Exhibit 10.17

                              EMPLOYMENT AGREEMENT

     This  Employment  Agreement (the  "Agreement')  is entered into as of April
1st,  2001,  between  OXiGENE Inc., a Delaware  corporation  ("OXiGENE,"  or the
"Company"), and Dr. David Chaplin (the "Executive").

                              W I T N E S S E T H:
                              - - - - - - - - - -

     WHEREAS,  Executive  will be employed  by OXiGENE in the  capacity of Chief
Operating Officer.

     NOW,  THEREFORE,  for good and  valuable  consideration,  the  receipt  and
sufficiency  of which are hereby  mutually  acknowledged,  OXiGENE and Executive
hereby agree as follows:

1. Employment

     1.1 Executive shall serve in the capacity of Chief Operating  Officer,  and
shall have the duties,  responsibilities  and authority assigned to Executive by
the Board of  Directors  of OXiGENE  ("Board")  consistent  with such  position.
Executive  shall report  directly to  OXiGENE's  President  and Chief  Executive
Officer.

     1.2 Executive,  so long as he is employed  hereunder,  (i) shall devote his
full  professional  time and  attention  to the  services  required of him as an
employee of  OXiGENE,  except as  otherwise  agreed and except as  permitted  in
accordance  with paid  vacation  time  subject to  OXiGENE's  existing  vacation
policy,  and subject to OXiGENE's  existing  policies  pertaining  to reasonable
periods of absence due to sickness,  personal injury or other  disability,  (ii)
shall use his best efforts to promote the interests of OXiGENE,  and (iii) shall
discharge his  responsibilities  in a diligent and faithful  manner,  consistent
with sound business practices.

     1.3 Executive will be required to allocate all of his professional time and
activities to OXiGENE. As a result, you will not be allowed to exercise any paid
or unpaid  professional  activities,  whether in a competing  field or not,  for
others than for OXIGENE, except after having obtained prior written consent from
OXiGENE,  produced,  however,  that nothing herein shall prevent  executive from
rendering services in the United Kingdom on behalf of David Chaplin  Consultants
Ltd. In connection with the performance of that certain  Independent  Contractor
Agreement for Consulting  Services between OXiGENE and David Chaplin Consultants
Ltd. of even date herewith.

     1.4 Executive shall perform his duties and  responsibilities,  and exercise
his authority  pursuant to this Agreement  exclusively with the United States of
America.  Without  limiting the foregoing  sentence,  Executive is  specifically
prohibited from performing any of his duties or responsibilities,  or exercising
his authority as Chief Operating Officer, within the United Kingdom. Executive's
violation of the  restrictions of this Paragraph 1.4 shall constitute a material
breach of this Agreement.

     On the basis of the  information  you have provided  OXIGENE with, and more
specifically  considering  your 16.7% capital share in Angiogene  Pharmaceutical
Ltd., you are authorised to continue to hold this  financial  participation.  In
addition you are  authorised to retain a position as  non-executive  director of
Angiogene  Pharmaceutical Ltd. Any raise in your capital share of Angiogene Ltd.
or participation  in the scientific or strategic  management  however,  shall be
subject to OXiGENE's prior written consent.

2. Term

     The term of Executive's  employment  under this Agreement shall commence as
of April 1,  2001,  and shall  continue  until  terminated  by  either  party in
accordance with Section 6 hereof (the "Employment Term").

3. Base Salary

     3.1 During the  Employment  Term,  Executive  shall  receive an annual base
salary in an annual  amount of  $160,000  (including  bonus the "Base  Salary"),
payable in twelve (12) equal  installments in accordance with OXiGENE's  payroll
schedule  from time to time in  effect.  Executive's  salary  shall be  reviewed
annually by the Board.

4. Benefits

     Executive shall be entitled to five (5) weeks vacation

5. Business Expenses

     Executive  shall  be  entitled  to  receive  prompt  reimbursement  for all
reasonable  and  customary  expenses  incurred  by  him in  performing  services
hereunder during the Employment  Term;  provided that such expenses are incurred
and accounted for in accordance with the policies and procedures  established by
OXiGENE.

6. Termination

     6.1 OXiGENE may, upon giving  Executive  sixty (180) days' written  notice,
terminate  Executive's  employment  subject to all provisions of this Agreement.
Notwithstanding the foregoing,  OXiGENE may terminate Executive's employment for
Cause (as defined in Section 6.5 hereof)  without prior notice.  Executive  may,
upon giving OXiGENE thirty (30) days' notice,  terminate Executive's  employment
hereunder. If Executive terminates his employment following a material breach of
the  Agreement  by OXiGENE,  which  breach  remains  uncured ten (10) days after
written  notice  thereof  is  received  by  OXiGENE  (a  "Termination  with Good
Reason"),  Executive  shall be treated as if his  employment  was  terminated by
OXiGENE without Cause.

     6.2 If Executive's employment is terminated by OXiGENE other than for Cause
(as  defined  below) or in the event of a  Termination  with Good  Reason,  then
OXiGENE shall provide the following to Executive:

     (a) as  soon  as  practicable  after  the  effective  date  of  Executive's
termination of employment  ("Termination Date") a lump sum cash payment equal to
the portion of Executive's  then current Base Salary accrued to the  Termination
Date but unpaid as of the Termination Date (the "Unpaid Salary"); plus

     (b) the greater of six (6) months of salary or two (2) months of salary for
each year of the Executive's employment at OXiGENE; plus

     (c) All stock options,  stock  appreciation  rights,  restricted stock, and
other incentive  compensation  granted to the Executive by OXiGENE shall, to the
extent vested, remain exercisable in accordance with the terms of the Stock Plan
(or prior  applicable  plan) and the agreement  entered pursuant thereto and the
Executive  may exercise all such vested  options and rights,  and shall  receive
payments and distributions accordingly.

     6.3 Except as  otherwise  set forth in this Section 6, all  obligations  of
OXiGENE under this Agreement shall cease if, during the Employment Term, OXiGENE
terminates  Executive for Cause or the Executive  resigns his  employment  other
than in a Termination with Good Reason.  Upon such termination,  Executive shall
be entitled to receive in a lump sum cash payment as soon as  practicable  after
the Termination Date an amount equal to the Unpaid Salary.

     a. 6.3(a) If,  following  any Change in Control (as such term is defined in
the Stock  Plan) and prior to  expiration  of one (1) year from the date of such
Change in Control,  (1)  Executive's  employment is terminated by OXiGENE (other
than for Cause) or in the event of a Termination with Good Reason, then

     1) OXiGENE shall provide the following to the Executive:

     (i) the Unpaid Salary,  as soon as practicable  after the Termination Date;
plus

     an amount  equal to twelve (12) months of  Executive's  then  current  Base
Salary.6.4 The foregoing payments upon Executive's  termination shall constitute
the exclusive  payments due Executive upon  termination from his employment with
OXiGENE under this  Agreement or otherwise,  provided,  however,  that except as
stated above,  such payments  shall have no effect on any benefits  which may be
payable to Executive  under any plan of OXiGENE which  provides  benefits  after
termination of employment.

     6.5 For the purposes of this Agreement,  the term "Cause" shall mean any of
the following:

     (a) the (i)  continued  failure by Executive to perform  substantially  his
duties on behalf of OXiGENE if Executive  fails to remedy that breach within ten
(10) days of OXiGENE's  written  notice to  Executive  of such  breach;  or (ii)
material  breach of any other  provision of this Agreement by the Executive,  if
the  Executive  fails to remedy  that breach  within ten (10) days of  OXiGENE's
written notice to Executive of such breach; or

     (b) any act of fraud,  material  misrepresentation  or  material  omission,
misappropriation, dishonesty, embezzlement or similar conduct against OXiGENE or
any  affiliate,  or conviction of Executive for a felony or any crime  involving
moral turpitude.

     6.6 Upon  termination of Executive's  employment for any reason,  Executive
shall resign from the Board of OXiGENE, and the board of directors of any of its
affiliates of which he is then a director;  such resignations shall be effective
not later  than the  effective  date of  termination  of his  employment  unless
otherwise mutually agreed by Executive and the Board.

7. No Solicitation; Confidentiality; Work for Hire

     7.1 For a period  of one year  after  the  Termination  Date,  neither  the
Executive nor any  Executive-Controlled  Person (as defined below) will, without
the prior  written  consent of the Board,  directly  or  indirectly  solicit for
employment,  or make an unsolicited  recommendation  to any other person that it
employ or solicit  for  employment  any person who is or was, at any time during
the nine (9) month period prior to the Termination  Date, an officer,  executive
or key  employee  of OXiGENE or of any  affiliate  of  OXiGENE.  As used in this
Agreement,  the term  "Executive-Controlled  Person"  shall  mean  any  company,
partnership,  firm or other entity as to which Executive possesses,  directly or
indirectly,  the power to direct or cause the  direction of the  management  and
policies of such entity, whether through the ownership of voting securities,  by
contract or otherwise.  Notwithstanding the foregoing,  this provision shall not
apply to the  solicitation  of  individuals  who have, for at least one (1) year
prior to the Termination Date, not been employed by OXiGENE,

     7.2(a) Executive  acknowledges  that, through his status as Chief Operating
Officer of OXiGENE, he has, and will have, possession of important, confidential
information  and  knowledge  as to the  business of OXiGENE and its  affiliates,
including,  but not  limited  to,  information  related  to drugs and  compounds
developed  or  under   development  by  the  Company,   financial   results  and
projections,  future plans, the provisions of other important  contracts entered
into  by  OXiGENE  and  its  affiliates,   possible   acquisitions  and  similar
information.   Executive   agrees  that  all  such  knowledge  and   information
constitutes a vital part of the business of OXiGENE and its affiliates and is by
its nature trade secrets and confidential information proprietary to OXIGENE and
its affiliates (collectively, "Confidential Information"). Executive agrees that
he shall not,  at any time,  whether  while  employed  by  OXiGENE or  following
termination of Executive's  employment  with OXiGENE for any reason,  whether by
OXiGENE  or by  Executive,  divulge,  communicate,  furnish  or make  accessible
(whether orally or in writing or in books,  articles or any other medium) to any
individual,  firm, partnership or corporation, any knowledge or information with
respect to Confidential  Information directly or indirectly useful in any aspect
of the business of OXIGENE or any of its  affiliates.  As used in the  preceding
sentence,   "Confidential  Information"  shall  not  include  any  knowledge  or
information that: (i) is or becomes available to others,  other than as a result
of breach by Executive of this Section 7.2; (ii) was available to Executive on a
nonconfidential basis prior to its disclosure to Executive through his status as
an officer or employee of OXiGENE or any affiliate;  (iii) becomes  available to
Executive on a nonconfidential basis from a third party (other than OXIGENE, any
affiliate  or any  of its or  their  representatives)  who is not  bound  by any
confidentiality  obligation to OXiGENE or any  affiliate;  (iv) was known by the
Executive  prior to his  employment  by  OXiGENE  as  evidenced  by  Executive's
pre-existing written records; (v) was not maintained as confidential information
by OXiGENE;  (vi) is otherwise  information  known or available within OX1GENE's
industry;  or (vii) is information that is not otherwise  entitled to protection
under applicable law.

     (b) All memoranda, notes, lists, records and other documents or papers (and
all copies  thereof),  including  such items  stored in  computer  memories,  on
microfiche or by any other means,  made or compiled by or on behalf of Executive
or made  available  to him  relating  to  OXiGENE  are and  shall be and  remain
OXiGENE's  property  and  shall  be  delivered  to  OXiGENE  promptly  upon  the
termination  of  Executive's  employment  with  OXiGENE  or at any other time on
request and such information  shall be held  confidential by Executive after the
termination of his employment with OXiGENE for any reason, whether by OXiGENE or
by Executive.

     7.3 The Executive grants the Company and each affiliate of the Company,  as
appropriate,  all rights in and to the contribution made by the Executive to any
projects or matters on which the Executive  worked during the  Employment  Term.
The Executive  acknowledges  that each such matter and the contribution  made by
the Executive  thereto shall  constitute a work made for hire within the meaning
of the United  States  copyright  law and other  applicable  laws,  The  Company
reserves  all rights  with  respect to  information  relating  to the  Company's
products, including, but not limited to, the right to apply for patents.

     7.4 The  provisions  contained  in this  Section 7 as to the time  periods,
scope of activities,  persons or entities affected,  and territories  restricted
shall be deemed divisible so that, if any provision  contained in this Section 7
is determined to be invalid or  unenforceable,  such provisions  shall be deemed
modified  so as to  be  valid  and  enforceable  to  the  full  extent  lawfully
permitted.

     7.5 Executive  agrees that the  provisions of this Section 7 are reasonable
and necessary for the  protection of OXiGENE and that they may not be adequately
enforced by an action for damages and that, in the event of a breach  thereof by
Executive or any Executive-Controlled Person, OXiGENE shall be entitled to apply
for and  obtain  injunctive  relief in any court of  competent  jurisdiction  to
restrain  the breach or  threatened  breach of such  violation  or  otherwise to
enforce  specifically  such  provisions  against  such  violation,  without  the
necessity of the posting of any bond by OXiGENE. Executive further covenants and
agrees  that if he shall  violate  any of his  covenants  under this  Section 7,
OXiGENE  shall be  entitled  to an  accounting  and  repayment  of all  profits,
compensation,   commissions,  remuneration  or  other  benefits  that  Executive
directly or indirectly  has realized  and/or may realize as a result of, growing
out of or in connection with any such violation.  Such a remedy shall,  however,
be  cumulative  and not  exclusive  and shall be in addition  to any  injunctive
relief  or other  legal  or  equitable  remedy  to  which  OXiGENE  is or may be
entitled.

8. Taxes

     Any  amounts  payable  to the  Executive  hereunder  shall  be  paid to the
Executive  subject to all  applicable  taxes  required to be withheld by OXiGENE
pursuant  to  federal,  state or  local  law.  The  Executive  shall  be  solely
responsible  for all taxes  imposed on the Executive by reason of his receipt of
any amounts of compensation or benefits payable hereunder.

     8A. Indemnification

     OXiGENE shall  indemnify the  Executive for all claims,  losses,  expenses,
costs,  obligations,  and liabilities of every nature whatsoever incurred by the
Executive  as a result of the  Executive's  acts or  omissions as an employee of
OXiGENE, but excluding from such indemnification any claims,  losses,  expenses,
costs, obligations,  or liabilities incurred by the Executive as a result of the
Executive's bad faith, willful misconduct or gross negligence.

     8B. Attorney's Fees and Expenses

     OXiGENE and the Executive agree that in the event of litigation arising out
of or  relating to this  Agreement,  the  prevailing  party shall be entitled to
reimbursement from the other party of the prevailing party's reasonable attorney
fees and expenses.

9. Amendments

     This Agreement may not be altered,  modified or amended except by a written
instrument signed by each of the parties hereto.

10. Assignment

     [Neither  this  Agreement  nor any of the rights or  obligations  hereunder
shall be assigned or  delegated by any party  hereto  without the prior  written
consent of the other party;  provided,  however,  that any payments and benefits
owed to Executive  under this Agreement  shall inure to the benefit of his heirs
and personal representatives

11. Waiver

     Waiver by any party  hereto of any breach or default by any other  party of
any of the terms of this  Agreement  shall not  operate as a waiver of any other
breach or default,  whether  similar to or different  from the breach or default
waived.

12. Severability

     In the event that any one or more of the provisions of this Agreement shall
be or become  invalid,  illegal or  unenforceable  in any respect the  validity,
legality and enforceability of the remaining  provisions  contained herein shall
not be affected thereby.

13. Notices

     All notices and other  communications  provided for in this Agreement shall
be in  writing  and shall be deemed to have  been  duly  given  when  personally
delivered or when mailed by registered mail, return receipt  requested,  postage
prepaid, addressed as follows:

                           If to Executive, to him as follows:

                           Dr. David Chaplin
                           14, Plowden Park
                           Aston Rowant
                           Watlington
                           Oxfordshire  OX9 5SX
                           U.K.

                           If to OXiGENE, to it as follows:

                           OXiGENE Inc.
                           321 Arsenal St.
                           Watertown, MA 02472
                           Attention:  Fred Driscoll

or to such other  address or such other  person as  Executive  or OXiGENE  shall
designate in writing in  accordance  with this  Section 13,  except that notices
regarding changes in notices shall be effective only upon receipt.

14. Headings

     Headings to  Sections  in this  Agreement  are for the  convenience  of the
parties  only and are not  intended to be a part of, or to affect the meaning or
interpretation of, this Agreement.

15. Governing Law

     This  Agreement  shall  be  governed  by the  laws of the  Commonwealth  of
Massachusetts  without  reference to the principles of conflict of laws. Each of
the parties hereto consents to the  jurisdiction of the federal and state courts
of the Commonwealth of Massachusetts in connection with any claim or controversy
arising out of or connected  with this  Agreement,  and said courts shall be the
exclusive forum for the resolution of any such claim or controversy.  Service of
process in any such  proceeding  may be made upon each of the parties  hereto at
the address of such party as determined  in  accordance  with Section 13 of this
Agreement,  subject to the applicable rules of the court in which such action is
brought

16. All Other Agreements Superseded

     This Agreement  contains the entire agreement between Executive and OXiGENE
with respect to all matters relating to Executive's employment with OXIGENE and,
as of the date hereof, will supersede and replace any other agreements,  written
or oral,  between the parties relating to the terms or conditions of Executive's
employment with OXiGENE, provided, however, that nothing in this Agreement shall
amend or affect any  options  previously  granted to  Executive  pursuant to the
Stock Plan.

     IN WITNESS WHEREOF,  OXiGENE and Executive have caused this Agreement to be
executed as of the date first above written.


                           /s/ David Chaplin
                           -----------------
                               David Chaplin


                           OXiGENE Inc.

                           By:/s/ Frederick W. Driscoll
                           ----------------------------
                           Name:  Frederick W. Driscoll
                           Title: President & CFO