Exhibit 10.15
                              EMPLOYMENT AGREEMENT


     This Employment  Agreement (the  "Agreement") is entered into as of October
23,  2000,  between  OXiGENE  Inc.,  a Delaware  corporation  ("OXiGENE"  or the
"Company"), and Mr. Frederick W. Driscoll (the "Executive").

                              W I T N E S S E T H:
                              - - - - - - - - - -

     WHEREAS, Executive and OXIGENE desire to enter into an employment agreement
relating to the position of OXiGENE's President and Managing Director, Finance &
Operations, located in Boston, pursuant to which position Executive shall report
to Dr. Bjorn Nordenvall, OXiGENE's Chairman Chief Executive Officer.

     NOW,  THEREFORE,  for good and  valuable  consideration,  the  receipt  and
sufficiency  of which are hereby  mutually  acknowledged,  OXiGENE and Executive
hereby agree as follows:

     1. Employment

     1.1  Executive  shall  serve in the  capacity  of  President  and  Managing
Director, Finance & Operations, and shall have the duties,  responsibilities and
authority  assigned to Executive by the Board of Directors of OXiGENE  ("Board")
consistent  with such  position.  Executive  shall report  directly to OXiGENE's
Chairman and Chief Executive Officer.

     1.2 Executive,  so long as he is employed  hereunder,  (i) shall devote his
full  professional  time and  attention  to the  services  required of him as an
employee of  OXiGENE,  except as  otherwise  agreed and except as  permitted  in
accordance with paid vacation time subject to OX1GENE's existing vacation policy
and subject to OX1GENE's  existing policies  pertaining to reasonable periods of
absence due to sickness, personal injury or other disability, (ii) shall use his
best efforts to promote the interests of OXiGENE,  and (iii) shall discharge his
responsibilities  in a  diligent  and  faithful  manner,  consistent  with sound
business practices.

     2. Term

     The term of Executive's  employment  under this Agreement shall commence as
of October 23, 2000,  and shall  continue  until  terminated  by either party in
accordance with Section 6 hereof (the "Employment Term").

     3. Base Salary; Stock Options

     3.1 During the  Employment  Term,  Executive  shall  receive an annual base
salary in the amount of $250,003  (such amount as  adjusted,  from time to time,
the "Base Salary"), payable in twenty four (24) equal installments in accordance
with OXiGENE's payroll schedule from time to time in effect.  Executive's salary
shall be reviewed annually by the Board.

     3.2  OXiGENE  shall  grant  to  Executive,   subject  to  approval  by  the
Compensation  Committee of the Board,  pursuant to the OXiGENE  Inc.  1996 Stock
Incentive Plan (the "Stock Plan"), an option to purchase 40,000 shares of common
stock of OXiGENE,  $.01 par value per share.  Such option shall have an exercise
price equal to the Fair Market  Value (as defined in the Stock Plan) on the date
of grant of such option, and shall vest and become exercisable after one year of
employment.  Thereafter,  Executive will be a participant of the Stock Plan, and
will be eligible to receive an annual grant of an equivalent  number of options,
which shall  contain  the  customary  terms and  provisions  of options  granted
generally to key executives under the Stock Plan.

     3.3 Nothing  hereunder  shall preclude the Board from extending  bonuses or
other  compensation  to  Executive  during  the  Employment  Term  at  the  sole
discretion of the Board.

     4. Benefits

     Executive shall be entitled to participate in or receive benefits under any
employee  benefit plan,  arrangement  or perquisite  generally made available by
OXIGENE  during  the  Employment  Term  to its  executives  and  key  management
employees.  These  benefits  shall  consist of a minimum of paid health and life
insurance plans and four (4) weeks vacation.

     5. Business Expenses

     Executive  shall  be  entitled  to  receive  prompt  reimbursement  for all
reasonable  and  customary  expenses  incurred  by  him in  performing  services
hereunder during the Employment Terra;  provided that such expenses are incurred
and accounted for in accordance with the policies and procedures  established by
OXiGENE,

     6. Termination

     6.1 OXIGENE may,  upon giving  Executive  six (6) months'  written  notice,
terminate  Executive's  employment  subject to all provisions of this Agreement.
Notwithstanding the foregoing,  OXiGENE may terminate Executive's employment for
Cause (as defined in Section 6.6 hereof) without prior notice.

     6.2 (a)  Executive  may,  upon giving  OXIGENE  thirty  (30) days'  notice,
terminate  Executive's  employment  hereunder following a material breach of the
Agreement  by  OXiGENE,  which  breach  remains  uncured  thirty (30) days after
written  notice  thereof  is  received  by  OXiGENE  (a  "Termination  with Good
Reason").  If Executive has not  otherwise  materially  breached the  Agreement,
Executive's  Termination  with Good Reason shall be treated as if his employment
was terminated by OXiGENE other than for Cause.

     (b) The Executive may  voluntarily  resign from employment with the Company
upon  written  notice  to the  Company  specifying  the  effective  date of such
resignation,  which  effective date shall not be less than ninety (90) days from
the date of such notice. Upon the effective date of Executive's resignation, the
Company shall have no further  obligations or  liabilities to Executive,  except
for  obligations  due to Executive for services  rendered prior to the effective
date of Executive's resignation, and Executive shall have no further obligations
to perform duties as specified in Section 1 of this Agreement.

     6.3A If,  following  any Change in Control  (as such term is defined in the
Stock Plan) and prior to expiration of one (1) year from the date of such Change
in Control, (1) Executive's  employment is terminated by OXiGENE (other than for
Cause) or (2) in the event of a Termination with Good Reason, then

     (a) OXiGENE shall provide the following to Executive:

     (i)  the Unpaid Salary,  as soon as practicable after the Termination Date;
          plus

     (ii) an amount equal to twelve (12) months of Executive's then current Ease
          Salary; and

     (b) all stock options,  stock  appreciation  rights,  restricted stock, and
other incentive  compensation  granted to the Executive by OXIGENE shall, to the
extent vested, remain exercisable in accordance with the terms of the Stock Plan
(or prior applicable plan) and the agreement entered pursuant  thereto,  and the
Executive  may exercise all such vested  options and rights,  and shall  receive
payments and distributions accordingly.

     6.3 If Executive's employment is terminated by OXIGENE other than for Cause
(as defined below) or in the event of a Termination  with Good Reason,  then (a)
OXiGENE shall provide the following to Executive:

     (i)  as  soon as  practicable  after  the  effective  date  of  Executive's
          termination of employment ("Termination Date") a lump sum cash payment
          equal to the portion of  Executive's  then current Base Salary accrued
          to the  Termination  Date but unpaid as of the  Termination  Date (the
          "Unpaid Salary"); plus

     (ii) an amount equal to three (3) months of  Executive's  then current Base
          Salary;

     and (b) all stock options, stock appreciation rights, restricted stock, and
other incentive  compensation  granted to the Executive by OXIGENE shall, to the
extent vested, remain exercisable in accordance with the terms of the Stock Plan
(or prior applicable plan) and the agreement entered pursuant  thereto,  and the
Executive  may exercise all such vested  options and rights,  and shall  receive
payments and distributions accordingly.

     6.4 Except as  otherwise  set forth in this Section 6, all  obligations  of
OXIGENE under this Agreement shall cease if, during the Employment Term, OXIGENE
terminates  Executive for Cause or the Executive  resigns his  employment  other
than in a Termination with Good Reason,  Upon such termination,  Executive shall
be entitled to receive in a lump sum cash payment as soon as  practicable  after
the Termination Date an amount equal to the Unpaid Salary.

     6.5 The foregoing  payments upon Executive's  termination  shall constitute
the exclusive  payments due Executive upon  termination from his employment with
OXiGENE under this  Agreement or otherwise,  provided,  however,  that except as
stated above,  such payments  shall have no effect on any benefits  which may be
payable to Executive  under any plan of OXIGENE which  provides  benefits  after
termination of employment.

     6.6 For the purposes of this Agreement,  the term "Cause" shall mean any of
the following:

     (a) the (i)  continued  failure by Executive to perform  substantially  his
duties on behalf of OXIGENE if Executive  fails to remedy that breach within ten
(10) days of OXiGENE's  written  notice to  Executive  of such  breach;  Or (ii)
material  breach of any other  provision of this Agreement by the Executive,  if
the  Executive  falls to remedy  that breach  within ten (10) days of  OXiGENE's
written notice to Executive of such breach; or

     (b) any act of fraud,  material  misrepresentation  or  material  omission,
misappropriation, dishonesty, embezzlement or similar conduct against OXiGENE or
any  affiliate,  or conviction of Executive for a felony or any crime  involving
moral turpitude.

     7. No Solicitation; Confidentiality; Work for Hire

     7.1 For a period  of one year  after  the  Termination  Date,  neither  the
Executive nor any  Executive-Controlled  Person (as defined below) will, without
the prior  written  consent of the Board,  directly  or  indirectly  solicit for
employment,  or make an unsolicited  recommendation  to any other person that it
employ or solicit for  employment,  any person who is or was, at any time during
the nine (9) month period prior to the Termination  Date, an officer,  executive
or key  employee  of OXiGENE or of any  affiliate  of  OXiGENE.  As used in this
Agreement,  the term  "Executive-Controlled  Person"  shall  mean  any  company,
partnership,  firm or other entity as to which Executive possesses,  directly or
indirectly,  the power to direct or cause the  direction of the  management  and
policies of such entity, whether through the ownership of voting securities,  by
contract or otherwise.  Notwithstanding the foregoing,  this provision shall not
apply to the  solicitation  of  individuals  who have, for at least one (1) year
prior to the Termination Date, not been employed by OXiGENE.

     7.2 (a) Executive  acknowledges  that,  through his status as President and
Managing  Director,  Finance &  Operations  of OXiGENE,  he has,  and will have,
possession  of  important,  confidential  information  and  knowledge  as to the
business  of  OXiGENE  and  its  affiliates,  including,  but  not  limited  to,
information  and  knowledge  related to drugs and  compounds  developed or under
development  by the  Company or any of its  affiliates,  financial  results  and
projections,  future plans, the provisions of other important  contracts entered
into  by  OXiGENE  and  its  affiliates,   possible   acquisitions  and  similar
information.   Executive   agrees  that  all  such   information  and  knowledge
constitutes a vital part of the business of OXiGENE and its affiliates and is by
its nature trade secrets and confidential information proprietary to OXiGENE and
its affiliates (collectively, "Confidential Information"). Executive agrees that
he  shall  not,  so long as the  Company  or any of its  affiliates  remains  in
existence, divulge,  communicate,  furnish Or make accessible (whether orally or
in writing or in books,  articles or any other medium) to any individual,  firm,
partnership,  corporation  or other entity,  any knowledge or  information  with
respect to Confidential  Information directly or indirectly useful in any aspect
of the business of OXiGENE or any of its  affiliates.  As used in the  preceding
sentence,   "Confidential  Information"  shall  not  include  any  knowledge  or
information that; (i) is or becomes available to others,  other than as a result
of a breach by Executive of this Section 7.2; (ii) was available to Executive on
a nonconfidential  basis prior to its disclosure to Executive through his status
as an officer or employee of OXiGENE or any affiliate;  (iii) becomes  available
to Executive on a nonconfidential  basis from a third party (other than OXiGENE,
any  affiliate or any of its or their  representatives)  who is not bound by any
confidentiality  obligation to OXiGENE or any  affiliate;  (iv) was known by the
Executive  prior to his  employment  by  OXiGENE  as  evidenced  by  Executive's
pre-existing written records; (v) was not maintained as confidential information
by OXiGENE; (vi) is otherwise information generally known or available to others
within OXiGENE's industry; or (vii) is information that is legally compelled, by
applicable law, to be disclosed by Executive, provided, however, that in such an
event Executive shall give prompt notice to OXiGENE of such  requirement so that
OXiGENE may seek a protective order or other appropriate remedy.

     (b) All memoranda, notes, lists, records and other documents or papers (and
all copies  thereof),  including  such items  stored in  computer  memories,  on
microfiche or by any other means,  made or compiled by or on behalf of Executive
or made  available  to him  relating  to the  business  of OXiGENE or any of its
affiliates are and shall be and remain OXiGENE's property and shall be delivered
to OXIGENE promptly upon the termination of Executive's  employment with OXIGENE
or at any other tine on request and such information  shall be held confidential
by Executive after the termination of his employment with OXiGENE.

     7.3 The Executive grants the Company and each affiliate of the Company,  as
appropriate, all rights in and to the contributions made by the Executive to any
projects  or  matters  on which the  Executive  worked  prior to, or during  the
Employment  Term.  The  Executive  acknowledges  that each such  matter  and the
contribution made by the Executive thereto shall constitute a work made for hire
within the meaning of the United States copyright law and other applicable laws.
The Company  reserves  all rights with  respect to  information  relating to the
Company's  products,  including,  but not  limited  to,  the  right to apply for
patents.

     7.4 The  provisions  contained  in this  Section 7 as to the time  periods,
scope of activities,  persons or entities affected,  and territories  restricted
shall be deemed divisible so that, if any provision  contained in this Section 7
is determined to be invalid or  unenforceable,  such provisions  shall be deemed
modified  so as to  be  valid  and  enforceable  to  the  full  extent  [awfully
permitted.

     7.5 Executive  agrees that the  provisions of this Section 7 are reasonable
and necessary for the  protection of OXiGENE and that they may not be adequately
enforced by an action for damages and that, in the event of a breach  thereof by
Executive or any Executive-Controlled Person, OXiGENE shall be entitled to apply
for and  obtain  injunctive  relief in any court of  competent  jurisdiction  to
restrain  the breach or  threatened  breach of such  provision  or  otherwise to
enforce  specifically  such  provisions  against  such  violation,  without  the
necessity of the posting of any bond by OXiGENE. Executive further covenants and
agrees  that if he shall  violate  any of his  covenants  under this  Section 7,
OXiGENE  shall be  entitled  to an  accounting  and  repayment  of all  profits,
compensation,   commissions,  remuneration  or  other  benefits  that  Executive
directly or indirectly  has realized  and/or may realize as a result of, growing
out of or in connection with any such violation.  Such a remedy shall,  however,
be  cumulative  and not  exclusive  and shall be in addition  to any  injunctive
relief  or other  legal  or  equitable  remedy  to  which  OXiGENE  is or may be
entitled.

     8. Taxes

     Any  amounts  payable  to the  Executive  hereunder  shall  be  paid to the
Executive  subject to all  applicable  taxes  required to be withheld by OXiGENE
pursuant  to  federal,  state or  local  law.  The  Executive  shall  be  solely
responsible  for all taxes  imposed on the Executive by reason of his receipt of
any amounts of compensation or benefits payable hereunder.

     8A. Indemnification

     OXiGENE shall  indemnify the  Executive for all claims,  losses,  expenses,
costs,  obligations,  and liabilities of every nature whatsoever incurred by the
Executive  as a result of the  Executive's  acts or  omissions as an employee of
OXiGENE, but excluding from such indemnification any claims,  losses,  expenses,
costs, obligations,  or liabilities incurred by the Executive as a result of the
Executive's bad faith, willful misconduct or gross negligence.

     8B. Attorney's Fees and Expenses

     OXiGENE and the Executive agree that in the event of litigation arising out
of or  relating to this  Agreement,  the  prevailing  party shall be entitled to
reimbursement from the other party of the prevailing party's reasonable attorney
fees and expenses.

     9. Amendments

     This Agreement may not be altered,  modified Or amended except by a written
Instrument signed by each of the parties hereto,

     10. Assignment

     Neither this Agreement nor any of the rights or obligations hereunder shall
be assigned or delegated by any party hereto  without the prior written  consent
of the other party;  provicle4,  however, that any payments and benefits owed to
Executive  under  this  Agreement  shall  inure to the  benefit of his heirs and
personal representatives.

     11. Waiver

     Waiver by any party  hereto of any breach or default by any other  party of
any of the terms of this  Agreement  shall not  operate as a waiver of any other
breach or default,  whether  similar to or different  from the breach or default
waived.

     12. Severability

     In the event that any one or more of the provisions of this Agreement shall
be or become invalid,  illegal or  unenforceable  in any respect,  the validity,
legality and enforceability of the remaining  provisions  contained herein shall
not be affected thereby.

     13. Notices

     All notices and other  communications  provided for in this Agreement shall
be in  writing  and shall be deemed to have  been  duly  given  when  personally
delivered or when mailed by registered mail, return receipt  requested,  postage
prepaid, addressed as follows:

                  If to Executive, to him as follows:

                  Mr. Frederick W. Driscoll
                  15 Crestwood Road
                  North Reading, MA  01864

                  If to OXiGENE, to it as follows:

                  OXiGENE Inc.
                  321 Arsenal Street
                  Watertown, MA 02472
                  Attention:  Bjorn Nordenvall

     or to such other address or such other person as Executive or OXIGENE shall
designate in writing in  accordance  with this  Section 13,  except that notices
regarding changes in notices shall be effective only upon receipt.

     14. Headings

     Headings to  Sections  in this  Agreement  are for the  convenience  of the
parties  only and are not  intended to be a part of, or to affect the meaning or
interpretation of, this Agreement.

     15. Governing Law

     This  Agreement  shall  be  governed  by the  laws of the  Commonwealth  of
Massachusetts  without  reference to the principles of conflict of laws. Each of
the parties hereto consents to the  jurisdiction of the federal and state courts
of the Commonwealth of Massachusetts in connection with any claim or controversy
arising out of or connected  with this  Agreement,  and said courts shall be the
exclusive forum for the resolution of any such claim or controversy.  Service of
process in any such  proceeding  may be made upon each of the parties  hereto at
the address of such party as determined  in  accordance  with Section 13 of this
Agreement,  subject to the applicable rules of the court in which such action is
brought.

     16. All Other Agreements Superseded

     This Agreement  contains the entire agreement between Executive and OXiGENE
with respect to all matters relating to Executive's employment with OXiGENE and,
as of the date hereof, will supersede and replace any other agreements,  written
or oral,  between the parties relating to the terms or conditions of Executive's
employment with OXiGENE, provided, however, that nothing in this Agreement shall
amend or affect any  options  previously  granted to  Executive  pursuant to the
Stock Plan,

     IN WITNESS WHEREOF,  OXIGENE and Executive have caused this Agreement to be
executed as of the date first above written.



                           /s/ Frederick W. Driscoll
                           -------------------------
                               Frederick W. Driscoll


                               OXiGENE Inc.


                           By: /s/ Bjorn Nordenvall
                           ------------------------
                           Name:   Bjorn Nordenvall
                           Title:  Chairman and CEO