Exhibit 10.15











                        PLAN AND AGREEMENT OF LIQUIDATION

                                  BY AND AMONG

                        PEREGRINE PHARMACEUTICALS, INC.,

                                  OXiGENE, INC.

                                       AND

                             ARCUS THERAPEUTICS LLC






                        PLAN AND AGREEMENT OF LIQUIDATION

     This Plan and Agreement of Liquidation  (this  "Agreement") is entered into
as of  February  28,  2002,  by and among  Peregrine  Pharmaceuticals,  Inc.,  a
Delaware  corporation  ("Peregrine"),  OXiGENE,  Inc.,  a  Delaware  corporation
("OXiGENE"),  and Arcus  Therapeutics  LLC, a Delaware limited liability company
("Arcus").

                                    RECITALS

     WHEREAS,   in  connection  with  that  certain  Limited  Liability  Company
Agreement of Arcus Therapeutics LLC by and between Peregrine  (formerly known as
Techniclone  Corporation) and OXiGENE, dated May 11, 2000 (the "LLC Agreement"),
Peregrine  assigned  to  Arcus  certain  license  agreements  identified  on the
attached  Exhibit A (the "License  Agreements")  relating to vascular  targeting
agent technology (the "VTA Technology") and contributed to Arcus the Techniclone
Contributed Technology (as defined in the LLC Agreement), in consideration for a
membership interest in Arcus (the "Peregrine  Membership  Interest") and OXiGENE
contributed to Arcus the OXiGENE  Contributed  Technology (as defined in the LLC
Agreement) and agreed to provide certain monies to fund the on-going research of
Arcus;

     WHEREAS,  pursuant to the terms of this Agreement and in consideration  for
OXiGENE's and Peregrine's mutual undertakings  hereunder,  (i) Peregrine desires
to pay to OXiGENE the sum of Two Million Dollars ($2,000,000),  (ii) OXiGENE and
Peregrine  desire to cause  Arcus to transfer  and  distribute  the  Techniclone
Contributed  Technology  in-kind  to  Peregrine,  including  the  assignment  to
Peregrine of the License Agreements, (iii) OXiGENE and Peregrine desire to cause
Arcus to transfer and distribute the OXiGENE  Contributed  Technology in-kind to
OXiGENE;  and (iv)  Arcus,  Peregrine  and  OXiGENE  desire to exchange a mutual
general release in connection herewith; and

     WHEREAS,  OXiGENE and Peregrine  desire to liquidate and dissolve  Arcus in
accordance with the terms hereof and applicable Delaware law.

     NOW,  THEREFORE,  in consideration  of the mutual promises  hereinafter set
forth and other good and valuable consideration,  the receipt of which is hereby
acknowledged, the parties hereby agree as follows:

     1. Payment, Distribution and Release.

     1.1  Transfer  and  Payment to  OXiGENE.  Subject to and upon the terms and
conditions of this Agreement, at the Closing (as defined below), Peregrine shall
deliver to OXiGENE by wire transfer of  immediately  available  funds the sum of
Two Million Dollars ($2,000,000) (the "Cash Payment").

     1.2 Distribution to Peregrine. Subject to and upon the terms and conditions
of this Agreement,  including, without limitation, Sections 2.2 and 10.3, at the
Closing, OXiGENE and Peregrine shall cause Arcus to distribute,  and Arcus shall
distribute,  to  Peregrine  all of Arcus'  rights,  title and  interests  to the




Techniclone  Contributed Technology (as defined in the LLC Agreement) including,
without  limitation,  the  following,  but not  including  those  contracts  and
agreements  set forth in Schedule 1.2 hereto,  which  contracts  and  agreements
require the consents of third parties in connection with the assignment  thereof
(the "Peregrine Excluded Contracts"),

     (a) all rights,  title and interests of Arcus under the License  Agreements
and any other contracts,  agreements or other  instruments set forth on Schedule
2.6 attached hereto (collectively, the "Peregrine Contracts");

     (b) copies of all books, records, correspondence, manuals, studies, reports
or summaries relating to the Techniclone Contributed Technology,  including such
as may have  been  developed  by Arcus  during  term of the LLC  Agreement  (the
"Peregrine Records"); and

     (c) all rights,  title and  interests of Arcus to all  intangible  property
rights,  including but not limited to  inventions,  discoveries,  trade secrets,
processes,  formulas,  know-how,  United  States  and  foreign  patents,  patent
applications, trade names, trademarks, trademark registrations, applications for
trademark registrations,  copyrights,  copyright registrations,  owned or, where
not  owned,  used  by  Arcus  arising  out of or  relating  to  the  Techniclone
Contributed  Property and all licenses and other  agreements to which Arcus is a
party (as  licensor  or  licensee)  or by which  Arcus is bound  relating to the
Techniclone  Contributed  Technology  (collectively,  the "Peregrine  Intangible
Property",  and together with the Peregrine Contracts and the Peregrine Records,
the "Peregrine Assets").

     The foregoing  Peregrine  Assets shall include all of Arcus' rights,  title
and interests to any and all additions,  modifications  and enhancements to, and
developments  and  discoveries  based  upon or  arising  from,  the  Techniclone
Contributed  Technology made by or on behalf of Arcus during the term of the LLC
Agreement,  including  any of the  foregoing  which  arose  due to or out of the
funding by Arcus of Dr. Philip Thorpe's laboratory.

     At any  time  and from  time to time  after  the  Closing,  at  Peregrine's
reasonable  request and without  further  consideration,  Arcus  and/or  OXiGENE
promptly  shall  execute  and  deliver  such  instruments  of  sale,   transfer,
conveyance,  assignment  and  confirmation,  and  take  such  other  action,  as
Peregrine may reasonably request to more effectively transfer, convey and assign
to Peregrine,  and to confirm  Peregrine's  title to, the Peregrine  Assets,  to
assist  Peregrine in exercising all rights with respect thereto and to carry out
the purpose and intent of this Agreement.

     1.3  Distribution to OXiGENE.  Subject to and upon the terms and conditions
of this  Agreement,  at the Closing,  OXiGENE and Peregrine shall cause Arcus to
distribute,  and Arcus shall distribute,  to OXiGENE all of Arcus' rights, title
and  interests  to the  OXiGENE  Contributed  Technology  (as defined in the LLC
Agreement), including, without limitation,:

     (a)  all  rights,  title  and  interests  of  Arcus  under  the  contracts,
agreements  or other  instruments  set forth on  Schedule  2.7  attached  hereto
(collectively, the "OXiGENE Contracts");

                                      -2-


     (b) copies of all books, records, correspondence, manuals, studies, reports
or summaries relating to the OXiGENE Contributed  Technology,  including such as
may have been  developed by Arcus during term of the LLC Agreement (the "OXiGENE
Records");

     (c) all rights,  title and  interests of Arcus to all  intangible  property
rights,  including but not limited to  inventions,  discoveries,  trade secrets,
processes,  formulas,  know-how,  United  States  and  foreign  patents,  patent
applications, trade names, trademarks, trademark registrations, applications for
trademark registrations,  copyrights,  copyright registrations,  owned or, where
not owned,  used by Arcus arising out of or relating to the OXiGENE  Contributed
Property  and all licenses  and other  agreements  to which Arcus is a party (as
licensor  or  licensee)  or by  which  Arcus is bound  relating  to the  OXiGENE
Contributed Technology (collectively, the "OXiGENE Intangible Property"); and

     (d) all of the remaining assets of Arcus, after the distributions described
in Section 1.2 and in Subsections  1.3(a),  (b) and (c) have been completed (the
"Remaining  Assets"  and  together  with  the  OXiGENE  Contracts,  the  OXiGENE
Intangible  Property and the OXiGENE Records the "OXiGENE  Assets";  the OXiGENE
Assets together with the Peregrine Assets, collectively, the "Assets").

     The foregoing OXiGENE Assets shall include all of Arcus' rights,  title and
interests  to any and all  additions,  modifications  and  enhancements  to, and
developments and discoveries based upon or arising from, the OXiGENE Contributed
Technology  made by or on behalf of Arcus during the term of the LLC  Agreement,
including any of the foregoing which arose due to or out of the funding by Arcus
of Dr. Philip Thorpe's laboratory.

     At any  time  and  from  time to  time  after  the  Closing,  at  OXiGENE's
reasonable  request and without further  consideration,  Arcus and/or  Peregrine
promptly  shall  execute  and  deliver  such  instruments  of  sale,   transfer,
conveyance,  assignment and confirmation, and take such other action, as OXiGENE
may  reasonably  request  to more  effectively  transfer,  convey  and assign to
OXiGENE,  and to confirm  OXiGENE's  title to,  the  OXiGENE  Assets,  to assist
OXiGENE in  exercising  all rights  with  respect  thereto  and to carry out the
purpose and intent of this Agreement.

     1.4 Assumption of Liabilities. Arcus shall transfer the Peregrine Assets to
Peregrine  and the  OXiGENE  Assets to  OXiGENE  free and  clear of all  claims,
liabilities, liens, pledges, charges, encumbrances and security interests of any
kind.  At the  Closing,  OXiGENE  shall  assume  and agree to  perform,  pay and
discharge,  and shall remain  unconditionally liable for only those obligations,
liabilities and commitments,  fixed or contingent, of Arcus, which were incurred
or accrued in the ordinary  course of Arcus'  business prior to the Closing Date
and which are set forth on  Schedule  1.4  hereto  (other  than  liabilities  of
Peregrine described in Sections 1.7(b), 3.4, 5.3 and 10.3) as well as any legal,
accounting and filing fees and expenses  incurred by Arcus following the Closing
Date in connection  with the  liquidation and dissolution of Arcus (the "OXiGENE
Assumed Liabilities").

                                      -3-


     1.5 Mutual General Release.  At the Closing,  Peregrine,  Arcus and OXiGENE
shall deliver to each other a mutual general release in the form of the attached
Exhibit 1.5.

     1.6 The Closing.  The Closing shall take place by the exchange of documents
by facsimile or courier  service and the delivery of the Cash Payment to OXiGENE
on such date or at such  location as is mutually  agreeable  to the parties (the
"Closing Date").

     1.7 The Liquidation and Dissolution.

     (a)  Immediately  following the Closing,  subject to Section 10.3,  OXiGENE
shall  take all  necessary  steps to  liquidate  Arcus  in  accordance  with the
requirements of the Delaware Limited Liability Company Act and to cause Arcus to
be  dissolved  in  Delaware  and in any other  jurisdiction  in which  Arcus has
qualified to do business;

     (b) In  connection  with such  liquidation,  OXiGENE  and  Peregrine  shall
jointly be responsible for, and, subject to the provisions of Sections 3.4, 4.4,
5.3 and 10.3  hereof,  each  agrees  to pay fifty  percent  (50%) of any and all
amounts associated with, the payment of, or ensuring payment of, all liabilities
and debts of Arcus for which  members of Arcus may  legally be held  liable (the
"Arcus  Liabilities"),  other than the OXiGENE  Assumed  Liabilities,  and shall
cause the remaining assets of Arcus (subject to the prior consummation of all of
the transfers contemplated in this Agreement) to be distributed to OXiGENE, free
and clear of any  liabilities or obligations  related  thereto.  Notwithstanding
anything  to the  contrary  set forth  herein,  the first one  hundred  thousand
dollars  ($100,000) of Arcus Liabilities shall be paid by, and shall be the sole
and exclusive obligation of, OXiGENE.

     (c) OXiGENE  shall cause draft tax returns to be prepared for all years for
which  returns of Arcus have not yet been filed and will  provide to Peregrine a
draft of all such tax returns at least 30 days before the filing  thereof.  Both
OXiGENE and  Peregrine  shall be bound by any  position  taken on any such filed
return  (and may not file any  statements  with their  respective  returns of an
inconsistent position).

     2. Representations Regarding Arcus

     OXiGENE represents to Peregrine,  to the best of OXiGENE's  knowledge,  and
Peregrine  represent  to  OXiGENE,  to the  best of  Peregrine's  knowledge,  as
follows:

     2.1  Organization.  Arcus is a limited  liability  company duly  organized,
validly  existing and in good standing  under the laws of the state of Delaware,
and has all  requisite  power and  authority  (corporate  and  other) to own its
properties,  to carry on its  business  as now being  conducted,  to execute and
deliver this Agreement and the agreements contemplated herein, and to consummate
the transactions contemplated hereby and thereby.

     2.2  Authorization.  The execution and delivery of this Agreement by Arcus,
and the agreements  provided for herein,  and the  consummation  by Arcus of all
transactions  contemplated hereby and thereby,  have been duly authorized by all
requisite  manager  and  member  action.  This  Agreement  and  all  such  other
agreements and  obligations  entered into and undertaken in connection  with the

                                      -4-


transactions  contemplated  hereby  and  thereby  to  which  Arcus  is  a  party
constitute  the valid and  legally  binding  obligations  of Arcus,  enforceable
against Arcus in accordance with their respective terms.  Except as set forth in
Schedule 1.2, the execution, delivery and performance by Arcus of this Agreement
and the agreements  provided for herein,  and the  consummation  by Arcus of the
transactions  contemplated  hereby and  thereby,  will not,  with or without the
giving of notice or the passage of time or both,  (a) violate the  provisions of
any law, rule or regulation  applicable to Arcus;  (b) violate the provisions of
the LLC  Agreement or any other  operating  agreement or document  pertaining to
Arcus;  (c)  violate  any  judgment,  decree,  order  or  award  of  any  court,
governmental body or arbitrator; or (d) conflict with or result in the breach or
termination of any term or provision of, or constitute a default under, or cause
any acceleration under, or cause the creation of any lien, charge or encumbrance
upon the properties or assets of Arcus pursuant to any indenture, mortgage, deed
of trust or other  instrument or agreement to which Arcus is a party or by which
Arcus or any of its properties is or may be bound.  Schedule 1.2 attached hereto
sets forth a true, correct and complete list of all contracts for which consents
and  approvals  of  third  parties  that are  required  in  connection  with the
consummation by Arcus of the transactions contemplated by this Agreement.

     2.3 Transfer of the Assets. At the Closing,  Arcus will distribute,  assign
and  transfer to  Peregrine  all of Arcus'  rights,  title and  interests to the
Peregrine  Assets.  The delivery to Peregrine of the  instruments of transfer of
ownership  contemplated  by this  Agreement will vest in Peregrine all of Arcus'
rights, title and interests to the Peregrine Assets.

     At the Closing,  Arcus will distribute,  assign and transfer to OXiGENE all
of Arcus'  rights,  title and interests to the OXiGENE  Assets.  The delivery to
OXiGENE  of the  instruments  of  transfer  of  ownership  contemplated  by this
Agreement will vest in OXiGENE all of Arcus' rights,  title and interests to the
OXiGENE Assets.

     2.4 Absence of  Undisclosed  Liabilities.  Except for the  OXiGENE  Assumed
Liabilities and as and to the extent set forth on Schedule 2.5 attached  hereto,
either  individually or in the aggregate,  to Arcus'  knowledge,  Arcus does not
have any liability or  obligation,  secured or unsecured,  affecting the Assets,
whether accrued, absolute,  contingent,  or, to Arcus' knowledge,  unasserted or
otherwise.

     2.5 Litigation.  Except as set forth on Schedule 2.5 attached hereto, Arcus
is not a party to,  or to  Arcus'  knowledge  threatened  with,  and none of the
Assets are subject to, any litigation, suit, action,  investigation,  proceeding
or controversy  before any court,  administrative  agency or other  governmental
authority  relating to or affecting the Assets.  Arcus is not in violation of or
in default with respect to any judgment, order, writ or injunction of any court,
administrative  agency  or  governmental  authority  or  any  regulation  of any
administrative agency or governmental authority.

     2.6 Peregrine Contracts.

     (a) Schedule 2.6 attached hereto contains a true, complete and correct list
and description of the License  Agreements and each other contract or agreement,
whether  verbal or oral,  the subject matter of which relates to or is dependent
upon any of the Techniclone Contributed Technology;

                                      -5-


     (b) Except as set forth on Schedule 2.6 attached hereto:

          (i)  Arcus does not have any knowledge that any Peregrine  Contract is
               not a valid and binding agreement of the other parties thereto;

          (ii) Arcus has fulfilled all material obligations required pursuant to
               the  Peregrine  Contracts to have been  performed by Arcus on its
               part prior to the date hereof;

          (iii)Arcus  is  not  in  breach  of or  default  under  any  Peregrine
               Contract,  and no event has  occurred  which with the  passage of
               time or giving of notice or both would constitute such a default,
               result in a loss of rights or result in the creation of any lien,
               charge or encumbrance, thereunder or pursuant thereto; and

          (iv) to the knowledge of Arcus, there is no existing breach or default
               by any other party to any  Peregrine  Contract,  and no event has
               occurred  which  with the  passage of time or giving of notice or
               both would constitute a default by such other party,  result in a
               loss of rights or result in the  creation of any lien,  charge or
               encumbrance thereunder or pursuant thereto.

     (c) Except for those  contracts and  agreements  set forth on Schedule 1.2,
the continuation, validity and effectiveness of each Peregrine Contract will not
be affected by the transfer  thereof to Peregrine  under this  Agreement and all
such Peregrine  Contracts are assignable to Peregrine  without  consent from any
other  party,  or if a third party  consent is required,  such consent  shall be
obtained by Peregrine following the Closing and Arcus shall consent thereto.

     (d) True,  correct  and  complete  copies  of all  Peregrine  Contracts  on
Schedule 2.6 have previously been delivered by Arcus to Peregrine.

     2.7 OXiGENE Contracts.

     (a) Schedule 2.7 attached hereto contains a true, complete and correct list
and  description of the OXiGENE  Contracts and each other contract or agreement,
whether  verbal or oral,  the subject matter of which relates to or is dependent
upon any of the OXiGENE Contributed Technology;

     (b) Except as set forth on Schedule 2.7 attached hereto:

          (i)  Arcus does not have any  knowledge  that any OXiGENE  Contract is
               not a valid and binding agreement of the other parties thereto;

          (ii) Arcus has fulfilled all material obligations required pursuant to
               the OXiGENE Contracts to have been performed by Arcus on its part
               prior to the date hereof;

                                      -6-


          (iii)Arcus is not in breach of or default under any OXiGENE  Contract,
               and no event  has  occurred  which  with the  passage  of time or
               giving of notice or both would constitute such a default,  result
               in a loss of rights or result in the creation of any lien, charge
               or encumbrance, thereunder or pursuant thereto; and

          (iv) to the knowledge of Arcus, there is no existing breach or default
               by any  other  party to any  OXiGENE  Contract,  and no event has
               occurred  which  with the  passage of time or giving of notice or
               both would constitute a default by such other party,  result in a
               loss of rights or result in the  creation of any lien,  charge or
               encumbrance thereunder or pursuant thereto.

     (c) The  continuation,  validity and effectiveness of each OXiGENE Contract
will not be affected by the transfer thereof to OXiGENE under this Agreement and
all such OXiGENE  Contracts are assignable to OXiGENE  without  consent from any
other  party,  or if a third party  consent is required,  such consent  shall be
obtained by OXiGENE following the Closing.

     (d) True,  correct and complete copies of all OXiGENE Contracts on Schedule
2.7 have previously been delivered by Arcus to OXiGENE.

     2.8 Other Intangible Property.  Arcus has received no notice of, and has no
knowledge  of any basis for, a claim  against it that any of Arcus'  operations,
activities,  products or publications infringes on any patent, trademark,  trade
name,  copyright  or other  property  right of a third  party,  or that Arcus is
illegally or otherwise using the trade secrets,  formulae or any property rights
of others.  Arcus has no  disputes  with or claims  against  any third party for
infringement by such third party of any trade name or other Intangible  Property
of Arcus.  Arcus has taken all steps reasonably  necessary to protect its right,
title and interest in and to the Intangible Property.

     2.9 Disclosure. No representation or warranty by Arcus in this Agreement or
in any Exhibit hereto,  or in any list,  statement,  document or information set
forth in or attached to any Schedule  delivered  or to be delivered  pursuant to
this Agreement, contains or will contain any untrue statement of a material fact
or  omits  or will  omit  any  material  fact  necessary  in  order  to make the
statements  contained  therein not misleading.  Arcus has disclosed to Peregrine
and to OXiGENE all material facts pertaining to the transactions contemplated by
this Agreement.

     3. Representations Regarding Peregrine

     Peregrine represents and warrants to OXiGENE as follows:

     3.1 Organization and Authority.  Peregrine is a corporation duly organized,
validly  existing and in good standing  under the laws of the state of Delaware,
and  has  requisite  power  and  authority  (corporate  and  other)  to own  its
properties  and to carry on its business as now being  conducted.  Peregrine has
full  power  to  execute  and  deliver  this  Agreement  and to  consummate  the
transactions contemplated hereby and thereby.

                                      -7-


     3.2  Authorization.  The  execution  and  delivery  of  this  Agreement  by
Peregrine,  and the  agreements  provided for herein,  and the  consummation  by
Peregrine of all transactions  contemplated hereby, have been duly authorized by
all requisite corporate action. This Agreement and all such other agreements and
written   obligations  entered  into  and  undertaken  in  connection  with  the
transactions  contemplated  hereby  constitute  the  valid and  legally  binding
obligations of Peregrine, enforceable against Peregrine in accordance with their
respective terms. The execution,  delivery and performance of this Agreement and
the agreements  provided for herein,  and the  consummation  by Peregrine of the
transactions  contemplated  hereby and  thereby,  will not,  with or without the
giving of notice or the passage of time or both,  (a) violate the  provisions of
any law, rule or regulation applicable to Peregrine;  (b) violate the provisions
of Peregrine's Certificate of Incorporation or Bylaws; (c) violate any judgment,
decree,  order or award of any court,  governmental  body or arbitrator;  or (d)
conflict  with or result in the breach or  termination  of any term or provision
of, or constitute a default under, or cause any acceleration under, or cause the
creation of any lien,  charge or  encumbrance  upon the  properties or assets of
Peregrine pursuant to any indenture,  mortgage, deed of trust or other agreement
or instrument to which it or its properties is a party or by which  Peregrine is
or may be bound.

     3.3  Disclosure.  No  representation  or  warranty  by  Peregrine  in  this
Agreement  or in any  Exhibit  hereto,  or in any list,  statement,  document or
information  set  forth  in or  attached  to  any  Schedule  delivered  or to be
delivered  pursuant  hereto,  contains or will contain any untrue statement of a
material fact or omits or will omit any material fact necessary in order to make
the statements contained therein not misleading.

     3.4 Third Party Claims.  Except as set forth on Schedule 3.4, Peregrine has
not had any  meetings  with any  third  parties  regarding  the  possibility  of
licensing any of Arcus'  proprietary  technology.  To the extent that any claims
against  Arcus or its members are asserted  after the Closing Date (i) by any of
the parties listed on Schedule 3.4 hereto in connection  with any of the matters
discussed  at such  meetings,  or (ii)  as a  result  of any  actions  taken  or
omissions  made, on behalf of Arcus,  by  Peregrine,  then  Peregrine  agrees to
indemnify and hold harmless the other parties hereto in connection with any such
claims.

     3.5 No  Knowledge.  Peregrine is not aware,  and has no  knowledge,  of any
breach,  or the basis  for any  potential  breach,  of the  representations  and
warranties of OXiGENE or of Arcus  contained in this Agreement  which could give
rise to any claim  against  OXiGENE  or Arcus  under this  Agreement.  Peregrine
acknowledges  and agrees that  OXiGENE is  relying,  in part,  on the  foregoing
representations in entering into this Agreement and, therefore, Peregrine waives
all rights  and claims  that may now exist or may  hereafter  arise,  including,
without  limitation,  claims seeking  indemnification  under Section 4.4 of this
Agreement,  the assertion of which rights or claims would be  inconsistent  with
the preceding sentence.

     4. Representations Regarding OXiGENE.

     OXiGENE represents and warrants to Peregrine as follows:

                                      -8-


     4.1  Organization  and Authority.  OXiGENE is a corporation duly organized,
validly  existing and in good standing  under the laws of the state of Delaware,
and  has  requisite  power  and  authority  (corporate  and  other)  to own  its
properties and to carry on its business as now being conducted. OXiGENE has full
power to execute and deliver this Agreement and to consummate  the  transactions
contemplated hereby and thereby.

     4.2 Authorization. The execution and delivery of this Agreement by OXiGENE,
and the agreements  provided for herein,  and the consummation by OXiGENE of all
transactions  contemplated  hereby,  have been duly  authorized by all requisite
corporate  action.  This  Agreement  and all such other  agreements  and written
obligations  entered into and  undertaken  in connection  with the  transactions
contemplated  hereby  constitute  the valid and legally  binding  obligations of
OXiGENE,  enforceable against OXiGENE in accordance with their respective terms.
The  execution,  delivery and  performance  of this Agreement and the agreements
provided  for  herein,  and the  consummation  by  OXiGENE  of the  transactions
contemplated hereby and thereby,  will not, with or without the giving of notice
or the passage of time or both,  (a) violate the  provisions of any law, rule or
regulation  applicable  to  OXiGENE;  (b) violate the  provisions  of  OXiGENE's
Certificate of Incorporation or Bylaws; (c) violate any judgment,  decree, order
or award of any court,  governmental body or arbitrator; or (d) conflict with or
result in the breach or termination of any term or provision of, or constitute a
default under,  or cause any  acceleration  under,  or cause the creation of any
lien, charge or encumbrance upon the properties or assets of OXiGENE pursuant to
any indenture, mortgage, deed of trust or other agreement or instrument to which
it or its properties is a party or by which OXiGENE is or may be bound.

     4.3 Disclosure.  No representation or warranty by OXiGENE in this Agreement
or in any Exhibit hereto, or in any list, statement, document or information set
forth in or attached  to any  Schedule  delivered  or to be  delivered  pursuant
hereto,  contains or will  contain any untrue  statement  of a material  fact or
omits or will omit any material fact  necessary in order to make the  statements
contained therein not misleading.

     4.4 Third Party Claims.  Except as set forth on Schedule  4.4,  OXiGENE has
not had any  meetings  with any  third  parties  regarding  the  possibility  of
licensing and research of Arcus' proprietary technology.  To the extent that any
claims  against Arcus or its members are asserted  after the Closing Date (i) by
any of the parties  listed on Schedule 4.4 hereto in connection  with any of the
matters discussed at such meetings,  or (ii) as a result of any actions taken or
omissions made on behalf of Arcus, by OXiGENE,  then OXiGENE agrees to indemnify
and hold harmless the other parties hereto in connection with any such claims.

     4.5 No  Knowledge.  OXiGENE  is not  aware,  and has no  knowledge,  of any
breach,  or the basis  for any  potential  breach,  of the  representations  and
warranties of Peregrine or of Arcus contained in this Agreement which could give
rise to any claim  against  Peregrine  or Arcus  under this  Agreement.  OXiGENE
acknowledges  and agrees that  Peregrine is relying,  in part,  on the foregoing
representations in entering into this Agreement and,  therefore,  OXIGENE waives
all rights  and claims  that may now exist or may  hereafter  arise,  including,
without  limitation,  claims seeking  indemnification  under Section 3.4 of this
Agreement,  the assertion of which rights or claims would be  inconsistent  with
the preceding sentence.

                                      -9-


     5. Covenants of Peregrine and OXiGENE.

     5.1 Taxes.  OXiGENE shall be  responsible  for and will, on a timely basis,
file all tax  returns  for and pay any and all taxes,  penalties,  interest  and
additions  to tax which shall become due or shall have accrued on account of the
ownership of the Assets by Arcus on or prior to the Closing Date.

     5.2 Satisfaction of Conditions. The  parties hereto  covenant and  agree to
use their  commercially  reasonable  efforts to  obtain the  satisfaction of the
conditions specified in this Agreement.

     5.3 Third Party Claims.  Except as set forth on Schedule  5.3,  OXiGENE and
Peregrine  have not had any meetings  together with any third parties  regarding
the possibility of licensing any of Arcus' proprietary technology. To the extent
that any claims against Arcus or its members are asserted after the Closing Date
by any of the parties  listed on Schedule 5.3 hereto in  connection  with any of
the matters  discussed at such meetings,  OXiGENE and Peregrine  agree that they
shall be jointly  responsible for, and each agrees to pay fifty percent (50%) of
any and all amounts  associated with any liabilities,  costs or expenses arising
out of, such claims for which Members of Arcus may legally be held liable.

     6. [Intentionally omitted.]

     7. Conditions to Obligations of Peregrine.

     The  obligations  of  Peregrine  under this  Agreement  are  subject to the
fulfillment, at the Closing Date, of the following conditions precedent, each of
which may be waived in writing in the sole discretion of Peregrine:

     7.1  Continued  Truth  of   Representations   and  Warranties  of  OXiGENE;
Compliance with Covenants and Obligations. The representations and warranties of
OXiGENE  (as set forth in Section 4, as updated at the  Closing  Date)  shall be
true on and as of the Closing Date as though such representations and warranties
were made on and as of such date,  except for any changes permitted by the terms
hereof or consented to in writing by Peregrine. OXiGENE shall have performed and
complied with all terms,  conditions,  covenants,  obligations,  agreements  and
restrictions  required by this  Agreement to be performed or complied with by it
prior to or at the Closing Date.

     7.2 Approval and Authorization. The manager and members of Arcus shall have
duly authorized the transactions contemplated by this Agreement. All proceedings
required  to be  taken  on the part of  Arcus  to  authorize  or carry  out this
Agreement and to distribute,  assign,  transfer and deliver the Peregrine Assets
to Peregrine shall have been taken. All corporate and other proceedings required
to be taken on the part of  OXiGENE  to  authorize  or carry out this  Agreement
shall have been taken.

                                      -10-


     7.3  Consents of Third  Parties.  Following  the Closing,  Peregrine  shall
obtain the  requisite  consents and approvals of all third parties whose consent
or approval  is  required in order for Arcus or OXiGENE,  as the case may be, to
consummate the transactions contemplated by this Agreement,  including,  without
limitation, from all of the parties to the contracts and agreements set forth on
Schedule 1.2 attached hereto and Arcus shall consent thereto.

     7.4 Adverse Proceedings.  No action or proceeding by or before any court or
other  governmental  body or any other third party shall have been instituted or
threatened by any  governmental  body or third party whatsoever which shall seek
to  restrain,  prohibit or  invalidate  the  transactions  contemplated  by this
Agreement  or  which  might  affect  the  right of  Peregrine  to own or use the
Peregrine Assets after the Closing.

     7.5 The Peregrine  Assets.  At the Closing,  Peregrine  shall receive good,
clear,  record and marketable title to the Peregrine  Assets,  free and clear of
all  liens,  liabilities,  security  interests  and  encumbrances  of any nature
whatsoever.

     7.6 Closing  Deliveries.  Peregrine  shall have received at or prior to the
Closing each of the following items:

     (a) such  instruments  of  conveyance,  assignment and transfer in form and
substance satisfactory to Peregrine, as shall be appropriate to convey, transfer
and  assign  to,  and to vest in,  Peregrine,  all of Arcus'  rights,  title and
interests to the Peregrine  Assets,  including  the  Assignment  and  Assumption
Agreement in substantially the form of Exhibit 7.6(a) attached hereto;

     (b) a  duly  executed  mutual  general  release  from  OXiGENE  and  Arcus,
substantially in the form of the attached Exhibit 1.5;

     (c) such  contracts,  files and other data and documents  pertaining to the
Peregrine Assets as Peregrine may reasonably request;

     (d) a  certificate  of the  officers of OXiGENE,  and such other  documents
evidencing  satisfaction  of the  conditions  specified  in Section 7 (including
without limitation, this Section 7.6) as Peregrine shall reasonably request;

     (e)  certificates  of the  Secretary of Arcus and the  Secretary of OXiGENE
attesting  to the  incumbency  of Arcus'  manager  and the  officers of OXiGENE,
respectively,   and  the   authenticity  of  the  resolutions   authorizing  the
transactions contemplated by this Agreement;

     (f) the schedules listed in Section 2; and

     (g) such other  documents,  instruments  or  certificates  as Peregrine may
reasonably request.

                                      -11-


     8. Conditions to Obligations of OXiGENE.

     The  obligations  of Arcus and OXiGENE under this  Agreement are subject to
the  fulfillment,  at the Closing Date, of the following  conditions  precedent,
each of which may be  waived  in  writing  at the sole  discretion  of Arcus and
OXiGENE:

     8.1  Continued  Truth  of  Representations  and  Warranties  of  Peregrine;
Compliance with Covenants and Obligations. The representations and warranties of
Peregrine  (as set forth in Section 3 and as updated  prior to the  Closing)  in
this  Agreement  shall  be true on and as of the  Closing  Date as  though  such
representations  and warranties were made on and as of such date, except for any
changes  consented to in writing by OXiGENE.  Peregrine shall have performed and
complied with all terms,  conditions,  obligations,  agreements and restrictions
required by this Agreement to be performed or complied with by it prior to or at
the Closing Date.

     8.2 Corporate Proceedings. The manager and members of Arcus shall have duly
authorized the  transactions  contemplated  by this  Agreement.  All proceedings
required  to be  taken  on the part of  Arcus  to  authorize  or carry  out this
Agreement and to distribute,  assign, transfer and deliver the OXiGENE Assets to
OXiGENE shall have been taken. All corporate and other  proceedings  required to
be taken on the part of Peregrine to authorize or carry out this Agreement shall
have been taken.

     8.3  Consents of Third  Parties.  Following  the Closing,  Peregrine  shall
obtain the  requisite  consents and approvals of all third parties whose consent
or approval is required in order for Arcus or Peregrine,  as the case may be, to
consummate the transactions contemplated by this Agreement,  including,  without
limitation, from all of the parties to the contracts and agreements set forth on
Schedule 1.2 attached hereto and Arcus shall consent thereto.

     8.4 Adverse Proceedings.  No action or proceeding by or before any court or
other  governmental  body or any  third  party  shall  have been  instituted  or
threatened by any  governmental  body or third party whatsoever which shall seek
to  restrain,  prohibit or  invalidate  the  transactions  contemplated  by this
Agreement  or which might  affect the right of OXiGENE to own or use the OXiGENE
Assets after the Closing.

     8.5 The OXiGENE Assets. At the Closing,  OXiGENE shall receive good, clear,
record and marketable title to the OXiGENE Assets,  free and clear of all liens,
liabilities, security interests and encumbrances of any nature whatsoever.

     8.6  Closing  Deliveries.  OXiGENE  shall have  received at or prior to the
Closing each of the following items:

     (a) such  instruments of conveyance,  assignment and transfer,  in form and
substance  satisfactory to OXiGENE, as shall be appropriate to convey,  transfer
and  assign  to,  and to vest in,  OXiGENE,  all of  Arcus'  rights,  title  and
interests  to the  OXiGENE  Assets,  including  the  Assignment  and  Assumption
Agreement in substantially the form of Exhibit 8.6(a) attached hereto;

                                      -12-


     (b)  a  certificate  of  Peregrine's  officers  and  such  other  documents
evidencing   satisfaction  of  the  conditions   specified  in  this  Section  8
(including,  without  limitation,  this Section 8.6) as OXiGENE shall reasonably
request;

     (c)  certificates  of the Secretary of Arcus and the Secretary of Peregrine
attesting to the  incumbency  of Arcus'  manager and the officers of  Peregrine,
respectively,   and  the   authenticity  of  the  resolutions   authorizing  the
transactions contemplated by this Agreement;

     (d) such other  documents,  instruments  or  certificates  as  OXiGENE  may
reasonably request;

     (e) the Cash Payment (which shall be delivered at the Closing).

     (f) a duly  executed  mutual  general  release  from  Peregrine  and Arcus,
substantially in the form of the attached Exhibit 1.5;

     (g) such  contracts,  files and other data and documents  pertaining to the
OXiGENE Assets as OXiGENE may reasonably request;

     (h) the schedules listed in Section 2; and

     (i) such other  documents,  instruments  or  certificates  as  OXiGENE  may
reasonably request.

     9. [Intentionally omitted.]

     10. Post-Closing Agreements

     Peregrine and OXiGENE agree that from and after the Closing Date:

     10.1 Proprietary Information.

     (a)  Peregrine  and OXiGENE  shall hold in  confidence,  and use their best
efforts to have all of their respective  officers,  directors and personnel hold
in  confidence,  all  knowledge  and  information  that has not been  previously
disclosed  to the public with  respect to the  Peregrine  Assets and the OXiGENE
Assets  and shall not  disclose,  publish  or make use of the same  without  the
consent of the  other,  except to the extent  that such  information  shall have
become public knowledge other than by breach of this Agreement by the other.

     (b)  Peregrine  and OXiGENE  agree that the remedy at law for any breach of
this  Section  10.1  would be  inadequate  and that each  shall be  entitled  to
injunctive relief in addition to any other remedy it may have upon breach of any
provision of this Section 10.1.

                                      -13-


     10.2 Liquidation and  Dissolution.  OXiGENE shall carry out its obligations
to liquidate and cause the  dissolution  of Arcus  pursuant to the terms of this
Agreement and the LLC Agreement  (provided,  however,  that this Agreement shall
control in the event of a conflict).

     10.3 Consents.

     (a) Following the Closing Date,  Peregrine  shall deliver to OXiGENE all of
the consents and  approvals  relating to the  assignment  of the  contracts  and
agreements  set forth in Schedule  1.2 hereto (the  "Consents")  and Arcus shall
consent thereto. Upon delivery to OXiGENE of all of the Consents,  the Peregrine
Excluded  Contracts  shall be  transferred  to Peregrine  effective  immediately
therewith.

     (b) In the event Peregrine fails to deliver to OXiGENE all of the Consents,
then the Peregrine Excluded Contracts shall remain with Arcus.  Peregrine agrees
to indemnify  and hold  harmless  both Arcus and OXiGENE from any and all costs,
fees and  expenses  incurred  as a result of  Peregrine's  failure to obtain and
deliver to OXiGENE all of the  Consents and Arcus'  retention  of the  Peregrine
Excluded Contracts,  including, without limitation, all of OXiGENE's costs, fees
and  expenses  as a  result  of  any  delay  or  deterrence  in  satisfying  its
obligations  hereunder with respect to the liquidation and dissolution of Arcus.
Peregrine  further agrees to reimburse OXiGENE and Arcus for all costs, fees and
expenses  associated with the Peregrine Excluded Contracts which arise after the
Closing Date.

     11. Termination of Agreement

     11.1  Termination  by  Agreement  of the  Parties.  This  Agreement  may be
terminated by the mutual written agreement of the parties hereto.

     11.2  Termination by Reason of Breach.  All of the  obligations  hereunder,
including,  without limitation,  the obligation to purchase and sell the OXiGENE
Assets and the Peregrine  Assets and to pay the Cash Payment,  may be terminated
by  OXiGENE,  if at any time prior to the  Closing  there shall occur a material
breach of any of the  representations,  warranties  or covenants of Peregrine or
the  failure by  Peregrine  to perform  any  material  condition  or  obligation
hereunder,  and may be  terminated  by  Peregrine,  if at any time  prior to the
Closing  there  shall  occur a  material  breach of any of the  representations,
warranties  or  covenants  of OXiGENE or the  failure of OXiGENE to perform  any
material condition or obligation hereunder.

     12. Notices

     Except to the  extent  otherwise  provided  herein,  any  notices  or other
communications  required or permitted  hereunder shall be sufficiently  given if
delivered  personally  or sent by federal  express or other  overnight  delivery
service,  registered or certified mail, postage prepaid, addressed as follows or
to such other address of which the parties may have given notice:

                                      -14-


      To OXiGENE:             OXiGENE, Inc.
                              321 Arsenal Street
                              Watertown, MA 02472
                              Attn: Fred Driscoll

      And a copy to:          Mintz Levin Cohn Ferris  Glovsky and Popeo PC
                              One Financial Center
                              Boston, MA 02111
                              Attn: Jeffrey M. Wiesen, Esq.

      To Peregrine:           Peregrine Pharmaceuticals, Inc.
                              14282 Franklin Avenue
                              Tustin, CA 92780
                              Attention:  Edward Legere

      With a copy to:         Jeffers, Shaff, & Falk, LLP
                              18881 Von Karman Avenue, Suite 1400
                              Irvine, California  92612
                              Attention: Mark R. Ziebell, Esq.

Unless otherwise specified herein, such notices or other communications shall be
deemed received (a) on the date delivered,  if delivered  personally;  (b) three
business days after being sent, if sent by registered or certified  mail; or (c)
on the date of actual receipt, if delivered by any other method.

     13. Dispute Resolution.  Subject to Section 10.1, in the event of a dispute
arising in connection  with this  Agreement,  each party hereto agrees to notify
the other parties  hereto of the specific  complaints or points of  disagreement
and to use good faith efforts to resolve any conflicts without legal action. Any
controversy  or claim arising out of or relating to this Agreement or any breach
thereof  that is not resolved by the parties in the manner set forth above shall
be  settled by  binding  arbitration  in  Chicago,  Illinois  under the Rules of
Commercial  Arbitration of the American Arbitration  Association before a single
arbitrator  mutually  selected  by the  parties.  The costs of the  arbitration,
including  administration  fees, shall be shared by the parties in proportion to
their fault as determined by the arbitrator.  Notwithstanding the foregoing, the
parties agree that if any breach or threatened  breach of this  Agreement  would
necessarily result in immediate, irreparable injury to any party, that party, in
addition to any other remedies  available under this  Agreement,  shall have the
right to seek injunctive relief in any court of competent jurisdiction.

     14. Successors and Assigns

     This  Agreement  shall be  binding  upon and  inure to the  benefit  of the
parties hereto and their respective successors and assigns,  except that none of
the parties hereto may assign their respective obligations hereunder without the
prior written consent of each of the other parties hereto.

                                      -15-


     15. Entire Agreement: Amendments; Attachments

     15.1 This Agreement,  all Schedules and Exhibits hereto, and all agreements
and  instruments to be delivered by the parties  pursuant  hereto  represent the
entire  understanding and agreement among the parties hereto with respect to the
subject  matter  hereof  and  supersede  all  prior  oral  and  written  and all
contemporaneous oral negotiations,  commitments and understandings  between such
parties.  The parties hereto may amend or modify this Agreement,  in such manner
as may be agreed upon, by a written instrument executed by the parties hereto.

     15.2 If the  provisions  of any Schedule or Exhibit to this  Agreement  are
inconsistent  with the  provisions  of this  Agreement,  the  provisions of this
Agreement  shall prevail.  The Exhibits and Schedules  attached  hereto or to be
attached hereafter are hereby incorporated as integral parts of this Agreement.

     16. Expenses

     Except as otherwise  expressly  provided  herein,  the parties hereto shall
each pay their own fees and expenses in connection  with this  Agreement and the
transactions  contemplated hereby. Subject to the terms of Sections 1.7(b), 3.4,
5.3 and 10.3, all expenses of Arcus,  including,  without limitation,  all legal
and accounting fees and expenses  incurred in connection with this Agreement and
the preparation and filing of all tax returns  referred to herein and all costs,
fees and expenses  associated  with the  dissolution  and  liquidation of Arcus,
shall  be  borne  and  paid by  OXiGENE,  except  that  all of the  expenses  of
Peregrine's  accountants  and of Jeffers,  Shaff & Falk, LLP, shall be borne and
paid by Peregrine.

     17. Press Releases; Publicity

     Each of Peregrine and OXiGENE  shall issue its own press release  following
the Closing Date and the parties shall agree on and use the same language in the
first two (2) paragraphs of such press releases.  Each party shall also have the
right to review  and  comment on the  entire  press  release to be issued by the
other  prior to such  issuance.  Except,  as may be required  (i) by  applicable
federal securities laws, (ii) by a court of competent jurisdiction,  or (iii) to
enforce a party's rights hereunder, neither party may disclose the terms of this
Agreement.

     18. Governing Law

     This  Agreement  shall be governed by and construed in accordance  with the
laws of the State of Delaware.

     19. Section Headings

     The section  headings are for the  convenience of the parties and in no way
alter,  modify,  amend,  limit, or restrict the  contractual  obligations of the
parties.

     20. Severability

     The invalidity or unenforceability of any provision of this Agreement shall
not  affect  the  validity  or  enforceability  of any other  provision  of this
Agreement.

                                      -16-


     21. Counterparts

     This  Agreement  may be  executed  in one or more  counterparts,  including
electronically  transmitted  counterparts each of which shall be deemed to be an
original, but all of which shall be one and the same document.

     22. Definitions.

     All  capitalized  terms used in this  Agreement and not  otherwise  defined
herein shall have the meanings ascribed to them in the LLC Agreement.

     23. Amendment of LLC Agreement.

     To the extent that any of the terms set forth in this Agreement  related to
the liquidation and dissolution of Arcus are  inconsistent  with those set forth
in the LLC Agreement,  the terms of this Agreement shall supercede and amend the
LLC Agreement.


     [The remainder of this page has been intentionally left blank.]

                                      -17-


     IN WITNESS WHEREOF,  the parties hereto have caused this Plan and Agreement
of Liquidation to be duly executed by their authorized representatives as of the
date first above written.


                                          OXiGENE, Inc.


                                          By:   /s/ Frederick W. Driscoll
                                               --------------------------
                                          Name:     Frederick W. Driscoll
                                               --------------------------
                                          Its:      President
                                               --------------


                                          Peregrine Pharmaceuticals, Inc.


                                          By:   /s/ Paul Lytle
                                               ---------------
                                          Name:     Paul Lytle
                                               ---------------
                                          Its:      VP Finance
                                               ---------------


                                          Arcus Therapeutics LLC

                                          By:  OXiGENE, Inc.
                                          Its: Member

                                               By: /s/ Frederick W. Driscoll
                                               -----------------------------
                                               Name:   Frederick W. Driscoll
                                               -----------------------------
                                               Its:    President
                                               -----------------

                                          and

                                          By:  Peregrine Pharmaceuticals, Inc.
                                          Its: Member

                                               By: /s/ Paul Lytle
                                               ------------------
                                               Name:   Paul Lytle
                                               ------------------
                                               Its:    VP Finance
                                               ------------------

                                      -18-