel to the Registrant.(j)
    12    -- Tax opinion of Sidley Austin LLP, tax counsel for the Registrant, the Fund and the BlackRock Fund.
    13(a) -- Form of Administration Agreement between the Registrant and BlackRock Advisors, LLC.(k)
      (b) -- Form of Administrative Services Agreement between Registrant and State Street Bank and Trust Company.(i)
      (c) -- Form of Unified Transfer Agency, Dividend Disbursing Agency and Shareholder Servicing Agency Agreement between the
             Registrant and PFPC, Inc.(h)
    14(a) -- Consent of Deloitte & Touche LLP independent registered public accounting firm for the Registrant.(j)
      (b) -- Consent of Deloitte & Touche LLP independent registered public accounting firm for the BlackRock Fund.(j)
    15    -- None.
    16(a) -- Power of Attorney.(d)
    17(a) -- Prospectus and Statement of Additional Information of the Registrant, each dated February 24, 2006.(d)
      (b) -- Prospectus for Investor Shares, Prospectus for Institutional Shares, Prospectus for Service Shares and Statement of
              Additional Information of the BlackRock Fund, each dated January 31, 2006. (d)
      (c) -- Annual Report to Shareholders of the Registrant for the year ended October 31, 2005.(d)
      (d) -- Annual Report to Shareholders of the BlackRock Fund for the year ended September 30, 2005.(d)
      (e) -- Form of Proxy.(j)


- ----------------
(a)   Filed on October 20, 1999 as an Exhibit to the Registrant's Registration Statement on Form N-1A (File No. 333-89389) (the
      "Registration

                                                                 4







   
      Statement") under the Securities Act of 1933, as amended (the "Securities Act").
(b)   Filed on December 31, 2002 as an Exhibit to Post-Effective Amendment No. 4 to the Registration Statement.
(c)   Filed on February 27, 2004 as an Exhibit to Post-Effective Amendment No. 6 to the Registration Statement.
(d)   Filed on May 8, 2006 as an Exhibit to the Registrant's Registration Statement on Form N-14 under the Securities Act (File No.
      333-133900).
(e)   Reference is made to Article II, Article IV, Article V (sections 2, 3, 4, 6, 7 and 8), Article VI, Article VII and Article IX
      of the Registrant's Articles of Incorporation, as amended, filed as Exhibit (1), to the Registration Statement, and to Article
      II, Article III (sections 1, 3, 5, 6 and 17), Article VI, Article VII, Article XII, Article XIII and Article XIV of the
      Registrant's Amended and Restated By-Laws filed as Exhibit (2) to the Registration Statement.
(f)   Incorporated by reference to an Exhibit to Post-Effective Amendment No. 38 to the Registration Statement on Form N-1A of
      Merrill Lynch Bond Fund, Inc. (File No. 2-62329), filed July 21, 2006.
(g)   Filed on December 22, 1999 as an Exhibit to Pre-Effective Amendment No. 1 to the Registration Statement.
(h)   Incorporated by reference to an Exhibit to Post-Effective Amendment No. 39 to the Registration Statement on Form N-1A of
      Merrill Lynch Bond Fund, Inc. (File No. 2-62329), filed on September 15, 2006.
(i)   Incorporated by reference to Exhibit 8(d) to Post-Effective Amendment No. 1 to the Registration Statement on Form N-1A of
      Merrill Lynch Focus Twenty Fund, Inc. (File No. 333-89775), filed on March 20, 2001.
(j)   Previously filed on June 15, 2006 as an Exhibit to Pre-Effective Amendment No. 1 to the Registrant's Registration Statement on
      Form N-14 (File No. 333-133900).
(k)   Filed on September 22, 2006 as an Exhibit to Post-Effective Amendment No. 10 to the Registration Statement.





Item 17. Undertakings

      (1) The undersigned registrant agrees that prior to any public
reoffering of the securities registered through the use of a prospectus which
is a part of this registration statement by any person or party who is deemed
to be an underwriter within the meaning of Rule 145(c) of the Securities Act,
the reoffering prospectus will contain the information called for by the
applicable registration form for reofferings by persons who may be deemed
underwriters, in addition to the information called for by other items of the
applicable form.

      (2) The undersigned registrant agrees that every prospectus that is
filed under paragraph (1) above will be filed as a part of an amendment to the
registration statement and will not be used until the amendment is effective,
and that, in determining any liability under the Securities Act of 1933, each
post-effective amendment shall be deemed to be a new registration statement
for the securities offered therein, and the offering of the securities at that
time shall be deemed to be the initial bona fide offering of them.

      (3) The undersigned registrant agrees to file, by post-effective
amendment, an opinion of counsel supporting the tax consequences of the
Reorganization within a reasonably prompt time after receipt of such opinion.

                                      5




                                  SIGNATURES

      Pursuant to the requirements of the Securities Act of 1933, the
Registrant has duly caused this Registration Statement to be signed on its
behalf by the undersigned, thereunto duly authorized, in the Township of
Plainsboro, and State of New Jersey, on the 5th day of February, 2007.

                                 BLACKROCK LARGE CAP SERIES FUNDS, INC.
                                   (Registrant)


                                 BY:          /s/ Donald C. Burke
                                      ----------------------------------
                                      (Donald C. Burke, Vice President
                                      and Treasurer)


      As required by the Securities Act of 1933, this Registration Statement
has been signed by the following persons in the capacities and on the dates
indicated.





                Signature                                      Title                              Date
                ---------                                      -----                              ----
                                                                                    
           Robert C. Doll, Jr.*               President (Principal Executive Officer)
      -----------------------------                        and Director
          (Robert C. Doll, Jr.)

             Donald C. Burke*                 Vice President and Treasurer (Principal
       ---------------------------               Financial and Accounting Officer)
            (Donald C. Burke)

            James H. Bodurtha*                                Director
       ---------------------------
           (James H. Bodurtha)

             Kenneth A. Froot*                                Director
      -----------------------------
            (Kenneth A. Froot)

               Joe Grills*                                    Director
   ------------------------------------
               (Joe Grills)

            Herbert I. London*                                Director
- -      -----------------------------
           (Herbert I. London)

           Roberta Cooper Ramo*                               Director
        --------------------------
          (Roberta Cooper Ramo)

         Robert S. Salomon, Jr.*                              Director
      -----------------------------
         (Robert S. Salomon, Jr.)

*By            /s/  Donald C. Burke                                                         February 5, 2007
       -----------------------------------
                 (Donald C. Burke,
                 Attorney-in-Fact)

                                                               6








                                  SIGNATURES

      Master Large Cap Series Trust has duly caused this Registration
Statement of BlackRock Large Cap Series Funds, Inc. to be signed on its behalf
by the undersigned, thereunto duly authorized, in the Township of Plainsboro,
and State of New Jersey, on the 5th day of February, 2007.

                                      MASTER LARGE CAP SERIES TRUST
                                        (Registrant)

                                      BY:          /s/ Donald C. Burke
                                           ------------------------------------
                                           (Donald C. Burke, Vice President
                                           and Treasurer)

      The Registration Statement of BlackRock Large Cap Series Funds, Inc. has
been signed by the following persons in the capacities and on the dates
indicated.




                Signature                                      Title                              Date
                ---------                                      -----                              ----
                                                                                       
           Robert C. Doll, Jr.*               President (Principal Executive Officer)
      -----------------------------                         and Trustee
          (Robert C. Doll, Jr.)

             Donald C. Burke*                 Vice President and Treasurer (Principal
       ---------------------------               Financial and Accounting Officer)
            (Donald C. Burke)

            James H. Bodurtha*                                Trustee
       ---------------------------
           (James H. Bodurtha)

             Kenneth A. Froot*                                Trustee
      -----------------------------
            (Kenneth A. Froot)

               Joe Grills*                                    Trustee
   ------------------------------------
               (Joe Grills)

            Herbert I. London*                                Trustee
- -      -----------------------------
           (Herbert I. London)

           Roberta Cooper Ramo*                               Trustee
        --------------------------
          (Roberta Cooper Ramo)

          Robert S. Salomon, Jr.*                             Trustee
      -----------------------------
         (Robert S. Salomon, Jr.)

*By            /s/  Donald C. Burke                                                         February 5, 2007
       -----------------------------------
                 (Donald C. Burke,
                 Attorney-in-Fact)

                                                          7





                       SCHEDULE OF EXHIBITS TO FORM N-14

Exhibit
Number            Description

- ------            -----------

  12      --      Tax opinion of Sidley Austin LLP, tax counsel for the
                  Registrant, the Fund and the BlackRock Fund.




                                       8