Exhibit 10.16

            Independent Contractor Agreement For Consulting Services

     This Independent Contractor Agreement (the "Agreement") is made and entered
into as of April 1, 2001,  by and between  OXiGENE,  Inc. (the  "Company"),  and
David Chaplin Consultants, Ltd. (the "Consultant").

                                  WITNESSETH:

     WHEREAS,  the Company  desires to engage the Consultant to perform  certain
professional services specified herein; and the Consultant desires to be engaged
as an  independent  contractor in accordance  with the terms and  conditions set
forth  in  this  Agreement;

     NOW,  THEREFORE,  in  consideration  of the mutual covenants and agreements
contained  herein and other good and  valuable  consideration,  the  receipt and
sufficiency of which is hereby  acknowledged  by the Company and the Consultant,
the parties agree as follows:

1. Scope of Services and Responsibilities of the Consultant

     (a) The Consultant shall provide the Company with the following  Consulting
Services:

     (i) The Consultant  shall provide  monitoring  and reporting  services with
respect to the Company's  existing research  programs  established in connection
with Bristol-Meyers Squibb, the University of Lund, and Baylor University.  (ii)
The Consultant shall provide  monitoring and reporting  services with respect to
other   contracted   research  and   development   personnel  in  the  Company's
laboratories  outside of the United  States  (iii) The  Consultant  shall review
pertinent   scientific   journals  and  other  academic   literature  and  trade
publications   and  prepare  reports  to  the  Company   concerning   scientific
developments  and other  information  pertinent  to the  Company's  existing and
prospective  business (b) The Consultant  shall perform the Consulting  Services
entirely  outsideof  the United  States and shall  perform no  services  for the
Company except those called for by this Agreement or any subsequent modification
thereof. The performance by the Consultant of any Consulting Services within the
United  States shall  constitute a material  breach of this  Agreement,  and the
Company shall have no obligation to compensate the Consultant for any Consulting
Services performed within the United States Consultant shall perform no services
for the Company except as is provided herein. The Consultant,  in performing the
Consulting  Services,  shall have no authority to  establish  Company  policy or
business  objectives,  nor to bind the Company,  nor to hire or fire any Company
employee.  The  Consultant  shall  maintain  sole control and  discretion  as to
exactly when the  Consulting  Services are  performed.  However,  the Consultant
shall all devote as much time as is necessary  for the  provision of  Consulting
Services  to the  Company's  reasonable  satisfaction,  and  shall  satisfy  all
reasonable  deadlines  imposed by the Company for the  provision  of  particular
services and shall meet (whether in person,  by telephone or by e-mail) with the
official(s)  designated  by the Company to monitor and evaluate  the  Consulting
Services.  (c) In performing services under this Agreement,  the Consultant will
(i) use diligent  efforts and  professional  skills and  judgment;  (ii) perform
professional services in accordance with recognized professional standards;  and
(iii) comply with the by-laws,  rules,  policies and  regulations of the Company
and any of its affiliates and/or  subsidiaries to which the Consulting  Services
are  provided.  (d) The  Consultant  shall  comply  fully  with  all  applicable
employment and labor laws,  regulations and rules relating to the services to be
performed by the Consultant.

2. Independent Contractor Status

     It is  understood  and  agreed  that the  Consultant  will act solely as an
independent  contractor,  and nothing in this  Agreement  shall be  construed to
render the  Consultant  or any owner,  employee,  or agent of the  Consultant an
employee of the Company or to entitle the Consultant or any owner,  employee, or
agent  of the  Consultant  to  participate  in any  Company  benefit  plan.  The
Consultant,  therefore,  agrees to secure,  pay for and maintain all insurances,
licenses and/or permits  necessary to perform any of the services required under
this Agreement.  The Consultant  understands and recognizes that, except insofar
as  the  Company  may  expressly  delegate  to  Consultant  authority  to  bind,
represent,  or speak for the Company with respect to specific projects,  clients
or  prospective  clients of the Company,  the  Consultant is not an agent of the
Company and has no authority  to and shall not bind,  represent or speak for the
Company  for any  purpose  whatsoever.  , The  Company  will  not  withhold  any
employment  taxes on the  Consultant's  behalf.  The Consultant  shall be solely
responsible  for all taxes imposed on the  Consultant by reason of  Consultant's
receipt of any fees payable hereunder.

3. Fees To Be Paid To Consultant

     (a)  In  consideration  of  the  Consulting   Services   performed  by  the
Consultant,  the Company  agrees to pay the  Consultant  fees for projects to be
undertaken as agreed between the company and consultant:

     The  Consultant  shall be  responsible  for  providing  all  equipment  and
facilities necessary for the provision of the Consulting Services,  however, the
Company  shall  reimburse  Consultant  for expenses  which have been approved in
advance by the Company in writing.

     The  Company  shall  pay  fees in equal  monthly  installments,  and  shall
reimburse  incidental  expenses,  subject to Consultant's  submission of monthly
invoices, as provided in Paragraph 3(b) below.

     (b) The  Consultant  shall  maintain  records of time spent  providing  the
Consulting  Services  and  shall,  on the  last day of each  month or the  first
business day  thereafter,  submit to the designated  Company  representative  an
invoice  accompanied  by a statement  reflecting  the dates on which  Consulting
Services  were  performed  during the  preceding  month,  a  description  of the
services   provided  on  each  day  Consulting   services  were   performed,   a
certification  that all consulting  services were performed ouside of the United
States,  and a description of pre-approved  expenses for which  Consultant seeks
reimbursement.  The Company shall pay such  invoices  within 30 days of receipt.
The Company shall have no obligation to make payment unless the Consultant is in
compliance  with  all of  Consultant's  covenants,  agreements,  and  warranties
hereunder.

4. Termination

     4.1 The Company may,  upon giving the  Consultant  sixty (60) days' written
notice,  terminate this Agreement,  subject to all provisions of this Agreement.
Notwithstanding  the  foregoing,  the Company may terminate  this  Agreement for
Cause (as defined in Section 6.5 hereof)  without prior notice.  The  Consultant
may, upon giving the Company thirty (180 days' notice, terminate this Agreement.
If the Consultant  terminates this Agreement  following a material breach of the
Agreement  by the  Company,  which  breach  remains  uncured ten (10) days after
written  notice  thereof is received by the  Company (a  "Termination  with Good
Reason"),  the  Consultant  shall  be  compensated  as  if  this  Agreement  was
terminated by the Company without Cause.

     4.2 If this Agreement is terminated by the Company other than for Cause (as
defined  below) or in the event of a  Termination  with  Good  Reason,  then the
Company pay the Consultant as follows:

     (a) as soon as practicable  after the effective date of the  termination of
this Agreement  ("Termination Date") a lump sum cash payment equal to any unpaid
fees due for such  Consulting  Services as may have been  rendered  prior to the
Termination Date ; plus

     (b) a sum of $120,000 or

     (c)If,  following  any  Change in  Control  (as such term is defined in the
Stock Plan) and prior to expiration of one (1) year from the date of such Change
in Control, (1) Executive's  employment is terminated by OXiGENE (other than for
Cause) or in the event of a Termination with Good Reason, then

1) OXiGENE shall provide the following to the Executive:

     (i) the Unpaid Salary,  as soon as practicable  after the Termination Date;
plus

2) an amount  equal to twelve  (12)  months of  Executive's  then  current  Base
Salary.

     4.3 Except as otherwise set forth in this  Paragraph 4, all  obligations of
the Company  under this  Agreement  shall cease if the Company  terminates  this
Agreement for Cause or the Consultant  terminates this Agreement other than in a
Termination  with Good Reason.  Upon such  termination,  the Consultant shall be
entitled to receive in a lump sum cash payment as soon as practicable  after the
Termination  Date an amount  equal to any  unpaid  fees due for such  Consulting
Services as may have been rendered prior to the Termination Date (.

     4.4 The foregoing  payments shall constitute the exclusive payments due the
Consultant upon termination of this Agreement.

     4.5 For the purposes of this Agreement,  the term "Cause" shall mean any of
the following:

     (a) the (i) continued  failure by the  Consultant to provide the Consulting
     Services  in a  manner  reasonably  satisfactory  to  the  Company  if  the
     Consultant  fails to  remedy  that  failure  within  ten  (10)  days of the
     Company's written notice to the Consultant of such breach; or (ii) material
     breach of any other provision of this Agreement by the  Consultant,  if the
     Consultant  fails  to  remedy  that  breach  within  ten  (10)  days of the
     Company's written notice to the Consultant of such breach; or

     (b) any act of fraud,  material  misrepresentation  or  material  omission,
     misappropriation,  dishonesty,  embezzlement or similar conduct against the
     Company or any affiliate, or conviction of any owner, agent, or employee of
     the Consultant for a felony or any crime involving moral turpitude.

     5. No Solicitation; Confidentiality; Work for Hire

     5.1 For a period  of one year  after  the  Termination  Date,  neither  the
Consultant nor any Consultant-Controlled Person (as defined below) will, without
the prior  written  consent of the  Company's  Board of  Directors,  directly or
indirectly solicit for employment, or make an unsolicited  recommendation to any
other person that it employ or solicit for  employment any person who is or was,
at any time during the nine (9) month period prior to the  Termination  Date, an
officer,  executive  or key  employee of the Company or of any  affiliate of the
Company.  As used in this  Agreement,  the term  "Consultant-Controlled  Person"
shall  mean any  company,  partnership,  firm or other  entity  as to which  the
Consultant  or any  owner,  agent,  or  employee  of the  Consultant  possesses,
directly  or  indirectly,  the power to direct  or cause  the  direction  of the
management and policies of such entity,  whether through the ownership of voting
securities,  by contract  or  otherwise.  Notwithstanding  the  foregoing,  this
provision  shall not apply to the  solicitation  of individuals who have, for at
least one (1) year  prior to the  Termination  Date,  not been  employed  by the
Company.

     5.2(a) The Consultant  acknowledges  that,  through the  performance of the
Consulting  Services  specified in this Agreement,  the Consultant has, and will
have, possession of important,  confidential information and knowledge as to the
business  of the  Company  and its  affiliates,  including,  but not limited to,
information related to drugs and compounds developed or under development by the
Company,  financial  results and  projections,  future plans,  the provisions of
other  important  contracts  entered  into by the  Company  and its  affiliates,
possible  acquisitions and similar  information.  The Consultant agrees that all
such knowledge and  information  constitutes a vital part of the business of the
Company and its affiliates  and is by its nature trade secrets and  confidential
information  proprietary  to  the  Company  and  its  affiliates  (collectively,
"Confidential  Information").  The  Consultant  agrees that it shall not, at any
time, whether during the term of this Agreement or following termination of this
Agreement for any reason, whether by the Company or by the Consultant,  divulge,
communicate,  furnish  or make  accessible  (whether  orally or in writing or in
books,  articles or any other medium) to any  individual,  firm,  partnership or
corporation,   any  knowledge  or  information   with  respect  to  Confidential
Information  directly or indirectly  useful in any aspect of the business of the
Company  or  any  of  its  affiliates.   As  used  in  the  preceding  sentence,
"Confidential  Information" shall not include any knowledge or information that:
(i) is or becomes  available to others,  other than as a result of breach by the
Consultant  or any of the  Consultant of this Section 5.2; (ii) was available to
the  Consultant  on a  nonconfidential  basis  prior  to its  disclosure  to the
Consultant in connection with the performance of the Consulting Services;  (iii)
becomes  available to the  Consultant  on a  nonconfidential  basis from a third
party  (other  than  the  Company,   any  affiliate  or  any  of  its  or  their
representatives)  who is not  bound  by any  confidentiality  obligation  to the
Company  or any  affiliate;  (iv)  was  known  by the  Consultant  prior  to the
effective date of this Agreement as evidenced by the  Consultant's  pre-existing
written  records;  (v) was not  maintained as  confidential  information  by the
Company;  (vi) is otherwise  information known or available within the Company's
industry;  or (vii) is information that is not otherwise  entitled to protection
under applicable law.

     (b) All memoranda, notes, lists, records and other documents or papers (and
all copies  thereof),  including  such items  stored in  computer  memories,  on
microfiche  or by any  other  means,  made or  compiled  by or on  behalf of the
Consultant or made available to the  Consultant  relating to the Company are and
shall be and remain the Company's property and shall be delivered to the Company
promptly upon the  termination of this Agreement or at any other time on request
and such  information  shall be held  confidential  by the Consultant  after the
termination of this  Agreement for any reason,  whether by the Company or by the
Consultant.

     5.3 The Consultant grants the Company and each affiliate of the Company, as
appropriate, all rights in and to the contribution made by the Consultant to any
projects or matters on which the  Consultant  worked during the period for which
this agreement is in force.  The Consultant  acknowledges  that each such matter
and the contribution made by the Consultant thereto shall constitute a work made
for hire  within  the  meaning  of the  United  States  copyright  law and other
applicable  laws,  The Company  reserves all rights with respect to  information
relating to the Company's products,  including, but not limited to, the right to
apply for patents. The Consultant agrees to cooperate fully with the Company and
to perform all acts deemed necessary or desirable by the Company (whether before
or after the Termination  Date), at the Company's cost and expense,  in order to
more  full  vest in the  Company  or to  establish  as a matter  of  record  all
ownership  rights in  projects  or  matters  created  through  the  Consultant's
services  hereunder  and in those rights  transferred  by the  Consultant to the
Company,  and to secure patent,  copyright,  or other  protections in the United
States or any foreign countries, including, without limitation, the execution of
any  instruments  and the giving of  evidence  and  testimony,  without  further
compensation beyond the Consultant's agreed compensation.

     5.4 The  provisions  contained  in this  Section 5 as to the time  periods,
scope of activities,  persons or entities affected,  and territories  restricted
shall be deemed divisible so that, if any provision  contained in this Section 5
is determined to be invalid or  unenforceable,  such provisions  shall be deemed
modified  so as to  be  valid  and  enforceable  to  the  full  extent  lawfully
permitted.

     5.5 The  Consultant  agrees  that  the  provisions  of this  Section  5 are
reasonable and necessary for the protection of the Company and that they may not
be  adequately  enforced by an action for  damages  and that,  in the event of a
breach  thereof  by the  Consultant  or any  Consultant-Controlled  Person,  the
Company shall be entitled to apply for and obtain injunctive relief in any court
of competent  jurisdiction  to restrain the breach or threatened  breach of such
violation or  otherwise to enforce  specifically  such  provisions  against such
violation,  without the necessity of the posting of any bond by the Company. The
Consultant  further  covenants  and agrees  that if he shall  violate any of his
covenants  under this Section 5, the Company  shall be entitled to an accounting
and repayment of all profits, compensation,  commissions,  remuneration or other
benefits  that the  Consultant  directly or indirectly  has realized  and/or may
realize as a result of, growing out of or in connection with any such violation.
Such a remedy shall,  however,  be cumulative  and not exclusive and shall be in
addition to any  injunctive  relief or other legal or equitable  remedy to which
the Company is or may be entitled.

6. Indemnification

     The  Consultant  shall  indemnify  and  hold  harmless  the  Company,   its
employees,  officers  and agents from and  against any and all claims,  demands,
losses,  damages or expenses (including  attorneys' fees) that arise as a result
of Consultant's  performance or  non-performance  of the Consulting  Services or
relate in any way to Consultant's representations and obligations herein.

7. Attorney's Fees and Expenses

     The  Company  and the  Consultant  agree  that in the  event of  litigation
arising out of or  relating to this  Agreement,  the  prevailing  party shall be
entitled  to  reimbursement  from  the  other  party of the  prevailing  party's
reasonable attorney fees and expenses.

8. Amendments

     This Agreement may not be altered,  modified or amended except by a written
instrument signed by each of the parties hereto.

9. Assignment

     Neither this Agreement nor any of the rights or obligations hereunder shall
be assigned or delegated by any party hereto  without the prior written  consent
of the other party provided, that this Agreement shall be binding upon and shall
inure to the benefit of the Company and its  successors  and assigns  whether by
merger,  operation of law,  consolidation,  purchase,  or other  acquisition  of
controlling interest in the business of the Company.

10. Waiver

     Waiver by any party  hereto of any breach or default by any other  party of
any of the terms of this  Agreement  shall not  operate as a waiver of any other
breach or default,  whether  similar to or different  from the breach or default
waived.

11. Severability

     In the event that any one or more of the provisions of this Agreement shall
be or become  invalid,  illegal or  unenforceable  in any respect the  validity,
legality and enforceability of the remaining  provisions  contained herein shall
not be affected thereby.

12. Notices

     All notices and other  communications  provided for in this Agreement shall
be in  writing  and shall be deemed to have  been  duly  given  when  personally
delivered or when mailed by registered mail, return receipt  requested,  postage
prepaid, addressed as follows:

                           If to the Consultant:

                           David Chaplin Consultants, Ltd.
                           14,Plowden Park
                           Aston Rowant
                           Watlington   OX49 5SX
                           Oxfordshire

                           If to the Company:

                           OXiGENE Inc.
                           321 Arsenal Street
                           Watertown MA

                           Attention:  Bjorn Nordenvall

or to such other  address or such other person as the  Consultant or the Company
shall  designate  in writing in  accordance  with this  Section 11,  except that
notices regarding changes in notices shall be effective only upon receipt.

13. Headings

     Headings to  Sections  in this  Agreement  are for the  convenience  of the
parties  only and are not  intended to be a part of, or to affect the meaning or
interpretation of, this Agreement.

14. Governing Law; Waiver of Jury Trial

     This  Agreement  shall  be  governed  by the  laws of the  Commonwealth  of
Massachusetts  without  reference to the principles of conflict of laws. Each of
the parties hereto consents to the  jurisdiction of the federal and state courts
of the Commonwealth of Massachusetts in connection with any claim or controversy
arising out of or connected  with this  Agreement,  and said courts shall be the
exclusive forum for the resolution of any such claim or controversy.  Service of
process in any such  proceeding  may be made upon each of the parties  hereto at
the address of such party as determined  in  accordance  with Section 11 of this
Agreement,  subject to the applicable rules of the court in which such action is
brought.  Both  parties  further  agree  that  any  action,   demand,  claim  or
counterclaim  shall be resolved by a judge alone,  and both parties hereby waive
and forever renounce the right to a trial before a civil jury.

15. All Other Agreements Superseded

     This Agreement contains the entire agreement between the Consultant and the
Company with respect to all matters relating to the Consulting  Services and, as
of the date hereof,  will supersede and replace any other agreement,  written or
oral, between the parties relating to the Consulting Services.

     IN WITNESS  WHEREOF,  the  Company  and the  Consultant  have  caused  this
Agreement to be executed as of the date first above written.

                           David Chaplin Consultants, Ltd.

                           By: /s/ David Chaplin
                           ---------------------
                                   David Chaplin


                           OXiGENE Inc.

                           By: /s/ Frederick Driscoll
                           --------------------------
                           Name:   Frederick Driscoll